2142:
2130:
1685:
Omenn, Gilbert S.; Lane, Lydie; Overall, Christopher M.; Paik, Young-Ki; Cristea, Ileana M.; Corrales, Fernando J.; Lindskog, Cecilia; Weintraub, Susan; Roehrl, Michael H. A.; Liu, Siqi; Bandeira, Nuno; Srivastava, Sudhir; Chen, Yu-Ju; Aebersold, Ruedi; Moritz, Robert L.; Deutsch, Eric W. (3 December
203:
has been debated in the scientific literature. The results of this debate and a series of meetings at the World
Congresses of the Human Proteome Organization in 2009, 2010 and 2011 has been the decision to define the Human Proteome Project as being composed of two sub-projects, C-HPP and B/D-HPP. The
680:
Omenn, Gilbert S.; States, David J.; Adamski, Marcin; Blackwell, Thomas W.; Menon, Rajasree; Hermjakob, Henning; Apweiler, Rolf; Haab, Brian B.; Simpson, Richard J.; Eddes, James S.; Kapp, Eugene A.; Moritz, Robert L.; Chan, Daniel W.; Rai, Alex J.; Admon, Arie (August 2005).
546:
Based on a comparison of nine major annotation portals gave a spread of human protein counts from 21,819 to 18,891 (as of 2017). The 2021 Metrics of the HPP show that protein expression has now been credibly detected 92.8% of the predicted proteins coded in the human genome.
1509:
Horvatovich, Péter; Lundberg, Emma K.; Chen, Yu-Ju; Sung, Ting-Yi; He, Fuchu; Nice, Edouard C.; Goode, Robert J.; Yu, Simon; Ranganathan, Shoba; Baker, Mark S.; Domont, Gilberto B.; Velasquez, Erika; Li, Dong; Liu, Siqi; Wang, Quanhui (2015-09-04).
542:
Updates on the Human
Proteome Project are regularly published, e.g. in the Journal of Proteome Research (2014). Metrics for the level of confidence associated with protein observations have been published as has been a "MissingProteinPedia".
1302:
Paik, Young-Ki; Jeong, Seul-Ki; Omenn, Gilbert S.; Uhlen, Mathias; Hanash, Samir; Cho, Sang Yun; Lee, Hyoung-Joo; Na, Keun; Choi, Eun-Young; Yan, Fangfei; Zhang, Fan; Zhang, Yue; Snyder, Michael; Cheng, Yong; Chen, Rui (2012-03-07).
2065:
860:"Towards standard protocols and guidelines for urine proteomics: a report on the Human Kidney and Urine Proteome Project (HKUPP) symposium and workshop, 6 October 2007, Seoul, Korea and 1 November 2007, San Francisco, CA, USA"
683:"Overview of the HUPO Plasma Proteome Project: results from the pilot phase with 35 collaborating laboratories and multiple analytical groups, generating a core dataset of 3020 proteins and a publicly-available database"
1560:
Baker, Mark S.; Ahn, Seong Beom; Mohamedali, Abidali; Islam, Mohammad T.; Cantor, David; Verhaert, Peter D.; Fanayan, Susan; Sharma, Samridhi; Nice, Edouard C.; Connor, Mark; Ranganathan, Shoba (2017-01-24).
803:
Hamacher, Michael; Stephan, Christian; Hardt, Tanja; Eisenacher, Martin; Henkel, Andreas; Wiltfang, Jens; Jimenez, Connie R.; Park, Young Mok; Marcus, Katrin; Meyer, Helmut E. (May 2008).
658:
204:
C-HPP will be organized into 25 groups, one per human chromosome. The B/D-HPP will be organized into groups by the biological and disease relevance of proteins.
518:
Data reduction, analysis and validation of MS/MS based proteomics results is being provided by Eric
Deutsch at the Institute for Systems Biology, Seattle, USA (
2060:
1511:
196:. It has also been responsible for projects associated with specific technology and standards necessary for the large scale study of proteins.
591:
Legrain, P.; Aebersold, Rued; Kumar, Bala; Beretta, Laura; Costello, Catherine E.; Borchers, Christoph H.; Corthals, Garry L. (29 April 2011).
