50:
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130:
pruritic and axillary papules in one study. However, irritation limited drug use to short term only. Clindamycin mixed with pimecrolimus cream and benzoyl peroxide was also effective. Clindamycin is used to inhibit bacterial growth and is used when treating staphylococcal and streptococcal infections.
102:
Symptoms may appear suddenly following any condition of heat, humidity, or friction. The apocrine glands (sweat glands) are the site of the Fox–Fordyce disease. Sudden appearance of raised bumps (papules) near the apocrine glands is characteristic of the disease. Papules are mostly skin colored, dome
138:
It most commonly affects women aged 13–35 years, approximately puberty through their prime. Some reports show affected women to men at 9:1. Rare cases have been shown to affect post-menopausal women, children, and men. Incident report is currently unknown. Although rare, men and children have been
129:
With only a small number of case reports, treatment can be difficult and focuses primarily on axillary disease and specific symptoms. First line treatment includes topical and intralesional glucocorticoids. Specific therapies include estrogen hormones and steroid creams. Use of tretinoin reduced
120:
Clinical evaluation along with identification of typical symptoms such as the eruption of papules on the apocrine glands along with a patient history report is used to diagnose the disease. Surgical removal along with a microscopic evaluation by a dermatopathologist is the most reliable form of
111:
Exact cause of Fox-Fordyce is currently unknown. Studies have not been able to confirm if apocrine gland duct obstruction is required for development. It is speculated that gland duct rupture causes inflammation. Inflammatory response includes white blood cells.
139:
shown to be affected. Heat, humidity, stress, and exercise have been shown to worsen symptoms. Rate of incidence is currently unknown. Fox-Fordyce has also been shown to be severe during menstruation and spontaneously disappear during pregnancy.
86:. The inflammation is often accompanied by intense itching. In general, the disease often causes skin to darken near the affected area and raised bumps or papules to appear. In addition, hair follicles can become damaged which cause hair loss.
381:
366:
103:
shaped, and itchy. Papules can be found at the sweat glands in addition to periareolar, inframammary and pubic areas. Hair follicles can become damaged as well and can result in hair loss in the affected area.
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90:
is very similar, but tends to have a secondary bacterial infection so that pus-draining sinuses are formed. It is a very devastating
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1991:
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888:
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735:
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267:
205:
188:
38:
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2187:
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2018:
1628:
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1326:
908:
853:
800:
750:
588:
557:
311:
148:
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1981:
1927:
1907:
1822:
1389:
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1174:
1112:
1088:
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508:
333:
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290:
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2001:
1728:
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390:
79:
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2154:
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878:
720:
715:
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690:
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549:
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2573:
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2384:
2109:
1959:
1944:
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1458:
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87:
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544:
531:
67:
43:
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459:
412:
285:
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2144:
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1244:
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583:
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513:
375:
315:
2593:
2335:
2330:
2194:
2172:
2047:
2011:
1802:
1259:
1204:
1147:
1137:
1004:
843:
824:
630:
575:
442:
418:
338:
238:
75:
2099:
1876:
1794:
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1618:
1264:
1159:
1154:
863:
829:
620:
71:
31:
358:
2578:
2038:
2006:
1899:
1219:
370:
302:"Two Cases of a Rare Papular Disease Affecting the Axillary Region".
423:
1374:
91:
83:
1849:
463:
237:
Meehan, Shane A.; Robinson, Maria; Yost, John (December 2012).
94:
disease that does not have universally curative treatments.
1845:
206:"Fox Fordyce Disease - Symptoms, Causes, Treatment | NORD"
348:
2536:
2474:
2235:
2163:
2118:
2027:
1898:
1883:
1821:
1793:
1694:
1683:
1484:
1425:
1372:
1337:
1218:
1074:
1063:
995:
823:
814:
498:
433:
352:
37:
26:
21:
1507:Disseminate and recurrent infundibulofolliculitis
606:Congenital onychodysplasia of the index fingers
272:NORD (National Organization for Rare Disorders)
1861:
1517:Erythromelanosis follicularis faciei et colli
475:
185:Fitzpatrick's Dermatology in General Medicine
8:
2150:Reproductive endocrinology and infertility
1895:
1868:
1854:
1846:
1691:
1071:
820:
482:
468:
460:
349:
48:
18:
2491:Bachelor of Medicine, Bachelor of Surgery
1512:Erosive pustular dermatosis of the scalp
932:Central centrifugal cicatricial alopecia
176:
1492:Acrokeratosis paraneoplastica of Bazex
7:
2629:
2390:Physical medicine and rehabilitation
1532:Intermittent hair–follicle dystrophy
262:
260:
258:
256:
232:
230:
228:
226:
2639:
1469:Recurrent palmoplantar hidradenitis
1350:Idiopathic facial aseptic granuloma
987:Marie Unna hereditary hypotrichosis
2526:Medical Scientist Training Program
1210:Lupus miliaris disseminatus faciei
957:Dissecting cellulitis of the scalp
187:. (6th ed.). McGraw-Hill. p. 709.
