20:
449:
176:
1018:
Bernstein, Mark; Al-Anazi, Abdul Rahman; Kucharczyk, Walter; Manninen, Pirjo; Bronskill, Michael; Henkelman, Mark (2000). "Brain tumor surgery with the
Toronto open magnetic resonance imaging system: Preliminary results for 36 patients and analysis of advantages, disadvantages, and future prospects".
917:
Sherrington, R; Rogaev, E. I.; Liang, Y; Rogaeva, E. A.; Levesque, G; Ikeda, M; Chi, H; Lin, C; Li, G; Holman, K; Tsuda, T; Mar, L; Foncin, J. F.; Bruni, A. C.; Montesi, M. P.; Sorbi, S; Rainero, I; Pinessi, L; Nee, L; Chumakov, I; Pollen, D; Brookes, A; Sanseau, P; Polinsky, R. J.; Wasco, W; Da
524:
In 2013, Krembil expanded into an additional 325,000 sq ft (30,200 m) of space, spanning nine floors, in the
Krembil Discovery Tower. The Tower space includes 150,000 sq ft (14,000 m) of "wet" laboratory bench space for Krembil basic science researchers.
146:
degenerative diseases are the focus of the researchers in the musculoskeletal research program at the
Krembil as part of the UHN Arthritis and Autoimmunity Research Centre. Their investigations are aimed at revealing the causes of, and generating therapies for, these
1097:
Winer, Shawn; Astsaturov, Igor; Cheung, Roy; Tsui, Hubert; Song, Aihua; Gaedigk, Roger; Winer, Daniel; Sampson, Anastasia; McKerlie, Colin; Bookman, Arthur; Dosch, H-Michael (2002). "Primary Sjögren's syndrome and deficiency of ICA69".
277:(PSP; Steele-Richardson-Olszewski Syndrome) as a unique form of dementia and neurodegenerative disease involving the gradual deterioration and death of specific volumes of the brain (J. Steele, J. Richardson & J. Olszewski, 1963)
1190:
Kennedy, Sidney H.; Giacobbe, P; Rizvi, S. J.; Placenza, F. M.; Nishikawa, Y; Mayberg, H. S.; Lozano, A. M. (2011). "Deep Brain
Stimulation for Treatment-Resistant Depression: Follow-Up After 3 to 6 Years".
635:
Richardson, J. C.; Steele, J; Olszewski, J (1963). "Supranuclear
Ophthalmoplegia, Pseudobulbar Palsy, Nuchal Dystonia and Dementia. A Clinical Report on Eight Cases of 'heterogenous System Degeneration'".
81:
care responsibilities for the UHN group. In 1980, the
Playfair Neuroscience Institute was created. In 1999, it was renamed the Toronto Western Research Institute. The Institute added research areas in
540:
The
Krembil has many strategic research alliances, nationally and internationally, to facilitate and enhance the delivery of its research mandate. Two of the strategic research alliances are:
31:, formerly known as the Toronto Western Research Institute, is an academic medical research institute in Toronto. It is one of the largest research institutes in Canada focusing on human
663:
Carlen, P.; Wortzman, G; Holgate, R.; Wilkinson, D.; Rankin, J. (1978). "Reversible cerebral atrophy in recently abstinent chronic alcoholics measured by computed tomography scans".
423:
Christopher
Wallace MD, MSc, FRCSC, a neurosurgeon and neurophysiologist, was the first official director of the Krembil; his research focussed on therapeutic approaches to vascular
545:
1386:
918:
Silva, H. A.; Haines, J. L.; Perkicak-Vance, M. A.; Tanzi, R. E.; et al. (1995). "Cloning of a gene bearing missense mutations in early-onset familial
Alzheimer's disease".
1752:
90:. By 2004, under the founding leadership of neurosurgeon C. Wallace, the Krembil had emerged as one of the largest research institutes in Canada with a neuroscience emphasis.
1141:
Richter, Suzanne; Vandezande, Kirk; Chen, Ning; Zhang, Katherine; Sutherland, Joanne; Anderson, Julie; Han, Liping; Panton, Rachel; Branco, Patricia; Gallie, Brenda (2003).
