128:) appear to have three transmembrane segments (TMSs). Members of the Hol-X family appear to have two putative TMSs. The missing TMS in family 34 proteins is the N-terminal TMS as revealed by multiple alignments. These seven families have average sizes of 110, 96, 105, 112, 143, 159 and 108 amino acyl residues (aas), respectively. Notice that the only family with members predicted to have just two TMSs is the one containing the largest homologues; this is due to hydrophilic extensions. The average size of proteins in the entire superfamily is 114 aas with a standard deviation o 23 aas.
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in total. In general, these proteins are thought to play a role in regulated cell death, although functionality varies between families and individual members.
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172:"Topological and phylogenetic analyses of bacterial holin families and superfamilies"
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Members of all families (with the exception of the Hol-X family;
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Members of the holin superfamily III are derived from
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170:Reddy, Bhaskara L.; Saier, Milton H. (2013-11-01).
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The
Putative Actinobacterial Holin-X (Hol-X) Family
176:Biochimica et Biophysica Acta (BBA) - Biomembranes
55:. This superfamily includes seven TC families:
119:The Deinococcus/Thermus Holin (D/T-Hol) Family
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88:The PRD1 Phage P35 Holin (P35 Holin) Family
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148:Transporter Classification Database
28:. It is one of the seven different
269:. You can help Knowledge (XXG) by
79:The LydA Holin (LydA Holin) Family
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71:- The P2 Holin (P2 Holin) Family
64:The λ Holin S (λ Holin) Family
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188:10.1016/j.bbamem.2013.07.004
101:Hol Holin (Hol Holin) Family
26:membrane transport proteins
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326:Membrane protein stubs
265:–related article is a
99:Pseudomonas aeruginosa
321:Protein superfamilies
18:Holin Superfamily III
30:holin superfamilies
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182:(11): 2654–2671.
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263:membrane protein
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45:Actinomycetota
37:Pseudomonadota
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271:expanding it
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49:Deinococcota
41:Synergistota
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24:of integral
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22:superfamily
310:Categories
154:References
126:TC# 1.E.34
196:0006-3002
214:23856191
132:See also
240:Biology
205:3788059
53:Archaea
316:Holins
226:Portal
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115:1.E.41
106:1.E.34
93:1.E.20
51:, and
261:This
143:Lysin
138:Holin
84:1.E.5
75:1.E.4
69:1.E.3
60:1.E.2
20:is a
267:stub
210:PMID
192:ISSN
180:1828
97:The
16:The
200:PMC
184:doi
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