156:
epithelial cells to bring out the mechanism of innate defense that manages the attack of extracellular pathogens. The IL-28 subfamily of cytokine are type III interferon (IFN) family. This subfamily share intersecting biology and signaling pathways with type I IFN family cytokines but the difference is that the type III INF family cytokines prefer to target the tissues of the epithelial cell.
79:
The IL-10 family is one of the important types of cytokines, that can stop the inflammation. In general. these cytokines have a helical structure of homodimers. The difference that the members of IL-10 family have between each other is that they have various receptor-binding residues, which help with
155:
Based on the functions of the cytokine, the IL-10 family can be separated into three subfamily groups. IL-10 subfamily cytokine selects the innate and adaptive immune response and can prevent the function to reduce tissue damage. The IL-20 subfamily of cytokine works on tissues in the stroma and
80:
interaction with specific cytokine receptors. The features of the IL-10 family consists of their genomic structure being similar, their primary and secondary protein structures being similar, their a clustering of encoding genes, and their utilization the similar receptor complexes.
104:
by dendritic cells (DC) and antigen-presenting cells (APC), and of T cells, decreasing their cytokine production, therefore, controlling their activation. IL-10 plays a big role in regulating allergies by inhibiting cytokines responsible for allergic inflammation.
113:
Interleukin 19 is produced mainly in monocytes, and can be found in big concentrations in patients with allergic disorders and psoriasis. IL-19 plays a big role in the CNS by regulating the inflammation process through a delayed production of it.
122:
IL-20 - induces cheratin proliferation and Stat-3 signal transduction pathway; is expressed in the CNS, myeloid cells, and keratinocytes. When IL-20 is inhibited in the CNS can stop such inflammations as acute ischemic brain injury.
88:
Interleukin 10 is produced by regulatory T lymphocytes, B cells, and monocytes. It is a homodimer that functions through the IL-10R1 and IL-10R2 receptor complexes, activating such kinases as
1804:
560:"Distribution of interleukin-10 family cytokines in serum and synovial fluid of patients with inflammatory arthritis reveals different contribution to systemic and joint inflammation"
1193:
147:
IL-26 is a newly discovered cytokine produced by memory T cells and monocytes. IL-26 assist with the process of human T cell transformation after their infections.
1797:
1790:
1269:
340:
Trivella, Daniela
Barretto Barbosa; Ferreira-Júnior, José Ribamar; Dumoutier, Laure; Renauld, Jean-Christophe; Polikarpov, Igor (September 2010).
523:"Role of Interleukins on Physiological and Pathological Bone Resorption and Bone Formation: Effects by Cytokines in The IL-6 and IL-10 Families"
3002:
2269:
1664:
3006:
2992:
2952:
534:
3021:
131:
IL-22 mediates inflammation and binds class II cytokine receptor heterodimers IL-22 RA1/CRF2-4; is involved in immuno-regulatory responses
208:
Commins S, Steinke JW, Borish L (May 2008). "The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29".
689:
2926:
1874:
1555:
71:
The IL-10 family are helical cytokines categorized based on their specific similarities and can be classified as class 2 cytokines.
1085:
173:
Conti P, Kempuraj D, Frydas S, et al. (September 2003). "IL-10 subfamily members: IL-19, IL-20, IL-22, IL-24 and IL-26".
2887:
2866:
862:
558:
Scrivo, R.; Conigliaro, P.; Riccieri, V.; Di Franco, M.; Alessandri, C.; Spadaro, A.; Perricone, R.; Valesini, G. (2015).
1698:
1248:
1023:
96:. IL-10R2 receptor is presented in most cells, when IL-10R1 receptor is IL-10 is also an inhibitor of expressions of
1731:
1533:
1243:
1652:
1337:
293:
Fickenscher, Helmut; Hör, Simon; Küpers, Heide; Knappe, Andrea; Wittmann, Sabine; Sticht, Heinrich (2002-02-01).
