97:: The plasma insulin concentration is acutely raised and maintained at 100 ÎĽU/ml by a continuous infusion of insulin. Meanwhile, the plasma glucose concentration is held constant at basal levels by a variable glucose infusion. When the steady-state is achieved, the glucose infusion rate equals glucose uptake by all the
87:: The plasma glucose concentration is acutely raised to 125 mg/dl above basal levels by a continuous infusion of glucose. This hyperglycemic plateau is maintained by adjustment of a variable glucose infusion, based on the rate of insulin secretion and
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respond to glucose. The hyperinsulinemic clamp, which requires maintaining a high insulin level by perfusion or infusion with insulin, is a way to quantify how sensitive the tissue is to insulin. The hyperinsulinemic clamp is also called
91:. Because the plasma glucose concentration is held constant, the glucose infusion rate is an index of insulin secretion and glucose metabolism. The hyperglycemic clamps are often used to assess insulin secretion capacity.
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Two types of clamp are quite commonly used. The hyperglycemic clamp, which requires maintaining a high blood sugar level by perfusion or infusion with glucose, is a way to quantify how fast
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Marcus
Hompesch and Klaus Rave. “An Analysis of How to Measure Glucose during Glucose Clamps: Are Glucose Meters Ready for Research?” J. Diabetes Sci. Technol. 2008, 2, 896–898.
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drug development and diagnostics evaluation. In human clinical trials, manual glucose clamps as well as the more modern method of automated glucose clamp find common use.
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DeFronzo RA, Tobin JD, Andres R. “Glucose Clamp
Technique: a Method for Quantifying Insulin Secretion and Resistance.” Am. J. Physiol. 1979, 237, E214–E223.
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Professors DeFronzo, Andres and Tobin in 1979. It has since been the gold standard for
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secretion and resistance. It is used to measure either how well an individual
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239:"ClampArt and other glucose clamps at Profil"
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