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which simulate the proliferation of eosinophil precursor cells and are thereby responsible for the eosinophilia. It is suggested that most forms of Gleich's syndrome are due to a similar aberrant T cell mechanism and are a subtype of lymphocyte-variant eosinophilia.
72:(which features eosinophilia but alternative symptoms). Some studies have shown that edema attacks are associated with degranulation (release of enzymes and mediators from eosinophils), and others have demonstrated
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Gleich GJ, Schroeter AL, Marcoux JP, Sachs MI, O'Connell EJ, Kohler PF (1984). "Episodic angioedema associated with eosinophilia".
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in that there is little or no evidence that it leads to organ damage. Rather, recent studies report that a subset of
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84:
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91:(a special form of lymphocyte blood cell) found in several Gleich syndrome patients have an abnormal
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cell surface antigens. These same aberrant T cell immunophenotypes are found in
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Gleich syndrome has a good prognosis. Attack severity may improve with
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is a rare disease in which the body swells up episodically (
103:, a disease in which the aberrant T cells overproduce
210:"Blood and Bone Marrow Evaluation for Eosinophilia"
26:
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83:Gleich's syndrome is not a form of the idiopathic
68:(which may cause similar swelling episodes) and
214:Archives of Pathology & Laboratory Medicine
80:(cells lining blood vessels) in the condition.
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64:Its cause is unknown, but it is unrelated to
8:
45:), associated with raised antibodies of the
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31:Episodic angioedema with eosinophilia
7:
177:Emonet S, Kaya G, Hauser C (2000).
61:). It was first described in 1984.
14:
101:lymphocyte-variant eosinophilia
95:, i.e. they express CD3-, CD4+
49:type and increased numbers of
1:
70:eosinophilia-myalgia syndrome
153:10.1056/NEJM198406213102501
282:
97:cluster of differentiation
85:hypereosinophilic syndrome
227:10.5858/arpa.2016-0223-RA
256:Urticaria and angioedema
261:Immune system disorders
66:capillary leak syndrome
51:eosinophil granulocytes
183:Ann Dermatol Venereol
22:Gleich's syndrome
179:"Gleich's syndrome"
208:Boyer DF (2016).
55:white blood cells
39:Gleich's syndrome
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16:Medical condition
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57:, in the blood (
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93:immunophenotype
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220:(10): 1060–7.
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189:(6–7): 616–8.
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147:(25): 1621–6.
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59:eosinophilia
53:, a type of
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119:treatment.
78:endothelium
27:Other names
250:Categories
123:References
74:antibodies
43:angioedema
266:Syndromes
105:cytokines
236:27684977
195:10930860
107:such as
76:against
161:6727934
117:steroid
89:T cells
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232:PMID
191:PMID
157:PMID
222:doi
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187:127
149:doi
145:310
47:IgM
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