507:
484:
1352:
381:
406:
3300:
3285:
513:
412:
4386:
230:
2334:
Corey EJ, Cheng CH, Baker CH, Matsuda SP, Li D, Song X (February 1997). "Methodology for the
Preparation of Pure Recombinant S. cerevisiae Lanosterol Synthase Using a Baculovirus Expression System. Evidence That Oxirane Cleavage and A-Ring Formation Are Concerted in the Biosynthesis of Lanosterol
2862:
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T,
2235:
Corey EJ, Cheng CH, Baker CH, Matsuda SP, Li D, Song X (February 1997). "Studies on the
Substrate Binding Segments and Catalytic Action of Lanosterol Synthase. Affinity Labeling with Carbocations Derived from Mechanism-Based Analogs of 2, 3-Oxidosqualene and Site-Directed Mutagenesis Probes".
3043:
Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution".
256:
2978:
Peffley DM, Gayen AK, Morand OH (Aug 1998). "Down-regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA levels and synthesis in syrian hamster C100 cells by the oxidosqualene cyclase inhibitor -(4-bromophenyl)-me thanone (Ro 48-8071): comparison to simvastatin".
2510:"A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content"
1468:). Isolation of monocyclic and bicyclic products from lanosterol synthase mutants has further weakened the hypothesis of a concerted mechanism. Evidence suggests that epoxide ring opening and A ring formation is concerted, though.
2263:
Wu TK, Wang TT, Chang CH, Liu YT, Shie WS (Nov 2008). "Importance of
Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase tyrosine 707 residue for chair-boat bicyclic ring formation and deprotonation reactions".
3340:
2397:
Corey EJ, Gross SK (Aug 1967). "Formation of sterols by the action of 2,3-oxidosqualene-sterol cyclase on the factitious substrates 2,3:22,23-dioxidosqualene and 2,3-oxido-22,23-dihydrosqualene".
2184:
Thoma R, Schulz-Gasch T, D'Arcy B, Benz J, Aebi J, Dehmlow H, Hennig M, Stihle M, Ruf A (Nov 2004). "Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase".
3089:
Pyrah IT, Kalinowski A, Jackson D, Davies W, Davis S, Aldridge A, Greaves P (2001). "Toxicologic lesions associated with two related inhibitors of oxidosqualene cyclase in the dog and mouse".
3333:
1436:
of the enzyme, the role of D455 as a proton donor to the substrate's epoxide was confirmed, though it was found that D455 is more likely stabilized by hydrogen bonding from two
3161:
Ruf A, Müller F, D'Arcy B, Stihle M, Kusznir E, Handschin C, Morand OH, Thoma R (Mar 2004). "The monotopic membrane protein human oxidosqualene cyclase is active as monomer".
2094:
Ruf A, Müller F, D'Arcy B, Stihle M, Kusznir E, Handschin C, Morand OH, Thoma R (Mar 2004). "The monotopic membrane protein human oxidosqualene cyclase is active as monomer".
3326:
1750:
constructed from the amino acid sequences of OSCs in diverse organisms suggest a single common ancestor, and that the synthesis pathway evolved only once. The discovery of
2299:
Joubert BM, Hua L, Matsuda SP (Feb 2000). "Steric bulk at position 454 in
Saccharomyces cerevisiae lanosterol synthase influences B-ring formation but not deprotonation".
2745:
2753:
Ma J, Dempsey AA, Stamatiou D, Marshall KW, Liew CC (Mar 2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects".
520:
419:
184:
203:
2473:
Boutaud O, Dolis D, Schuber F (Oct 1992). "Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase".
2784:"Selective up-regulation of LXR-regulated genes ABCA1, ABCG1, and APOE in macrophages through increased endogenous synthesis of 24(S),25-epoxycholesterol"
1448:
Epoxide protonation activates the substrate, setting off a cascade of ring forming reactions. Four rings in total (A through D) are formed, producing the
3710:
3705:
962:
342:
943:
3536:
1742:(OSCs, the class to which lanosterol cyclase belongs) evolved from bacterial squalene-hopene cyclase (SHC), which is involved with the formation of
3482:
2865:"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes"
2011:
Baker CH, Matsuda SP, Liu DR, Corey EJ (Aug 1995). "Molecular cloning of the human gene encoding lanosterol synthase from a liver cDNA library".
