225:, Erhardt succeeded Bockmühl as the head of the entire pharmaceutical research division of Hoechst AG. In 1951 he became a deputy member of the Board, and two years later a regular member of Hoechst AG's Board of Directors. During his time on the Board of Hoechst AG and after his retirement in 1961 Ehrhart maintained a laboratory which he personally supervised.
276:
as a central structural element. In late 1939 they gave the compound (±)-6-dimethylamino-4, 4-diphenylheptan-3-one the development code VA 10820. In the first animal experiments, Ehrhart and Bockmühl found that VA 10820 had a five- to ten-fold stronger analgesic effect than pethidine. In mid-1941, VA
667:
281:. Bockmühl and Ehrhart filed a patent on 11 September 1938 for the whole substance class. Due to the turmoil of the Second World War, Amidon was not clinically tested any further. Due to the expropriation of
269:
Ehrhart's main focus was the development of new analgesics (painkillers). His most notable contribution is the development of methadone, which he synthesized together with his boss Bockmühl in 1939.
258:
516:
302:. In January 1949 Hoechst AG, which had re-formed after the dissolution of IG Farben with Ehrhart as its research director, marketed methadone as a strong
221:. Two years later he became the deputy of Max Bockmühl, the head of the pharmaceutical research laboratories of the company. In 1949, after the
652:
647:
672:
328:
286:
615:
642:
466:
Zwischen
Tradition und Fortschritt. Aus der Geschichte der Pharmabereiche von Bayer, Hoechst und Schering von 1935 - 1975.
242:
550:
Deutsches
Reichspatent Nr. 711069, Anmeldedatum: 11. September 1938, Veröffentlichung: 25. September 1941
198:
99:
246:
350:
464:
272:
In the winter of 1937-38, Erhart and Bockmühl began the synthesis of over 300 compounds which contained
250:
662:
657:
238:
234:
217:. Ehrhart received the Victor-Meyer Award for his dissertation. In 1923 he started working for
591:
573:
430:
422:
399:
367:
359:
324:
202:
138:
610:
581:
414:
254:
222:
209:. He served as an artillery officer. After the war he resumed his studies and was awarded a
273:
214:
206:
182:
115:
469:(PDF; 2.3 MB) Dissertation, Johann Wolfgang Goethe-Universität, 2001, pp. 245.
586:
561:
418:
348:
Lindner, E (December 1969). "75th birth anniversary of
Professor Dr. Gustav Ehrhart".
636:
619:
46:
531:Über eine neue Klasse von spasmolytisch und analgetisch wirkenden Verbindungen (I).
285:'s patents and recipes, VA 10820 came to the United States, where it was given the
68:
42:
303:
218:
148:
577:
426:
363:
323:(Drug: Development, Action, Representation). Volume 1, Verlag Chemie, 1973,
295:
290:
282:
210:
194:
178:
174:
133:
110:
668:
Commanders
Crosses of the Order of Merit of the Federal Republic of Germany
595:
434:
371:
167:
164:
89:
79:
233:
Ehrhart was awarded honorary doctorate degrees by the universities of
171:
64:
495:
448:
Prof. Dr. phil. Dr. Dr. h.c. Gustav
Ehrhart wurde 75 Jahre.
479:Österreichisches Ehrendoktorat für Professor Ehrhart.
259:
Grand Merit Cross of the
Federal Republic of Germany
144:
129:
105:
95:
85:
75:
53:
28:
21:
512:Polamidon, ein neues, stark wirkendes Analgetikum.
400:"The early history of methadone. Myths and facts"
548:Verfahren zur Darstellung von basischen Estern.
337:(A century of Chemistry). Econ Verlag, 1900063.
321:Arzneimittel: Entwicklung, Wirkung, Darstellung
393:
391:
389:
8:
163:(21 December 1894 – 11 December 1971) was a
170:. He synthesized the first fully synthetic
213:degree in 1922. One of his professors was
18:
585:
566:Bulletin of the World Health Organization
562:"On pethidine and methadone derivatives"
385:
333:E. Bäumler, G. Ehrhart, V. Muthesius:
257:Medal, and in 1970 he was awarded the
205:. His studies were interrupted by the
7:
189:Education and professional positions
253:. In 1952 Ehrhart was awarded the
14:
537:Volume 561, 1949, pp. 52-85.
520:Volume 3, 1949, pp. 605-606.
398:Defalque, RJ; Wright, AJ (2007).
298:marketed it under the brand name
287:international nonproprietary name
277:10820 was given the generic name
501:Volume 51, 1970, pp. 258.
407:Bulletin of Anesthesia History
1:
653:20th-century German inventors
485:Volume 51, 1970, pp. 390
454:Volume 51, 1970, pp. 64.
419:10.1016/s1522-8649(07)50035-1
648:20th-century German chemists
689:
510:G. Ehrhart, O. Schaumann:
319:H. Alpermann, G. Ehrhart:
294:in 1949. In the same year
16:German chemist (1894–1971)
546:M. Bockmühl, G. Ehrhart:
529:M. Bockmühl, G. Ehrhart:
154:
122:
673:People from Ludwigshafen
624:Die PTA IN DER APOTHEKE.
499:Der praktische Tierarzt.
483:Der praktische Tierarzt.
452:Der praktische Tierarzt.
199:University of Heidelberg
100:University of Heidelberg
643:German organic chemists
626:11, 2011, pp. 20.
