676:. Because GABA-T degrades GABA, the inhibition of this enzyme has been the target of many medical studies. The goal of these studies is to find a way to inhibit GABA-T activity, which would reduce the rate that GABA and 2-oxoglutarate are converted to semialdehyde and L-glutamate, thus raising GABA concentration in the brain. There is also a genetic disorder in humans which can lead to a deficiency in GABA-T. This can lead to developmental impairment or mortality in extreme cases.
3032:
683:, GABA can be produced as a stress response. Plants also use GABA to for internal signaling and for interactions with other organisms near the plant. In all of these intra-plant pathways, GABA-T will take on the role of degrading GABA. It has also been demonstrated that the succinate produced in the GABA shunt makes up a significant proportion of the succinate needed by the mitochondrion.
40:
686:
In fungi, the breakdown of GABA in the GABA shunt is key in ensuring a high level of activity in the critic acid cycle. There is also experimental evidence that the breakdown of GABA by GABA-T plays a role in managing oxidative stress in fungi.
1355:"Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin"
2514:
1641:
1402:
Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT (August 2009). "Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity".
1126:
Ricci L, Frosini M, Gaggelli N, Valensin G, Machetti F, Sgaragli G, Valoti M (May 2006). "Inhibition of rabbit brain 4-aminobutyrate transaminase by some taurine analogues: a kinetic analysis".
3008:
2507:
435:
993:
Cao J, Barbosa JM, Singh N, Locy RD (July 2013). "GABA transaminases from
Saccharomyces cerevisiae and Arabidopsis thaliana complement function in cytosol and mitochondria".
2060:
2500:
1634:
205:
262:
224:
1627:
2997:
2671:
2140:
661:. The critic acid cycle can then produce 2-oxoglutarate, which can be used to make glutamate, which can in turn be made into GABA, continuing the cycle.
600:
641:
The primary role of GABA-T is to break down GABA as part of the GABA-Shunt. In the next step of the shunt, the semialdehyde produced by GABA-T will be
1514:
Schousboe A, Wu JY, Roberts E (July 1973). "Purification and characterization of the 4-aminobutyrate--2,ketoglutarate transaminase from mouse brain".
2130:
2053:
1779:
3077:
3052:
1544:
757:
of 4-aminobutyrate transaminase include Lys-329, which are found on each of the two subunits of the enzyme. This site will also bind with a
3062:
650:
2145:
3067:
2814:
2190:
1956:
1922:
1908:
1765:
286:
2990:
2223:
2046:
931:
1196:
1036:
Fait A, Fromm H, Walter D, Galili G, Fernie AR (January 2008). "Highway or byway: the metabolic role of the GABA shunt in plants".
668:
in animal brains, and a low concentration of GABA in mammalian brains has been linked to several neurological disorders, including
2120:
1917:
274:
217:
168:
144:
2379:
267:
1799:
1714:
1264:"Disruption of the GABA shunt affects mitochondrial respiration and virulence in the cereal pathogen Fusarium graminearum"
3022:
703:
accession codes, and published in peer-reviewed journals. At least 4 such structures have been solved using pig enzymes:
2983:
2546:
2492:
770:
738:
734:
730:
726:
716:
712:
708:
704:
2135:
1662:
1485:
Aurich H (October 1961). "" [On the beta-alanine-alpha-ketoglutarate transaminase from
Neurospora crassa].
2364:
2878:
2480:
2467:
2454:
2441:
2428:
2415:
2402:
2181:
2162:
2125:
2086:
1994:
1774:
791:
2656:
2374:
575:, and vice versa. In the case of GABA-T, it takes a nitrogen group from GABA and uses it to create L-glutamate.
162:
2830:
2776:
2328:
2271:
2077:
1600:
1313:"Crystal structures of unbound and aminooxyacetate-bound Escherichia coli gamma-aminobutyrate aminotransferase"
548:
442:
387:
55:
149:
2835:
2760:
2591:
2276:
1853:
1834:
1694:
509:
497:
567:
groups from one molecule to another. As a transaminase, GABA-T's role is to move functional groups from an
2850:
2523:
2098:
1903:
827:
673:
669:
616:
462:
2697:
2571:
420:
229:
2538:
2297:
2216:
2022:
1948:
1596:
501:
332:
137:
2369:
279:
1161:
Sherif FM, Ahmed SS (April 1995). "Basic aspects of GABA-transaminase in neuropsychiatric disorders".
