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deficiencies, no clear evidence exists that vaccines cause similar exacerbations." Another unclear aspect of Hannah's case is whether she had a pre-existing mitochondrial disorder that vaccinations aggravated, or whether vaccinations caused that disorder. Hannah's mother, Terry Poling, has stated that "The government chose to believe the first theory," but added that "We don’t know that she had an underlying disorder." However, the
Polings' neurologist, Andrew Zimmerman, wrote in a letter to the Polings' attorneys that there was a pre-existing mitochondrial dysfunction. Dr. Zimmerman wrote, "The cause for regressive encephalopathy in Hannah at age 19 months was underlying mitochondrial dysfunction, exacerbated by vaccine-induced fever and immune stimulation that exceeded metabolic energy reserves."
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wrote a letter to Dr. Novella in which he states, among other things, that "The only thing unique about my little girl’s case is the level of medical documentation--5 to 20% of patients with ASDs have mitochondrial dysfunction." Novella's response to this letter, posted on July 23, 2008, argued that "Hannah Poling’s history has many features that are not typical of autism – like a history of otitis media with frequent fevers, seizures, and what sounds like a rare encephalitis that probably did result from vaccines. Even if we put her mitochondrial mutation aside – this is not a typical case of autism."
182:. In 2008, after the government conceded his daughter's vaccine injury case, Dr Poling said, “Many in the autism community and their champions believe that the result in this case may well signify a landmark decision as it pertains to children developing autism following vaccinations. This still remains to be seen, but currently there are almost 5,000 other cases pending.” Hannah's case had originally been placed with the almost 5,000
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posted an article on
Neurologica, his blog, in which he briefly mentioned the Poling case, saying, "The case was settled (not judged in Poling’s favor, but settled) because both sides realized it was a special case that could not be extrapolated to other vaccine-autism cases." In response, Dr. Poling
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has argued that the VICP's concession to Hannah was "poorly reasoned" and contended that this program had "turned its back on science" in recent years. Offit also noted that "whereas it is clear that natural infections can exacerbate symptoms of encephalopathy in patients with mitochondrial enzyme
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said, "Let me be very clear that the government has made absolutely no statement indicating that vaccines are a cause of autism." It has also been noted that Hannah's mitochondrial disease is very rare, and that no evidence proves that it is possible for vaccines to cause or worsen mitochondrial
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contended that "...this was not a case of vaccines causing autism. Rather, this is a case where the court deemed it plausible that vaccines aggravated an underlying disease caused by bad mitochondria, and that some of the symptoms Hannah showed were similar to autism," and
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on
October 25, 2002. In 2006, Jon, along with three other researchers, all of whom were affiliated with Johns Hopkins at the time, published a case report and chart review retrospective series regarding the association of mitochondrial disease and autism in the
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Others have speculated that in the Poling case, all that was really conceded was that "the vaccines, given to Hannah in 2000, aggravated a pre-existing condition that then manifested as autism-like symptoms." Similarly,
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Hannah, Jon's daughter, was born in 1999 and received five vaccines in one day in 2000 at the age of 19 months; this occurred because she had fallen behind on her vaccine schedule as a result of a series of
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216:
On
September 3, 2010, autism blogger Matt Carey broke the story about the settlement deal including a $ 1.5M initial payment and an annuity to cover costs of the life care plan.
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Poling, J. S.; Karanian, J. W.; Salem Jr, N.; Vicini, S. (1995). "Time- and voltage-dependent block of delayed rectifier potassium channels by docosahexaenoic acid".
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in 2008 because Hannah manifested encephalopathy after being vaccinated by MMR. Hannah had underlying mitochondrial disease, which exacerbated her symptoms.
