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267:"The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex"
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Aravind L, Koonin EV (1998). "The HORMA domain: a common structural denominator in mitotic checkpoints, chromosome synapsis and DNA repair".
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crystal structure of mad1-mad2 reveals a conserved mad2 binding motif in mad1 and cdc20.
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This article incorporates text from the public domain
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229:Humans proteins containing this domain include:
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197:and act as an adaptor that recruits other
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205:-specific protein, Rev7 is required for
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181:that has been suggested to recognise
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265:He X, Patterson TE, Sazer S (1997).
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363:Eukaryotic Linear Motif resource
193:breaks or non-attachment to the
217:upon detection of a defect in
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338:10.1016/S0968-0004(98)01257-2
97:Available protein structures:
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157:In molecular biology, the
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271:Proc Natl Acad Sci U S A
292:10.1073/pnas.94.15.7965
185:states resulting from
283:1997PNAS...94.7965H
326:Trends Biochem Sci
161:(named after the
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146:structure summary
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396:Protein domains
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277:(15): 7965–70.
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219:mitotic spindle
191:double stranded
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357:External links
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365:motif class
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201:. Hop1 is a
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159:HORMA domain
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19:HORMA domain
221:integrity.
211:mutagenesis
187:DNA adducts
36:Identifiers
252:References
215:cell cycle
207:DNA damage
109:structures
382:IPR003511
183:chromatin
169:ev7p and
67:IPR003511
390:Category
378:InterPro
367:LIG_MAD2
225:Examples
209:induced
199:proteins
175:proteins
126:RCSB PDB
62:InterPro
346:9757827
311:9223296
279:Bibcode
238:HORMAD2
234:HORMAD1
203:meiosis
195:spindle
177:) is a
55:PF02301
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246:MAD2L2
242:MAD2L1
141:PDBsum
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87:SUPFAM
41:Symbol
302:21538
165:p1p,
83:SCOPe
74:SCOP2
44:HORMA
376:and
374:Pfam
342:PMID
307:PMID
134:PDBj
130:PDBe
113:ECOD
103:Pfam
79:1duj
50:Pfam
334:doi
297:PMC
287:doi
173:D2
121:PDB
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171:MA
163:Ho
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167:R
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
