321:. In the placenta, the Kurloff cell was occasionally surrounded by a cloud of tiny droplets of material, which gives a similar staining result as the inclusion particles. That material was frequently observed displaying on the luminal surface of the inner placenta compartment. It was obvious that the Kurloff cell must have a role during pregnancy in the guinea-pig because of a significant increase in the number of these cells in the blood and tissues. The inclusion material has been proved to prevent immunological damage to target cells when purified. Studies were done on the effect of extracted inclusion body material in purified form, on inflammatory cells in vitro. The results showed marked toxic effects on macrophages with first clumping follow by cell death. The evidence suggests that Kurloff cells may play a part in preventing immunological damage to the trophoblast by maternal defensive cells.
110:. The Kurloff cell contains a characteristic proteoglycan-containing inclusion body. In the guinea pig, Kurloff cells are more numerous in the adult female than the adult male. A marked increase in the number of circulating Kurloff cells is present in the peripheral blood during pregnancy and after estrogen treatment in male and female animals. A relatively smaller number of cells take place in immature, non-pregnant, and non-estrogen-treated animals. The exact function of Kurloff cells remains unknown, but it has some of the characteristics of both
29:
146:
staining. The
Kurloff cell has an egg shape and the axis of the cell varies from 8 to 12 μm in length, and 10-25 μm in diameter. The inclusion body, which is round in shape and 1-8 μm in diameter, occupies most of the cell's
238:. During pregnancy and after treatment, a large number of Kurloff cells circulated in the blood. At the placenta of a pregnant guinea pig, Kurloff cells are more concentrated at the vascular channels of the labyrinth than the
198:. In the thymus, clumps of Kurloff cells are occasionally seen at the cortico-medullary junction, scattered single cells are seen in the cortex, and numerous Kurloff cells are spotted in
186:
In pregnant and estrogen-treated male and female guinea pigs, clumps of
Kurloff cells containing inclusion bodies of different sizes are present in large numbers in stromal tissue of the
297:
The
Kurloff cells were suggested to have an impact on the immunological status of the guinea-pig placenta. The fate of cells in pregnant guineas pig has been studied by
613:
Eremin O, Wilson AB, Coombs RR, Ashby J, Plumb D (October 1980). "Antibody-dependent cellular cytotoxicity in the guinea pig: the role of the
Kurloff cell".
286:. The results of antibody-dependent cellular cytotoxicity assay on guineas-pig Kurloff cells strongly indicate an immunological role of the cells as the
174:
is low. On the other hand, cells with large inclusion bodies were first observed among low-density cells. Over time, they are found where the density of
575:
Debout C, Quillec M, Izard J (September 1984). "Natural killer activity of
Kurloff cells: a direct demonstration on purified Kurloff cell suspensions".
206:. In the spleen, Kurloff cells are absent in the lymphoid tissue of the white pulp, whereas there are large numbers in the red pulp. In the vertebral
262:
white pulp, thymus parenchyma, and lymph node follicles. The second shared characteristic is that the
Kurloff cell has a receptor for cytophilic
823:
554:
452:
230:
blood supply. It has been suggested that
Kurloff cells might be produced at these sites. A small amount of Kurloff cells are observed within
118:. In guinea-pigs, it has been proposed that Kurloff cells mainly involve in the function of the immune system, such as acting as a
66:
258:. The first characteristic that Kurloff cells share with monocytes is the presence in the blood and organ but absence from the
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composition, and different level of killer cell activities depends mostly on varying degrees of
Kurloff cell contamination.
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155:. The nucleus of Kurloff cell is sickle-shaped and is pushed toward the periphery of the cell by the inclusion body.
317:
results showed that during pregnancy circulating
Kurloff cells release their inclusion particles inside the
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290:. The data also suggest that the Kurloff cell is probably the predominant cytotoxic line in guinea pig
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of these tissues contain a significantly large number of
Kurloff cells relative to the numbers in the
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of the inclusion body. The satisfactory staining of the inclusion particle was extracted from the
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within cells. The cells with small and medium-sized inclusions are present when the density of
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by maternal defensive cells. Also, Kurloff cells present antibody-dependent cytotoxic activity
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266:. On the other hand, Kurloff cells have many lymphocytic features such as it does not contain
210:, Kurloff cells are seen scattered as single cells and in clumps in random pattern among the
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capacity, and last, the Kurloff cell with the early inclusion body possesses a lymphocyte
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724:"Kurloff Cell Levels in the Peripheral Blood of Normal and Oestrogen Treated Guinea-Pigs"
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Sandberg, G.; Hagelin, M. (1986). "Kinetic study of Kurloff cells in guinea pig thymus".