1687:
1114:
1090:
2845:
2805:
2784:
2728:
2696:
2655:
2613:
2567:
2486:
2460:
2404:
2363:
2337:
2311:
1965:
682:
2420:
2280:
2260:
2239:
2158:
2097:
2041:
1995:
1919:
1824:
1015:
522:
1930:
3042:
247:
2825:
1813:
1541:
294:
1955:
411:
2816:
2374:
2169:
1945:
1839:
1383:
2686:
2681:
3067:
2666:
2578:
2557:
2006:
1940:
1899:
1843:
1816:
1550:
1507:
1422:
1265:
1129:
675:
653:
387:
2547:
2415:
2322:
2301:
2052:
2021:
2016:
1960:
1879:
2593:
2026:
1854:
1849:
2199:
2184:
2148:
2118:
1864:
1414:
1033:
899:
645:
637:
589:
530:
503:
485:
439:
431:
379:
361:
322:
314:
275:
267:
225:
190:
93:
3037:
1726:
1647:
1515:
1204:
1038:
627:
579:
571:
493:
475:
423:
412:"The extended IL-10 superfamily: IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28, and IL-29"
369:
353:
306:
259:
217:
182:
2513:
2509:
2505:
2829:
1253:
939:
342:"Structure and function of interleukin-22 and other members of the interleukin-10 family"
374:
341:
3027:
3017:
3012:
2998:
2984:
2974:
2969:
2916:
2898:
2877:
2856:
2835:
2821:
2795:
2739:
2707:
2671:
2634:
2629:
2624:
2588:
2583:
2497:
2476:
2430:
2379:
2348:
2327:
2062:
2031:
1767:
1762:
1617:
1613:
1595:
1590:
1393:
1388:
1378:
1373:
1368:
1363:
1358:
1354:
1323:
1318:
1313:
1292:
1287:
1282:
1277:
1232:
1227:
1222:
1217:
1165:
1150:
1141:
698:
584:
559:
498:
463:
61:
51:
47:
43:
39:
35:
31:
310:
186:
3061:
2769:
2425:
2291:
2250:
2174:
2108:
2057:
2011:
1950:
1835:
1757:
1752:
1747:
1693:
1642:
1308:
1212:
1188:
1183:
1160:
1155:
1146:
1137:
919:
657:
616:"IL-10 Family Cytokines IL-10 and IL-22: from Basic Science to Clinical Translation"
391:
2943:
2764:
2450:
2445:
2440:
2189:
2128:
2087:
1238:
1070:
89:
1782:
263:
632:
615:
2774:
2754:
2717:
2552:
2542:
2394:
2389:
2224:
2194:
2133:
1975:
1935:
1894:
1889:
1659:
1605:
1346:
1105:
1028:
24:
427:
221:
2759:
2749:
2644:
2537:
2532:
2353:
2214:
2204:
2138:
2072:
1985:
1980:
1909:
1712:
1405:
1095:
1055:
357:
58:
641:
489:
480:
435:
365:
318:
271:
2229:
2219:
2209:
2082:
717:
667:
649:
593:
507:
443:
383:
326:
279:
229:
194:
1869:
1707:
702:
2988:
2471:
575:
2603:
1585:
1482:
1477:
1472:
1467:
1462:
1457:
1175:
980:
964:
959:
954:
949:
944:
934:
929:
2910:
2906:
2902:
2521:
2517:
2501:
1621:
1580:
1575:
1570:
1565:
1560:
1497:
1487:
1452:
1447:
1442:
1437:
1432:
1427:
1080:
1075:
1065:
1050:
1045:
924:
914:
909:
904:
894:
889:
883:
867:
857:
852:
847:
842:
837:
832:
827:
822:
816:
811:
806:
801:
796:
791:
786:
781:
464:"The Interleukin-10 Family of Cytokines and Their Role in the CNS"
65:
1545:
1492:
1060:
1001:
996:
776:
771:
766:
761:
755:
749:
743:
737:
732:
101:
97:
1786:
671:
2978:
410:
Commins, Scott; Steinke, John W.; Borish, Larry (2008-05-01).
2962:
2942:
2935:
2886:
2865:
2844:
2804:
2783:
2727:
2695:
2654:
2612:
2566:
2485:
2459:
2403:
2362:
2336:
2310:
2279:
2259:
2238:
2157:
2096:
2040:
1994:
1918:
1823:
1677:
1635:
1604:
1532:
1506:
1413:
1404:
1345:
1336:
1301:
1264:
1202:
1174:
1128:
1113:
1104:
1014:
989:
973:
876:
725:
716:
709:
139:IL-24 produced by activated monocytes and T-cells.
1798:
683:
462:Burmeister, Amanda R.; Marriott, Ian (2018).
8:
614:Ouyang, Wenjun; O’Garra, Anne (2019-04-16).
2939:
1805:
1791:
1783:
1410:
1342:
1125:
1110:
722:
713:
690:
676:
668:
529:, Oxford: Academic Press, pp. 67–87,
416:Journal of Allergy and Clinical Immunology
631:
583:
497:
479:
373:
2970:Interleukin 14 (taxilin alpha, HMW-BCGF)
295:"The interleukin-10 family of cytokines"
165:
2268:See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ)
609:
607:
605:
603:
405:
403:
401:
7:
564:Clinical and Experimental Immunology
553:
551:
457:
455:
453:
346:Cellular and Molecular Life Sciences
252:Cytokine & Growth Factor Reviews
241:
239:
468:Frontiers in Cellular Neuroscience
14:
2796:Interleukin 27 (interleukin 30)
151:Three subgroups of IL-10 family
57:Some sources also include the
1:
521:Lerner, Ulf H. (2020-01-01),
311:10.1016/S1471-4906(01)02149-4
264:10.1016/j.cytogfr.2010.11.001
187:10.1016/S0165-2478(03)00087-7
633:10.1016/j.immuni.2019.03.020
527:Encyclopedia of Bone Biology
246:Sabat, Robert (2010-10-01).