2102:
1454:"Metrics for the Human Proteome Project 2015: Progress on the Human Proteome and Guidelines for High-Confidence Protein Identification"
1787:
1358:
Aebersold, Ruedi; Bader, Gary D.; Edwards, Aled M.; van Eyk, Jennifer E.; Kussmann, Martin; Qin, Jun; Omenn, Gilbert S. (2013-01-04).
597:
2134:
2080:
2173:
1452:
Omenn, Gilbert S.; Lane, Lydie; Lundberg, Emma K.; Beavis, Ronald C.; Nesvizhskii, Alexey I.; Deutsch, Eric W. (2015-09-04).
2108:
1360:"The biology/disease-driven human proteome project (B/D-HPP): enabling protein research for the life sciences community"
2024:
173:
153:
68:
2178:
526:). Overall integration and reporting informatics are the responsibility of Lydie Lane at SIB, Geneva, Switzerland (
522:). Data handling associated with antibody methods is being coordinated by Kalle von Feilitzen, Stockholm, Sweden (
2114:
1405:
Paik, Young-Ki; Omenn, Gilbert S.; Thongboonkerd, Visith; Marko-Varga, Gyorgy; Hancock, William S. (2014-01-03).
1025:
Archakov, Alexander; Bergeron, John J. M.; Khlunov, Alexander; Lisitsa, Andrey; Paik, Young-Ki (September 2009).
970:
Orchard, Sandra; Taylor, Chris; Hermjakob, Henning; Zhu, Weimin; Julian, Randall; Apweiler, Rolf (August 2004).
2070:
1915:
1847:
2055:
1927:
805:"Applications in brain proteomics: 8(th) HUPO Brain Proteome Project Workshop 7 October 2007, Seoul, Korea"
2096:
2012:
1815:
1780:
1688:"Progress Identifying and Analyzing the Human Proteome: 2021 Metrics from the HUPO Human Proteome Project"
858:
Yamamoto, Tadashi; Langham, Robyn G.; Ronco, Pierre; Knepper, Mark A.; Thongboonkerd, Visith (June 2008).
2075:
2029:
1086:"Building the 'practical' human proteome project - the next big thing in basic and clinical proteomics"
1835:
1820:
1574:
531:
200:
2168:
2045:
2019:
1877:
1864:
1825:
649:
561:
523:
1999:
1810:
1725:
1340:
1226:
1192:
1161:
1007:
952:
895:
840:
785:
728:
2050:
1859:
1773:
1717:
1667:
1649:
1608:
1590:
1542:
1534:
1491:
1473:
1434:
1426:
1387:
1379:
1332:
1324:
1284:
1266:
1218:
1210:
1153:
1145:
1105:
1097:
1066:
1048:
999:
991:
944:
936:
887:
879:
832:
824:
777:
769:
720:
712:
662:
626:
212:
The current set of working groups are listed below, in order of the chromosome to be studied.
86:
1305:"The Chromosome-Centric Human Proteome Project for cataloging proteins encoded in the genome"
1974:
1969:
1707:
1699:
1657:
1639:
1598:
1582:
1526:
1481:
1465:
1418:
1371:
1316:
1274:
1256:
1202:
1135:
1056:
1038:
983:
926:
871:
816:
759:
702:
694:
616:
606:
412:
1989:
1979:
1964:
1900:
469:
63:
1578:
1181:"Is a gene-centric human proteome project the best way for proteomics to serve biology?"
2146:
1984:
1887:
1830:
1712:
1687:
1662:
1627:
1603:
1562:
1486:
1453:
1279:
1244:
1061:
1026:
621:
592:
355:
180:
research projects associated with specific human tissues of clinical interest, such as
1512:"Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project"
2162:
1959:
1905:
1869:
1729:
1344:
1407:"Genome-wide proteomics, Chromosome-Centric Human Proteome Project (C-HPP), part II"
1230:
1165:
1011:
956:
899:
844:
789:
1949:
1910:
1842:
1644:
732:
572:
519:
181:
161:
1703:
1469:
1922:
1854:
128:
1261:
1179:
Rabilloud, Thierry; Hochstrasser, Denis; Simpson, Richard J. (September 2010).