14:
2685:Conditions of the skin appendages
1474:Neutrophilic eccrine hidradenitis
1233:Granulomatous perioral dermatitis
2658:
2648:
2638:
2628:
2619:
2618:
2659:
1634:Traumatic anserine folliculosis
1345:Granulomatous facial dermatitis
2516:Doctor of Osteopathic Medicine
1950:Oral and maxillofacial surgery
651:Malalignment of the nail plate
1:
1282:Erythrotelangiectatic rosacea
74:inflammatory response to the
2496:Bachelor of Medical Sciences
2263:Neurosurgical anesthesiology
1537:Keratosis pilaris atropicans
1440:Folliculitis nares perforans
165:List of cutaneous conditions
70:ducts with a secondary, non-
1307:Persistent edema of rosacea
2701:
1739:Postmiliarial hypohidrosis
1567:Menkes kinky hair syndrome
982:Frontal fibrosing alopecia
786:Staining of the nail plate
646:Longitudinal erythronychia
641:Lichen planus of the nails
243:Dermatology Online Journal
183:Freedberg, et al. (2003).
2614:
1624:Rubinstein–Taybi syndrome
1452:Pseudofolliculitis barbae
746:Pterygium inversum unguis
316:10.1001/archderm.138.1.16
2450:Transplantation medicine
2341:Clinical neurophysiology
2258:Obstetric anesthesiology
2178:Interventional radiology
1938:Digestive system surgery
1666:Uncombable hair syndrome
1650:Trichorrhexis invaginata
1464:Hidradenitis suppurativa
1322:Periorificial dermatitis
2321:Intensive care medicine
2295:Mass gathering medicine
2140:Maternal–fetal medicine
1644:Trichomycosis axillaris
1577:Parakeratosis pustulosa
1094:Acne miliaris necrotica
875:(male-pattern baldness)
839:noncicatricial alopecia
756:Purpura of the nail bed
304:Archives of Dermatology
1913:Cardiothoracic surgery
1661:Trichostasis spinulosa
1355:Periorbital dermatitis
1272:Papulopustular rosacea
1190:Acne with facial edema
1180:Acne keloidalis nuchae
967:Folliculitis decalvans
962:Graham-Little syndrome
711:Onychoptosis defluvium
2564:Personalized medicine
2423:Reproductive medicine
2348:Occupational medicine
2302:Evolutionary medicine
1831:Sebaceous hyperplasia
1746:Granulosis rubra nasi
1609:Pityriasis amiantacea
1562:Loose anagen syndrome
1502:Bubble hair deformity
1292:Gram-negative rosacea
1055:Nevoid hypertrichosis
927:Pseudopelade of Brocq
806:Twenty-nail dystrophy
676:Nail–patella syndrome
656:Median nail dystrophy
268:"Fox Fordyce Disease"
239:"Fox-Fordyce disease"
2584:Traditional medicine
2544:Alternative medicine
2411:Addiction psychiatry
2225:Transfusion medicine
2220:Medical microbiology
2135:Gynecologic oncology
1987:Reproductive surgery
1714:Miliaria crystalline
1655:Trichorrhexis nodosa
922:cicatricial alopecia
904:Alopecia neoplastica
899:Trichorrhexis nodosa
527:Yellow nail syndrome
153:John Addison Fordyce
2606:History of medicine
2589:Veterinary medicine
2396:Preventive medicine
2248:Adolescent medicine
2090:Infectious diseases
1813:Fox–Fordyce disease
