258:. Simply put, genes are read in groups of three letters, but you need to let the ribosome know where to start. For example, if you read "Our dog can see the cat", it makes sense, but if you shift the starting point by one letter, it becomes "urd ogc ans eet hec ato". The SD sequence tells the bacteria where to start protein synthesis so that the genes are read correctly.
222:
In 1968 Dalgarno accepted a post at ANU as a Senior
Lecturer, and then as a Reader from 1983 until 1996, when he subsequently became a Research Fellow. His graduate student John Shine said Dalgarno was "a fantastic, enthusiastic lecturer, who was turned on by this molecular biology."
266:
Especially noteworthy was the work of Lynn
Dalgarno and his PhD student John Shine. Their pioneering work on the nature of initiating signals for protein synthesis in prokaryotic cells was published in
1285:
1104:"Personal Recollections of Fyfe Bygrave, The Department of Biochemistry 1967-2000 - Now the Division of Biochemistry And Molecular Biology, Faculty of Science, the Australian National University"
466:
Dalgarno, L.; Gros, F. (18 March 1968). "RNA synthesis in "relaxed" and "stringent" Escherichia coli. Breakdown of performed ribonucleoprotein particles and subsequent RNA synthesis".
553:
Dalgarno, L.; Martin, E.M.; Liu, S.-L.; Work, T.S. (January 1966). "Characterization of the products formed by the RNA polymerases of cells infected with encephalomyocarditis virus".
277:
of prokaryotes is involved in a direct, base-pairing interaction with a purine-rich section (known as the Shine-Dalgarno sequence) of the ribosome binding site of messenger RNA.
207:
supported by a
University of Melbourne Traveling Scholarship to London (with Edward M. Martin, collaborating with E. Horton, S. L. Liu, T. S. Work, and R. A. Cox); second, with
613:"Development of Ribonucleic Acid Polymerase in Cells Infected with Encephalomyocarditis Virus and the Synthesis of Single- and Double-Stranded RNA by the Isolated Polymerase"
1224:
1114:
524:
Dalgarno, L.; Cox, R.A.; Martin, E.M. (18 April 1967). "Polyribosomes in normal Krebs 2 ascites tumor cells and in cells infected with encephalomyocarditis virus".
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212:
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and received much international acclaim. More specifically they proposed that the pyrimidine-rich 3'- terminal ten nucleotides of the small
216:
164:
156:
The son of
Frederick Leslie Roy Dalgarno and Nadine Ilma (née Rankin) Dalgarno, Lynn Dalgarno was born at Berklea Private Hospital,
234:
In 1973, Lynn
Dalgarno, from the ANU Department of Biochemistry, and his PhD student John Shine, proposed an initiating signal for
582:
Dalgarno, L; Martin, E.M (July 1965). "Studies on EMC viral RNA synthesis and its localization in infected krebs ascites cells".
1260:
1196:
1048:
215:
on an MRC-CNRS Exchange
Scholarship; and third, a postdoctoral fellowship assisted by a U.S. Public Health Research Grant at
176:
66:
1103:
495:
Dalgarno, L.; Gros, F. (March 1968). "Completion of ribosomal particles in E. coli during inhibition of protein synthesis".
1140:
1044:
Transforming
Biology: A History of the Department of Biochemistry and Molecular Biology at the University of Melbourne
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834:
779:
724:
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184:
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125:
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became known as the Shine-Dalgarno (SD) sequence. It enables initiation of protein synthesis by aligning the
1229:
227:
172:
141:
93:
76:
1275:
243:
956:"Increase in the process of accumulation of amino acids in carrot slices with prolonged aerobic washing"
1255:
624:
303:
157:
47:
1166:
674:"Free fatty acids in carrot-tissue preparations and their effect on isolated carrot mitochondria"
656:
417:"Process of infection with bacteriophage phiX174. XXIV. New type of temperature-sensitive mutant"
327:
294:
Shine, John; Dalgarno, Lynn (1975). "Determinant of cistron specificity in bacterial ribosomes".
1197:"The Shine-Dalgarno sequence - the beginnings of biotechnology | ANU Research School of Biology"
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993:
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533:
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352:
311:
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208:
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120:
729:"The activities of some particulate and non-particulate oxidative enzymes in carrot tissue"
628:
307:
988:
955:
871:
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816:
783:
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728:
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673:
357:
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199:
In his early career (between 1963 and 1967) Dalgarno conducted research, first at the
1249:
595:
537:
508:
274:
611:
Horton, E.; Liu, S.-L.; Dalgarno, L.; Martin, E. M.; Work, T. S. (17 October 1964).