1043:
931:
914:
764:
747:
530:). All data generated as part of HPP contributions are deposited to one of the
2007:
1954:
1944:
1939:
1745:
1245:"A gene-centric human proteome project: HUPO--the Human Proteome organization"
265:
177:
1653:
1594:
1538:
1477:
1430:
1383:
1328:
1270:
1214:
1149:
1101:
1052:
995:
987:
940:
883:
828:
773:
716:
2066:
Matrix-assisted laser desorption ionization-time of flight mass spectrometer
1934:
1406:
1359:
1304:
1180:
1085:
971:
859:
804:
682:
644:
611:
1721:
1671:
1612:
1546:
1495:
1438:
1391:
1336:
1288:
1222:
1206:
1157:
1109:
1070:
1003:
948:
891:
875:
836:
820:
781:
724:
698:
666:
630:
90:
1140:
1123:
1796:
707:
567:
527:
157:
48:
1586:
1563:"Accelerating the search for the missing proteins in the human proteome"
1895:
556:
1530:
1422:
1375:
1628:"Last rolls of the yoyo: Assessing the human canonical protein count"
1320:
199:
The structure and goals of a larger project that would parallel the
1197:
193:
189:
185:
16:
Scientific project coordinated by the Human
Proteome Organization
748:"Human liver proteome project: plan, progress, and perspectives"
593:"The Human Proteome Project: Current State and Future Direction"
135:
1769:
1760:
43:
protein sequence, phosphorylation, acetylation, glycosylation
1765:
156:. Its stated goal is to experimentally observe all of the
1750:
106:
1755:
176:
has served as a coordinating body for many long-running
116:
659:
American
Society for Biochemistry and Molecular Biology
645:"HUPO (Human Proteome Organization) 1st World Congress"
915:"Antibody-based proteomics for human tissue profiling"
2089:
2038:
1998:
1886:
1803:
972:"Current status of proteomic standards development"
127:
101:
96:
82:
74:
62:
57:
47:
37:
29:
24:
1027:"The Moscow HUPO Human Proteome Project workshop"
1756:Chromosome-centric HPP web site (www.c-hpp.org)
152:) is a collaborative effort coordinated by the
913:Uhlen, Mathias; Ponten, Fredrik (April 2005).
160:produced by the sequences translated from the
1781:
8:
19:
2061:Matrix-assisted laser desorption ionization
2129:
1788:
1774:
1766:
18:
1711:
1661:
1643:
1602:
1485:
1278:
1260:
1196:
1139:
1090:Current Opinion in Molecular Therapeutics
1060:
1042:
930:
763:
706:
620:
610:
214:
583:
1761:BD HPP web site (www.hupo.org/B/D-HPP)
2103:European Molecular Biology Laboratory
7:
1249:Molecular & Cellular Proteomics
1031:Molecular & Cellular Proteomics
919:Molecular & Cellular Proteomics
752:Molecular & Cellular Proteomics
598:Molecular & Cellular Proteomics
360:India, Singapore, Taiwan, Thailand
14:
2141:
2140:
2128:
1124:"The call of the human proteome"
1084:Baker, Mark S. (December 2009).
2081:Chromosome conformation capture
1746:HPP project page (www.hupo.org)
33:Whole-proteome characterization
1645:10.12688/f1000research.11119.1
1:
2109:National Institutes of Health
1751:HPP web site (www.thehpp.org)
1704:10.1021/acs.jproteome.1c00590
1626:Southan, Christopher (2017).
1470:10.1021/acs.jproteome.5b00499
1255:(2): 427–429. February 2010.