1598:Pili pseudoannulati
1552:Lichen planopilaris
1527:Hair follicle nevus
1445:Tufted folliculitis
1228:Perioral dermatitis
977:Triangular alopecia
894:Lichen planopilaris
873:Androgenic alopecia
776:Splinter hemorrhage
771:Shell nail syndrome
616:Half and half nails
334:Fox-Fordyce Disease
60:Fox–Fordyce disease
22:Fox–Fordyce disease
2554:Molecular oncology
2511:Doctor of Medicine
2501:Master of Medicine
2418:Radiation oncology
2290:Emergency medicine
2243:Addiction medicine
2210:Clinical chemistry
2205:Clinical pathology
1997:Transplant surgery
1955:Orthopedic surgery
1933:Colorectal surgery
1734:Occlusion miliaria
1724:Miliaria pustulosa
1614:Plica neuropathica
1312:Rosacea conglobata
1123:Acne medicamentosa
942:Traumatic alopecia
796:Subungual hematoma
434:External resources
98:Signs and symptoms
2672:
2671:
2506:Master of Surgery
2470:
2469:
2455:Tropical medicine
2401:Prison healthcare
2316:Hospital medicine
2280:Disaster medicine
2270:Aviation medicine
2085:Hospital medicine
1992:Surgical oncology
1977:Pediatric surgery
1971:
1918:Endocrine surgery
1843:
1842:
1839:
1838:
1719:Miliaria profunda
1679:
1678:
1671:Woolly hair nevus
1557:Lichen spinulosus
1395:Trichilemmal cyst
1368:
1367:
1287:Glandular rosacea
1240:Phymatous rosacea
1170:Occupational acne
952:Hot comb alopecia
937:Pressure alopecia
914:Alopecia mucinosa
889:Traction alopecia
884:Telogen effluvium
457:
456:
57:
56:
16:Medical condition
2692:
2662:
2661:
2652:
2642:
2641:
2632:
2631:
2622:
2621:
2326:Medical genetics
2311:General practice
2188:Nuclear medicine
2063:Gastroenterology
2019:Vascular surgery
1969:
1896:
1870:
1863:
1856:
1847:
1692:
1629:Setleis syndrome
1593:Pili multigemini
1327:Pyoderma faciale
1072:
909:Anagen effluvium
821:
751:Pterygium unguis
671:Muehrcke's lines
558:Onychotillomania
484:
477:
470:
461:
350:
320:
319:
299:
293:
282:
276:
275:
264:
251:
250:
234:
221:
220:
218:
216:
210:rarediseases.org
202:
196:
181:
149:George Henry Fox
147:It is named for
66:blockage of the
53:
52:
19:
2700:
2699:
2695:
2694:
2693:
2691:
2690:
2689:
2675:
2674:
2673:
2668:
2610:
2599:Chief physician
2532:
2477:
2466:
2460:Travel medicine
2445:Sports medicine
2428:Sexual medicine
2368:Palliative care
2363:Pain management
2307:Family medicine
2285:Diving medicine
2231:
2159:
2121:
2114:
2030:
2023:
1982:Plastic surgery
1928:General surgery
1908:Cardiac surgery
1889:
1887:
1879:
1874:
1844:
1835:
1817:
1789:
1686:
1675:
1648:Trichorrhexis (
1480:
1421:
1390:Epidermoid cyst
1364:
1333:
1297:Steroid rosacea
1214:
1175:Acne aestivalis
1113:Excoriated acne
1089:Acne conglobata
1066:
1059:
991:
828:
810:
781:Spotted lunulae
741:Psoriatic nails
696:Onychomatricoma
509:Onychogryphosis
494:
492:skin appendages
488:
458:
453:
452:
429:
428:
361:
347:
329:
327:Further reading
324:
323:
310:(1): 16. 2002.
