Knowledge (XXG)

Immunosequencing

Source 📝

268: 66:. As an immune system reacts to infections and other events, the number of different antibodies and TCRs it contains changes. The makeup and quantity of these proteins is sometimes referred to as an 309: 89:
Immunosequencing in its modern context started being discussed in scientific literature in the early 2010s with the advent of more powerful
62:(TCRs) and produce a huge diversity of slightly different antibodies and TCRs. The diversity allows for the recognition of a wide array of 116: 74: 338: 333: 77:
that allows for the sequencing and quantification of the large diversity of antibody and TCR genes composing an individual's
343: 328: 302: 169: 295: 217: 51: 244: 186: 145: 78: 67: 279: 234: 226: 178: 135: 125: 59: 239: 212: 140: 111: 90: 322: 275: 230: 213:"Rep-Seq: uncovering the immunological repertoire through next-generation sequencing" 31: 182: 130: 164: 248: 190: 149: 55: 54:
a number of organisms take a relatively small number of genes coding for
63: 47: 165:"Immunosequencing: applications of immune repertoire deep sequencing" 267: 30:, is a method for analyzing the genetic makeup of an individual's 43: 283: 112:"Immune monitoring technology primer: immunosequencing" 303: 8: 310: 296: 73:Immunosequencing is a technique utilizing 238: 139: 129: 102: 7: 264: 262: 117:Journal for ImmunoTherapy of Cancer 75:multiplex polymerase chain reaction 16:Method for analyzing genetic makeup 282:. You can help Knowledge (XXG) by 42:In most areas of biology a single 14: 266: 231:10.1111/j.1365-2567.2011.03527.x 46:codes for one or a few possible 1: 170:Current Opinion in Immunology 110:Kirsch, Ilan (25 June 2015). 211:Benichou, Jennifer (2012). 22:, sometimes referred to as 360: 261: 183:10.1016/j.coi.2013.09.017 131:10.1186/s40425-015-0076-y 339:DNA profiling techniques 163:Robbins, Harlem (2013). 334:Laboratory techniques 218:Journal of Immunology 24:repertoire sequencing 344:Biotechnology stubs 52:V(D)J recombination 329:Molecular biology 291: 290: 79:immune repertoire 68:immune repertoire 351: 312: 305: 298: 270: 263: 253: 252: 242: 208: 202: 201: 199: 197: 160: 154: 153: 143: 133: 107: 60:T-cell receptors 20:Immunosequencing 359: 358: 354: 353: 352: 350: 349: 348: 319: 318: 317: 316: 259: 257: 256: 210: 209: 205: 195: 193: 162: 161: 157: 109: 108: 104: 99: 91:gene sequencing 87: 40: 17: 12: 11: 5: 357: 355: 347: 346: 341: 336: 331: 321: 320: 315: 314: 307: 300: 292: 289: 288: 271: 255: 254: 225:(3): 183–191. 203: 177:(5): 646–652. 155: 101: 100: 98: 95: 86: 83: 39: 36: 15: 13: 10: 9: 6: 4: 3: 2: 356: 345: 342: 340: 337: 335: 332: 330: 327: 326: 324: 313: 308: 306: 301: 299: 294: 293: 287: 285: 281: 278:article is a 277: 276:biotechnology 272: 269: 265: 260: 250: 246: 241: 236: 232: 228: 224: 220: 219: 214: 207: 204: 192: 188: 184: 180: 176: 172: 171: 166: 159: 156: 151: 147: 142: 137: 132: 127: 123: 119: 118: 113: 106: 103: 96: 94: 92: 84: 82: 80: 76: 71: 69: 65: 61: 57: 53: 49: 45: 37: 35: 33: 32:immune system 29: 25: 21: 284:expanding it 273: 258: 222: 216: 206: 194:. Retrieved 174: 168: 158: 121: 115: 105: 93:techniques. 88: 72: 41: 27: 23: 19: 18: 323:Categories 97:References 56:antibodies 50:. Through 38:Background 249:22043864 191:24140071 150:26113978 64:antigens 48:proteins 240:3311040 196:6 April 141:4480450 85:History 28:Rep-Seq 247:  237:  189:  148:  138:  124:: 29. 274:This 280:stub 245:PMID 198:2023 187:PMID 146:PMID 58:and 44:gene 235:PMC 227:doi 223:135 179:doi 136:PMC 126:doi 26:or 325:: 243:. 233:. 221:. 215:. 185:. 175:25 173:. 167:. 144:. 134:. 120:. 114:. 81:. 70:. 34:. 311:e 304:t 297:v 286:. 251:. 229:: 200:. 181:: 152:. 128:: 122:3

Index

immune system
gene
proteins
V(D)J recombination
antibodies
T-cell receptors
antigens
immune repertoire
multiplex polymerase chain reaction
immune repertoire
gene sequencing
"Immune monitoring technology primer: immunosequencing"
Journal for ImmunoTherapy of Cancer
doi
10.1186/s40425-015-0076-y
PMC
4480450
PMID
26113978
"Immunosequencing: applications of immune repertoire deep sequencing"
Current Opinion in Immunology
doi
10.1016/j.coi.2013.09.017
PMID
24140071
"Rep-Seq: uncovering the immunological repertoire through next-generation sequencing"
Journal of Immunology
doi
10.1111/j.1365-2567.2011.03527.x
PMC

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.