1692:Journal of Proteome Research
1519:Journal of Proteome Research
1458:Journal of Proteome Research
1411:Journal of Proteome Research
1364:Journal of Proteome Research
506:
503:
500:
495:
492:
489:
484:
481:
478:
473:
468:
465:
460:
457:
454:
449:
446:
443:
438:
435:
432:
427:
424:
421:
416:
411:
408:
403:
400:
397:
392:
389:
386:
381:
378:
375:
370:
367:
364:
359:
354:
351:
346:
343:
340:
335:
332:
329:
324:
321:
318:
313:
310:
307:
302:
299:
296:
291:
288:
285:
280:
277:
274:
269:
264:
261:
256:
253:
250:
245:
242:
239:
234:
231:
228:
223:
220:
217:
2025:Structure-based drug design
976:Expert Review of Proteomics
746:He, Fuchu (December 2005).
661:: 651–752. September 2002.
174:Human Proteome Organization
154:Human Proteome Organization
69:Human Proteome Organization
2195:
1262:10.1074/mcp.H900001-MCP200
1134:(9): 661. September 2010.
1044:10.1074/mcp.H900009-MCP200
932:10.1074/mcp.R500009-MCP200
765:10.1074/mcp.R500013-MCP200
2124:
2115:Wellcome Sanger Institute
493:Ghasem Hosseini Salekdeh
2071:Microfluidic-based tools
1916:Human Connectome Project
1848:Human Microbiome Project
988:10.1586/14789450.1.2.179
2056:Electrospray ionization
1928:Human Epigenome Project
612:10.1074/mcp.M111.009993
514:Computational resources
303:Australia, New Zealand
2097:DNA Data Bank of Japan
2013:Human proteome project
1816:Computational genomics
1207:10.1002/pmic.201000220
876:10.1002/pmic.200800138
821:10.1002/pmic.200701120
699:10.1002/pmic.200500358
146:Human Proteome Project
20:Human Proteome Project
2174:Human genome projects
2076:Isotope affinity tags
2030:Expression proteomics
1567:Nature Communications
1141:10.1038/nmeth0910-661
224:National affiliation
1836:Human Genome Project
1821:Comparative genomics
1309:Nature Biotechnology
201:Human Genome Project
2046:2-D electrophoresis
2020:Call-map proteomics
1878:Structural genomics
1865:Population genomics
1826:Functional genomics
1587:10.1038/ncomms14271
1579:2017NatCo...814271B
650:Mol Cell Proteomics
564:- Protein databases
562:Human Protein Atlas
524:Human Protein Atlas
436:György Marko-Varga
289:Christoph Borchers
208:Projects and groups
21:
2000:Structural biology
1811:Cognitive genomics
605:(7): M111.009993.
401:Fernando Corrales
390:Gilberto B Domont
278:Peter Horvatovich
2179:Protein databases
2156:
2155:
2051:Mass spectrometer
1860:Personal genomics
1698:(12): 5227–5240.
1531:10.1021/pr5013009
1423:10.1021/pr4011958
1376:10.1021/pr301151m
1191:(17): 3067–3072.
870:(11): 2156–2159.
758:(12): 1841–1848.
693:(13): 3226–3245.
511:
510:
482:Yasushi Ishihama
254:Takeshi Kawamura
142:
141:
2186:
2144:
2143:
2132:
2131:
1975:Pharmacogenomics
1970:Pharmacogenetics
1790:
1783:
1776:
1767:
1734:
1733:
1715:
1682:
1676:
1675:
1665:
1647:
1623:
1617:
1616:
1606:
1557:
1551:
1550:
1525:(9): 3415–3431.
1516:
1506:
1500:
1499:
1489:
1464:(9): 3452–3460.
1449:
1443:
1442:
1402:
1396:
1395:
1355:
1349:
1348:
1321:10.1038/nbt.2152
1299:
1293:
1292:
1282:
1264:
1241:
1235:
1234:
1200:
1176:
1170:
1169:
1143:
1120:
1114:
1113:
1081:
1075:
1074:
1064:
1046:
1037:(9): 2199–2200.
1022:
1016:
1015:
967:
961:
960:
934:
910:
904:
903:
855:
849:
848:
815:(9): 1750–1753.