2908:
2840:
2115:
2018:
1760:
1262:
Bönnighausen J, Gebhard D, Kröger C, Hadeler B, Tumforde T, Lieberei R, et al. (December 2015).
1221:
856:"In silico analysis of the inhibitory activities of GABA derivatives on 4-aminobutyrate transaminase"
493:
72:
591:
group from 2-oxoglutarate to GABA. This produces succinate semialdehyde and L-glutamate. In plants,
2845:
2781:
2333:
1814:
1809:
776:
758:
513:
458:
165:
67:
89:
2631:
2266:
2171:
1427:
1384:
1293:
1018:
696:
1451:
2651:
3057:
2903:
1804:
1577:
1531:
1502:
1473:
1419:
1376:
1332:
1285:
1241:
1178:
1143:
1105:
1053:
1010:
927:
700:
658:
410:
156:
1353:
Storici P, De Biase D, Bossa F, Bruno S, Mozzarelli A, Peneff C, et al. (January 2004).
2893:
2702:
2555:
2535:
2312:
2307:
2281:
2209:
1654:
1567:
1559:
1523:
1494:
1463:
1411:
1366:
1324:
1275:
1233:
1170:
1135:
1095:
1087:
1045:
1002:
973:
965:
919:
914:
Tunnicliff G (1986). "4-Aminobutyrate
Transaminase". In Boulton AA, Baker GB, Yu PH (eds.).
867:
721:
665:
608:
446:
336:
327:
2038:
125:
2883:
2359:
2343:
2256:
1960:
1719:
1608:
887:
797:
572:
481:
356:
101:
1619:
741:. There are actually some differences between the enzyme structure for these organisms.
60:
3036:
2786:
2727:
2717:
2692:
2626:
2397:
2338:
2014:
1572:
1311:
Liu W, Peterson PE, Carter RJ, Zhou X, Langston JA, Fisher AJ, Toney MD (August 2004).
596:
454:
200:
1468:
1100:
1075:
180:
3072:
3046:
2933:
2913:
2865:
2804:
2794:
2616:
2302:
2261:
1975:
1830:
1174:
953:
802:
654:
646:
477:
175:
1431:
1388:
1297:
2898:
2596:
2251:
2090:
1940:
1312:
1022:
888:"BRENDA - Information on EC 2.6.1.19 - 4-aminobutyrate-2-oxoglutarate transaminase"
854:
Iftikhar H, Batool S, Deep A, Narasimhan B, Sharma PC, Malhotra M (February 2017).
592:
560:
505:
2687:
2576:
1237:
1049:
583:
In animals, fungi, and bacteria, GABA-T helps facilitate a reaction that moves an
872:
855:
303:
17:
2962:
2954:
2732:
2475:
2410:
2246:
2069:
1741:
1498:
923:
754:
564:
556:
552:
539:). Pigs have often been used when studying how this protein may work in humans.
473:
466:
366:
184:
3031:
1452:"Soluble gamma-aminobutyric-glutamic transaminase from Pseudomonas fluorescens"
2923:
2918:
2887:
2873:
2855:
2737:
2646:
2606:
2581:
2531:
1887:
1139:
807:
786:
781:
745:
enzymes of GABA-T lack an iron-sulfur cluster that is found in the pig model.
