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84:, the usage of this term is sometimes inconsistent. The Chronic Lymphocytic Leukemia Research Consortium defines a lymphoblast as "A lymphocyte that has become larger after being stimulated by an antigen. Lymphoblasts look like immature lymphocytes, and were once thought to be precursor cells." Commonly, when speaking about leukemia, "blast" is used as an abbreviation for lymphoblasts.
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with altered cell morphology. It occurs when the lymphocyte is activated by an antigen and increased in volume by nucleus and cytoplasm growth as well as new mRNA and protein synthesis. The lymphoblast then starts dividing two to four times every 24 hours for three to five days, with a single
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lymphoblast making approximately 1000 clones of its original naive lymphocyte, with each clone sharing the originally unique antigen specificity. Finally the dividing cells differentiate into effector cells, known as
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103:. However these morphologic distinctions are not absolute and a definitive diagnosis relies on antibody
74:(ALL), lymphoblasts proliferate uncontrollably and are found in large numbers in the peripheral blood.
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Although commonly lymphoblast refers to a precursor cell in the maturation of
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Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson; Aster, Jon C. (2010).
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70:. Normally, lymphoblasts are found in the bone marrow, but in
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Lymphoblasts can also refer to immature cells which typically
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Microscopic
Haematology: A Practical Guide for the Laboratory
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Lymphoblasts can be distinguished microscopically from
262:(8th ed.). Philadelphia: Saunders. p. 602.
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List of human cell types derived from the germ layers
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183:"Lymphoblasts - National Library of Medicine"
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212:. Elsevier Australia. pp. 106–.
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521:Mucosal associated invariant T cell
206:Gillian Rozenberg (23 March 2011).
673:. You can help Knowledge (XXG) by
77:The size is between 10 and 20 μm.
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171:, 9th edition, Chapter 1, page 23
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557:Lymphokine-activated killer cell
124:
1:
602:Type 3 innate lymphoid cells
590:Type 2 innate lymphoid cells
585:Type 1 innate lymphoid cells
572:Uterine natural killer cells
552:Cytokine-induced killer cell
143:Acute lymphoblastic leukemia
72:acute lymphoblastic leukemia
107:for the presence of unique
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109:cluster of differentiation
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91:by having less distinct
629:Hematopoietic stem cell
388:Lymphoplasmacytoid cell
169:Janeway's Immunobiology
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535:Innate lymphoid cells
511:Natural killer T cell
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725:Colony forming units
101:cytoplasmic granules
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42:is a modified naive
503:Innate-like T cells
383:Transitional B cell
245:2006-02-11 at the
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118:Additional images
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53:cytotoxic T cells
16:(Redirected from
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223:. Retrieved
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190:. Retrieved
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49:plasma cells
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18:Lymphoblasts
720:Blood cells
634:Lymphoblast
332:Plasmablast
311:Lymphocytes
89:myeloblasts
68:lymphocytes
40:lymphoblast
34:Lymphoblast
714:Categories
448:Regulatory
421:Helper CD4
347:Follicular
192:2015-11-17
156:References
82:leukocytes
44:lymphocyte
607:LTi cells
562:Null cell
410:Thymocyte
112:receptors
97:chromatin
27:Cell type
667:oncology
595:Nuocytes
544:NK cells
376:B10 cell
243:Archived
137:See also
93:nucleoli
398:T cells
327:B1 cell
319:B cells
342:Memory
337:Plasma
266:
225:29 May
216:
55:, and
665:This
454:Naïve
362:Pre-B
357:Naïve
671:stub
414:αβ (
371:cell
264:ISBN
227:2011
214:ISBN
369:reg
716::
516:γδ
490:VM
482:RM
474:EM
466:CM
446:/
444:17
438:/
430:/
427:FH
423:/
185:.
114:.
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38:A
702:e
695:t
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677:.
488:T
480:T
472:T
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442:h
440:T
436:3
434:h
432:T
425:T
367:B
303:e
296:t
289:v
272:.
229:.
195:.
20:)
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