2146:Antisense oligonucleotides:
248:"IL-10 family of cytokines"
3084:
428:10.1016/j.jaci.2008.02.026
222:10.1016/j.jaci.2008.02.026
1653:Colony-stimulating factor
358:10.1007/s00018-010-0380-0
1688:proinflammatory cytokine
525:, in Zaidi, Mone (ed.),
481:10.3389/fncel.2018.00458
210:J. Allergy Clin. Immunol
2836:Interleukin-29 (IFN-λ1)
1981:Daclizumab (dacliximab)
1966:Tucotuzumab celmoleukin
2817:Interferon λ4 (IFN-λ4)
1910:Rilonacept (IL-1 Trap)
819:/PARC/DCCK1/AMAC1/MIP4
16:Family of interleukins
2740:Interleukin 23 (SGRF)
2421:Cintredekin besudotox
2349:Interleukin 11 (AGIF)
2328:Interleukin 10 (CSIF)
1814:Interleukin receptor
299:Trends in Immunology
1946:Denileukin diftitox
1384:Interferon type III
75:Biological activity
2518:E (interleukin 25)
3055:
3054:
3051:
3050:
3020:(signals through
3001:(signals through
2987:(signals through
2977:(signals through
2601:Binding proteins:
1931:Adargileukin alfa
1780:
1779:
1673:
1672:
1631:
1630:
1528:
1527:
1524:
1523:
1332:
1331:
1010:
1009:
576:10.1111/cei.12449
536:978-0-12-814082-6
352:(17): 2909–2935.
94:tyrosine kinase 2
3075:
3043:Efineptakin alfa
3038:Efavaleukin alfa
2940:
1907:Decoy receptors:
1807:
1800:
1793:
1784:
1411:
1343:
1126:
1111:
723:
714:
692:
685:
678:
669:
662:
661:
635:
611:
598:
597:
587:
555:
546:
545:
544:
543:
518:
512:
511:
501:
483:
459:
448:
447:
422:(5): 1108–1111.
407:
396:
395:
377:
337:
331:
330:
290:
284:
283:
243:
234:
233:
205:
199:
198:
170:
3083:
3082:
3078:
3077:
3076:
3074:
3073:
3072:
3058:
3057:
3056:
3047:
2958:
2931:
2882:
2861:
2840:
2800:
2779:
2723:
2720:(against IL-22)
2691:
2650:
2647:(against IL-20)
2608:
2562:
2481:
2455:
2399:
2358:
2332:
2306:
2275:
2255:
2234:
2153:
2092:
2036:
1990:
1914:
1819:
1811:
1781:
1776:
1742:
1721:
1679:
1669:
1627:
1600:
1520:
1502:
1400:
1328:
1297:
1260:
1198:
1170:
1121:
1119:
1117:
1100:
1006:
985:
969:
872:
705:
696:
666:
665:
613:
612:
601:
557:
556:
549:
541:
539:
537:
520:
519:
515:
461:
460:
451:
409:
408:
399:
339:
338:
334:
292:
291:
287:
245:
244:
237:
207:
206:
202:
172:
171:
167:
162:
153:
145:
137:
129:
120:
111:
86:
77:
30:In addition to
23:is a family of
17:
12:
11:
5:
3081:
3079:
3071:
3070:
3060:
3059:
3053:
3052:
3049:
3048:
3046:
3045:
3040:
3031:
3030:
3028:Interleukin 35
3025:
3018:Interleukin 34
3015:
3013:Interleukin 32
3010:
2999:Interleukin 26
2996:
2985:Interleukin 24
2982:
2975:Interleukin 16
2972:
2966:
2964:
2960:
2959:
2957:
2956:
2948:
2946:
2937:
2933:
2932:
2930:
2929:
2920:
2919:
2917:Interleukin 38
2914:
2899:Interleukin 36
2892:
2890:
2884:
2883:
2881:
2880:
2878:Interleukin 33
2871:
2869:
2863:
2862:
2860:
2859:
2857:Interleukin 31
2850:
2848:
2842:
2841:
2839:
2838:
2833:
2822:Interleukin 28
2819:
2810:
2808:
2802:
2801:
2799:
2798:
2789:
2787:
2781:
2780:
2778:
2777:
2772:
2767:
2762:
2757:
2752:
2743:
2742:
2733:
2731:
2725:
2724:
2722:
2721:
2711:
2710:
2708:Interleukin 22
2701:
2699:
2693:
2692:
2690:
2689:
2684:
2675:
2674:
2672:Interleukin 21
2669:
2660:
2658:
2652:
2651:
