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Aderans
Research Institute, a Japanese company, worked on what they called the "Ji Gami" process, which involved the removal of a small strip of the scalp, which is broken down into individual follicular stem cells. After the extraction, these cells are cultured and injected back into the bald areas
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One of the first companies to begin experimenting with hair cloning was
Intercytex. Intercytex tried to clone new hair follicles from the stem cells harvested from the back of the neck. They hoped that if they multiplied the follicles and then implanted them back in the scalp in the bald areas, they
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are completely absent from the scalp, so they cannot be regenerated. However, the follicles are not entirely absent, as there are stem cells in the bald scalp from which the follicles naturally arise. The behavior of these follicles is suggested to be the result of
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can be extracted from the subject from areas that are not bald and are not suffering hair loss. They can be multiplied (cloned) by various culturing methods and the new cells can be injected back into the bald scalp, where they would produce healthy hair.
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in
Germany, with Intercytex and several other research teams, took animal cells and created follicles by using them. As a result, they produced follicles "thinner than normal". They were able to clone one or two follicles from an extracted hair.
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In 2012, scientists from the
University of Pennsylvania School of Medicine published their own findings regarding hair cloning. During their investigation, they found that non-bald and bald scalps have the same number of stem cells, but the
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number was significantly depleted in the case of the latter. Based on this, they concluded that it is not the absence of the stem cells that are responsible for hair loss but the unsuccessful activation of said cells.
81:, is a proposed technique to counter hair loss. The technology is in its early stages, but multiple groups have demonstrated pieces of the technology at a small scale, with a few in commercial development.
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and dermal cell therapy. The hair was aligned properly with a 3D-printed biodegradable shaft. The hairs were permanent and regenerated naturally. Stemson intends to enter clinical trials in 2026.
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would be successful in regrowing the hair itself. In 2008, Intercytex interpreted that they failed in fully developing the hair cloning therapy and decided to discontinue all research.
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171:–based company, was founded in 2018 and has demonstrated growing a patch of human hair on a mouse. In July 2019, a researcher from San Diego–based Stemson Therapeutics, partnered with
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In
October 2022, researchers from the Japan-based Yokohama National University successfully cloned fully-grown mouse hair follicles for the first time in history.
334:"Therapeutic strategy for hair regeneration: hair cycle activation, niche environment modulation, wound-induced follicle neogenesis, and stem cell engineering"
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of the scalp. The trials continued in 2012. Aderans decided to discontinue the funding of its hair multiplication research in July 2013.
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160:, and when implanted in a mouse, the skin grew hairs successfully. The group has formed partnerships with Organ Technologies and
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In 2015, initial trials for human hair were successful in generating new follicles, but the hairs grew in varying directions.
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315:"Perelman School of Medicine Experts Identify Inhibitor Causing Male Pattern Baldness and Target for Hair Loss Treatments"
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461:"Kyocera Corporation, RIKEN And Organ Technologies Launch Joint Research In Regenerative Medicine To Treat Hair Loss"
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The first time scientists were able to grow artificial hair follicles from stem cells was in 2010. Scientists at the
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In 2016, scientists in Japan announced they had successfully grown human skin in a lab. The skin was created using
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405:"Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model"
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Takagi R, Ishimaru J, Sugawara A, Toyoshima KE, Ishida K, Ogawa M, et al. (April 2016).
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552:"Reprogramming of three-dimensional microenvironments for in vitro hair follicle induction"
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Kageyama T, Shimizu A, Anakama R, Nakajima R, Suzuki K, Okubo Y, Fukuda J (October 2022).
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293:"Aderans to no Longer Fund its Hair Multiplication Research | Hair Loss Q & A"
243:"Hair Care and Trichology | Health Articles | The Future of Hair Restoration"
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Chueh SC, Lin SJ, Chen CC, Lei M, Wang LM, Widelitz R, et al. (March 2013).
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268:"Detail How Intercytex Failed Fully In Developing Hair Cloning Therapy"
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Scientists previously assumed that in the case of complete baldness,
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530:"Hair Cloning Research And Progress 2023 – Follicle Thought"
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175:, successfully grew his own follicles on a mouse using
486:"Going bald? Lab-grown hair cells could be on the way"
512:"Functional hair follicles grown from stem cells"
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62:Learn how and when to remove this message
510:Prebys, Sanford Burnham (27 June 2019).
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16:Proposed technique to counter hair loss
245:. Worldwidehealth.com. 31 January 2014
164:to commercially develop the research.
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338:Expert Opinion on Biological Therapy
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100:is that healthy follicle cells or
34:tone or style may not reflect the
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384:. columbia.edu. 14 December 2013
223:. hairforlife.info. 21 July 2020
44:guide to writing better articles
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201:Follicular unit transplantation
295:. Regrowhair.com. 30 July 2013
158:induced pluripotent stem cells
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124:Technische Universität Berlin
350:10.1517/14712598.2013.739601
93:deficiency in these areas.
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611:Cell Therapy for Hair Loss
135:University of Pennsylvania
221:"Methods of Hair cloning"
96:The basic idea of hair
38:used on Knowledge (XXG)
576:10.1126/sciadv.add4603
429:10.1126/sciadv.1500887
42:See Knowledge (XXG)'s
490:MIT Technology Review
382:"Grow New Follicles"
568:2022SciA....8D4603K
421:2016SciA....2E0887T
162:Kyocera Corporation
75:Hair multiplication
642:Tissue engineering
319:Penn Medicine News
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36:encyclopedic tone
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616:Hair restoration
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114:Early trials
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623:(in German)
277:12 February
149:Development
647:Trichology
637:Human hair
631:Categories
621:Haarklinik
516:Eurekalert
299:5 February
249:5 February
207:References
181:epithelial
535:9 January
495:3 October
470:3 October
196:Hair loss
179:-derived
86:follicles
594:36269827
465:BioSpace
447:27051874
368:23289545
190:See also
109:Research
585:9586475
564:Bibcode
438:4820374
417:Bibcode
388:21 July
359:3706200
227:21 July
98:cloning
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537:2024
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443:PMID
390:2020
364:PMID
301:2014
279:2023
251:2014
229:2020
177:iPSC
173:UCSD
580:PMC
572:doi
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