800:
794:
793:
767:
743:
737:
736:
710:
677:
671:
670:
641:
635:
634:
624:
614:
588:
458:Albert Sickmann
413:Gilbert S. Omenn
356:Ravi Sirdeshmukh
215:
138:
123:
120:
118:
113:
110:
108:
83:Primary citation
22:
2194:
2193:
2189:
2188:
2187:
2185:
2184:
2183:
2159:
2158:
2157:
2152:
2120:
2085:
2034:
1994:
1990:Transcriptomics
1980:Systems biology
1965:Paleopolyploidy
1901:Cheminformatics
1882:
1799:
1794:
1742:
1737:
1684:
1683:
1679:
1625:
1624:
1620:
1559:
1558:
1554:
1514:
1508:
1507:
1503:
1451:
1450:
1446:
1404:
1403:
1399:
1357:
1356:
1352:
1301:
1300:
1296:
1243:
1242:
1238:
1178:
1177:
1173:
1122:
1121:
1117:
1083:
1082:
1078:
1024:
1023:
1019:
969:
968:
964:
912:
911:
907:
857:
856:
852:
802:
801:
797:
745:
744:
740:
679:
678:
674:
643:
642:
638:
590:
589:
585:
581:
553:
540:
532:ProteomeXchange
516:
470:Akhilesh Pandey
379:Charles Pineau
210:
170:
134:
115:
114:
105:
64:Research center
39:
17:
12:
11:
5:
2192:
2190:
2182:
2181:
2176:
2171:
2161:
2160:
2154:
2153:
2151:
2150:
2138:
2125:
2122:
2121:
2119:
2118:
2112:
2106:
2100:
2093:
2091:
2087:
2086:
2084:
2083:
2078:
2073:
2068:
2063:
2058:
2053:
2048:
2042:
2040:
2039:Research tools
2036:
2035:
2033:
2032:
2027:
2022:
2017:
2016:
2015:
2004:
2002:
1996:
1995:
1993:
1992:
1987:
1985:Toxicogenomics
1982:
1977:
1972:
1967:
1962:
1957:
1952:
1947:
1942:
1937:
1932:
1931:
1930:
1920:
1919:
1918:
1908:
1903:
1898:
1892:
1890:
1888:Bioinformatics
1884:
1883:
1881:
1880:
1875:
1867:
1862:
1857:
1852:
1851:
1850:
1840:
1839:
1838:
1831:Genome project
1828:
1823:
1818:
1813:
1807:
1805:
1801:
1800:
1795:
1793:
1792:
1785:
1778:
1770:
1764:
1763:
1758:
1753:
1748:
1741:
1740:External links
1738:
1736:
1735:
1677:
1618:
1552:
1501:
1444:
1397:
1350:
1315:(3): 221–223.
1294:
1236:
1171:
1128:Nature Methods
1115:
1096:(6): 600–602.
1076:
1017:
982:(2): 179–183.
962:
925:(4): 384–393.
905:
850:
795:
738:
672:
636:
582:
580:
577:
576:
575:
570:
565:
559:
552:
549:
539:
538:Current status
536:
534:repositories.