365:
Neural adult stem cell transplantation findings show promising results in repairing spinal cord damage and restoring mobility in rats. (M. Fehlings & S. Karimi, 2006)
528:
Krembil receives support from the
Toronto General/Toronto Western Hospital Foundation which is currently embarked upon a $ 200 million "Brain Campaign" to support
1883:
1689:
120:
The Krembil is also home to the Vision Science Research Program, a joint UHN/University of Toronto Program. This research is directed into the following areas:
1474:
1304:
Smith, Gwenn S.; Laxton, Adrian W.; Tang-Wai, David F.; McAndrews, Mary Pat; Diaconescu, Andreea Oliviana; Workman, Clifford I.; Lozano, Andres M. (2012).
470:
614:
1761:
1745:
93:
On November 13, 2015, the Krembil took on its current name from the Krembil family. In 2013, the Krembil Discovery Tower opened at Toronto Western.
1888:
1956:
1878:
1791:
1684:
1513:
1228:"Delayed Transplantation of Adult Neural Precursor Cells Promotes Remyelination and Functional Neurological Recovery after Spinal Cord Injury"
555:
Toronto Dementia Research Alliance (TDRA) is a Toronto-wide network of researchers focused on the understanding and treatment of all forms of
706:
Mailis, A; Wade, J (1994). "Profile of Caucasian women with possible genetic predisposition to reflex sympathetic dystrophy: A pilot study".
1704:
1390:
240:
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19:
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1951:
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509:
Krembil occupies 105,000 sq ft (9,800 m) at Toronto Western Hospital for basic science, clinical, imaging and
474:
274:
226:
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316:
105:
as they develop treatments for neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, epilepsy,
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1533:
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208:
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1714:
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1651:
1898:
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459:
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and PhD geneticist, was the second full-time director of the Krembil; his research focussed on the genetic basis of
1661:
1493:
1460:
327:
478:
463:
186:
1823:
1616:
39:
579:
Rutka, J. T.; Wallace, C (2010). "Excellence in neurosurgery program building: Enhancing the academic mission".
1873:
1848:
1838:
1679:
1641:
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1566:
606:
43:
326:
First in Canada to use Image-Guided Minimally Invasive Therapy (IGMIT) during surgery allowing for real-time
1576:
1556:
552:, under the umbrella of the Faculty of Medicine, with a focus on the spectrum of neurodegenerative diseases.
320:
969:
St George-Hyslop, P; McLachlan, D. C.; Tsuda, T; Rogaev, E; Karlinsky, H; Lippa, C. F.; Pollen, D (1994).
402:
368:
Performed the world's first deep brain stimulation for treatment of Alzheimer's Disease (A. Lozano, 2012),
312:
299:
295:
50:
1694:
1143:"Sensitive and Efficient Detection of RB1 Gene Mutations Enhances Care for Families with Retinoblastoma"
1054:
Davis, K. D.; Lozano, A. M.; Tasker, R. R.; Dostrovsky, J. O. (1998). "Brain targets for pain control".
549:
233:
32:
1277:
Laxton, A. W.; Sankar, T; Lozano, A. M.; Hamani, C (2012). "Deep brain stimulation effects on memory".
417:
1803:
1586:
982:
927:
875:
672:
155:
133:
66:
62:
1437:
1226:
Karimi-Abdolrezaee, S.; Eftekharpour, E; Wang, J; Morshead, C. M.; Fehlings, M. G. (29 March 2006).
1771:
1523:
1503:
341:
337:
517:
researchers, 206 technical/support staff and 157 research trainees, who collectively produced 515
1508:
1123:
1079:
951:
899:
731:
308:
with same day discharge for brain tumor removal using image guided approach. (M. Bernstein, 1996)
121:
106:
87:
1412:
1368:
1327:
1286:
1259:
1208:
1172:
1115:
1071:
1036:
1000:
943:
891:
848:
807:
766:
723:
688:
645:
588:
432:
359:
1358:
1317:
1249:
1239:
1200:
1162:
1154:
1107:
1063:
1028:
990:
935:
883:
838:
797:
758:
715:
680:
411:
305:
1306:"Increased Cerebral Metabolism After 1 Year of Deep Brain Stimulation in Alzheimer Disease"
291:
Showed genetic predisposition to developing Reflex Sympathetic Dystrophy. (A. Mailis, 1994)
372:
281:
129:
1433:
866:
St George-Hyslop, P. H. (2006). "Genetic Factors in the Genesis of Alzheimer's Disease".
986:
931:
879:
676:
1254:
1227:
887:
843:
826:
352:
333:
Identified the individual brain cells that control pain. (K. Davis and A. Lozano, 1998)
102:
1347:"Stroke: Neuroprotection for patients with stroke moves one step closer to the clinic"
1167:
1142:
1111:
749:
Ponce, F. A.; Lozano, A. M. (2011). "The surgical management of Parkinson's disease".