660:
331:
140:(born 12 November 1935) is an Australian geneticist known for the discovery of the
1042:
432:
375:
255:
928:
145:
1022:
979:
902:
862:
807:
752:
697:
644:
479:
440:
399:
376:"Conserved Terminal Sequence in 18S rRNA May Represent Terminator Anticodons"
839:"Aspects of malate metabolism by slices and mitochondria from carrot tissue"
997:
880:
825:
784:"Preparation and properties of a mitochondrial fraction from carrot tissue"
770:
715:
652:
603:
391:
1080:
1012:
612:
574:
545:
516:
487:
458:
407:
108:
526:
Biochimica et
Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
497:
Biochimica et
Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis
366:
323:
251:
971:
854:
799:
744:
689:
636:
315:
102:
1014:
Respiratory metabolism and processes of uptake in a plant tissue
181:
Respiratory metabolism and processes of uptake in a plant tissue
109:
Respiratory metabolism and processes of uptake in a plant tissue
247:
230:, described by ANU as "the beginnings of biotechnology":
341:"Terminal-Sequence Analysis of Bacterial Ribosomal RNA"
1286:
Academic staff of the
Australian National University
171:
at the Departments of Biochemistry and Agriculture,
119:
101:
89:
72:
62:
54:
30:
23:
415:Dalgarno, L.; Sinsheimer, R. L. (August 1968).
339:Shine, John; Dalgarno, Lynne (September 1975).
264:
232:
1073:"CNRS / Institut de Biologie Physico-Chimique"
954:Dalgarno, L.; Hird, F. J. R. (1 August 1960).
8:
374:Dalgarno, L.; Shine, J. (31 October 1973).
189:The Russell Grimwade School of Biochemistry
1141:"'Father of cloning' gets $ 300,000 prize"
20:
987:
870:
815:
760:
705:
448:
356:
1167:"Genetech pioneer awarded science prize"
929:"Four Year Old Traveller on Flying Boat"
894:
205:National Institute for Medical Research
1266:Australian National University alumni
1191:
1189:
1187:
213:Institut de Biologie Physico-Chimique
7:
1036:
1034:
1032:
262:One of Dalgarno's colleague wrote,
179:(ANU), with a dissertation titled,
1281:20th-century Australian biologists
1120:from the original on 23 March 2022
903:"Family Notices, Births: Dalgarno"
358:10.1111/j.1432-1033.1975.tb02294.x
217:California Institute of Technology
167:in 1958, conducting research with
14:
1139:Ja, Crystal (17 November 2010).
345:European Journal of Biochemistry
175:, and a Ph.D. in 1962, from the
1165:Holm, Carl (17 November 2010).
1049:Melbourne University Publishing
1041:Flesch, Juliet (1 April 2015).
1271:University of Melbourne alumni
177:Australian National University
97:Australian National University
67:Australian National University
1:
567:10.1016/S0022-2836(66)80210-3
468:Biochimica et Biophysica Acta
226:Dalgarno and Shine found the
219:, with Robert L. Sinsheimer.
596:10.1016/0042-6822(65)90008-5
555:Journal of Molecular Biology
538:10.1016/0005-2787(67)90492-3
509:10.1016/0005-2787(68)90263-3
433:10.1128/JVI.2.8.822-829.1968
1242:reviewed by Lynn Dalgarno).
191:, University of Melbourne.
144:with his graduate student,
1302:
935:. 14 March 1940. p. 6
1225:Interview with John Shine
1145:The Sydney Morning Herald
183:, with research advisor,
131:
82:
201:Medical Research Council
152:Early life and education
1011:Dalgarno, Lynn (1962).
788:The Biochemical Journal
246:in bacterial messenger
228:Shine-Dalgarno sequence
173:University of Melbourne
163:Dalgarno was awarded a
142:Shine-Dalgarno sequence
94:University of Melbourne
77:Shine-Dalgarno Sequence
1261:Australian geneticists
392:10.1038/newbio245261a0
285:
260:
244:ribosomal binding site
1102:Bygrave, Fye (2000).
288:Selected publications
160:on 13 November 1935.
16:Australian geneticist
1051:. pp. 130–133.
1230:"DNA — a three-man
960:Biochemical Journal
843:Biochemical Journal
733:Biochemical Journal
678:Biochemical Journal
629:1964Natur.204..247H
421:Journal of Virology
308:1975Natur.254...34S
158:Caulfield, Victoria
48:Caulfield, Victoria
1201:biology.anu.edu.au
909:. 16 November 1935
727:(1 January 1963).
380:Nature New Biology
1058:978-0-522-86771-8
972:10.1042/bj0760209
855:10.1042/bj0830202
800:10.1042/bj0830195
745:10.1042/bj0860046
690:10.1042/bj0870586
623:(4955): 247–250.