3900:
3650:
2819:"Suppression of 2,3-oxidosqualene cyclase by high fat diet contributes to liver X receptor-alpha-mediated improvement of hepatic lipid profile"
4411:
4406:
3264:
1846:
1828:
3419:
1523:. Residues of these fingerprint regions contain stacked sidechains which are thought to contribute to enzyme stability during the highly
3318:
3299:
3284:
1706:
cholesterol by a dual control mechanism. Studies in which lanosterol synthase is partially inhibited have shown both a direct decrease in
506:
253:
3838:
3794:
3697:
3477:
3786:
3722:
1190:
2551:"Regulation of sterol biosynthesis and of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in cultured cells by progesterone"
1197:
483:
4105:
3947:
196:
3594:
3424:
1815:
1794:
3575:
1452:
backbone. Though the idea of a concerted formation of all four rings had been entertained in the past, kinetic studies with
405:
380:
147:
123:
4261:
1811:
3910:
3617:
3565:
3498:
1790:
4376:
3010:"Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations"
2941:
Young M, Chen H, Lalioti MD, Antonarakis SE (May 1996). "The human lanosterol synthase gene maps to chromosome 21q22.3".
2046:
Young M, Chen H, Lalioti MD, Antonarakis SE (May 1996). "The human lanosterol synthase gene maps to chromosome 21q22.3".
322:
2706:
Roessler E, Mittaz L, Du Y, Scott HS, Chang J, Rossier C, Guipponi M, Matsuda SP, Muenke M, Antonarakis SE (Nov 1999).
2134:"Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis"
1476:
Lanosterol synthase is a two-domain monomeric protein composed of two connected (α/α) barrel domains and three smaller
3905:
3459:
3192:"Effects of a novel 2,3-oxidosqualene cyclase inhibitor on the regulation of cholesterol biosynthesis in HepG2 cells"
1911:
1358:
Lanosterol synthase mechanism. The discrete carbocation intermediates show the non-concerted nature of the mechanism.
4038:
4011:
2649:
Brocks JJ, Logan GA, Buick R, Summons RE (Aug 1999). "Archean molecular fossils and the early rise of eukaryotes".
1302:
519:
418:
4246:
4362:
4349:
4336:
4323:
4310:
4297:
4284:
4048:
3997:
3987:
3973:
3570:
3257:
2508:
Telford DE, Lipson SM, Barrett PH, Sutherland BG, Edwards JY, Aebi JD, Dehmlow H, Morand OH, Huff MW (Dec 2005).
1401:
1367:
4256:
512:
411:
141:
4210:
4153:
4072:
3964:
3472:
3236:
1627:
1606:
1253:
1011:
330:
34:
2708:"Structure of the human Lanosterol synthase gene and its analysis as a candidate for holoprosencephaly (HPE1)"
1683:
may negatively influence amounts of intermediates required for other biosynthetic pathways (e.g. synthesis of
313:, OSC, CTRCT44, lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase), lanosterol synthase, HYPT14, APMR4
128:
4158:
4006:
3982:
1664:
1520:
1433:
1421:
1397:
992:
988:
3541:
2666:
208:
4179:
4098:
4057:
3940:
3503:
2739:
1739:
1589:
1501:
1310:
394:
116:
4251:
3675:
3556:
3250:
3053:
2658:
2603:
2193:
1965:
1489:
51:
3008:
Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren WM, Wijmenga C, Feskens EJ, Boer JM (Dec 2008).
2671:
1726:
during partial lanosterol synthase inhibition, is believed to be responsible for this inhibition of
309:
4215:
2592:"Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus"
1655:
Interest has grown in lanosterol synthase inhibitors as drugs to lower blood cholesterol and treat
1148:
1144:
1140:
1089:
1085:
1081:
144:
46:
68:
4416:
4148:
4021:
4016:
3861:
3377:
3369:
3114:
3077:
2966:
2217:
2071:
1747:
1524:
1404:
was used to determine residues key to the enzyme's catalytic activity. It was determined that an
1363:
354:
3747:
1173:
1152:
1114:
1093:
3232:
3872:
3802:
3467:
3448:
3213:
3178:
3149:
3106:
3069:
3031:
2996:
2958:
2929:
2894:
2850:
2805:
2770:
2727:
2684:
2631:
2572:
2531:
2490:
2455:
2414:
2379:
2316:
2281:
2209:
2155:
2111:
2063:
2028:
1993:
1931:
1887:
1727:
1711:
1692:
1672:
1668:
1573:
1541:
1453:
1371:
1268:
302:
246:
135:
1912:"Lord of the rings--the mechanism for oxidosqualene:lanosterol cyclase becomes crystal clear"
4194:
4189:
4163:
4091:
3933:
3880:
3400:
3353:
3203:
3170:
3139:
3098:
3061:
3021:
2988:
2950:
2919:
2884:
2876:
2840:
2830:
2795:
2762:
2719:
2676:
2621:
2611:
2562:
2521:
2482:
2445:
2406:
2371:
2344:
2308:
2273:
2245:
2201:
2145:
2103:
2055:
2020:
1983:
1973:
1923:
1877:
1634:)-2,3-epoxysqualene, under partial inhibition conversion of 2,3;22,23-diepoxysqualene to 24(
1429:
1336:
599:
530:
474:
429:
2362:
Wendt KU, Poralla K, Schulz GE (Sep 1997). "Structure and function of a squalene cyclase".