1945:
1032:
784:
Castrioto, Anna; Lozano, A. M.; Poon, Y. Y.; Lang, A. E.; Fallis, M; Moro, E (2011).
719:
389:
114:
83:
58:
1127:
1083:
903:
735:
532:
research at Krembil. The campaign had raised over $ 273 million as of January 2016.
1244:
1204:
955:
529:
510:
424:
148:
78:
1428:
1322:
1305:
802:
785:
518:
448:
175:
762:
521:
publications supported by more than $ 43,612,000 of external research funding.
514:
285:
143:
1927:
1914:
1363:
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995:
970:
428:
139:
1372:
1331:
1290:
1263:
1212:
1176:
1119:
1075:
1040:
895:
811:
770:
684:
649:
592:
358:
Performed the world's first deep brain stimulation for treatment resistant
124:
of blinding eye diseases with brain disorders; treatment and biophysics of
1004:
947:
852:
727:
65:, neuro-ophthalmologic and other ocular disorders, multiple sclerosis and
692:
556:
348:
125:
110:
54:
330:
to guide surgeons to the location of a brain tumor. (M. Bernstein, 1998)
77:
In the early 1980s, Toronto Western took on additional neurological and
1452:
1067:
939:
607:"World Community Grid finds a new home at Krembil Research Institute"
1763:
Research hospitals of the University of Toronto Faculty of Medicine
1387:"Peter St George-Hyslop — Cambridge Institute for Medical Research"
1158:
786:"Ten-Year Outcome of Subthalamic Stimulation in Parkinson Disease"
18:
344:, as well as a vaccine to treat the condition. (A. Bookman, 2002)
1734:
1456:
1447:
442:
169:
159:
109:, cerebral ischemia (stroke), vascular brain malformations,
38:
Krembil is one of the principal research institutes of the
827:"Brain tumour surgery in the elderly: A brief reappraisal"
311:
Identified genes responsible for hereditary blindness,
546:
Tanz Centre for Research in Neurodegenerative Diseases
23:
Toronto Western Hospital's Krembil Neuroscience Centre
1442:
638:
Transactions of the American Neurological Association
101:
Krembil neuroscientists explore the function of the
1864:
1822:
1802:
1770:
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1650:
1615:
1585:
1565:
1547:
1522:
1492:
1413:"Krembil Welcomes New Director | UHN Research"
971:"Alzheimer's disease and possible gene interaction"
154:In September 2021, Krembil took ownership of the
513:research. In 2011, the Krembil was home to 122
1690:Holland Bloorview Kids Rehabilitation Hospital
16:Academic medical research institute in Toronto
1746:
1468:
751:CNS & Neurological Disorders Drug Targets
427:. Peter St George-Hyslop MD, PhD, FRCPC, a
371:Development of new experimental drug for the
8:
280:First in world to show the reversibility of
548:(Tanz CRND) is a research institute at the
477:. Unsourced material may be challenged and
1753:
1739:
1731:
1475:
1461:
1453:
1448:Faculty of Medicine, University of Toronto
868:Annals of the New York Academy of Sciences
1362:
1321:
1253:
1243:
1166:
994:
842:
801:
497:Learn how and when to remove this message
260:Learn how and when to remove this message
166:Krembil and UHN Neuroscience achievements
1056:Stereotactic and Functional Neurosurgery
375:treatment of stroke (M. Tymianski, 2012)
574:
572:
568:
435:diseases such as Alzheimer's dementia.
1879:Centre for Addiction and Mental Health
1792:Lunenfeld-Tanenbaum Research Institute
1685:Centre for Addiction and Mental Health
1147:The American Journal of Human Genetics
196:Please improve this section by adding
42:and is the research institute of the
7:
475:adding citations to reliable sources
362:. (A. Lozano & S. Kennedy, 2003)
351:that enhance care for families with
336:Identified of protein that triggers
128:; eye movement control mechanisms;
1429:Toronto Western Research Institute
888:10.1111/j.1749-6632.2000.tb05552.x
407:2011–2013 – Peter Carlen (interim)
288:with abstinence. (P. Carlen, 1978)
49:Krembil researches treatments for
14:
1894:Sunnybrook Health Sciences Centre
1710:Sunnybrook Health Sciences Centre
1279:Journal of Neurosurgical Sciences
298:in Canada to effectively control
1844:Toronto Rehabilitation Institute
1637:Toronto Rehabilitation Institute
1033:10.1097/00006123-200004000-00023
720:10.1097/00002508-199409000-00007
447:
323:. (P. St. George Hyslop, 1990s),
174:
1834:Princess Margaret Cancer Centre
1627:Princess Margaret Cancer Centre
617:from the original on 2021-09-13
398:1999–2004 – Christopher Wallace
347:Developed method for detecting
1889:The Hospital for Sick Children
1705:The Hospital for Sick Children
1389:. 1 April 2019. Archived from
1245:10.1523/JNEUROSCI.4184-05.2006
1205:10.1176/appi.ajp.2010.10081187
1193:American Journal of Psychiatry
1027:(4): 900–7, discussion 907–9.
