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level), and the condition improves in many patients when they move to lower altitudes. However, some patients who are affected already live at sea level.18,19,27 •Some authors are considering a food photosensitizer or a nutritional selective deficiency as a cause; however, no evidence proves this theory.27
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The cause for actinic prurigo is unknown, however researchers believe that protein in our bodies may be a cause to the condition also: •UV-A and UV-B light seem to be the main provoking agents. This observation is supported by the fact that most patients live at high altitudes (>1000 m above sea
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AP is characterized by itchy, inflamed papules, nodules, and plaques on the skin. Lesions typically appear hours or days after exposure of the skin to UV light, and follow a general pattern of sun-exposed areas. The face, neck, arms, hands, and legs are often affected, although lesions sometimes
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Torres-Alvarez, B; Baranda, L; Fuentes, C; Delgado, C; Santos-Martinez, L; Portales-Perez, D; Moncada, B; Gonzalez-Amaro, R (January 1998). "An immunohistochemical study of UV-induced skin lesions in actinic prurigo. Resistance of langerhans cells to UV light".
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HLA-DR4, is often called "Familial polymorphous light eruption of
American Indians" or "Hereditary polymorphous light eruption of American Indians" but some experts consider it to be a variant of the syndrome known as
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throughout the year, and even on cloudy or overcast days, as UVA light, unlike UVB light, is able to penetrate cloud cover and remains constant throughout the day.
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Draelos, Zoe
Kececioglu; Hansen, Ronald C. (November 1986). "Polymorphic Light Eruption in Pediatric Patients with American Indian Ancestry".
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to denote a rare photodermatosis that develops in childhood and is chronic and persistent; this rare photodermatosis, associated with the
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AP is a chronic disease, and symptoms usually worsen in the spring and summer as the day lengthens and exposure to sunlight increases.
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appear on skin that is covered by clothing and thus not exposed to UV light, thus making AP somewhat difficult to diagnose.
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Currently there is no cure for actinic prurigo, and treatment focuses on relieving the dermatologic symptoms, by way of
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is a rare sunlight-induced, pruritic, papular, or nodular skin eruption. Some medical experts use the term
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All patients with AP are encouraged to minimize sun exposure, and to use strong
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List of human leukocyte antigen alleles associated with cutaneous conditions
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has proven to be effective in controlling the symptoms of actinic prurigo.
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Actinic prurigo (AP) was first described by
Escalona in Mexico, in 1954.
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Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007).
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365:. Vol. 1. J. & A. Churchill. pp. 130–131.
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Lim, H. W.; Honigsmann, H.; Hawk, J. L., eds. (2007).
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