301:
300:
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17:
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5:
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2586:
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2546:
2540:
2538:
2537:Related topics
2534:
2533:
2531:
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2518:
2513:
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2503:
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2493:
2488:
2486:Medical school
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2472:
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2467:
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2464:
2463:
2462:
2452:
2447:
2442:
2440:Sleep medicine
2437:
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2415:
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2304:
2299:
2298:
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2277:
2272:
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2265:
2260:
2253:Anesthesiology
2250:
2245:
2239:
2237:
2233:
2232:
2230:
2229:
2228:
2227:
2222:
2217:
2212:
2207:
2202:
2192:
2191:
2190:
2185:
2183:Neuroradiology
2180:
2169:
2167:
2161:
2160:
2158:
2157:
2152:
2147:
2142:
2137:
2132:
2126:
2124:
2120:Obstetrics and
2116:
2115:
2113:
2112:
2107:
2102:
2097:
2092:
2087:
2082:
2077:
2072:
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2055:
2050:
2045:
2035:
2033:
2025:
2024:
2022:
2021:
2016:
2015:
2014:
2004:
2002:Trauma surgery
1999:
1994:
1989:
1984:
1979:
1974:
1973:
1972:
1965:Otolaryngology
1962:
1957:
1952:
1947:
1942:
1941:
1940:
1935:
1925:
1920:
1915:
1910:
1904:
1902:
1893:
1891:subspecialties
1881:
1880:
1875:
1873:
1872:
1865:
1858:
1850:
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1840:
1837:
1836:
1834:
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1790:
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1787:
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1785:
1775:
1774:
1773:
1768:
1763:
1753:
1751:Ross' syndrome
1748:
1743:
1742:
1741:
1736:
1731:
1729:Miliaria rubra
1726:
1721:
1716:
1711:
1709:Colloid milium
1700:
1698:
1689:
1681:
1680:
1677:
1676:
1674:
1673:
1668:
1663:
1658:
1652:
1646:
1641:
1636:
1631:
1626:
1621:
1616:
1611:
1606:
1600:
1595:
1590:
1588:Pili bifurcati
1585:
1579:
1574:
1569:
1564:
1559:
1554:
1549:
1547:Koenen's tumor
1544:
1539:
1534:
1529:
1524:
1519:
1514:
1509:
1504:
1499:
1497:Acroosteolysis
1494:
1488:
1486:
1482:
1481:
1479:
1478:
1477:
1476:
1471:
1466:
1455:
1454:
1449:
1448:
1447:
1442:
1431:
1429:
1423:
1422:
1420:
1419:
1414:
1413:
1412:
1407:
1401:Steatocystoma
1399:
1398:
1397:
1392:
1384:Sebaceous cyst
1379:
1377:
1370:
1369:
1366:
1365:
1363:
1362:
1360:SAPHO syndrome
1357:
1352:
1347:
1341:
1339:
1335:
1334:
1332:
1331:
1330:
1329:
1324:
1314:
1309:
1304:
1302:Ocular rosacea
1299:
1294:
1289:
1284:
1279:
1277:Lupoid rosacea
1274:
1269:
1268:
1267:
1262:
1257:
1252:
1247:
1237:
1236:
1235:
1224:
1222:
1216:
1215:
1213:
1212:
1207:
1202:
1200:Acne necrotica
1197:
1192:
1187:
1185:Acne mechanica
1182:
1177:
1172:
1167:
1165:Acne cosmetica
1162:
1157:
1152:
1151:
1150:
1145:
1140:
1130:
1120:
1118:Acne fulminans
1115:
1110:
1104:Infantile acne
1101:
1096:
1091:
1086:
1080:
1078:
1069:
1061:
1060:
1058:
1057:
1052:
1047:
1046:
1045:
1040:
1035:
1027:
1026:
1025:
1020:
1015:
1007:
1001:
999:
997:Hypertrichosis
993:
992:
990:
989:
984:
979:
970:
969:
964:
959:
954:
949:
947:Tumor alopecia
944:
939:
934:
929:
917:
916:
911:
906:
901:
896:
891:
886:
881:
876:
869:
868:
867:
866:
861:
856:
851:
834:
832:
818:
812:
811:
809:
808:
803:
798:
793:
791:Stippled nails
788:
783:
778:
773:
768:
763:
758:
753:
748:
743:
738:
736:Plummer's nail
733:
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353:Classification
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82:debris in the
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2569:Public health
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2549:Allied health
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2215:Cytopathology
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2155:Urogynecology
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2058:Endocrinology
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1808:Chromhidrosis
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1756:Hyperhidrosis
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1583:Pili annulati
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1250:Blepharophyma
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1108:Neonatal acne
1105:
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1099:Tropical acne
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1084:Acne vulgaris
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801:Terry's nails
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721:Onychoschizia
719:
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716:Onychorrhexis
714:
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701:Onychomycosis
699:
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550:Nail clubbing
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490:Disorders of
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291:Who Named It?