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diseases, with Chuck Mohan of the United
Mitochondrial Disease Foundation noting that "there is very little scientific research in this area." In addition,
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in 1991. In 1995, he was granted an NIH scholarship to attend the 1995 Woods Hole Marine
Biological Laboratory in
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249:"Docosahexaenoic acid block of neuronal voltage-gated K+ channels: Subunit selective antagonism by zinc"
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On the mechanism of potassium channel blockade by polyunsaturated fatty acids and cannabinoids
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292:"Anandamide, an endogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels"
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where he has worked at Athens
Neurological Associates since 2001. He has also worked at
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unit since 2002. His area of expertise is autoimmune neurological disorders such as
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126:. He is the father of Hannah Poling, who received an injury compensation from the
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428:"Developmental regression and mitochondrial dysfunction in a child with autism"
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727:"Dr. Jon Poling to Dr. Steven Novella: Don't Attack the Moms - AGE OF AUTISM"
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to continue studying neurobiology. He obtained his MD and PhD both from
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pending hearing 5 years before her case was conceded administratively.
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Poling, J. S.; Frye, R. E.; Shoffner, J.; Zimmerman, A. W. (2006).
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Poling, J. S.; Rogawski, M. A.; Salem Jr, N.; Vicini, S. (1996).
247:
Poling, J. S.; Vicini, S.; Rogawski, M. A.; Salem Jr, N. (1996).
150:, and both in 1997. He completed his residency in neurology at
658:"Vaccines and Autism Revisited — the Hannah Poling Case"
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Poling, J. S. (2008). "Vaccines and Autism
Revisited".
745:"Autism and Vaccines: Responding to Poling and Kirby"
702:"Celebrity Smackdown: Amanda Peet vs Jenny McCarthy"
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48:
38:
30:
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405:"Poling v. Secretary of Health and Human Services"
571:"Deal in an Autism Case Fuels Debate on Vaccine"
806:Georgetown University School of Medicine alumni
599:"Will a 9-Year-Old Change the Vaccine Debate?"
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173:National Vaccine Injury Compensation Program
138:Poling obtained his bachelor's degree from
171:, the Poling family filed a case with the
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627:"Analysis: Vaccine-autism link unproven"
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148:Georgetown University School of Medicine
43:Georgetown University School of Medicine
512:"Dad in Autism-Vaccine Case Speaks Out"
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771:"Damages awarded in the Poling case?"
7:
154:'s department of neurology in 2001.
118:and neuromuscular disorders such as
597:Parker-Pope, Tara (12 April 2008).
540:"What the Poling Autism Case Means"
538:Parikh, Rahul K. (13 March 2008).
14:
569:Harris, Gardiner (8 March 2008).
510:Doheny, Kathleen (6 March 2008).
378:"Case Study: Autism and Vaccines"
376:Wallis, Claudia (10 March 2008).
110:as the medical director of their
769:Carey, Matt (3 September 2010).
662:New England Journal of Medicine
477:New England Journal of Medicine
108:Athens Regional Medical Center
16:American physician (born 1970)
1:
625:Stobbe, Mike (7 March 2008).
444:10.1177/08830738060210021401
309:10.1016/0028-3908(96)00130-X
266:10.1016/0028-3908(96)00127-X
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432:Journal of Child Neurology
179:Journal of Child Neurology
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152:Johns Hopkins University
102:currently practicing in
821:MMR vaccine and autism
775:Left Brain Right Brain
228:Molecular Pharmacology
811:American neurologists
351:HANNAH Center Website
220:Selected publications
675:10.1056/NEJMp0802904
407:. Neurodiversity.com
184:Autism Omnibus cases
489:10.1056/NEJMc086269
604:The New York Times
576:The New York Times
357:on 23 October 2013
208:On July 21, 2008,
116:multiple sclerosis
668:(20): 2089–2091.
296:Neuropharmacology
253:Neuropharmacology
140:Boston University
124:Myasthenia Gravis
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167:. According to
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610:11 October
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551:11 October
523:11 October
411:11 October
389:11 October
361:12 October
334:References
202:Paul Offit
120:neuropathy
96:Jon Poling
632:USA Today
134:Education
112:apheresis
100:physician
684:18480200
656:(2008).
497:18687652
462:16566887
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279:S2CID
782:2013
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713:2013
680:PMID
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612:2013
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553:2013
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493:PMID
458:PMID
413:2013
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383:Time
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128:VICP
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31:Born
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