163:. The review concluded, “Physiological data and clinical outcomes demonstrate that bioidentical hormones are associated with lower risks, including the risk of breast cancer and cardiovascular disease, and are more efficacious than their synthetic and animal derived counterparts. Until evidence is found to the contrary, bioidentical hormones remain the preferred method of HRT. Further randomized controlled trials are needed to delineate these differences more clearly.” The conclusions were contrary to mainstream opinions on the use of bioidentical hormones. Additionally, many argue that the extensive use of compounded bioidentical hormones is risky because they can be inconsistent and unstable and are not always subject to FDA oversight.
197:
people with low thyroid. This is discussed extensively on the website of his nonprofit organization the
National Academy of Hypothyroidism. Instead, Holtorf advocates labs and diagnostics which look at all thyroid hormone levels, with a particular emphasis on free T3, triodothyronine, the active hormone both produced by the thyroid and converted from T4, levothyroxine, and reverse T3, a metabolite of T4 conversion usually created during times of stress or trauma. This is contrary to position statements by societies such as the American Thyroid Association and
228:(milnacipran HCL); while there are no FDA approved medications for the treatment of chronic fatigue syndrome. Other medications that are commonly used include tryicylcic antidepressants, SSRI antidepressants, Nonsteroidal anti-inflammatory drugs (NSAIDs) and muscle relaxants. In contrast, Dr Holtorf advocates a controversial six step plan that involves the treatment of hormone imbalances, mitochondrial dysfunction, sleep disturbances, and chronic infections.
140:, where he received his doctorate of medicine then returned to UCLA for residency training. He has maintained a clinical practice since 1994 and is a former medical director of the Fibromyalgia and Fatigue Centers, Inc. (FFC). Holtorf has published a number of endocrine reviews on complex topics in peer-reviewed journals on controversial diseases and treatments. He is a guest editor and peer-reviewer for a number of medical journals including
258:
return to normal intake of food or levels of exercise will not be substantial enough to return the metabolism to its previous state. According to his website, holtorfmed.com, this leads to a permanently or chronically suppressed metabolism and
Holtorf issues metabolic testing for patients exhibiting metabolism suppression, as well as labs denoting thyroid and other hormone levels.
146:, is the current AOL Health Expert in Endocrinology, and is a diplomate and board examiner of the American Board of Anti-Aging Medicine (ABAAM). He is a founding member of The Bioidentical Hormone Initiative (BHI), and a founder and director of the National Academy of Hypothyroidism (NAH). In 2001, Holtorf established the Holtorf Medical Group.
253:
Leptin resistance is described as a condition in which overweight individuals are unable to respond to the hormone’s signals appropriately, leading to a starvation response in the body as well as hypothyroid symptoms at the cellular level where they are more difficult to detect. Holtorf treats leptin
257:
A suppressed or "wrecked" metabolism is another cause of obesity commonly cited by
Holtorf. Holtorf claims the metabolism, when subjected to repeated or overzealous dieting and exercise, will regulate itself by repressing thyroid hormone levels in the body, resulting in a hypothyroid state. Even the
196:
Holtorf states that the standard thyroid tests which are typically relied upon by primary care and specialist physicians to diagnosis hypothyroidism (low thyroid) and determine dosage are insufficient because they focus on TSH levels as an indicator of thyroid function and miss a large percentage of
261:
Set-Point malfunction is another theory proposed and supported by
Holtorf, which suggests that the body is programmed to return to a set weight and that this point can be altered by numerous medications, resulting in weight gain. Holtorf prescribes naltrexone, an opioid receptor blocker, used most
175:
vaccine, in which
Holtorf plainly states he "definitely would not" administer the controversial vaccine to his own children, is one of the most highly deliberated. Holtorf likewise links high levels of vaccine adjuncts, such as mercury, to some cases of autism development in children during the
750:
Baskin, HJ; Cobin, RH; Duick, DS; Gharib, H; Guttler, RB; Kaplan, MM; Segal, RL; American
Association of Clinical Endocrinologists (2002). "American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and
166:
Holtorf has also taken an unpopular stance that children are over vaccinated and that vaccines may be associated with autism. Televised appearances and interviews have put
Holtorf's views front and center and invited criticism and debate. Among them, his 2009 appearance on
249:
Holtorf maintains a controversial stance that weight loss is not an issue of diet and exercise, citing causes for the inability to lose weight as leptin resistance, undiagnosed hypothyroidism, environmental toxins, hypometabolism and dysfunctional weight set-point.
