213:(e.g., ribosomal and transfer RNA), including the origin and history of translation and the genetic code. Phylogenomic analysis of RNA and protein molecules that make up the massive ribosomal ensemble shows that the most ancient ribosomal RNA structure interacted with the most ancient ribosomal protein and that this triggered a coordinated accretion process that ultimately resulted in a functional ribosomal core, half-way in evolution of life and prior to cellular diversification. These coevolutionary patterns challenge the ancient âRNA worldâ hypothesis and place the rise of genetics late in evolution.
28:
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in 2002 and became
University Scholar of the University of Illinois in 2010. His current research integrates structural biology, genomics and molecular evolution. He is particularly interested in evolution of macromolecular structure. His research group has recently reconstructed the history of the
212:
of life (LUCA). The group also found
Archaea was the first cellular lineage to arise in evolution from a universal ancestor that was complex at the molecular and cellular level. His team is currently exploring the role of structure and organization in the coevolution of proteins and functional RNA
175:
and plant systemic signals that control nodule number. While in
Tennessee he co-invented the technique of DNA amplification with arbitrary primers . This technique generates fingerprints of nucleic acids and molecular markers useful for genome mapping and molecular ecology and evolution. He also
278:
Mathesius U, Mulders S, Gao M, Teplitski M, Caetano-Anollés G, Rolfe BG, Bauer WD (2003) Extensive and specific responses of a eukaryote to bacterial-sensing signals. Proceedings of the
National Academy of Sciences USA 100(3)
240:
Kim KM, Win T, Jiang YY, Chen LL, Xiong M, Caetano-Anollés D, Zhang HY, Caetano-Anollés G (2012) Protein domain structure uncovers the origin of aerobic metabolism and the rise of planetary oxygen. Structure 20(1):
176:
developed widely used methods for the silver staining of DNA that are commercially available. He holds several US patents in molecular biology. He joined the faculty of the
Department of Biology at the
196:
protein world using information in entire genomes, revealed the existence of a 'big bang' of protein domain combinations late in evolution, traced evolution of proteins in biological networks (see the
200:), uncovered the origin of modern biological networks in pathways of nucleotide metabolism, and revealed important evolutionary reductive tendencies in the structural make up of proteins.
1014:
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Wang M, Yafremava LS, Caetano-Anollés D, Mittenthal JS, Caetano-Anollés G (2007) Reductive evolution of architectural repertoires in proteomes and the birth of the tripartite world"
254:
Sun FJ, Caetano-Anollés G (2008) Evolutionary patterns in the sequence and structure of transfer RNA: early origins of
Archaea and viruses. PLoS Computational Biology 4(3): e1000018.
221:
Caetano-Anollés and his wife Gloria have two children, both of whom have been part of his research team. Gloria is a surgical nurse and worked in the thoracic surgery team of
1019:
548:"The evolutionary history of protein fold families and proteomes confirms that the archaeal ancestor is more ancient than the ancestors of other superkingdoms"
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Nasir A, Kim KM, Caetano-Anollés G (2012) Viral evolution. Primordial cellular origins and late adaptation to parasitism. Mobile
Genetic Elements 2(5): 1-6.
184:
131:
105:
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Caetano-Anollés G (1996) Scanning of nucleic acids by in vitro amplification: new developments and applications. Nature
Biotechnology 14(13) 1668-1674.
208:
Recently, his group used genomic information to propose that viruses are derived from ancient cells and were the first lineage to arise from the
489:"Giant viruses coexisted with the cellular ancestors and represent a distinct supergroup along with superkingdoms Archaea, Bacteria and Eukarya"
244:
Kim KM, Caetano-Anollés G (2010) Emergence and evolution of modern molecular functions inferred from phylogenomic analysis of ontological data"
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Caetano-Anollés G, Wang M, Mittenthal JE (2009) The origin, evolution and structure of the protein world. Biochemical
Journal 417(3): 621-637.
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Caetano-Anollés G, Gresshoff PM (1991) Plant genetic control of nodulation. Annual Review in
Microbiology 45:345-382.
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Sun FJ, Caetano-Anollés G (2008) The origin and evolution of tRNA inferred from phylogenetic analysis of structure"
826:
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Wang M, Caetano-Anollés G (2006) Global phylogeny determined by the combination of protein domains in proteomes"
326:"The evolutionary mechanics of domain organization in proteomes and the rise of modularity in the protein world"
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Caetano-Anollés G, Caetano-Anollés D (2003) An evolutionarily structured universe of protein architecture"
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367:"The origin of modern metabolic networks inferred from phylogenomic analysis of protein architecture"
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Caetano-Anollés G (2002) Evolved RNA secondary structure and the rooting of the universal tree"
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607:"The ancient history of the structure of ribonuclease P and the early origins of Archaea"
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in Argentina and in the surgical department of the Baptist Hospital of East Tennessee.
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658:"The proteomic complexity and rise of the primordial ancestor of diversified life"
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Since 2003, he has been at the University of Illinois and is an affiliate of the
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Caetano-Anollés G (2002) Tracing the evolution of RNA structure in ribosomes"
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in 1998 and directed the laboratory of molecular ecology and evolution.