515:
512:
509:
508:
505:
504:Andrea Urbani
502:
498:
497:
494:
491:
487:
486:
483:
480:
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463:
462:
459:
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441:
440:
437:
434:
430:
429:
426:
425:Alex Archakov
423:
419:
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406:
405:
402:
399:
395:
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391:
388:
384:
383:
380:
377:
373:
372:
369:
368:Young Ki Paik
366:
362:
361:
358:
353:
349:
348:
345:
344:Jong Shin Yoo
342:
338:
337:
334:
333:Joshua Labaer
331:
327:
326:
323:
320:
316:
315:
312:
311:Pengyuan Yang
309:
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35:
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15:
13:
10:
9:
6:
4:
3:
2:
2191:
2180:
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2172:
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2167:
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2164:
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2139:
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2136:
2127:
2126:
2123:
2116:
2113:
2110:
2107:
2104:
2101:
2098:
2095:
2094:
2092:
2090:Organizations
2088:
2082:
2079:
2077:
2074:
2072:
2069:
2067:
2064:
2062:
2059:
2057:
2054:
2052:
2049:
2047:
2044:
2043:
2041:
2037:
2031:
2028:
2026:
2023:
2021:
2018:
2014:
2011:
2010:
2009:
2006:
2005:
2003:
2001:
1997:
1991:
1988:
1986:
1983:
1981:
1978:
1976:
1973:
1971:
1968:
1966:
1963:
1961:
1960:Nutrigenomics
1958:
1956:
1953:
1951:
1948:
1946:
1943:
1941:
1938:
1936:
1933:
1929:
1926:
1925:
1924:
1921:
1917:
1914:
1913:
1912:
1909:
1907:
1906:Chemogenomics
1904:
1902:
1899:
1897:
1894:
1893:
1891:
1889:
1885:
1879:
1876:
1874:
1872:
1868:
1866:
1863:
1861:
1858:
1856:
1853:
1849:
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1950:Metabolomics
1911:Connectomics
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322:Je-Yoel Cho
300:Edward Nice
281:Netherlands
246:Switzerland
211:
198:
182:blood plasma
171:
162:human genome
149:
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143:
53:Homo sapiens
1923:Epigenomics
1855:Pangenomics
243:Lydie Lane
218:Chromosome
129:Web service
30:Description
2169:Proteomics
2163:Categories
2008:Proteomics
1945:Lipidomics
1940:Immunomics
1417:(1): 1–4.
1185:Proteomics
864:Proteomics
809:Proteomics
687:Proteomics
579:References
447:Siqiu Liu
266:Yu-Ju Chen
178:proteomics
75:Laboratory
38:Data types
1935:Glycomics
1730:239050778
1654:2046-1402
1595:2041-1723
1573:: 14271.
1539:1535-3907
1478:1535-3907
1431:1535-3907
1384:1535-3907
1345:205276763
1329:1546-1696
1271:1535-9484
1215:1615-9861
1198:1007.5378
1150:1548-7105
1102:2040-3445
1053:1535-9484
996:1744-8387
941:1535-9476
884:1615-9861
829:1615-9861
774:1535-9476
717:1615-9853
49:Organisms
2147:Category
1873:genomics
1797:Genomics
1722:34670092
1672:28529709
1613:28117396
1547:26076068
1496:26155816
1439:24328071
1392:23259511
1337:22398612
1289:20124355
1231:14253657
1223:20648483
1166:41368976
1158:20827799
1110:20077630
1071:19734150
1012:21359913
1004:15966812
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949:15695805
900:13764796
892:18528840
845:20622786
837:18384107
790:34735692
782:16118399
725:16104056
667:12474872
631:21742803
568:NeXtProt
551:See also
528:NeXtProt
461:Germany
232:Ping Xu
158:proteins
91:22398612
40:captured
1896:Biochip
1713:9340669
1686:2021).
1663:5428527
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1604:5286205
1575:Bibcode
1487:4755311
1280:2830851
1062:2742447
733:2718659
622:3134076
557:BioPlex
439:Sweden
428:Russia
393:Brazil
382:France
292:Canada
270:Taiwan
168:History
109:.thehpp
102:Website
78:various
58:Contact
25:Content
1804:Fields
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507:Italy
485:Japan
450:China
404:Spain
371:Korea
347:Korea
314:China
257:Japan
235:China
119:.c-hpp
97:Access
89:
2111:(USA)
1871:Socio
1726:S2CID
1515:(PDF)
1341:S2CID
1227:S2CID
1193:arXiv
1162:S2CID
1008:S2CID
953:S2CID
896:S2CID
841:S2CID
786:S2CID
729:S2CID
657:(9).
496:Iran
194:urine
190:brain
186:liver
2135:List
2117:(UK)
2105:(EU)
2099:(JP)
1718:PMID
1668:PMID
1650:ISSN
1609:PMID
1591:ISSN
1543:PMID
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721:PMID
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663:PMID
627:PMID
474:USA
417:USA
336:USA
192:and
172:The
144:The
121:.org
111:.org
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1257:doi
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1136:doi
1057:PMC
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703:hdl
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617:PMC
607:doi
501:MT
466:22
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131:URL
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