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or acids, the differentiation pathways can be closely studied along with their dependence on surrounding conditions. Accordingly, studies of HT-29 cells have shown induced differentation as a result of
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Though HT-29 cells can proliferate in cell culture lacking growth factors with a doubling time of around 4 days, the doubling time can be reduced to one day with added
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Gout, S; et al. (1 October 2004). "Early enterocytic differentiation of HT-29 cells: biochemical changes and strength increases of adherens junctions".
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Initially derived in 1964 by Jorgen Fogh from a 44-year-old
Caucasian female, HT-29 cells form a tight monolayer while exhibiting similarity to
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153:. The cells have high glucose consumption, and in standard medium containing 25 mM glucose and 10% serum, remain undifferentiated.
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221:"Proliferation of the Human Colon Carcinoma Cell Line HT29: Autocrine Growth and Deregulated Expression of the c-myc Oncogene"
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255:"HT-29 cells are an in vitro model for the generation of cell polarity in epithelia during embryonic differentiation"
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Cohen, E; et al. (August 1999). "Induced differentiation in HT29, a human colon adenocarcinoma cell line".
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with rodents. HT-29 cells terminally differentiate into enterocytes with the replacement of
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is deregulated, but may have a relation with the growth factor requirements of HT-29 cells.
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tumor antigen, but have a mutation in the p53 gene at position 273, resulting in a
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In preclinical research, HT-29 cells have been studied for their ability to
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Martínez-Maqueda, D; et al. (2015). "HT29 Cell Line".
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Coudray, Anne-Marie; et al. (1 December 1989).
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The p53 protein, shown interacting with a strand of
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used extensively in biological and cancer research.
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179:. Springer. pp. 113–124.
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253:Hirn, M; et al. (1988).
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