104:(ABAAM), which is not recognized by established medical organizations. He is the founder and medical director of Holtorf Medical Group, a practice with five centers that offer treatment for conditions including fibromyalgia,
464:
Holtorf, K (2009). "The bioidentical hormone debate: Are bioidentical hormones (estradiol, estriol, and progesterone) safer or more efficacious than commonly used synthetic versions in hormone replacement therapy?".
154:
Holtorf has been the subject of criticism online and in the media for several years for his promotion of controversial diagnostic methods. He has been an advocate of bioidentical hormones, which has been labeled as
240:
is easily treated with a few weeks of antibiotics and that chronic Lyme disease does not exist. Their position is that standard blood tests are an accurate means of determining the presence of Lyme disease.
903:"The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America"
198:
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Wormser, Gary P.; Dattwyler, Raymond J.; Shapiro, Eugene D.; Halperin, John J.; Steere, Allen C.; Klempner, Mark S.; Krause, Peter J.; Bakken, Johan S.; et al. (2006).
382:
Schwartz, Erika T.; Holtorf, Kent (2008). "Hormones in
Wellness and Disease Prevention: Common Practices, Current State of the Evidence, and Questions for the Future".
572:
508:
North
American Menopause, Society (2010). "Estrogen and progestogen use in postmenopausal women: 2010 position statement of the North American Menopause Society".
176:
interview and is questionably identified on the program as an infectious disease expert. This view is contrary to the position statements of agencies such as the
216:
are two separate disorders that share many overlapping symptoms and are often cross-diagnosed. FDA approved therapies for the treatment of fibromyalgia include
876:
439:
121:
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726:"Treatment Guidelines for Patients With Hyperthyroidism and Hypothyroidism | Thyroid Cancer Guidelines from the American Thyroid Association"
137:
133:
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701:"Optimal Treatment for Hypothyroidism - Dr. Kent Holtorf Shares Thoughts About The Best Way to Treat an Underactive Thyroid and Hypothyroidism"
101:
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resistance in patients with a class of medications that are typically reserved for controlling blood sugar levels in diabetics.
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often to treat opiate addiction, and bupropion (Wellbutrin), a common antidepressant, to reduce the body's set-point.
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that are not recognised as effective. He has been criticized in the media for his controversial views on topics like
159:. He published an extensive review on the safety and efficacy of bioidentical hormones in the peer-reviewed journal
177:
209:
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201:. Holtorf condones treating hypothyroidism with compounded combinations of bioidentical thyroid hormones.
181:
112:), complex endocrine dysfunction, hypothyroidism, age management, chronic fatigue syndrome, low libido,
647:"Vaccine Safety | Immunization Facts For Parents | Immunization Safety - Mollen Immunization"
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188:, who state that there is no credible evidence that vaccines have any link to autism.
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University of
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557:“Diagnosis of hypothyroidism: Are we getting what we want from TSH testing?”
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690:“How Accurate is TSH Testing?” NAHypothyroidism.org. Retrieved 2011-10-02.
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668:"MMR Vaccine and Autism - CDC. (Measles, Mumps, and Rubella). FACT SHEET"
217:
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116:, migraines, PMS, perimenopause and menopause. His practice focuses on
221:
96:(born 1964) is an American physician and entrepreneur practicing in
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594:"The Endocrine Society Position Statement (bio-identical hormones)"
418:"AgeMD Advisory Board | AgeMD Bioidentical Hormone Doctors"
172:
1003:
946:"Kent Holtorf: Long Term Weight Loss - More Than Will Power?"
