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A is already fixed, or nearly fixed. Hence one should expect the time between the A mutation arising and the population becoming fixed for AB to be much longer in the absence of recombination. Hence recombination allows evolution to progress faster. There tends to be a correlation between the rate of recombination and the likelihood of the preferred haplotype (in the above example labeled as
161:(1932), although the verbal arguments were substantially different. Although the Hill-Robertson effect is usually thought of as describing a disproportionate buildup of fitness-reducing (relative to fitness increasing) LD over time, these effects also have immediate consequences for mean population fitness.
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will hence go to fixation. However, if there is no recombination, AB individuals can only occur if the latter mutation (B) happens to occur in an Ab individual. The chance of this happening depends on the frequency of new mutations, and on the size of the population, but is in general unlikely unless
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arises in a given individual, that individual's genes will through natural selection become more frequent in the population over time. However, if a separate advantageous mutant (
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will be in competition. If recombination is present, then individuals carrying both A and B (of genotype AB) will eventually arise. Provided there are no negative
370:
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Crouch DJ (October 2017). "Statistical aspects of evolution under natural selection, with implications for the advantage of sexual reproduction".
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This is most easily seen by considering the case of disequilibria caused by mutation: Consider a population of individuals whose
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in 1966. It provides an explanation as to why there may be an evolutionary advantage to
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has gone to fixation, and happens to arise in an individual who does not carry
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242:(4th ed.). Sunderland, Massachusetts, USA: Sinauer Associates.
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396:"Primo vascular system in the subarachnoid space of a mouse brain"
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In a population of finite but effective size which is subject to
149:(1974) showed this effect to be mathematically identical to the
265:"Graph-structured populations and the Hill-Robertson effect"
196:"The effect of linkage on limits to artificial selection"
400:
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Moon SH, Cha R, Lee GL, Lim JK, Soh KS (March 1932).
122:effects of carrying both, individuals of genotype
67:, and they will tend to slow down the process of
16:Evolutionary advantage for genetic recombination
322:"The evolutionary advantage of recombination"
126:will have a greater selective advantage than
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372:The Genetical Theory of Natural Selection
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59:(LD) will occur. These can be caused by
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194:Hill WG, Robertson A (December 1966).
143:) goes into fixation in a population.
31:, is a phenomenon first identified by
263:Whigham PA, Spencer HG (March 2021).
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240:Principles of Population genetics
500:Genetics in the United Kingdom
453:Journal of Theoretical Biology
320:Felsenstein J (October 1974).
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86:. If an advantageous mutant (
110:, then individuals carrying
375:. Oxford: Clarendon Press.
238:Hartl DL, Clark AG (2007).
29:Hill–Robertson interference
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473:10.1016/j.jtbi.2017.07.021
269:Royal Society Open Science
338:10.1093/genetics/78.2.737
213:10.1017/S0016672300010156
114:and individuals carrying
71:by natural selection.
57:linkage disequilibria
55:, varying extents of
41:genetic recombination
25:Hill–Robertson effect
510:Evolutionary biology
78:has only two genes,
505:Population genetics
465:2017JThBi.431...79C
289:10.1098/rsos.201831
281:2021RSOS....801831W
176:Genetic hitchhiking
171:Clonal interference
151:Fisher–Muller model
21:population genetics
369:Fisher RA (1930).
200:Genetical Research
249:978-1-4292-1145-1
134:individuals, and
53:natural selection
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157:(1930) and
47:Explanation
494:Categories
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182:References
98:) of gene
90:) of gene
459:: 79–86.
120:epistatic
69:evolution
33:Bill Hill
481:28779948
438:84301227
430:23781258
326:Genetics
307:33959343
165:See also
65:mutation
461:Bibcode
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356:4448362
347:1213231
298:8074956
277:Bibcode
222:5980116
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76:genome
63:or by
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27:, or
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404:2013
377:OCLC
352:PMID
303:PMID
244:ISBN
218:PMID
82:and
35:and
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130:or
19:In
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230:^
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141:AB
136:AB
132:Ab
128:aB
124:AB
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273:8
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204:8
116:A
112:B
108:A
104:A
100:b
96:B
92:a
88:A
84:b
80:a
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