104:
4241:
4225:
4138:
4067:
3632:
2766:
1691:). Thus, lanosterol synthase, which is more closely tied to cholesterol biosynthesis than
1656:
1604:
have been found to express lanosterol synthase; it has been found as a soluble protein in
1569:
1351:
574:
350:
80:
3057:
2662:
2607:
2197:
1969:
1428:, with H146 possibly intensifying the proton donor ability of the aspartic acid through
1256:
39:
4390:
4279:
4220:
3742:
3661:
3440:
2889:
2864:
2845:
2818:
2526:
2509:
1759:
1318:
179:
3208:
3191:
2992:
2782:
Beyea MM, Heslop CL, Sawyez CG, Edwards JY, Markle JG, Hegele RA, Huff MW (Feb 2007).
2626:
2591:
2567:
2550:
2450:
2433:
1988:
1953:
1882:
1618:
Lanosterol synthase also catalyzes the cyclization of 2,3;22,23-diepoxysqualene to 24(
1484:
is in the center of the protein, closed off by a constricted channel. Passage of the (
877:
872:
867:
862:
857:
852:
836:
831:
826:
821:
805:
800:
795:
790:
159:
4400:
4184:
4143:
2486:
1405:
777:
154:
3118:
3081:
2970:
2075:
1671:
activity. Because this enzyme catalyzes the formation of precursors far upstream of
334:
4133:
3642:
1577:
592:
371:
2680:
2375:
2221:
1865:
358:
4357:
4292:
4128:
3758:
3670:
3585:
3518:
3429:
3411:
3361:
1851:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1833:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1684:
1601:
1593:
1565:
1553:
1497:
1481:
1477:
1461:
1449:
1425:
1391:
1332:
1325:
1284:
163:
4385:
3174:
3102:
3026:
3009:
2596:
Proceedings of the
National Academy of Sciences of the United States of America
2107:
1958:
Proceedings of the
National Academy of Sciences of the United States of America
1927:
1770:
with OSCs and complex steroid machinery were present early in earth's history.
675:
3925:
3528:
3349:
1767:
1755:
1723:
1707:
1688:
1639:
1597:
1581:
1549:
1516:
1493:
1379:
1298:
1280:
1276:
491:
388:
338:
2132:
Lamb DC, Jackson CJ, Warrilow AG, Manning NJ, Kelly DE, Kelly SL (Aug 2007).
4331:
4305:
3956:
3866:
3833:
3687:
3609:
3128:"Normalization and subtraction: two approaches to facilitate gene discovery"
3065:
2616:
2150:
2133:
1791:
ENSG00000281289 GRCh38: Ensembl release 89: ENSG00000160285, ENSG00000281289
1763:
1743:
1715:
1585:
1512:
1409:
1306:
907:
735:
613:
558:
545:
457:
444:
346:
3182:
3110:
3073:
3035:
2898:
2854:
2835:
2809:
2800:
2783:
2774:
2731:
2688:
2635:
2535:
2320:
2285:
2213:
2159:
2115:
2024:
1935:
3217:
3153:
3000:
2962:
2933:
2723:
2576:
2494:
2459:
2418:
2383:
2067:
2032:
1997:
1978:
1891:
1237:
1232:
229:
3825:
3768:
3683:
3395:
1561:
1557:
1437:
1221:
1056:
1037:
2924:
2907:
2434:"Biosynthesis of 24,25-epoxycholesterol from squalene 2,3;22,23-dioxide"
2410:
2205:
1519:
motifs, which are also present in the highly analogous bacterial enzyme
1416:
hypothesized that the aspartic acid acts by protonating the substrate's
92:
3891:
3886:
3781:
3776:
3692:
3622:
3387:
3365:
3144:
3127:
2954:
2880:
2059:
1751:
1680:
1488:)-2,3-epoxysqualene substrate through the channel requires a change in
1417:
1340:
1321:
1260:
1023:
974:
111:
2348:
2312:
2277:
2249:
279:
275:
4344:
4114:
3960:
3812:
3807:
3735:
3730:
3357:
1660:
1375:
1314:
1264:
1205:
929:
191:
87:
75:
63:
2707:
1954:"Some properties of the microsomal 2,3-oxidosqualene sterol cyclase"
1642:
synthesis. This has relevance for disease prevention and treatment.