626:
568:
520:
489:
379:
310:
954:"4-Aminobutyrate (GABA): a metabolite and signal with practical significance"
2860:
2722:
2661:
2449:
2423:
1895:
1891:
1675:
1671:
406:
1581:
1506:
1477:
1423:
1380:
1371:
1354:
1336:
1289:
1245:
1147:
1109:
1057:
1014:
1535:
1182:
969:
488:. This enzyme participates in 5 metabolic pathways: alanine and aspartate
2641:
2621:
2611:
2073:
1936:
1737:
1733:
612:
315:
1545:"Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies"
1527:
390:
113:
2712:
2601:
1971:
1091:
630:
620:
132:
1563:
1328:
1280:
1263:
978:
2751:
2636:
2586:
2462:
2232:
1650:
1415:
1006:
588:
532:
528:
402:
298:
212:
108:
96:
84:
828:"4-aminobutyrate aminotransferase - Identical Protein Groups - NCBI"
599:
can be used in the place of 2-oxoglutarate. catalyzed by the enzyme
563:
sub-subclass. As a nitrogenous transferase, its role is to transfer
2672:
1076:"The Metabolism and Functions of [gamma]-Aminobutyric Acid"
2436:
1222:"Highway or byway: the metabolic role of the GABA shunt in plants"
680:
642:
584:
536:
524:
1607:
Pearl PL, Parviz M, Hodgeman R, Gibson KM, Reimschisel T (2015).
2707:
2150:
2108:
2103:
1952:
450:
291:
120:
2496:
2205:
2042:
1623:
1220:
Fait A, Fromm H, Walter D, Galili G, Fernie AR (January 2008).
39:
2201:
653:, resulting in succinate. This succinate will then enter
2815:
1543:
Parviz M, Vogel K, Gibson KM, Pearl PL (November 2014).
424:
3020:
719:, and at least 4 such structures have been solved in
423:
1487:
2953:
2946:
2813:
2759:
2750:
2677:
Tooltip
Vesicular inhibitory amino acid transporter
2670:
2554:
2545:
2388:
2352:
2321:
2290:
2239:
2180:
2161:
2085:
2003:
1983:
1970:
1935:
1886:
1862:
1842:
1829:
1788:
1749:
1732:
1703:
1683:
1670:
1661:
362:
352:
347:
326:
321:
309:
297:
285:
273:
261:
253:
248:
243:
223:
211:
199:
194:
174:
155:
143:
131:
119:
107:
95:
83:
78:
66:
54:
49:
32:
429:
486:4-aminobutanoate:2-oxoglutarate aminotransferase
2761:
1348:
1346:
849:
847:
2508:
2217:
2054:
1635:
8:
2524:
399:4-aminobutyrate aminotransferase, or GABA-T
44:4-Aminobutyrate transaminase homodimer, Pig
2950:
2756:
2551:
2515:
2501:
2493:
2224:
2210:
2202:
2141:Branched-chain amino acid aminotransferase
2061:
2047:
2039:
1980:
1839:
1746:
1680:
1667:
1642:
1628:
1620:
344:
191:
3009:Glutamate metabolism/transport modulators
1599:at the U.S. National Library of Medicine
1571:
1467:
1370:
1279:
1099:
977:
871:
587:group from GABA to 2-oxoglutarate, and a
480:, which transfer nitrogenous groups. The
422:
2909:Valproate semisodium (divalproex sodium)
2820:Tooltip Îł-Aminobutyrate aminotransferase
2556:
699:solved for this class of enzymes, given
3027:
819:
551:2.6.1.19. This means that it is in the
1780:Phenylethanolamine N-methyltransferase
240:
29:
1257:
1255:
947:
945:
943:
909:
907:
601:4-aminobutyrate—pyruvate transaminase
472:This enzyme belongs to the family of
7:
2131:Kynurenine—oxoglutarate transaminase
1121:
1119:
1074:Bown AW, Shelp BJ (September 1997).
1069:
1067:
651:succinate-semialdehyde dehydrogenase
437:succinate semialdehyde + L-glutamate
2597:Deramciclane (EGIS-3886, EGYT-3886)
1923:Acetylserotonin O-methyltransferase
1456:The Journal of Biological Chemistry
1359:The Journal of Biological Chemistry
952:Shelp BJ, Bown AW, Zarei A (2017).
430:{\displaystyle \rightleftharpoons }
1450:Scott EM, Jakoby WB (April 1959).
