49:, most notably that which is found in the knee joint, is generally characterized by very low friction, high wear resistance, and poor regenerative qualities. It is responsible for much of the compressive resistance and load bearing qualities of the knee joint and, without it, walking is painful to impossible.
172:
Techniques such as the EELS-TALC to enhance ACI and MACI with enabling chondrocytes to be tissue engineered with long term native knee cartilage phenotype maintenance in vitro and in vivo, with the engineered tissue construct containing stem cell progenitors along with those expressing pluripotency
160:
for approximately six weeks until the population reaches 10-12 million cells. Then these cells are seeded onto a film that is implanted into the area of cartilage damage and absorbed back into the tissue into the patient. The implanted chondrocytes then divide and integrate with surrounding tissue
53:
is a common condition of cartilage failure that can lead to limited range of motion, bone damage and invariably, pain. Due to a combination of acute stress and chronic fatigue, osteoarthritis directly manifests itself in a wearing away of the articular surface and, in extreme cases, bone can be
185:
may regenerate cartilage, cartilage growth in human knees using autologous cultured mesenchymal stem cells is under research and preliminary clinical use, and appears to be safe as of 2016. An advantage to this approach is that a person's own stem cells are used, avoiding
139:
The human body's own cartilage is still the best material for lining knee joints. This drives efforts to develop ways of using a person's own cells to grow, or re-grow cartilage tissue to replace missing or damaged cartilage. One cell-based replacement technique is called
854:
Saw, KY; Anz A; Merican S; Tay YG; Ragavanaidu K; Jee CS; McGuire DA (April 2011). "Articular cartilage regeneration with autologous peripheral blood progenitor cells and hyaluronic Acid after arthroscopic subchondral drilling: a report of 5 cases with histology".
194:. Stem cells enable surgeons to grow replacement cartilage, which gives the new tissue greater growth potential. While there are few long-term studies as of 2018, a history of knee problems and body weight are factors for how well the procedure will work.
151:
One ACI treatment, called MACI (autologous cultured chondrocytes on a porcine collagen matrix), is indicated for healthy patients 18–55 with medium to large sized damage to their cartilage. It is not applicable to osteoarthritis patients. The patient's
147:
A review evaluating autologous chondrocyte implantation was published in 2010. The conclusions are that it is an effective treatment for full thickness chondral defects. The evidence does not suggest ACI is superior to other treatments.
124:
The AMIC surgery is a single-step procedure. Once cartilage damage is assessed there are two methods to access the joint to proceed with the AMIC surgery. First is to perform a mini arthrotomy. Second is an all-arthroscopic procedure.
112:
The AMIC technique was developed to improve some of the shortfalls of microfracture surgery such as variable repair cartilage volume and functional deterioration over time. The collagen membrane protects and stabilizes the
532:"A three-dimensional in vitro culture environment of a novel polymer scaffold, yielding chondroprogenitors and mesenchymal stem cells in human chondrocytes derived from osteoarthritis-affected cartilage tissue"
168:
Another ACI technique, using "chondospheres", uses only chondrocytes and no matrix material. The cells grow in self-organized spheroid matrices which are implanted via injected fluid or inserted tissue matrix.
931:
156:
are removed arthroscopically from a non load-bearing area from either the intercondylar notch or the superior ridge of the medial or lateral femoral condyles. 10,000 cells are harvested and grown
233:
173:
markers and with added advantage of enriched hyaluronic acid (HA) expression by the cells have been reported which will contribute to improvised regenerative therapies for cartilage damage.
583:"Articular chondrocytes from osteoarthritic knee joints of elderly, in vitro expanded in thermo-reversible gelation polymer (TGP), exhibiting higher UEA-1 expression in lectin microarray"
634:"Enhanced expression of hyaluronic acid in osteoarthritis-affected knee-cartilage chondrocytes during three-dimensional in vitro culture in a hyaluronic-acid-retaining polymer scaffold"
331:
Vasiliadis, H.; Wasiak, J.; Salanti, G. (2010). "Autologous chondrocyte implantation for the treatment of cartilage lesions of the knee: a systematic review of randomized studies".
109:
bone marrow stimulating technique in combination with a collagen membrane. It is based on the microfracture surgery with the application of a bi-layer collagen I/III membrane.
924:
54:
exposed in the joint. Some additional examples of cartilage failure mechanisms include cellular matrix linkage rupture, chondrocyte protein synthesis inhibition, and
917:
374:
Thermann, H; Driessen, A; Becher, C (March 2008). "Autologous chondrocyte transplantation in the treatment of articular cartilage lesions of the talus".