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90:,) were described as mononuclear cells in the peripheral blood and organs of the
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Gómez Román, Victor Raúl; Murray, Joseph C.; Weiner, Louis M. (2014-01-01),
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493:"The distribution and ultrastructure of the Kurloff cell in the guinea-pig"
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656:"A light and electron microscope study on the origin of Foa-Kurloff cells"
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166:, Kurloff cells are categorized depending on the size and the number of
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845:"Proceedings of the Anatomical Society of Great Britain and Ireland"
47:
771:
Kortelainen, Leena; Korhonen, L. Kalevi (1976). "Kurloff Cells".
392:"Kurloff cells in peripheral blood and organs of wild capybaras"
390:
Jara LF, Sánchez JM, Alvarado H, Nassar-Montoya F (April 2005).
219:
99:
16:
Cells found in the blood and organs of guinea pigs and capybara
250:
In guinea pig, the Kurloff cells have some characteristics of
812:"Chapter 1 - Antibody-Dependent Cellular Cytotoxicity (ADCC)"
773:
Acta Pathologica et Microbiologica Scandinavica, Section A
681:
International Archives of Allergy and Applied Immunology
491:
Revell, P A; Vernon-Roberts, B; Gray, A (July 1971).
301:
methods, including an antiserum against the isolated
138:The structure of Kurloff cell was identified using
43:
38:
21:
360:(1940). "Sex hormones and the Foà-Kurloff cell".
234:, and those which are present are in sinuses and
543:Fox JG, Anderson LC, Loew FM, Quimby FW (2002).
549:(2nd ed.). Academic Press. p. 206.
33:Kurloff cell and a lymphocyte in a Guinea pig
8:
27:
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747:
728:British Journal of Experimental Pathology
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407:
362:The Journal of Pathology and Bacteriology
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331:Resistance to cancer in naked mole rats
151:. Also, the inclusion body resembles a
431:Revell PA (1977). "The Kurloff cell".
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849:Journal of Anatomy and Physiology
818:, Academic Press, pp. 1–27,
433:International Review of Cytology
67:Anatomical terms of microanatomy
855:(Pt 2): vii–xii. January 1888.
722:Revell, P. A. (December 1974).
1:
445:10.1016/S0074-7696(08)60229-6
122:and preventing damage to the
627:10.1016/0008-8749(80)90164-1
589:10.1016/0008-8749(84)90034-0
396:Journal of Wildlife Diseases
194:, and the pulp cords of the
810:; Nimmerjahn, Falk (eds.),
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546:Laboratory Animal Medicine
409:10.7589/0090-3558-41.2.431
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26:
374:10.1002/path.1700500202
274:, lack of nonspecific
808:Ackerman, Margaret E.
144:periodic-acid Schiff
615:Cellular Immunology
577:Cellular Immunology
288:natural killer cell
212:hematopoietic cells
182:Tissue distribution
120:natural killer cell
497:Journal of Anatomy
315:Immunofluorescence
825:978-0-12-394802-1
693:10.1159/000234064
556:978-0-08-053533-3
503:(Pt 2): 187–199.
454:978-0-12-364351-3
299:immunofluorescent
224:lymphatic vessels
88:Foà-Kurloff cells
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660:ResearchGate
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402:(2): 431–4.
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358:Ledingham JC
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264:immunoglobin
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192:bone marrows
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22:Kurloff cell
890:Blood cells
816:Antibody Fc
439:: 275–314.
319:trophoblast
303:mucoprotein
256:lymphocytes
232:lymph nodes
208:bone marrow
124:trophoblast
116:lymphocytes
56:guinea pigs
884:Categories
831:2020-04-30
665:2020-05-06
342:References
292:lymphocyte
284:morphology
280:phagocytic
272:phagosomes
240:plasmodial
200:lymphatics
176:thymocytes
172:thymocytes
153:lymphocyte
92:guinea pig
793:1600-0463
740:0007-1021
701:0020-5915
509:0021-8782
268:lysosomes
252:monocytes
178:is high.
149:cytoplasm
134:Structure
112:monocytes
871:17231747
418:16107679
325:See also
276:esterase
228:arterial
128:in vitro
96:capybara
60:capybara
44:Location
862:1288767
758:4447788
749:2072728
709:3721597
635:7428051
597:6467387
527:5558229
518:1270999
214:in the
204:venules
39:Details
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311:thymus
307:spleen
260:spleen
216:stroma
196:spleen
188:thymus
164:spleen
160:thymus
104:agouti
52:organs
220:veins
108:cavie
71:[
48:blood
867:PMID
820:ISBN
789:ISSN
754:PMID
736:ISSN
705:PMID
697:ISSN
631:PMID
593:PMID
551:ISBN
523:PMID
505:ISSN
459:PMID
449:ISBN
414:PMID
309:and
254:and
222:and
202:and
190:and
162:and
142:and
114:and
106:and
100:paca
58:and
50:and
857:PMC
781:doi
777:84A
744:PMC
689:doi
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513:PMC
501:109
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