417:4-aminobutanoate + 2-oxoglutarate
25:
918:. Vol. 5. pp. 389–420.
753:Amino acid residues found in the
3030:
2191:Pyridoxine 5'-phosphate synthase
1918:Aralkylamine N-acetyltransferase
38:
2766:Tooltip Glutamate decarboxylase
2146:Alanine—glyoxylate transaminase
1609:"GABA-transaminase deficiency"
1197:"GABA-TRANSAMINASE DEFICIENCY"
625:(2) 4-aminobutanoate (GABA) +
1:
2984:Receptor/signaling modulators
1800:Catechol-O-methyl transferase
1715:Histamine N-methyltransferase
1552:Journal of Pediatric Epilepsy
1469:10.1016/S0021-9258(18)70206-8
1238:10.1016/j.tplants.2007.10.005
1050:10.1016/j.tplants.2007.10.005
3078:Glutamate (neurotransmitter)
3053:Genes on human chromosome 16
3002:receptor positive modulators
1874:4-aminobutyrate transaminase
1597:4-Aminobutyrate+Transaminase
1175:10.1016/0009-9120(94)00074-6
873:10.1016/j.arabjc.2013.03.007
860:Arabian Journal of Chemistry
384:4-aminobutyrate transaminase
244:4-aminobutyrate transaminase
33:4-aminobutyrate transaminase
3063:Pyridoxal phosphate enzymes
2529:Tooltip Îł-Aminobutyric acid
1499:10.1515/bchm2.1961.326.1.25
771:GABA transaminase inhibitor
637:Cellular and metabolic role
629:⇌ succinate semialdehyde +
3094:
3068:Enzymes of known structure
2136:Ornithine aminotransferase
768:
2975:
2831:3-Hydrazinopropionic acid
2380:Michaelis–Menten kinetics
2126:Tyrosine aminotransferase
1995:Choline acetyltransferase
1913:-amino acid decarboxylase
1775:Dopamine beta-hydroxylase
1770:-amino acid decarboxylase
1140:10.1016/j.bcp.2006.02.007
924:10.1385/0-89603-079-2:389
792:Phenylethylidenehydrazine
759:pyridoxal 5'ôŹ°Ś- phosphate
664:GABA is a very important
343:
190:
37:
2991:GABA receptor modulators
2777:3-Mercaptopropionic acid
2561:Tooltip GABA transporter
2272:Diffusion-limited enzyme
1601:Medical Subject Headings
1128:Biochemical Pharmacology
916:Neurotransmitter Enzymes
695:There have been several
549:Enzyme Commission number
543:Enzyme Commission number
519:This enzyme is found in
484:of this enzyme class is
1854:Glutamate decarboxylase
1695:Histidine decarboxylase
1226:Trends in Plant Science
1038:Trends in Plant Science
657:and become part of the
557:nitrogenous transferase
498:beta-alanine metabolism
2099:Aspartate transaminase
1904:Tryptophan hydroxylase
1372:10.1074/jbc.M305884200
1268:Molecular Microbiology
892:www.brenda-enzymes.org
617:succinate semialdehyde
555:class of enzymes, the
463:succinate semialdehyde
431:
2365:Eadie–Hofstee diagram
2298:Allosteric regulation
2165:: Oximinotransferases
2023:Butyrylcholinesterase
1949:Nitric oxide synthase
1404:Phytotherapy Research
1163:Clinical Biochemistry
970:10.1139/cjb-2017-0135
502:propanoate metabolism
432:
2375:Lineweaver–Burk plot
2116:Alanine transaminase
2019:Acetylcholinesterase
1761:Tyrosine hydroxylase
832:www.ncbi.nlm.nih.gov
506:butanoate metabolism
494:glutamate metabolism
421:
2698:Chicago sky blue 6B
2572:4-Aminovaleric acid
1528:10.1021/bi00739a015
777:Aminooxyacetic acid
674:Parkinson's disease
670:Alzheimer's disease
514:pyridoxal phosphate
476:, specifically the
445:of this enzyme are
2334:Enzyme superfamily
2267:Enzyme promiscuity
2172:Oximinotransferase
1092:10.1104/pp.115.1.1
691:Structural Studies
559:sub-class and the
427:
3018:
3017:
2971:
2970:
2942:
2941:
2904:Valproate pivoxil
2868:
2841:Îł-Acetylenic-GABA
2746:
2745:
2490:
2489:
2199:
2198:
2121:GABA transaminase
2036:
2035:
2032:
2031:
1931:
1930:
1912:
1882:
1881:
1825:
1824:
1805:Monoamine oxidase
1769:
1728:
1727:
1655:neurotransmission
1613:MedLink Neurology
1564:10.3233/PEP-14097
1329:10.1021/bi049218e
1323:(34): 10896–905.