735:
Saw, Khay-Yong; Anz, Adam; Jee, Caroline Siew-Yoke; Merican, Shahrin; Ng, Reza Ching-Soong; Roohi, Sharifah A.; Ragavanaidu, Kunaseegaran (April 2013).
1324:
483:"Transplantation of autologous chondrocytes ex-vivo expanded using Thermoreversible Gelation Polymer in a rabbit model of articular cartilage defect"
1276:
202:
A 2011 study reported histologically confirmed hyaline cartilage regrowth in the knee. The successful protocol involved arthroscopic microdrilling/
96:
1441:
223:
1182:
141:
134:
1333:
737:"Articular cartilage regeneration with autologous peripheral blood stem cells versus hyaluronic acid: A randomized controlled trial"
1236:
1231:
808:"The interaction between weight and family history of total knee replacement with knee cartilage: a 10-year prospective study"
1128:
1436:
84:
678:"Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy – a review"
676:
Freitag, Julien; Bates, Dan; Boyd, Richard; Shah, Kiran; Barnard, Adele; Huguenin, Leesa; Tenen, Abi (26 May 2016).
1165:
106:
1269:
444:"In vitro culture of chondrocytes in a novel thermoreversible gelation polymer scaffold containing growth factors"
214:
scaffold on which injected PBPCs can be recruited and enhance chondrogenesis at the site of the contained lesion.
1446:
1291:
1082:
274:
Piontek, Tomasz; Ciemniewska-Gorzela Kinga; Szulc
Andrzej; Naczk Jakub; Słomczykowski Michał (30 August 2011).
736:
252:
1201:
1072:
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182:
206:
surgery followed by postoperative injections of autologous peripheral blood progenitor cells (PBPCs) and
1170:
203:
114:
1348:
807:
1259:
979:
806:
Pan, F.; Blizzard, L.; Tian, J.; Cicuttini, F.; Winzenberg, T.; Ding, C.; Jones, G. (February 2017).
253:"FDA approves first autologous cellularized scaffold for the repair of cartilage defects of the knee"
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61:. There are several different repair options available for cartilage damage or failure.
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276:"All-arthroscopic AMIC procedure for repair of cartilage defects of the knee"
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101:
Autologous matrix-induced chondrogenesis, which is also known as
959:
941:
913:
69:
83:
defects in the knee. This treatment has been approved by the
892:
741:
Arthroscopy: The
Journal of Arthroscopic and Related Surgery
234:
Spheroids of human autologous matrix-associated chondrocytes
895:
American
Academy of Orthopaedic Surgeons. February 2005.
198:
Microdrilling augmented with peripheral blood stem cells
144:(ACI) or autologous chondrocyte transplantation (ACT).
900:
Osteochondral
Grafting of Articular Cartilage Injury
1362:
1302:
1247:
1200:
1191:
1156:
1101:
1065:
1049:
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255:. US Food and Drug Administration. 13 December 2016
23:
18:
117:released through microfracture and enhances their
177:Autologous mesenchymal stem cell transplantation
333:Knee Surgery, Sports Traumatology, Arthroscopy
280:Knee Surgery, Sports Traumatology, Arthroscopy
925:
8:
1197:
964:
932:
918:
910:
893:Minimally Invasive Total Knee Replacement.
671:
669:
1325:Anterior cruciate ligament reconstruction
823:
711:
693:
649:
608:
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557:
547:
506:
307:
1277:Ulnar collateral ligament reconstruction
97:Autologous matrix-induced chondrogenesis
91:Autologous matrix-induced chondrogenesis
244:
105:, is a biological treatment option for
224:Meniscal cartilage replacement therapy
15:
7:
1183:Autologous chondrocyte implantation
142:autologous chondrocyte implantation
135:Autologous chondrocyte implantation
129:Autologous chondrocyte implantation
32:
1334:Unicompartmental knee arthroplasty
1178:Knee cartilage replacement therapy
783:"Can I Run After Knee Replacement"
87:in 2016 for adult treatment only.
19:Knee cartilage replacement therapy
14:
1442:Orthopedic surgical procedures
64:"Maci" or autologous cultured
1:
682:BMC Musculoskeletal Disorders
869:10.1016/j.arthro.2010.11.054
812:Osteoarthritis and Cartilage
781:Rinzel, Megan (2022-04-21).