275:Progressive Supranuclear Palsy
1:
1957:Research institutes in Canada
1112:10.1016/S0140-6736(02)11144-5
198:secondary or tertiary sources
1782:Hennick Bridgepoint Hospital
1534:Hennick Bridgepoint Hospital
1514:Scarborough General Hospital
708:The Clinical Journal of Pain
536:Strategic research alliances
302:symptoms. (A. Lozano, 1994),
209:"Krembil Research Institute"
1715:Toronto Grace Health Centre
1700:North York General Hospital
1653:William Osler Health System
1549:Toronto East Health Network
1323:10.1001/archneurol.2012.590
831:Canadian Journal of Surgery
803:10.1001/archneurol.2011.182
273:First in world to describe
132:; retinal degeneration and
1973:
1854:Krembil Research Institute
1662:Etobicoke General Hospital
1597:St. Joseph's Health Centre
1495:Scarborough Health Network
763:10.2174/187152711797247795
611:www.worldcommunitygrid.org
385:1980–1988 – William Tatton
328:magnetic resonance imaging
151:and orthopaedic ailments.
29:Krembil Research Institute
1825:University Health Network
1618:University Health Network
1443:University Health Network
40:University Health Network
1899:Women's College Hospital
1874:Baycrest Health Sciences
1849:Toronto Western Hospital
1839:Toronto General Hospital
1720:Women's College Hospital
1680:Baycrest Health Sciences
1642:Toronto Western Hospital
1632:Toronto General Hospital
1568:Trillium Health Partners
1438:Toronto Western Hospital
1364:10.1038/nrneurol.2012.44
1351:Nature Reviews Neurology
1345:Kingwell, Katie (2012).
825:Bernstein, Mark (1996).
395:1990–1999 – Peter Carlen
44:Toronto Western Hospital
1577:Queensway Health Centre
1557:Michael Garron Hospital
1232:Journal of Neuroscience
996:10.1126/science.8290965
53:, Parkinson's disease,
1814:St. Michael's Hospital
1602:St. Michael's Hospital
685:10.1126/science.653357
403:Peter St George-Hyslop
296:deep brain stimulation
185:relies excessively on
24:
1952:University of Toronto
1928:43.65338°N 79.40563°W
1695:Humber River Hospital
1607:Providence Healthcare
1310:Archives of Neurology
790:Archives of Neurology
581:Clinical Neurosurgery
550:University of Toronto
284:and dysfunction from
22:
1805:Unity Health Toronto
1787:Mount Sinai Hospital
1588:Unity Health Toronto
1539:Mount Sinai Hospital
1485:Hospitals in Toronto
471:improve this section
321:Huntington's disease
294:Performed the first
156:World Community Grid
134:diabetic retinopathy
113:, brain tumours and
107:spinal cord injuries
67:autoimmune disorders
63:spinal cord injuries
33:neurological disease
1933:43.65338; -79.40563
1924: /
1773:Sinai Health System
1525:Sinai Health System
1504:Birchmount Hospital
987:1994Sci...263..537S
932:1995Natur.375..754S
880:2000NYASA.924....1S
677:1978Sci...200.1076C
355:. (B. Gallie, 2003)
338:autoimmune response
97:Research Activities
86:, rheumatology and
51:Alzheimer's disease
1509:Centenary Hospital
342:Sjögren's syndrome
122:molecular genetics
25:
1907:
1906:
1884:Holland Bloorview
1728:
1727:
1068:10.1159/000029661
507:
506:
499:
433:neurodegenerative
380:Krembil Directors
270:
269:
262:
244:
1964:
1939:
1938:
1936:
1935:
1934:
1929:
1925:
1922:
1921:
1920:
1917:
1867:
1826:
1806:
1774:
1764:
1755:
1748:
1741:
1732:
1673:
1654:
1619:
1589:
1569:
1550:
1526:
1496:
1486:
1477:
1470:
1463:
1454:
1417:
1416:
1409:
1403:
1402:
1400:
1398:
1383:
1377:
1376:
1366:
1342:
1336:
1335:
1325:
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1295:
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1268:
1267:
1257:
1247:
1223:
1217:
1216:
1187:
1181:
1180:
1170:
1138:
1132:
1131:
1106:(9339): 1063–9.