1281:10.1111/mmi.13203
659:citric acid cycle
508:. It employs one
411:chemical reaction
395:GABA transaminase
376:
375:
372:
371:
239:
238:
235:
234:
138:metabolic pathway
18:GABA transaminase
16:(Redirected from
3085:
3035:
3034:
3026:
2951:
2894:Sodium valproate
2866:
2821:
2817:
2789:
2767:
2763:
2757:
2678:
2674:
2562:
2558:
2552:
2530:
2526:
2517:
2510:
2503:
2494:
2370:Hanes–Woolf plot
2313:Enzyme activator
2308:Enzyme inhibitor
2282:Enzyme catalysis
2226:
2219:
2212:
2203:
2063:
2056:
2049:
2040:
2008:
1988:
1981:
1910:
1867:
1847:
1840:
1793:
1767:
1754:
1747:
1708:
1688:
1681:
1668:
1644:
1637:
1630:
1621:
1616:
1585:
1575:
1549:
1539:
1510:
1481:
1471:
1436:
1435:
1416:10.1002/ptr.2712
1399:
1393:
1392:
1374:
1350:
1341:
1340:
1308:
1302:
1301:
1283:
1259:
1250:
1249:
1217:
1211:
1210:
1208:
1207:
1193:
1187:
1186:
1158:
1152:
1151:
1123:
1114:
1113:
1103:
1080:Plant Physiology
1071:
1062:
1061:
1033:
1027:
1026:
1007:10.1002/yea.2962
990:
984:
983:
981:
949:
938:
937:
911:
902:
901:
899:
898:
884:
878:
877:
875:
851:
842:
841:
839:
838:
824:
722:Escherichia coli
666:neurotransmitter
609:4-aminobutanoate
579:Reaction pathway
447:4-aminobutanoate
436:
434:
433:
428:
345:
241:
192:
42:
30:
27:Class of enzymes
21:
3093:
3092:
3088:
3087:
3086:
3084:
3083:
3082:
3043:
3042:
3041:
3029:
3021:
3019:
3014:
3001:
2967:
2938:
2884:Rosmarinic acid
2819:
2809:
2787:
2765:
2742:
2676:
2666:
2560:
2541:
2528:
2521:
2491:
2486:
2398:Oxidoreductases
2384:
2360:Enzyme kinetics
2348:
2344:List of enzymes
2317:
2286:
2257:Catalytic triad
2235:
2230:
2200:
2195:
2176:
2157:
2081:
2067:
2037:
2028:
2004:
1999:
1984:
1966:
1927:
1878:
1863:
1858:
1843:
1821:
1789:
1784:
1750:
1724:
1720:Diamine oxidase
1704:
1699:
1684:
1657:
1648:
1606:
1593:
1588:
1547:
1542:
1522:(15): 2868–73.
1513:
1484:
1449:
1445:
1443:Further reading
1440:
1439:
1401:
1400:
1396:
1352:
1351:
1344:
1310:
1309:
1305:
1261:
1260:
1253:
1219:
1218:
1214:
1205:
1203:
1195:
1194:
1190:
1160:
1159:
1155:
1125:
1124:
1117:
1073:
1072:
1065:
1035:
1034:
1030:
992:
991:
987:
964:(11): 1015–32.