753:10.1016/j.arthro.2012.12.008
119:chondrogenic differentiation
85:Food and Drug Administration
1463:
1166:Articular cartilage repair
825:10.1016/j.joca.2016.10.013
651:10.1016/j.knee.2021.02.019
600:10.1016/j.reth.2020.03.006
210:. The procedure creates a
132:
107:articular cartilage damage
94:
949:
695:10.1186/s12891-016-1085-9
549:10.1016/j.jor.2021.01.005
499:10.1016/j.jor.2017.01.003
388:10.1007/s00132-008-1215-7
345:10.1007/s00167-010-1050-3
292:10.1007/s00167-011-1657-z
161:and potentially generate
33:
1292:Finger joint replacement
1083:Distraction osteogenesis
460:10.1089/ten.2006.12.1237
632:Katoh, Shojiro (2021).
581:Katoh, Shojiro (2020).
530:Katoh, Shojiro (2021).
1073:Femoral head ostectomy
1041:Vertebral augmentation
536:Journal of Orthopedics
487:Journal of Orthopedics
442:Yasuda, Ayuko (2006).
382:(3, number 3): 232–9.
183:mesenchymal stem cells
1270:Weaver–Dunn procedure
1171:Microfracture surgery
940:Procedures involving
1260:Shoulder replacement
1222:Intervertebral discs
980:Orthognathic surgery
587:Regenerative Therapy
481:Arumugam, S (2007).
1437:Implants (medicine)
1412:Arthroscopic lavage
1144:Tension band wiring
229:Meniscus transplant
47:Articular cartilage
1354:Triple arthrodesis
1349:Broström procedure
1287:Brunelli procedure
1088:Ilizarov apparatus
1036:Vertebral fixation
952:Orthopedic surgery
448:Tissue Engineering
1424:
1423:
1420:
1419:
1390:Joint replacement
1344:Ankle replacement
1152:
1151:
1139:External fixation
1134:Internal fixation
985:Chin augmentation
339:(12): 1645–1655.
165:-like cartilage.
44:
43:
1454:
1330:Knee replacement
1255:Shoulder surgery
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37:edit on Wikidata
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1447:Knee treatments
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1310:Hip resurfacing
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1078:Astragalectomy
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887:External links
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787:Run In The Sun
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1375:Arthroplasty
1339:Ankle fusion
1282:Hand surgery
1237:Arthroplasty
1232:Annuloplasty
1177:
1031:Foraminotomy
1016:Laminoplasty
1001:Coccygectomy
898:
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837:. Retrieved
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790:. Retrieved
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154:chondrocytes
150:
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123:
111:
102:
100:
66:chondrocytes
63:
45:
1385:Arthroscopy
1380:Synovectomy
1210:Arthrodesis
1026:Facetectomy
1011:Laminectomy
857:Arthroscopy
839:19 December
766:19 December
644:: 365–373.
593:: 234–237.
542:: 138–141.
418:"EELS-TALC"
259:28 November
79:to correct
56:chondrocyte
1431:Categories
1400:Arthrogram
1370:Arthrotomy
1227:Discectomy
1021:Corpectomy
1006:Laminotomy
944:and joints
792:2022-04-24
688:(1): 230.
240:References
212:blood clot
29:orthopedic
1158:Cartilage
1129:Reduction
1119:Osteotomy
1109:Ostectomy
905:eMedicine
704:1471-2474
422:EELS-TALC
376:Orthopade
300:0942-2056
81:cartilage
77:treatment
59:apoptosis
25:Specialty
1395:imaging:
877:21334844
834:27789341
761:23380230
722:27229856
660:33690017
638:The Knee
619:32435676
568:33510554
517:28203047
468:16771637
427:20 March
404:22504245
396:18317730
353:20127071
318:21910000
218:See also
181:Because
158:in vitro
73:collagen
1363:General
1102:General
713:4880954
610:7229400
559:7815488
508:5293721
361:5632160
309:3332359
190:by the
163:hyaline
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960:Bones
942:bones
400:S2CID
357:S2CID
35:[
968:Face
873:PMID
841:2018
830:PMID
768:2018
757:PMID
718:PMID
700:ISSN
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513:PMID
464:PMID
429:2021
392:PMID
349:PMID
314:PMID
296:ISSN
261:2017
115:MSCs
103:AMIC
1303:Leg
1248:Arm
1066:Leg
1050:Arm
903:at
865:doi
820:doi
749:doi
708:PMC
690:doi
646:doi
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