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from different angles, exploring the role of bacterial attachment and
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is Professor of Bioinformatics in the Department of Crop Sciences,
974:
Gustavo Caetano-Anollés page at the Department of Crop Sciences:
743:"Ribosomal history reveals origins of modern protein synthesis"
985:
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Caetano-Anolles obtained his doctorate in biochemistry at the
430:"Reductive evolution of proteomes and protein structure"
134:. He is an expert in the field of evolutionary and
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85:
70:
44:
34:
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365:Caetano-Anollés G, Kim HS, Mittenthal JE (2007).
163:he studied the symbiosis between nitrogen-fixing
155:in Argentina in 1986. During his early career at
1015:University of Illinois Urbana-Champaign faculty
827:"Study of giant viruses shakes up tree of life"
854:"The rise of oxygen and aerobic biochemistry"
8:
716:"Life began with a planetary mega-organism"
487:Nasir A, Kim KM, Caetano-Anollés G (2012).
185:Carl R. Woese Institute for Genomic Biology
132:University of Illinois at Urbana-Champaign
106:University of Illinois at Urbana-Champaign
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1020:Argentine emigrants to the United States
979:Evolutionary Bioinformatics laboratory:
120:http://gca.cropsci.illinois.edu/gca.html
316:
920:"Transfer RNA transforms tree of life"
989:Molecular Ancestry Networks (MANET):
7:
741:Harish A, Caetano-Anollés G (2012).
984:Evolutionary Bioinformatics blog:
656:Kim KM, Caetano-Anollés G (2011).
605:Sun FJ, Caetano-Anollés G (2010).
546:Kim KM, Caetano-Anollés G (2012).
324:Wang M, Caetano-Anollés G (2009).
14:
801:"Your grandmother was a molecule"
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273:Molecular Biology and Evolution
246:Molecular Biology and Evolution
153:National University of La Plata
39:National University of La Plata
298:Journal of Molecular Evolution
259:Journal of Molecular Evolution
1:
805:blogs.scientificamerican.com
768:10.1371/journal.pone.0032776
428:, Caetano-Anollés G (2011).
147:Studies and early researches
1036:
1005:American bioinformaticians
871:10.1016/j.str.2011.12.006
343:10.1016/j.str.2008.11.008
111:
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962:Gustavo Caetano-Anollés
683:10.1186/1471-2148-11-140
624:10.1186/1471-2105-11-153
514:10.1186/1471-2148-12-156
573:10.1186/1471-2148-12-13
455:10.1073/pnas.1017361108
392:10.1073/pnas.0701214104
210:last universal ancestor
161:University of Tennessee
128:Gustavo Caetano-Anollés
20:Gustavo Caetano-Anollés
434:Proc Natl Acad Sci USA
371:Proc Natl Acad Sci USA
291:Nucleic Acids Research
167:-forming bacteria and
232:Selected publications
157:Ohio State University
90:Computational Biology
833:. September 13, 2012
136:comparative genomics
759:2012PLoSO...732776H
722:. November 25, 2011
674:2011BMCEE..11..140K
564:2012BMCEE..12...13K
505:2012BMCEE..12..156N
446:2011PNAS..10811954W
383:2007PNAS..104.9358C
193:molecular evolution
61:molecular evolution
959:has a profile for
611:BMC Bioinformatics
293:30(11) 2575-2587.
268:17(11) 1572-1585.
204:A new virus theory
187:. He received the
178:University of Oslo
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924:the-scientist.com
852:Saito MA (2012).
286:13(7) 1563-1571.
248:27(7) 1710-1733.
189:Emile Zuckerkandl
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80:Scientific career
74:Zuckerkandl Prize
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102:Institutions
93:Astrobiology
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57:silver stain
165:root nodule
49:Root nodule
999:Categories
964:(Q5621363)
930:8 December
864:(1): 1â2.
811:8 December
726:8 December
668:(1): 140.
499:(1): 156.
426:Kurland CG
311:References
279:1444-1449.
173:chemotaxis
51:research,
858:Structure
558:(1): 13.
330:Structure
191:Prize in
142:Biography
898:Phys.org
880:22244750
787:22427882
747:PLOS ONE
702:21612591
643:20334683
592:22284070
533:22920653
474:21730144
424:Wang M,
411:17517598
352:19141283
159:and the
96:Genomics
957:Scholia
904:11 July
837:11 July
831:nsf.gov
778:3299690
755:Bibcode
693:3123224
670:Bibcode
634:2858038
617:: 153.
583:3306197
560:Bibcode
524:3570343
501:Bibcode
465:3141956
442:Bibcode
402:1890499
379:Bibcode
169:legumes
116:Website
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217:Family
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71:Awards
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906:2012
876:PMID
839:2012
813:2012
783:PMID
728:2012
698:PMID
639:PMID
588:PMID
529:PMID
470:PMID
407:PMID
348:PMID
866:doi
773:PMC
763:doi
688:PMC
678:doi
629:PMC
619:doi
578:PMC
568:doi
519:PMC
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460:PMC
450:doi
438:108
397:PMC
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375:104
338:doi
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