951:
950:
941:
934:
913:
912:
905:
896:
894:
886:
885:
881:
853:
852:
845:
836:
834:
826:
825:
821:
816:
798:Rosmarinic acid
773:
767:
751:
693:
639:
581:
545:
482:systematic name
419:
418:
393:), also called
45:
28:
23:
22:
15:
12:
11:
5:
3091:
3089:
3081:
3080:
3075:
3070:
3065:
3060:
3055:
3045:
3044:
3040:
3039:
3016:
3015:
3013:
3012:
3005:
2999:
2994:
2987:
2980:
2976:
2973:
2972:
2969:
2968:
2966:
2965:
2959:
2957:
2955:Antivitamin B6
2948:
2944:
2943:
2940:
2939:
2937:
2936:
2927:
2926:
2921:
2916:
2911:
2906:
2901:
2896:
2891:
2881:
2876:
2871:
2863:
2858:
2853:
2848:
2843:
2838:
2833:
2824:
2822:
2811:
2810:
2808:
2807:
2798:
2797:
2792:
2784:
2779:
2770:
2768:
2754:
2748:
2747:
2744:
2743:
2741:
2740:
2735:
2730:
2728:Nipecotic acid
2725:
2720:
2718:N-Butyric acid
2715:
2710:
2705:
2700:
2695:
2693:Bafilomycin A1
2690:
2681:
2679:
2668:
2667:
2665:
2664:
2659:
2654:
2649:
2644:
2639:
2634:
2629:
2627:Nipecotic acid
2624:
2619:
2614:
2609:
2604:
2599:
2594:
2589:
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2323:
2322:Classification
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2305:
2300:
2294:
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2288:
2287:
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2259:
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2241:
2237:
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2231:
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2228:
2221:
2214:
2206:
2197:
2196:
2194:
2193:
2187:
2185:
2178:
2177:
2175:
2174:
2168:
2166:
2159:
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2156:
2155:
2154:
2153:
2143:
2138:
2133:
2128:
2123:
2118:
2113:
2112:
2111:
2106:
2095:
2093:
2083:
2082:
2068:
2066:
2065:
2058:
2051:
2043:
2034:
2033:
2030:
2029:
2027:
2026:
2015:Cholinesterase
2011:
2009:
2001:
2000:
1998:
1997:
1991:
1989:
1978:
1968:
1967:
1965:
1964:
1945:
1943:
1933:
1932:
1929:
1928:
1926:
1925:
1920:
1915:
1906:
1900:
1898:
1884:
1883:
1880:
1879:
1877:
1876:
1870:
1868:
1860:
1859:
1857:
1856:
1850:
1848:
1837:
1827:
1826:
1823:
1822:
1820:
1819:
1818:
1817:
1812:
1802:
1796:
1794:
1786:
1785:
1783:
1782:
1777:
1772:
1763:
1757:
1755:
1744:
1730:
1729:
1726:
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1723:
1722:
1717:
1711:
1709:
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1698:
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1691:
1689:
1678:
1665:
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1639:
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1624:
1618:
1617:
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1592:
1591:External links
1589:
1587:
1586:
1558:(4): 217–227.
1540:
1511:
1482:
1446:
1444:
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1438:
1437:
1410:(8): 1075–81.
1394:
1342:
1303:
1274:(6): 1115–32.
1251:
1212:
1188:
1153:
1134:(10): 1510–9.