2649:
2648:
2638:
2637:
2635:Interleukin 24
2632:
2630:Interleukin 20
2627:
2625:Interleukin 19
2618:
2616:
2610:
2609:
2607:
2606:
2597:
2596:
2591:
2589:Interleukin 37
2586:
2584:Interleukin 18
2581:
2572:
2570:
2564:
2563:
2561:
2560:
2555:
2550:
2545:
2540:
2535:
2526:
2525:
2498:Interleukin 17
2491:
2489:
2483:
2482:
2480:
2479:
2477:Interleukin 15
2474:
2465:
2463:
2457:
2456:
2454:
2453:
2448:
2443:
2434:
2433:
2431:Interleukin 13
2428:
2423:
2418:
2409:
2407:
2401:
2400:
2398:
2397:
2392:
2383:
2382:
2380:Interleukin 12
2377:
2368:
2366:
2360:
2359:
2357:
2356:
2351:
2342:
2340:
2334:
2333:
2331:
2330:
2325:
2316:
2314:
2308:
2307:
2305:
2304:
2295:
2294:
2285:
2283:
2277:
2276:
2274:
2273:
2265:
2263:
2257:
2256:
2254:
2253:
2244:
2242:
2236:
2235:
2233:
2232:
2227:
2222:
2217:
2212:
2207:
2202:
2197:
2192:
2187:
2178:
2177:
2172:
2163:
2161:
2155:
2154:
2152:
2151:
2142:
2141:
2136:
2131:
2122:
2121:
2112:
2111:
2102:
2100:
2094:
2093:
2091:
2090:
2085:
2076:
2075:
2066:
2065:
2063:Interleukin 13
2060:
2055:
2046:
2044:
2038:
2037:
2035:
2034:
2032:Promegapoietin
2029:
2024:
2019:
2014:
2009:
2000:
1998:
1992:
1991:
1989:
1988:
1983:
1978:
1969:
1968:
1963:
1958:
1956:Pegaldesleukin
1953:
1948:
1943:
1938:
1933:
1924:
1922:
1916:
1915:
1913:
1912:
1903:
1902:
1897:
1892:
1883:
1882:
1877:
1872:
1867:
1858:
1857:
1852:
1847:
1829:
1827:
1821:
1820:
1812:
1810:
1809:
1802:
1795:
1787:
1778:
1777:
1775:
1774:
1773:
1772:
1771:
1770:
1765:
1760:
1755:
1750:
1740:
1736:
1735:
1734:
1729:
1719:
1710:
1704:
1703:
1702:
1701:
1696:
1683:
1681:
1675:
1674:
1671:
1670:
1668:
1667:
1662:
1657:
1656:
1655:
1650:
1639:
1637:
1633:
1632:
1629:
1628:
1626:
1625:
1610:
1608:
1602:
1601:
1599:
1598:
1593:
1588:
1583:
1578:
1573:
1568:
1563:
1558:
1553:
1548:
1538:
1536:
1534:Ig superfamily
1530:
1529:
1526:
1525:
1522:
1521:
1519:
1518:
1512:
1510:
1504:
1503:
1501:
1500:
1495:
1490:
1485:
1480:
1475:
1470:
1465:
1460:
1455:
1450:
1445:
1440:
1435:
1430:
1425:
1419:
1417:
1408:
1402:
1401:
1399:
1398:
1397:
1396:
1391:
1381:
1376:
1371:
1366:
1361:
1351:
1349:
1340:
1334:
1333:
1330:
1329:
1327:
1326:
1321:
1316:
1311:
1305:
1303:
1299:
1298:
1296:
1295:
1290:
1285:
1280:
1274:
1272:
1262:
1261:
1259:
1258:
1257:
1256:
1251:
1246:
1241:
1230:
1225:
1220:
1215:
1209:
1207:
1200:
1199:
1197:
1196:
1191:
1186:
1180:
1178:
1172:
1171:
1169:
1168:
1163:
1158:
1153:
1144:
1134:
1132:
1123:
1108:
1102:
1101:
1099:
1098:
1093:
1088:
1083:
1078:
1073:
1068:
1063:
1058:
1053:
1048:
1043:
1042:
1041:
1036:
1026:
1020:
1018:
1012:
1011:
1008:
1007:
1005:
1004:
999:
993:
991:
987:
986:
984:
983:
977:
975:
971:
970:
968:
967:
962:
957:
952:
947:
942:
937:
932:
927:
922:
917:
912:
907:
902:
897:
892:
887:
880:
878:
874:
873:
871:
870:
865:
860:
855:
850:
845:
840:
835:
830:
825:
820:
814:
809:
804:
799:
794:
789:
784:
779:
774:
769:
764:
759:
753:
747:
741:
735:
729:
727:
720:
711:
707:
706:
699:Cell signaling
697:
695:
694:
687:
680:
672:
664:
663:
626:(4): 871–891.