1440:
residues (C456 and C533) than from the earlier suggested histidine.
1460:
analogs showed that product formation is achieved through discrete
4318:
1362:
Though some data on the mechanism has been obtained by the use of
1350:
1626:),25-epoxycholesterol. Since the enzyme affinity for this second
892:
888:
4031:
4026:
2817:
Dang H, Liu Y, Pang W, Li C, Wang N, Shyy JY, Zhu Y (Mar 2009).
1703:
1339:
as potential cholesterol-reducing drugs, to complement existing
1291:
326:
99:
4087:
3929:
3322:
3246:
2549:
Panini SR, Gupta A, Sexton RC, Parish EJ, Rudney H (Oct 1987).
1864:
Dean PD, Ortiz de
Montellano PR, Bloch K, Corey EJ (Jun 1967).
1287:
biosynthesis. In humans, lanosterol synthase is encoded by the
3242:
2908:"Molecular cloning of cDNA encoding human lanosterol synthase"
1699:
2863:
Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006).
1412:
residues (H146 and H234) were essential to enzyme function.
4083:
1722:),25-epoxylanosterol, which is preferentially formed over
1556:
biosynthesis. Thus, it in turn provides the precursor to
1511:
The enzyme contains five fingerprint regions containing
582:
1335:
biosynthesis, there is interest in lanosterol synthase
4374:
2906:
Sung CK, Shibuya M, Sankawa U, Ebizuka Y (Oct 1995).
1622:),25-epoxylanosterol, which is later converted to 24(
1500:
surface (6% of the total enzyme surface area) is the
747:
3840:
3796:
3788:
3724:
3699:
1698:
Lanosterol synthase inhibitors are thought to lower
4270:
4234:
4203:
4172:
4121:
4047:
3996:
3972:
3854:
3823:
3766:
3756:
3659:
3640:
3631:
3607:
3584:
3555:
3526:
3516:
3491:
3457:
3438:
3410:
3385:
3376:
3308:: STRUCTURE OF HUMAN OSC IN COMPLEX WITH LANOSTEROL
3293:: STRUCTURE OF HUMAN OSC IN COMPLEX WITH RO 48-8071
3163:
2475:
Biochemical and Biophysical Research Communications
2096:
Biochemical and Biophysical Research Communications
2013:
Biochemical and Biophysical Research Communications
1166:
1133:
1107:
1074:
202:
190:
178:
173:
153:
134:
122:
110:
98:
86:
74:
62:
57:
45:
33:
28:
23:
2514:Arteriosclerosis, Thrombosis, and Vascular Biology
1807:
1805:
1803:
1786:
1784:
1782:
529:
428:
3190:Mark M, Muller P, Maier R, Eisele B (Jan 1996).
2432:Nelson JA, Steckbeck SR, Spencer TA (Feb 1981).
1540:Lanosterol synthase catalyzes the conversion of
1651:Enzyme inhibitors as cholesterol-lowering drugs
1527:cyclization reactions catalyzed by the enzyme.
1812:GRCm38: Ensembl release 89: ENSMUSG00000033105
873:regulation of cholesterol biosynthetic process
4099:
3941:
3334:
3258:
2744:: CS1 maint: DOI inactive as of April 2024 (
8:
3126:Bonaldo MF, Lennon G, Soares MB (Sep 1996).
1866:"A soluble 2,3-oxidosqualene sterol cyclase"
1420:ring, thus increasing its susceptibility to
1386:Initial epoxide protonation and ring opening
2127:
2125:
1374:, it is still not fully understood how the
4106:
4092:
4084:
3948:
3934:
3926:
3763:
3637:
3523:
3382:
3341:
3327:
3319:
3265:
3251:
3243:
2590:Pearson A, Budin M, Brocks JJ (Dec 2003).
1947:
1945:
903:
773:
714:transitional epithelium of urinary bladder
570:
469:
366:
264:
170:
3235:at the U.S. National Library of Medicine
3207:
3143:
3025:
2923:
2888:
2844:
2834:
2799:
2670:
2625:
2615:
2566:
2525:
2449:
2149:
1987:
1977:
1881:
1665:LDL (low-density lipoprotein) cholesterol
3537:Farnesyl-diphosphate farnesyltransferase
2912:Biological & Pharmaceutical Bulletin
2399:Journal of the American Chemical Society
2179:
2177:
2175:
2173:
2171:
2169:
1396:Before the acquisition of the protein's
4381:
3483:Isopentenyl-diphosphate delta isomerase
3280:
2089:
2087:
2085:
1952:Yamamoto S, Lin K, Bloch K (May 1969).
