90:. He found that central neurons in the brain are pre-specified to form connections with specific incoming sensory neurons. Surprisingly, central dendrites can target independently of incoming sensory axons, suggesting a principle of independent coarse maps refined by contact-mediated matching. Returning to Cambridge in 2004 as a Wellcome research fellow, Jefferis combined genetic single cell labelling and image registration to build a 3D atlas of higher olfactory centers in Drosophila, showing that odors of different behavioral significance are spatially segregated.
101:, generated the first comprehensive description of circuit-level sex differences in the fly brain, overturning the prevailing view that sex-specific behaviors originated from largely isomorphic circuitry. His group subsequently showed that higher-order olfactory neurons form a bidirectional switch that sex-specifically routes pheromone signals.
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to study the neural circuit basis of memory storage and retrieval; this established the
Drosophila Connectomics group at the Department of Zoology, University of Cambridge. He has also received Starting and Consolidator grants from the
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Jefferis' group has also made significant efforts in the development of experimental and computational tools for circuit mapping. He is also a principal investigator of the
Virtual Fly Brain online resource.
144:. In 2012, Jefferis was appointed to the EMBO Young Investigator Programme, and in 2016 was elected to the FENS Kavli Network of Excellence. In 2018, he was announced as the winner of the
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process sensory information and transform it into behavior. His PhD uncovered principles of brain development using the olfactory system of the vinegar fly,
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148:'s Francis Crick Medal and Lecture "for his fundamental discoveries concerning the development and functional logic of sensory information processing".
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311:"Comprehensive maps of Drosophila higher olfactory centers: spatially segregated fruit and pheromone representation"
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in 1998. He was awarded a PhD in
Neurosciences for his work on the 'Wiring specificity in the olfactory system of
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in 2003 and was selected to deliver the Elkins
Memorial lecture at the Neurobiology of Drosophila Meeting in
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as a tenure-track
Programme Leader in 2008 and was awarded tenure in 2014. His group, in collaboration with
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499:"NBLAST: Rapid, Sensitive Comparison of Neuronal Structure and Construction of Neuron Family Databases"
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Jefferis has received numerous awards through his career. For his PhD work, Jefferis received a
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450:"A bidirectional circuit switch reroutes pheromone signals in male and female brains"
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known for his work on the circuit basis of olfactory perception in the vinegar fly,
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620:"Greg Jefferis awarded Francis Crick Medal and Lecture by the Royal Society"
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Jefferis has made significant contributions to our understanding of how
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180:"Gregory Jefferis - Department of Zoology - University of Cambridge"
253:"Target neuron prespecification in the olfactory map of Drosophila"
195:"Target neuron prespecification in the olfactory map of Drosophila"
38:(UK) and associated with the Department of Zoology at the
166:"Gregory Jefferis - MRC Laboratory of Molecular Biology"
606:"The Royal Society - Francis Crick Medal and Lecture"
575:"Neural Basis of Olfactory Perception in Drosophila"
74:. He became a Fellow of St John's College in 2004.
93:Jefferis joined the Neurobiology Division at the
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134:Harold M. Weintraub Graduate Student Award
30:. He is a tenured Programme Leader at the
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50:Jefferis studied Natural Sciences at the
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20:Gregory Stephen Xavier Edward Jefferis
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360:"Sexual dimorphism in the fly brain"
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515:10.1016/j.neuron.2016.06.012
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66:in 2003, supervised by
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40:University of Cambridge
28:Drosophila melanogaster
16:British neuroscientist
309:Jefferis, GS (2007).
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358:Cachero, S (2010).
272:2001Natur.414..204J
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72:Stanford University
142:Cold Spring Harbor
497:Costa, M (2016).
128:Awards and honors
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