599:
570:(2): 300–308.
547:
535:
513:
449:
397:
332:
285:
258:(5): 315–324.
235:
216:(5): 1108–11.
200:
164:
163:
161:
158:
152:
149:
144:
141:
136:
133:
128:
125:
119:
116:
110:
107:
85:
82:
76:
73:
34:, it includes
15:
13:
10:
9:
6:
4:
3:
2:
3080:
3069:
3066:
3065:
3063:
3044:
3041:
3039:
3036:
3033:
3032:
3029:
3026:
3023:
3019:
3016:
3014:
3011:
3008:
3004:
3000:
2997:
2994:
2990:
2986:
2983:
2980:
2976:
2973:
2971:
2968:
2967:
2965:
2961:
2954:
2950:
2949:
2947:
2945:
2941:
2938:
2934:
2928:
2925:
2922:
2921:
2918:
2915:
2912:
2908:
2904:
2900:
2897:
2894:
2893:
2891:
2889:
2885:
2879:
2876:
2873:
2872:
2870:
2868:
2864:
2858:
2855:
2852:
2851:
2849:
2847:
2843:
2837:
2834:
2831:
2827:
2823:
2820:
2818:
2815:
2812:
2811:
2809:
2807:
2803:
2797:
2794:
2791:
2790:
2788:
2786:
2782:
2776:
2773:
2771:
2770:Tildrakizumab
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2745:
2744:
2741:
2738:
2735:
2734:
2732:
2730:
2726:
2719:
2716:
2713:
2712:
2709:
2706:
2703:
2702:
2700:
2698:
2694:
2688:
2685:
2683:
2680:
2677:
2676:
2673:
2670:
2668:
2665:
2662:
2661:
2659:
2657:
2653:
2646:
2643:
2640:
2639:
2636:
2633:
2631:
2628:
2626:
2623:
2620:
2619:
2617:
2615:
2611:
2605:
2602:
2599:
2598:
2595:
2592:
2590:
2587:
2585:
2582:
2580:
2577:
2574:
2573:
2571:
2569:
2565:
2559:
2556:
2554:
2551:
2549:
2546:
2544:
2541:
2539:
2536:
2534:
2531:
2528:
2527:
2523:
2519:
2515:
2511:
2507:
2503:
2499:
2496:
2493:
2492:
2490:
2488:
2484:
2478:
2475:
2473:
2470:
2467:
2466:
2464:
2462:
2458:
2452:
2449:
2447:
2444:
2442:
2439:
2436:
2435:
2432:
2429:
2427:
2426:Interleukin 4
2424:
2422:
2419:
2417:
2414:
2411:
2410:
2408:
2406:
2402:
2396:
2393:
2391:
2388:
2385:
2384:
2381:
2378:
2376:
2375:Edodekin alfa
2373:
2370:
2369:
2367:
2365:
2361:
2355:
2352:
2350:
2347:
2344:
2343:
2341:
2339:
2335:
2329:
2326:
2324:
2321:
2318:
2317:
2315:
2313:
2309:
2303:
2300:
2297:
2296:
2293:
2292:Interleukin 9
2290:
2287:
2286:
2284:
2282:
2278:
2271:
2267:
2266:
2264:
2262:
2258:
2252:
2251:Interleukin 7
2249:
2246:
2245:
2243:
2241:
2237:
2231:
2228:
2226:
2223:
2221:
2218:
2216:
2213:
2211:
2208:
2206:
2203:
2201:
2198:
2196:
2193:
2191:
2188:
2186:
2183:
2180:
2179:
2176:
2175:Interleukin 6
2173:
2171:
2170:Atexakin alfa
2168:
2165:
2164:
2162:
2160:
2156:
2150:
2147:
2144:
2143:
2140:
2137:
2135:
2132:
2130:
2127:
2124:
2123:
2120:
2117:
2114:
2113:
2110:
2109:Interleukin 5
2107:
2104:
2103:
2101:
2099:
2095:
2089:
2086:
2084:
2081:
2078:
2077:
2074:
2071:
2068:
2067:
2064:
2061:
2059:
2058:Interleukin 4
2056:
2054:
2051:
2048:
2047:
2045:
2043:
2039:
2033:
2030:
2028:
2025:
2023:
2020:
2018:
2015:
2013:
2012:Interleukin 3
2010:
2008:
2005:
2002:
2001:
1999:
1997:
1993:
1987:
1984:
1982:
1979:
1977:
1974:
1971:
1970:
1967:
1964:
1962:
1959:
1957:
1954:
1952:
1951:Interleukin 2
1949:
1947:
1944:
1942:
1939:
1937:
1934:
1932:
1929:
1926:
1925:
1923:
1921:
1917:
1911:
1908:
1905:
1904:
1901:
1898:
1896:
1893:
1891:
1888:
1885:
1884:
1881:
1878:
1876:
1873:
1871:
1868:
1866:
1863:
1860:
1859:
1856:
1853:
1851:
1848:
1845:
1841:
1837:
1836:Interleukin 1
1834:
1831:
1830:
1828:
1826:
1822:
1818:
1815:
1808:
1803:
1801:
1796:
1794:
1789:
1788:
1785:
1769:
1766:
1764:
1761:
1759:
1756:
1754:
1751:
1749:
1746:
1745:
1744:
1737:
1733:
1730:
1728:
1725:
1724:
1723:
1716:
1715:
1714:
1711:
1709:
1706:
1705:
1700:
1697:
1695:
1692:
1691:
1690:
1689:
1685:
1684:
1682:
1676:
1666:
1663:
1661:
1658:
1654:
1651:
1649:
1646:
1645:
1644:
1643:Hematopoietic
1641:
1640:
1638:
1634:
1623:
1619:
1615:
1612:
1611:
1609:
1607:
1603:
1597:
1594:
1592:
1589:
1587:
1584:
1582:
1579:
1577:
1574:
1572:
1569:
1567:
1564:
1562:
1559:
1557:
1554:
1552:
1549:
1547:
1543:
1540:
1539:
1537:
1535:
1531:
1517:
1514:
1513:
1511:
1509:
1505:
1499:
1496:
1494:
1491:
1489:
1486:
1484:
1481:
1479:
1476:
1474:
1471:
1469:
1466:
1464:
1461:
1459:
1456:
1454:
1451:
1449:
1446:
1444:
1441:
1439:
1436:
1434:
1431:
1429:
1426:
1424:
1421:
1420:
1418:
1416:
1412:
1409:
1407:
1403:
1395:
1392:
1390:
1387:
1386:
1385:
1382:
1380:
1377:
1375:
1372:
1370:
1367:
1365:
1362:
1360:
1356:
1353:
1352:
1350:
1348:
1344:
1341:
1339:
1335:
1325:
1322:
1320:
1317:
1315:
1312:
1310:
1307:
1306:
1304:
1300:
1294:
1291:
1289:
1286:
1284:
1281:
1279:
1276:
1275:
1273:
1271:
1267:
1263:
1255:
1252:
1250:
1247:
1245:
1242:
1240:
1236:
1235:
1234:
1231:
1229:
1226:
1224:
1221:
1219:
1216:
1214:
1211:
1210:
1208:
1206:
1201:
1195:
1192:
1190:
1187:
1185:
1182:
1181:
1179:
1177:
1173:
1167:
1164:
1162:
1159:
1157:
1154:
1152:
1148:
1145:
1143:
1139:
1136:
1135:
1133:
1131:
1127:
1124:
1116:
1112:
1109:
1107:
1103:
1097:
1094:
1092:
1089:
1087:
1084:
1082:
1079:
1077:
1074:
1072:
1069:
1067:
1064:
1062:
1059:
1057:
1054:
1052:
1051:TNFSF5/CD40LG
1049:
1047:
1044:
1040:
1037:
1035:
1032:
1031:
1030:
1027:
1025:
1022:
1021:
1019:
1017:
1013:
1003:
1000:
998:
995:
994:
992:
988:
982:
979:
978:
976:
972:
966:
963:
961:
958:
956:
953:
951:
948:
946:
943:
941:
938:
936:
933:
931:
928:
926:
923:
921:
918:
916:
913:
911:
908:
906:
903:
901:
898:
896:
893:
891:
888:
885:
882:
881:
879:
875:
869:
866:
864:
861:
859:
856:
854:
851:
849:
846:
844:
841:
839:
836:
834:
831:
829:
826:
824:
821:
818:
815:
813:
810:
808:
805:
803:
800:
798:
795:
793:
790:
788:
785:
783:
780:
778:
775:
773:
770:
768:
765:
763:
760:
757:
754:
751:
748:
745:
742:
739:
736:
734:
731:
730:
728:
724:
721:
719:
715:
712:
708:
704:
700:
693:
688:
686:
681:
679:
674:
673:
670:
659:
655:
651:
647:
643:
639:
634:
629:
625:
621:
617:
610:
608:
606:
604:
600:
595:
591:
586:
581:
577:
573:
569:
565:
561:
554:
552:
548:
538:
532:
528:
524:
517:
514:
509:
505:
500:
495:
491:
487:
482:
477:
473:
469:
465:
458:
456:
454:
450:
445:
441:
437:
433:
429:
425:
421:
417:
413:
406:
404:
402:
398:
393:
389:
385:
381:
376:
371:
367:
363:
359:
355:
351:
347:
343:
336:
333:
328:
324:
320:
316:
312:
308:
304:
300:
296:
289:
286:
281:
277:
273:
269:
265:
261:
257:
253:
249:
242:
240:
236:
231:
227:
223:
219:
215:
211:
204:
201:
196:
192:
188:
184:
180:
176:
175:Immunol. Lett
169:
166:
159:
157:
150:
148:
142:
140:
134:
132:
126:
124:
117:
115:
108:
106:
103:
99:
95:
91:
83:
81:
74:
72:
69:
67:
63:
60:
55:
53:
49:
45:
41:
37:
33:
28:
26:
22:
3034:
3022:M-CSFR/CSF1R
3009:heterodimer)
2995:heterodimer)
2924:Antagonists:
2923:
2895:
2874:
2853:
2813:
2792:
2765:Risankizumab
2746:
2736:
2714:
2704:
2687:NNC0114-0006
2682:NNC0114-0005
2678:
2663:
2641:
2621:
2600:
2575:
2529:
2494:
2468:
2451:Tralokinumab
2446:Lebrikizumab
2441:Anrukinzumab
2437:
2412:
2386:
2371:
2345:
2319:
2298:
2288:
2247:
2190:Clazakizumab
2181:
2166:
2145:
2129:Benralizumab
2125:
2116:Antagonists:
2115:
2105:
2088:Pascolizumab
2079:
2070:Antagonists:
2069:
2049:
2003:
1972:
1927:
1906:
1886:
1862:Antagonists:
1861:
1832:
1738:
1717:
1686:
1678:By function/
1389:IL28/IFNL2+3
623:
619:
567:
563:
540:, retrieved
526:
516:
471:
467:
419:
415:
349:
345:
335:
305:(2): 89–96.
302:
298:
288:
255:
251:
213:
209:
203:
181:(3): 171–4.
178:
174:
168:
154:
146:
138:
130:
121:
112:
90:Janus kinase
87:
78:
70:
56:
29:
25:interleukins
21:IL-10 family
20:
18:
2775:Ustekinumab
2755:Briakinumab
2747:Antibodies:
2718:Fezakinumab
2715:Antibodies:
2679:Antibodies:
2667:Denenicokin
2642:Antibodies:
2579:Iboctadekin
2558:Vunakizumab
2553:Secukinumab
2543:Perakizumab
2530:Antibodies:
2438:Antibodies:
2395:Ustekinumab
2390:Briakinumab
2387:Antibodies:
2299:Antibodies:
2225:Tocilizumab
2195:Elsilimomab
2182:Antibodies:
2134:Mepolizumab
2126:Antibodies:
2080:Antibodies:
2007:Daniplestim
1976:Basiliximab
1973:Antibodies:
1941:Celmoleukin
1936:Aldesleukin
1900:Lutikizumab
1895:Gevokizumab
1890:Canakinumab
1887:Antibodies:
1606:IL17 family
1347:IL10 family
1266:IL12 family
1118:(grouped by
1106:Interleukin
1029:Lymphotoxin
59:interferons
2830:B (IFN-λ3)
2826:A (IFN-λ2)
2760:Guselkumab
2750:Brazikumab
2645:Fletikumab
2548:Remtolumab
2538:Ixekizumab
2533:Brodalumab
2416:Binetrakin
2354:Oprelvekin
2323:Ilodecakin
2302:Enokizumab
2215:Siltuximab
2205:Olokizumab
2139:Reslizumab
2073:Pitrakinra
2053:Binetrakin
2022:Milodistim
2017:Leridistim
1986:Inolimomab
1961:Teceleukin
1880:Isunakinra
1817:modulators
1713:Lymphokine
1551:IL1B/IL1F2
1546:IL1A/IL1F1
1542:IL1 family
1406:Interferon
1394:IL29/IFNL1
542:2020-11-24
160:References
3068:Cytokines
3035:Unsorted:
2896:Agonists:
2875:Agonists:
2854:Agonists:
2814:Agonists:
2793:Agonists:
2737:Agonists:
2705:Agonists:
2664:Agonists:
2622:Agonists:
2594:Tadekinig
2576:Agonists:
2495:Agonists:
2469:Agonists:
2413:Agonists:
2372:Agonists:
2346:Agonists:
2320:Agonists:
2289:Agonists:
2248:Agonists:
2230:Levilimab
2220:Sirukumab
2210:Sarilumab
2167:Agonists:
2106:Agonists:
2083:Dupilumab
2050:Agonists:
2027:Muplestim
2004:Agonists:
1928:Agonists:
1855:Pifonakin
1850:Mobenakin
1833:Agonists:
1591:33/IL1F11
1556:1Ra/IL1F3
1203:IL6 like/
920:CXCL8/IL8
718:Chemokine
710:By family
703:cytokines
658:122350808
642:1074-7613
490:1662-5102
436:0091-6749
366:1420-682X
319:1471-4906
272:1359-6101
3062:Category
2989:IL-22Rα1
2955:instead.