240:prokaryotic cells
236:protein synthesis
135:
134:
84:Scientific career
1293:
1239:The Double Helix
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1211:
1209:
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1129:
1127:
1125:
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1108:
1099:
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1088:
1083:on 27 March 2020
1079:. Archived from
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1038:
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991:
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837:(1 April 1962).
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709:
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637:10.1038/204247a0
607:
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386:(148): 261–262.
370:
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316:10.1038/254034a0
283:
121:Doctoral advisor
115:
44:
41:12 November 1935
40:
38:
21:
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1219:Further reading
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777:
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672:(1 June 1963).
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581:
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523:
494:
465:
414:
373:
338:
302:(5495): 34–38.
293:
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113:
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63:Alma mater
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45:
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36:
34:
26:
17:
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5:
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1183:
1171:www.abc.net.au
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1131:
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966:(2): 209–215.
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893:
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885:
849:(1): 202–211.
830:
794:(1): 195–202.
782:(April 1962).
778:Dalgarno, L.;
775:
720:
684:(3): 586–596.
665:
608:
590:(3): 450–465.
579:
550:
532:(2): 316–328.
521:
492:
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427:(8): 822–829.
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351:(1): 221–230.
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73:Known for
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275:ribosomal RNA
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209:François Gros
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169:F. J. R. Hird
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138:Lynn Dalgarno
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43:(age 88)
33:
29:
25:Lynn Dalgarno
22:
19:
1237:
1231:
1204:. Retrieved
1200:
1174:. Retrieved
1170:
1160:
1148:. Retrieved
1144:
1134:
1122:. Retrieved
1110:
1097:
1085:. Retrieved
1081:the original
1076:
1067:
1043:
1013:
1006:
963:
959:
949:
937:. Retrieved
932:
923:
911:. Retrieved
906:
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846:
842:
791:
787:
739:(1): 46–56.
736:
732:
681:
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620:
616:
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583:
561:(1): 77–91.
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503:(1): 52–63.
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474:(1): 64–75.
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383:
379:
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299:
295:
282:Fyfe Bygrave
268:
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180:
162:
155:
137:
136:
107:
90:Institutions
83:
18:
1256:1935 births
780:Birt, L. M.
256:start codon
165:B.Sc.(Agr.)
55:Nationality
1250:Categories
1111:anu.edu.au
1017:(Thesis).
889:References
185:L. M. Birt
146:John Shine
126:L. M. Birt
58:Australian
37:1935-11-12
1023:221785353
980:0306-3283
933:Telegraph
863:0006-2936
808:0264-6021
753:0006-2936
698:0006-2936
645:0028-0836
480:0006-3002
441:0022-538X
400:0090-0028
254:with the
1115:Archived
1077:istc.int
998:13813809
881:16748947
835:Birt, Lm
826:16748945
771:14024732
725:Birt, Lm
716:14024731
670:Birt, Lm
653:14212417
604:14319717
584:Virology
280:—
252:ribosome
989:1204694
872:1243528
817:1243527
762:1201709
707:1202005
661:4221643
625:Bibcode
575:4287898
546:4292778
517:4868250
488:4868547
459:4883013
408:4202225
332:4162567
304:Bibcode
242:. This
211:at the
1206:4 June
1176:4 June
1150:4 June
1124:4 June
1087:4 June
1055:
1021:
996:
986:
978:
939:6 June
913:6 June
879:
869:
861:
824:
814:
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617:Nature
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450:375696
447:
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406:
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367:809282
365:
330:
324:803646
322:
296:Nature
270:Nature
195:Career
114:(1962)
112:
103:Thesis
1232:scoop
1118:(PDF)
1107:(PDF)
907:Argus
657:S2CID
328:S2CID
1208:2022
1178:2022
1152:2022
1126:2022
1089:2022
1053:ISBN
1019:OCLC
994:PMID
976:ISSN
941:2023
915:2023
877:PMID
859:ISSN
822:PMID
804:ISSN
767:PMID
749:ISSN
712:PMID
694:ISSN
649:PMID
641:ISSN
600:PMID
571:PMID
542:PMID
513:PMID
484:PMID
476:ISSN
455:PMID
437:ISSN
404:PMID
396:ISSN
363:PMID
320:PMID
31:Born
984:PMC
968:doi
867:PMC
851:doi
812:PMC
796:doi
757:PMC
741:doi
702:PMC
686:doi
633:doi
621:204
592:doi
563:doi
534:doi
530:138
505:doi
501:157
472:157
445:PMC
429:doi
388:doi
384:245
353:doi
312:doi
300:254
248:RNA
238:in
203:'s
187:at
1252::
1199:.
1186:^
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1031:^
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35:(
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