1094:
1088:
1087:
1051:
1045:
1044:
1015:
1009:
1008:
998:
966:
960:
959:
940:10.1038/375754a0
926:(6534): 754–60.
914:
908:
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863:
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822:
816:
815:
805:
781:
775:
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746:
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739:
703:
697:
696:
671:(4345): 1076–8.
660:
654:
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632:
626:
625:
623:
622:
603:
597:
596:
576:
502:
495:
491:
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482:
451:
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418:Jaideep S. Bains
412:Donald F. Weaver
306:Awake craniotomy
265:
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178:
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1972:
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1967:
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1963:
1962:
1961:
1942:
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1926:
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1915:
1913:
1911:
1910:
1908:
1903:
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1824:
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1804:
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1548:
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1396:
1394:
1393:on 1 April 2019
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1339:
1303:
1302:
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1275:
1271:
1238:(13): 3377–89.
1225:
1224:
1220:
1189:
1188:
1184:
1140:
1139:
1135:
1096:
1095:
1091:
1053:
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1017:
1016:
1012:
968:
967:
963:
916:
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911:
865:
864:
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824:
823:
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783:
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778:
748:
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705:
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657:
634:
633:
629:
620:
618:
605:
604:
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578:
577:
570:
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511:epidemiological
503:
492:
486:
483:
468:
452:
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416:2022–present –
410:2013–present –
382:
373:neuroprotectant
282:brain shrinkage
266:
255:
249:
246:
203:
201:
195:
191:primary sources
179:
168:
144:rheumatological
142:and associated
130:neuronal damage
99:
75:
61:, concussions,
17:
12:
11:
5:
1970:
1968:
1960:
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1954:
1944:
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1423:External links
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796:(12): 1550–6.
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250:September 2014
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115:pain disorders
103:nervous system
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1316:(9): 1141–8.
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1199:(5): 502–10.
1198:
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1153:(2): 253–69.
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205:Find sources:
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183:This section
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84:ophthalmology
80:
79:neurosurgical
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59:brain tumours
56:
52:
47:
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36:
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1391:the original
1381:
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1309:
1299:
1285:(4): 341–4.
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1196:
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1103:
1099:
1092:
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1059:
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1021:Neurosurgery
1020:
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610:
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530:neuroscience
527:
523:
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469:Please help
457:
425:brain injury
422:
401:2004–2011 –
388:1988–1990 –
256:
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88:orthopaedics
76:
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28:
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1931: /
1672:Independent
429:neurologist
313:Alzheimer's
300:Parkinson's
1946:Categories
1919:79°24′20″W
1916:43°39′12″N
1397:18 January
1357:(4): 178.
1100:The Lancet
874:(1): 1–7.
621:2021-09-13
587:: 100–11.
564:References
515:biomedical
439:Facilities
360:depression
286:alcoholism
220:newspapers
187:references
149:autoimmune
57:, stroke,
458:does not
392:(interim)
140:Arthritis
111:aneurysms
1373:22430113
1332:22566505
1291:23111294
1264:16571744
1213:21285143
1177:12541220
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650:14272249
644:: 25–9.
615:Archived
593:21280502
557:dementia
126:glaucoma
55:epilepsy
1255:6673854
1005:8290965
983:Bibcode
975:Science
956:4308372
948:7596406
928:Bibcode
876:Bibcode
853:8769926
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728:7833579
673:Bibcode
665:Science
479:removed
464:sources
234:scholar
73:History
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1124:S2CID
1080:S2CID
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900:S2CID
732:S2CID
241:JSTOR
227:books
158:from
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1369:PMID
1328:PMID
1287:PMID
1260:PMID
1209:PMID
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589:PMID
544:The
462:any
460:cite
319:and
213:news
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1359:doi
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1250:PMC
1240:doi
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1163:PMC
1155:doi
1108:doi
1104:360
1064:doi
1029:doi
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