2272:instead.
2200:mAb 1339
2185:ARGX-109
2149:TPI ASM8
2119:YM-90709
1870:Anakinra
1865:AF-12198
1708:Monokine
1237:+non IL
1122:subunit)
1120:receptor
1091:TNFSF13B
1039:TNFC/LTB
1034:TNFB/LTA
650:30995504
620:Immunity
594:25178435
508:30542269
444:18405958
392:10926488
384:20454917
375:11115847
327:11929132
280:21112807
230:18405958
195:12941475
3007:IL-10Rβ
3003:IL-20Rα
2993:IL-20Rβ
2927:IL-36RA
2472:ALT-803
1596:18/IL1G
1338:Type II
1270:IL12RB1
1176:β chain
1130:γ chain
1086:TNFSF13
1081:TNFSF11
1076:TNFSF10
758:/RANTES
585:4298407
499:6277801
474:: 458.
2963:Others
2936:Others
2888:IL1RL2
2867:IL1RL1
2604:IL18BP
1875:IL-1RA
1586:IL1F10
1483:IFNA21
1478:IFNA17
1473:IFNA16
1468:IFNA14
1463:IFNA13
1458:IFNA10
1115:Type I
1071:TNFSF9
1066:TNFSF8
1061:TNFSF7
1056:TNFSF6
1046:TNFSF4
981:CX3CL1
965:CXCL17
960:CXCL16
955:CXCL15
950:CXCL14
945:CXCL13
940:CXCL12
935:CXCL11
930:CXCL10
752:/MIP1β
746:/MIP1α
656:
648:
640:
592:
582:
533:
506:
496:
488:
442:
434:
390:
382:
372:
364:
325:
317:
278:
270:
228:
193:
2846:IL-31
2806:IL-28
2785:IL-27
2729:IL-23
2697:IL-22
2656:IL-21
2614:IL-20
2568:IL-18
2487:IL-17
2461:IL-15
2405:IL-13
2364:IL-12
2338:IL-11
2312:IL-10
1648:KITLG
1636:Other
1622:IL17A
1581:IL1F9
1576:IL1F8
1571:IL1F7
1566:IL1F6
1561:IL1F5
1498:IFNW1
1488:IFNB1
1453:IFNA8
1448:IFNA7
1443:IFNA6
1438:IFNA5
1433:IFNA4
1428:IFNA2
1423:IFNA1
1302:Other
1205:gp130
1194:GMCSF
974:CX3CL
925:CXCL9
915:CXCL7
910:CXCL6
905:CXCL5
900:CXCL4
895:CXCL3
890:CXCL2
884:CXCL1
868:CCL28
863:CCL27
858:CCL26
853:CCL25
848:CCL24
843:CCL23
838:CCL22
833:CCL21
828:CCL20
823:CCL19
817:CCL18
812:CCL17
807:CCL16
802:CCL15
797:CCL14
792:CCL13
787:CCL12
782:CCL11
740:/MCP1
654:S2CID
388:S2CID
143:IL-26
135:IL-24
127:IL-22
118:IL-20
109:IL-19
84:IL-10
66:IL-29
62:IL-28
52:IL-26
48:IL-24
44:IL-22
40:IL-20
36:IL-19
32:IL-10
2953:here
2951:See
2281:IL-9
2270:here
2261:IL-8
2240:IL-7
2159:IL-6
2098:IL-5
2042:IL-4
1996:IL-3
1920:IL-2
1825:IL-1
1768:IL13
1763:IL10
1732:TNFβ
1727:IFNγ
1699:TNFA
1680:cell
1660:SPP1
1618:IL25
1614:IL17
1516:IFNG
1493:IFNK
1379:IL26
1374:IL24
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