288:
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193:0-07-138076-0
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36:
33:
29:
25:
20:
2574:Rural health
2559:Nanomedicine
2110:Rheumatology
2041: /
1960:Hand surgery
1945:Neurosurgery
1812:
1778:Hypohidrosis
1771:Palmoplantar
1639:Trichomegaly
1542:Kinking hair
1459:Hidradenitis
1435:Folliculitis
1427:Inflammation
1316:
1133:Halogen acne
1127:steroid acne
973:
920:
837:
761:Racquet nail
731:Pincer nails
706:Onychophosis
666:Melanonychia
636:Ingrown nail
626:Hapalonychia
601:Chevron nail
571:Ingrown nail
563:Onychophagia
537:Azure lunula
522:Beau's lines
441:
417:
406:
395:
380:
365:
332:
307:
303:
297:
284:
280:
271:
246:
242:
213:. Retrieved
209:
200:
184:
179:
146:
137:
134:Epidemiology
128:
119:
110:
101:
88:Hidradenitis
59:
58:
2644:Wikiproject
2433:Venereology
2378:Neonatology
2275:Dermatology
2130:Gynaecology
2122:gynaecology
2105:Pulmonology
1923:Eye surgery
1885:Specialties
1761:Generalized
1572:Monilethrix
1373:Follicular
1255:Gnathophyma
1195:Pomade acne
1050:Prepubertal
1033:generalised
1029:Congenital
1018:generalised
859:universalis
766:Red lunulae
726:Platonychia
686:Onycholysis
661:Mees' lines
611:Green nails
582:ungrouped:
545:Koilonychia
532:Leukonychia
507:thickness:
121:diagnosis.
68:sweat gland
44:Dermatology
27:Other names
2406:Psychiatry
2392:(PM&R)
2385:Phlebology
2373:Pediatrics
2200:Anatomical
2165:Diagnostic
2145:Obstetrics
2095:Nephrology
2080:Hematology
2075:Geriatrics
2068:Hepatology
2053:Cardiology
2043:Immunology
1783:Anhidrosis
1603:Pili torti
1522:Hair casts
1245:Rhinophyma
1143:Bromoderma
974:ungrouped:
584:Paronychia
556:behavior:
514:Onychauxis
408:DiseasesDB
171:References
76:secretions
2594:Physician
2478:education
2336:Neurology
2331:Narcology
2195:Pathology
2173:Radiology
2048:Angiology
2012:Andrology
1823:Sebaceous
1803:Body odor
1766:Gustatory
1485:Ungrouped
1410:multiplex
1338:Ungrouped
1260:Metophyma
1205:Blackhead
1148:Chloracne
1138:Iododerma
1065:Acneiform
1038:localised
1023:patterned
1013:localised
1009:Acquired
1005:Hirsutism
825:Hair loss
631:Hook nail
576:Anonychia
443:eMedicine
419:SNOMED CT
339:eMedicine
286:synd/1512
125:Treatment
116:Diagnosis
72:bacterial
39:Specialty
30:Apocrine
2679:Category
2624:Category
2100:Oncology
2031:medicine
2029:Internal
1877:Medicine
1795:Apocrine
1704:Miliaria
1619:Poliosis
1317:variants
1265:Otophyma
1160:Tar acne
1155:Oil acne
1067:eruption
1043:X-linked
864:Ophiasis
844:Alopecia
830:Baldness
621:Hangnail
448:derm/160
424:65038009
215:28 April
159:See also
80:cellular
32:miliaria
2664:Outline
2634:Commons
2579:Therapy
2476:Medical
2039:Allergy
2007:Urology
1900:Surgery
1696:Eccrine
1405:simplex
1220:Rosacea
1125:(e.g.,
854:totalis
594:Chronic
569:other:
543:shape:
520:color:
402:D005588
64:chronic
2654:Portal
2521:MD–PhD
1687:glands
1581:Pili (
849:areata
391:705.82
191:
143:Eponym
107:Causes
46:
2236:Other
1685:Sweat
1417:Milia
1375:cysts
589:Acute
413:30029
376:L75.2
249:(12).
84:cysts
62:is a
1076:Acne
816:Hair
500:Nail
397:MeSH
386:9-CM
217:2023
189:ISBN
151:and
92:skin
78:and
1970:ENT
1888:and
382:ICD
367:ICD
337:at
312:doi
308:138
289:at
2681::
2309:/
1386:"
446::
422::
411::
400::
389::
374::
371:10
306:.
270:.
255:^
247:18
245:.
241:.
225:^
208:.
155:.
1869:e
1862:t
1855:v
1657:)
1605:)
1382:"
1129:)
1106:/
924::
841::
827:/
483:e
476:t
469:v
384:-
369:-
359:D
318:.
314::
274:.
219:.
195:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