1115:
1063:
1028:
985:
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903:
879:
843:
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455:2-oxoglutarate
441:Thus, the two
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2949:
2945:
2935:
2934:3-Methyl-GABA
2932:
2929:
2928:
2925:
2922:
2920:
2917:
2915:
2914:Valproic acid
2912:
2910:
2907:
2905:
2902:
2900:
2897:
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2892:
2889:
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2882:
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2837:
2834:
2832:
2829:
2826:
2825:
2823:
2818:
2812:
2806:
2805:3-Methyl-GABA
2803:
2800:
2799:
2796:
2795:Semicarbazide
2793:
2791:
2790:-Allylglycine
2785:
2783:
2780:
2778:
2775:
2772:
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2769:
2764:
2758:
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2655:
2653:
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2648:
2645:
2643:
2640:
2638:
2635:
2633:
2630:
2628:
2625:
2623:
2620:
2618:
2617:Ibotenic acid
2615:
2613:
2610:
2608:
2605:
2603:
2600:
2598:
2595:
2593:
2590:
2588:
2585:
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2575:
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2570:
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2339:Enzyme family
2337:
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2332:
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2327:
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2324:
2320:
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2311:
2309:
2306:
2304:
2303:Cooperativity
2301:
2299:
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2289:
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2262:Oxyanion hole
2260:
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2255:
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2110:
2107:
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2100:
2097:
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2091:Transaminases
2088:
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2079:
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2064:
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2016:
2013:
2012:
2010:
2007:
2002:
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1976:Acetylcholine
1973:
1969:
1962:
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1001:(7): 279–89.
1000:
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986:
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975:
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948:
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933:0-89603-079-2
929:
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803:Valproic acid
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655:mitochondrion
652:
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647:succinic acid
644:
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624:
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491:
487:
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479:
478:transaminases
475:
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468:
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456:
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448:
444:
416:
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404:
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389:
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231:
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219:
216:
214:
210:
207:
204:
202:
198:
193:
189:
186:
182:
179:
177:
176:Gene Ontology
173:
170:
167:
164:
161:
158:
154:
151:
148:
146:
142:
139:
136:
134:
130:
127:
124:
122:
118:
115:
114:NiceZyme view
112:
110:
106:
103:
100:
98:
94:
91:
88:
86:
82:
77:
74:
71:
69:
65:
62:
59:
57:
53:
48:
41:
36:
31:
19:
3007:
2996:
2989:
2982:
2930:
2899:Valnoctamide
2869:-Cycloserine
2827:
2801:
2773:
2684:
2568:
2476:Translocases
2473:
2460:
2447:
2434:
2421:
2411:Transferases
2408:
2395:
2252:Binding site
2005:
1985:
1873:
1864:
1844:
1790:
1751:
1705:
1685:
1653:involved in
1612:
1555:
1551:
1519:
1516:Biochemistry
1515:
1490:
1486:
1462:(4): 932–6.
1459:
1455:
1407:
1403:
1397:
1362:
1358:
1320:
1317:Biochemistry
1316:
1306:
1271:
1267:
1229:
1225:
1215:
1204:. Retrieved
1201:www.omim.org
1200:
1191:
1166:
1162:
1156:
1131:
1127:
1083:
1079:
1041:
1037:
1031:
998:
994:
988:
961:
957:
915:
895:. Retrieved
891:
882:
866:: S1267–75.
863:
859:
835:. Retrieved
831:
822:
752:
749:Active sites
742:
720:
694:
685:
678:
663:
640:
582:
561:transaminase
546:
518:
485:
474:transferases
471:
440:
398:
394:
383:
377:
335:
102:BRENDA entry
2963:Ginkgotoxin
2931:Activators:
2828:Inhibitors:
2802:Activators:
2774:Inhibitors:
2733:Valinomycin
2685:Inhibitors:
2632:NNC 05-2090
2569:Inhibitors:
2547:Transporter
2247:Active site
2074:nitrogenous
2070:Transferase
2006:catabolism:
1865:catabolism:
1791:catabolism:
1742:epinephrine
1706:catabolism:
1232:(1): 14–9.
1044:(1): 14–9.
761:co-enzyme.
755:active site
573:α-keto acid
565:nitrogenous
553:transferase
535:(including
521:prokaryotes
467:L-glutamate
357:Swiss-model
249:Identifiers
90:IntEnz view
50:Identifiers
3047:Categories
2924:Vigabatrin
2919:Valpromide
2888:lemon balm
2874:Phenelzine
2856:Gabaculine
2738:Vigabatrin
2703:Evans blue
2647:SKF-89976A
2607:Gabaculine
2582:Arecaidine
2539:modulators
2532:metabolism
2450:Isomerases
2424:Hydrolases
2291:Regulation
1986:anabolism:
1888:tryptophan
1845:anabolism:
1752:anabolism:
1686:anabolism:
1206:2020-10-18
1086:(1): 1–5.
