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available, it can only increase a patient's life by three months. Sabio researches p38gamma, a kinase protein that is expressed excessively in patients with hepatocellular carcinoma, and whether inhibition of this protein could reduce the cancer. She is developing drugs that inhibit p38gamma for the
141:, and graduated in 2000 with an extraordinary award. She has said that she chose to study veterinary science as she liked animals very much, and that this could help her understand the origins of diseases. She moved to the
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197:, as an endocrine organ she believes people will think more carefully about how to care for it. She believes that the best antidotes to obesity are exercise and diet. In 2017 Sabio was inducted into the
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Sabio has been involved in several initiatives to promote women in science. She has called for more research into the symptoms of disease experienced by women.
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in 2011. Sabio is investigating the molecular mechanisms that are associated with obesity, and how they can predispose patients to other conditions such as
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She believes that obesity will be a major challenge for future generations, and it should be taken as seriously as smoking. By considering fat,
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181:. Hepatocellular carcinoma is a type of liver carcinoma, and the second most common cause of cancer-related deaths. Whilst there is
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European graduate student. She completed her doctorate on p38 delta kinases in 2005. Whilst her PhD had taught her how to research
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121:. Her research considers stress-activated kinases and the development of diseases associated with obesity. She was awarded the
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in 1977. She attended the
Colegio del Santo Ángel and the Institute of San Fernando. She studied veterinary sciences at the
681:
965:"Guadalupe Sabio, Ana Pastor, Olga Felip, Joana Pastrana, Sonia Díez y Mar González, galardonadas en la VI Premios MAS"
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816:"Guadalupe Sabio: "la presencia minoritaria de mujeres en la ciencia es algo que se está empezando a corregir ahora""
157:, Sabio was keen to translate her research into mouse models. She joined the research group of Roger Davis at the
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607:"Investigar con perspectiva de género es básico para salvar la vida de las mujeres y prevenir enfermedades"
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733:"La investigadora del CNIC Guadalupe Sabio defiende en la UCLM el papel de la grasa como órgano endocrino"
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757:
758:"Hay muchas farmacéuticas en busca de la pastilla contra la obesidad. Pero aún no existe nada efectivo"
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Scientist Prize in 2012 and selected as one of the Top 100 Women
Leaders in Spain in 2017.
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841:"Las científicas españolas incrementan su presencia en Knowledge (XXG) - Grupo L'Oréal"
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216:"A stress signalling pathway in adipose tissue regulates hepatic insulin resistance"
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where she studied the impact of stress on kinases proteins. In 2009 she was awarded
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940:"Nueve mujeres sobresalientes y una recién nacida, ganadoras de los Premios MAS"
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790:"Guadalupe Sabio entra a formar parte de los jóvenes más brillantes de la EMBO"
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915:"La pacense Guadalupe Sabio, premiada por una investigación sobre la obesidad"
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267:"Phosphorylation by p38 MAPK as an Alternative Pathway for GSK3β Inactivation"
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682:"Guadalupe Sabio: "Hacen falta medidas más drásticas contra la obesidad""
657:"Descubren una nueva diana terapéutica para tratar el cáncer de hígado"
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44:
579:"La científica Guadalupe Sabio: Estar obeso es jugar a la ruleta rusa"
361:"p38γ is essential for cell cycle progression and liver tumorigenesis"
632:"Guadalupe Sabio defiende el papel de la grasa como órgano endocrino"
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496:"Vencer la obesidad puede ser más difícil que vencer el cáncer"
113:(born 4 June 1977) is a Spanish scientist and Professor at the
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treatment of liver cancer. She has also investigated the
890:"Guadalupe Sabio: 'La base del éxito es saber fracasar'"
866:"Guadalupe Sabio, 2012 FPdGi Scientific Research Award"
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funding to join a biotechnology laboratory in Spain.
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427:Guadalupe Sabio winning three Star of Madrid award
190:(JNK) protein, which is known to control obesity.
636:eldiadigital.es Periódico de Castilla-La Mancha
175:Spanish National Cardiovascular Research Centre
145:for her doctoral studies, where she joined the
115:Spanish National Cardiovascular Research Centre
85:Spanish National Cardiovascular Research Centre
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434:European Society for Clinical Investigation
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441:L'Oréal-UNESCO For Women in Science Award
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436:Young Investigator Award Basic Research.
318:"TNF and MAP kinase signalling pathways"
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460:European Molecular Biology Organization
199:European Molecular Biology Organization
455:2014, 2015, 2017 Top 100 Women Leaders
472:2019 Woman to Watch, Science Category
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731:Mancha, Universidad de Castilla-La.
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551:"Alumni Interview | Guadalupe Sabio"
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452:2014 Star of the Community of Madrid
737:Universidad de Castilla - La Mancha
1016:Alumni of the University of Dundee
521:"Jurado-Dra. Guadalupe Sabio Buzo"
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756:Moreno, Ana García (2019-08-06).
502:(in European Spanish). 2016-12-18
630:ELDIAdigital, eldiadigital es.
359:Sabio, Guadalupe (2019-05-02).
316:Sabio, Guadalupe (2014-06-01).
265:Sabio, Guadalupe (2008-05-02).
214:Sabio, Guadalupe (2008-12-05).
159:Howard Hughes Medical Institute
89:Howard Hughes Medical Institute
525:Premios a la investigación FJS
462:Leonardo de Biomedicina Fellow
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447:Princess of Girona Foundation
123:Princess of Girona Foundation
707:"Peligros sobre la obesidad"
119:Carlos III Health Institute
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814:López, Pepa (2019-07-19).
334:10.1016/j.smim.2014.02.009
385:10.1038/s41586-019-1112-8
139:University of Extremadura
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64:University of Extremadura
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1006:Spanish women scientists
921:(in Spanish). 2018-09-13
896:(in Spanish). 2014-03-27
796:(in Spanish). 2017-11-03
688:(in Spanish). 2019-10-27
663:(in Spanish). 2019-04-10
188:C-Jun N-terminal kinases
179:hepatocellular carcinoma
151:Medical Research Council
129:Early life and education
1011:Spanish women academics
291:10.1126/science.1156037
240:10.1126/science.1160794
117:, which is part of the
469:Young Researcher Award
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322:Seminars in Immunology
163:Santiago Ramón y Cajal
944:MAS: Mujeres a seguir
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208:Selected publications
147:University of Dundee
111:Guadalupe Sabio Buzo
68:University of Dundee
377:2019Natur.568..557T
283:2008Sci...320..667T
232:2008Sci...322.1539S
226:(5907): 1539–1543.
169:Research and career
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419:Awards and honours
394:20.500.12105/11565
133:Sabio was born in
16:Spanish biochemist
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870:en.fpdgi.org
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990:Categories
975:2019-11-03
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925:2019-11-03
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477:References
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411:106411585
103:Sabio Lab
403:30971822
352:24647229
309:18451303
258:19056984
155:in vitro
894:ELMUNDO
762:El País
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373:Bibcode
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