351:Arzneimittel-Forschung
335:Ein Jahrhundert Chemie
314:Selected publications
306:under the brand name
265:Products synthesized
560:Wolff, PO (1949).
201:, with a focus on
203:organic chemistry
158:
157:
139:Organic chemistry
124:Scientific career
680:
627:
607:
601:
599:
589:
557:
551:
544:
538:
535:Liebig Ann Chem.
527:
521:
508:
502:
492:
486:
476:
470:
461:
455:
445:
439:
438:
404:
395:
375:
255:Adolf von Baeyer
223:Second World War
193:Ehrhart studied
181:, together with
60:
57:11 December 1971
39:21 December 1894
38:
36:
19:
688:
687:
683:
682:
681:
679:
678:
677:
633:
632:
631:
630:
612:M wie Methadon.
608:
604:
559:
558:
554:
545:
541:
528:
524:
517:Med Monatsschr.
509:
505:
493:
489:
477:
473:
462:
458:
446:
442:
402:
397:
396:
387:
382:
347:
344:
342:Further reading
316:
274:diphenylmethane
267:
231:
215:Theodor Curtius
207:First World War
191:
137:
113:
96:Alma mater
71:
62:
58:
49:
40:
34:
32:
24:
17:
12:
11:
5:
686:
684:
676:
675:
670:
665:
660:
655:
650:
645:
635:
634:
629:
628:
618:2012-09-09 at
602:
572:(2): 193–204.
552:
539:
522:
503:
487:
471:
456:
440:
384:
383:
381:
378:
377:
376:
343:
340:
339:
338:
331:
315:
312:
266:
263:
230:
227:
190:
187:
161:Gustav Ehrhart
156:
155:
152:
151:
146:
142:
141:
131:
127:
126:
120:
119:
107:
106:Known for
103:
102:
97:
93:
92:
87:
83:
82:
77:
73:
72:
63:
61:(aged 76)
55:
51:
50:
41:
30:
26:
25:
23:Gustav Ehrhart
22:
15:
13:
10:
9:
6:
4:
3:
2:
685:
674:
671:
669:
666:
664:
661:
659:
656:
654:
651:
649:
646:
644:
641:
640:
638:
625:
621:
620:archive.today
617:
614:
613:
609:E. M. Stoya:
606:
603:
597:
593:
588:
583:
579:
575:
571:
567:
563:
556:
553:
549:
543:
540:
536:
532:
526:
523:
519:
518:
513:
507:
504:
500:
496:
491:
488:
484:
480:
475:
472:
468:
467:
463:W. Bartmann:
460:
457:
453:
449:
444:
441:
436:
432:
428:
424:
420:
416:
412:
408:
401:
394:
392:
390:
386:
379:
373:
369:
365:
361:
357:
353:
352:
346:
345:
341:
336:
332:
330:
329:3-527-25375-0
326:
322:
318:
317:
313:
311:
309:
305:
301:
297:
293:
292:
288:
284:
280:
275:
270:
264:
262:
260:
256:
252:
248:
244:
240:
236:
228:
226:
224:
220:
216:
212:
208:
204:
200:
196:
188:
186:
184:
180:
176:
173:
169:
166:
162:
153:
150:
147:
143:
140:
135:
132:
128:
125:
121:
117:
112:
109:Synthesis of
108:
104:
101:
98:
94:
91:
88:
84:
81:
78:
74:
70:
66:
56:
52:
48:
44:
31:
27:
20:
623:
611:
605:
569:
565:
555:
547:
542:
534:
530:
525:
515:
511:
506:
498:
494:
490:
482:
478:
474:
465:
459:
451:
447:
443:
410:
406:
358:(12): 2030.
355:
349:
334:
320:
307:
299:
289:
278:
271:
268:
232:
192:
183:Max Bockmühl
160:
159:
145:Institutions
123:
116:Max Bockmühl
69:West Germany
59:(1971-12-11)
43:Ludwigshafen
663:1971 deaths
658:1894 births
413:(3): 13–6.
86:Citizenship
76:Nationality
637:Categories
380:References
308:Polamidone
304:painkiller
219:Hoechst AG
149:Hoechst AG
35:1894-12-21
578:1564-0604
427:1522-8649
364:0004-4172
300:Dolophine
296:Eli Lilly
291:methadone
283:IG Farben
247:Stuttgart
243:Frankfurt
211:doctorate
195:chemistry
179:methadone
175:analgesic
134:Chemistry
111:methadone
616:Archived
596:15409516
435:20506765
587:2553950
372:4908264
197:at the
168:chemist
47:Germany
594:
584:
576:
433:
425:
370:
362:
327:
279:Amidon
251:Gießen
249:, and
229:Honors
172:opioid
165:German
130:Fields
114:(with
90:German
80:German
403:(PDF)
239:Mainz
65:Mainz
622:In:
592:PMID
574:ISSN
533:In:
514:In:
497:In:
481:In:
450:In:
431:PMID
423:ISSN
368:PMID
360:ISSN
325:ISBN
235:Graz
54:Died
29:Born
582:PMC
415:doi
639::
590:.
580:.
568:.
564:.
429:.
421:.
411:25
409:.
405:.
388:^
366:.
356:19
354:.
310:.
261:.
245:,
241:,
237:,
185:.
177:,
136:,
67:,
45:,
600:.
598:.
570:2
437:.
417::
374:.
118:)
37:)
33:(
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.