979:1807/79639
897:2020-09-24
837:2020-09-29
814:References
808:Vigabatrin
787:Phenelzine
782:Gabaculine
765:Inhibitors
697:structures
627:glyoxylate
597:glyoxylate
569:amino acid
547:GABA-T is
490:metabolism
457:. The two
443:substrates
380:enzymology
353:Structures
348:Search for
322:Other data
159:structures
126:KEGG entry
73:9037-67-6
2861:Isoniazid
2723:Nigericin
2688:β-Alanine
2662:Tiagabine
2652:SNAP-5114
2577:β-Alanine
2536:transport
2329:EC number
1909:Aromatic
1896:melatonin
1892:serotonin
1831:glutamate
1766:Aromatic
1676:histamine
1672:histidine
1663:monoamine
1493:: 25–33.
611:(GABA) +
425:⇌
407:catalyzes
304:NM_020686
263:NCBI gene
79:Databases
3058:EC 2.6.1
2979:See also
2642:Riluzole
2622:Muscimol
2612:Guvacine
2353:Kinetics
2277:Cofactor
2240:Activity
2076:groups (
1937:arginine
1738:dopamine
1734:tyrosine
1582:25485164
1507:13863304
1478:13654294
1432:23127112
1424:19165747
1389:42918710
1381:14534310
1337:15323550
1298:45755014
1290:26305050
1246:18155636
1148:16540097
1110:12223787
1058:18155636
1015:23740823
643:oxidized
613:pyruvate
593:pyruvate
510:cofactor
459:products
401:, is an
391:2.6.1.19
367:InterPro
230:proteins
218:articles
206:articles
163:RCSB PDB
61:2.6.1.19
3037:Biology
2713:Glycine
2602:EF-1502
2463:Ligases
2233:Enzymes
2184:: Other
1972:choline
1651:Enzymes
1573:4256671
1536:4719123
1183:7628073
1023:1303165
743:E. coli
631:glycine
621:alanine
533:animals
363:Domains
333:Chr. 16
311:UniProt
185:QuickGO
150:profile
133:MetaCyc
68:CAS no.
3023:Portal
2816:GABA-T
2752:Enzyme
2637:NO-711
2587:CI-966
2437:Lyases
2182:2.6.99
1603:(MeSH)
1580:
1570:
1534:
1505:
1476:
1430:
1422:
1387:
1379:
1335:
1296:
1288:
1244:
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681:plants
589:ketone
571:and a
537:humans
531:, and
525:plants
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403:enzyme
316:P80404
299:RefSeq
292:137150
254:Symbol
213:PubMed
195:Search
181:AmiGO
169:PDBsum
109:ExPASy
97:BRENDA
85:IntEnz
56:EC no.
2947:Other
2673:VIAAT
2389:Types
2163:2.6.3
2087:2.6.1
1548:(PDF)
1428:S2CID
1385:S2CID
1294:S2CID
1019:S2CID
995:Yeast
794:(PEH)
585:amine
529:fungi
405:that
337:p13.2
328:Locus
145:PRIAM
3073:GABA
2998:GABA
2846:AOAA
2836:DABA
2782:AAOA
2708:GABA
2657:TACA
2592:DABA
2534:and
2525:GABA
2481:list
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2468:list
2461:EC6
2455:list
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2442:list
2435:EC4
2429:list
2422:EC3
2416:list
2409:EC2
2403:list
2396:EC1
2151:AGXT
2109:GOT2
2104:GOT1
2080:2.6)
1961:NOS3
1957:NOS2
1953:NOS1
1835:GABA
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1532:PMID
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1420:PMID
1377:PMID
1333:PMID
1286:PMID
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409:the
287:OMIM
275:HGNC
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225:NCBI
166:PDBe
121:KEGG
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1560:doi
1524:doi
1495:doi
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1367:doi
1363:279
1325:doi
1276:doi
1234:doi
1171:doi
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1096:PMC
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1003:doi
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920:doi
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397:or
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