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Mousnier, Aurélie; Bell, Andrew S.; Swieboda, Dawid P.; Morales-Sanfrutos, Julia; Pérez-Dorado, Inmaculada; Brannigan, James A.; Newman, Joseph; Ritzefeld, Markus; Hutton, Jennie A.; Guedán, Anabel; Asfor, Amin S.; Robinson, Sean W.; Hopkins-Navratilova, Iva; Wilkinson, Anthony J.; Johnston,
311:. IMP-1088 works to keep cells from generating infectious virus by targeting the cell instead of the rhinovirus itself. It does this by blocking the NMT protein of the host cell which prevents the virus from assembling its
315:, since viral capsid myristoylation by host NMT is essential for assembly. It is thought unlikely that viruses will evolve resistance to such an approach since IMP-1088 works against the human cell and not the virus.
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335:"Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus"
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Sebastian L.; Leatherbarrow, Robin J.; Tuthill, Tobias J.; Solari, Roberto; Tate, Edward W. (14 May 2018).
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replication, an area of research relating to potential treatment of the
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Except where otherwise noted, data are given for materials in their
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CC1=NN(C)C(=C1CCOC2=C(C=CC(=C2F)F)C3=CC=C4C(=C3)C(=NN4C)CN(C)C)C
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182:Key: SOXNKJCQBRQUMS-UHFFFAOYSA-N
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416:Houser, Kristin (19 May 2018).
396:Chemical & Engineering News
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474:Dimethylamino compounds
303:capable of preventing
53:-dimethylmethanamine
37:Preferred IUPAC name
351:2018NatCh..10..599M
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449:Enzyme inhibitors
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60:Identifiers
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309:common cold
212:Properties
443:Categories
319:References
305:rhinoviral
256:Molar mass
88:3D model (
67:CAS Number
469:Biphenyls
459:Pyrazoles
454:Indazoles
126:132274735
17:IMP-1088
377:29760414
289:IMP-1088
368:6015761
347:Bibcode
261:453.538
113:PubChem
427:20 May
401:20 May
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313:capsid
291:is an
196:SMILES
31:Names
174:InChI
90:JSmol
429:2018
403:2018
373:PMID
301:NMT2
299:and
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363:PMC
355:doi
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51:N
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47:N
43:H
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