324:"Information Systems Can Prevent Errors and Improve Quality"
622:"FOX News Broadcasts Bad Advice From H1N1 Flu "Expert""
328:
Journal of the American Medical Informatics Association
302:"Dr. Kent Holtorf – Bringing Hope Where There Was None"
877:"A Confounding Condition on ADVANCE for Healthy Aging"
236:
The Infectious Disease Society of America states that
83:
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559:The Non-Profit National Academy of Hypothyroidism.
787:"Highlights of Prescribing Medication - Cymbalta"
573:"The Truth About 'Bio-identical' Hormone Therapy"
832:"Highlights of Prescribing Medication - Savella"
440:"Saturday Quack - Bio-Identical Hormone Therapy"
199:American Association of Clinical Endocrinologist
811:"Highlights of Prescribing Medication - Lyrica"
703:. Thyroid.about.com. 2010-12-22. Archived from
205:Diagnosis and treatment of CFS and fibromyalgia
879:. Healthy-aging.advanceweb.com. Archived from
8:
1044:University of California, Los Angeles alumni
295:
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982:. Hormoneandlongevitycenter.com. 2005-09-20
561:Nahypothyroidism.org. Retrieved 2011-10-25.
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192:Diagnosis and treatment of hypothyroidism
384:Primary Care: Clinics in Office Practice
122:bioidentical hormone replacement therapy
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728:. Thyroidguidelines.net. Archived from
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232:Diagnosis and treatment of Lyme disease
138:St. Louis University School of Medicine
134:University of California at Los Angeles
624:. Stinkyjournalism.org. Archived from
438:Robert W. Griffith, MD (2009-12-21).
102:American Board of Anti-Aging Medicine
7:
128:Professional status and publications
1014:The Bioidentical Hormone Initiative
1009:National Academy of Hypothyroidism
948:. Huffingtonpost.com. 13 June 2009
813:. Dailymed.nlm.nih.gov. 2011-06-21
442:. Healthandage.com. Archived from
14:
100:. He is a board examiner of the
875:Kent Holtorf, MD (2008-12-03).
136:. He is also a graduate of the
1054:People in alternative medicine
620:Ashford, Molika (2009-10-08).
575:. U.S. News & World Report
571:Gardner, Amanda (2009-01-30).
186:American Academy of Pediatrics
1:
1049:Saint Louis University alumni
649:. Flushotsusa.com. 2008-03-03
599:. The Endocrine Society. 2006
132:Holtorf is a graduate of the
907:Clinical Infectious Diseases
522:10.1097/gme.0b013e3181d0f6b9
220:(duloxetine hydrochloride),
184:, and societies such as the
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855:"Fibromyalgia Medications"
340:10.1136/jamia.2001.0080398
178:Center for Disease Control
1029:American endocrinologists
765:10.4158/1934-2403-8.6.457
396:10.1016/j.pop.2008.07.015
479:10.3810/pgm.2009.01.1949
210:Chronic fatigue syndrome
857:. Webmd.com. 2009-10-21
287:. Retrieved 2011-09-28.
98:Los Angeles, California
161:Post Graduate Medicine
110:non-existent condition
1004:Holtorf Medical Group
467:Postgraduate Medicine
300:Wilson, Lori (2008).
182:Institute of Medicine
118:alternative therapies
87:Holtorf Medical Group
322:Balas, E A. (2001).
114:chronic Lyme disease
285:The Huffington Post
753:Endocrine Practice
224:(pregabalin), and
171:in regards to the
751:hypothyroidism".
304:. Lastheplace.com
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36:June 23, 1964
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984:. Retrieved
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673:. www.in.gov
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238:Lyme disease
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214:fibromyalgia
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94:Kent Holtorf
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55:Postgraduate
20:Kent Holtorf
1039:1964 births
420:. Agemd.org
245:Weight loss
150:Controversy
44:Nationality
1023:Categories
986:2011-11-26
952:2011-11-26
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861:2011-11-26
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450:2011-11-26
424:2011-11-26
308:2011-11-26
266:References
212:(CFS) and
68:Occupation
32:1964-06-23
510:Menopause
143:Endocrine
52:Education
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226:Savella
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354:PMID
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