1778:
1275:to a protosterol cation and finally to
16:Mammalian protein found in Homo sapiens
3901:Steroidogenic acute regulatory protein
2737:
1614:Catalysis of epoxylanosterol formation
219:
20:
2767:10.1016/j.atherosclerosis.2006.05.032
1905:
1903:
1901:
1638:),25-epoxylanosterol is favored over
1283:is a key four-ringed intermediate in
534:
495:
490:
433:
392:
387:
7:
1758:in 2.7-billion year-old shales from
1596:synthesis is mostly associated with
1552:, a key four-ringed intermediate in
3478:Pyrophosphomevalonate decarboxylase
3396:Acetyl-Coenzyme A acetyltransferase
2823:The Journal of Biological Chemistry
2788:The Journal of Biological Chemistry
2555:The Journal of Biological Chemistry
2438:The Journal of Biological Chemistry
1870:The Journal of Biological Chemistry
1630:is greater than for the monoepoxy (
796:intramolecular transferase activity
2527:10.1161/01.ATV.0000189158.28455.94
1916:Trends in Pharmacological Sciences
1313:. Some evidence suggests that the
1163:
1130:
1104:
1071:
1047:
1028:
1002:
979:
953:
934:
752:
670:
608:
587:
14:
1536:Catalysis of lanosterol formation
878:triterpenoid biosynthetic process
4384:
3298:
3283:
1910:Huff MW, Telford DE (Jul 2005).
1695:, is an attractive drug target.
868:cholesterol biosynthetic process
518:
511:
505:
482:
417:
410:
404:
379:
228:
3651:Cholesterol side-chain cleavage
3595:24-Dehydrocholesterol reductase
3425:3-hydroxybutyrate dehydrogenase
2138:Molecular Biology and Evolution
853:regulation of protein stability
3576:7-Dehydrocholesterol reductase
1663:drugs currently used to lower
827:endoplasmic reticulum membrane
736:More reference expression data
652:right hemisphere of cerebellum
1:
3911:Reverse cholesterol transport
3499:Dimethylallyltranstransferase
3209:10.1016/S0022-2275(20)37643-4
2993:10.1016/S0006-2952(98)00083-5
2681:10.1126/science.285.5430.1033
2568:10.1016/S0021-9258(18)47813-1
2451:10.1016/S0021-9258(19)69921-7
2376:10.1126/science.277.5333.1811
1883:10.1016/S0021-9258(18)99606-7
1504:membrane-binding region (see
806:beta-amyrin synthase activity
690:epithelium of small intestine
503:
402:
4412:Steroid hormone biosynthesis
4407:Genes on human chromosome 21
2487:10.1016/0006-291X(92)91140-L
1710:formation and a decrease in
1331:Due to the enzyme's role in
1301:, lanosterol synthase is an
863:steroid biosynthetic process
801:lanosterol synthase activity
3906:Cholesterol total synthesis
1584:the enzyme is bound to the
1432:. After acquisition of the
1378:catalyzes the formation of
4433:
4039:Phosphoenolpyruvate mutase
4012:Bisphosphoglycerate mutase
3618:Cholesterol 7α-hydroxylase
3566:Lanosterol 14α-demethylase
3175:10.1016/j.bbrc.2004.01.052
3103:10.1080/019262301317052440
3027:10.1194/jlr.M800232-JLR200
2108:10.1016/j.bbrc.2004.01.052
1928:10.1016/j.tips.2005.05.004
1389:
1303:integral monotopic protein
4262:Michaelis–Menten kinetics
3988:Precorrin-8X methylmutase
3571:Sterol-C5-desaturase-like
3278:
3196:Journal of Lipid Research
3014:Journal of Lipid Research
2335:from 2,3-Oxidosqualene".
1847:"Mouse PubMed Reference:"
1829:"Human PubMed Reference:"
1402:site-directed mutagenesis
1236:
1231:
1227:
1220:
1204:
1185:
1170:
1137:
1126:
1111:
1078:
1067:
1054:
1050:
1035:
1031:
1022:
1009:
1005:
986:
982:
973:
960:
956:
941:
937:
928:
913:
906:
902:
886:
776:
772:
760:
755:
746:
733:
682:
673:
620:
611:
581:
573:
569:
552:
539:
502:
481:
472:
468:
451:
438:
401:
378:
369:
365:
320:
317:
307:
300:
295:
272:
267:
250:
245:
240:
236:
227:
222:
169:
4154:Diffusion-limited enzyme
4073:Methylmalonyl-CoA mutase
3473:Phosphomevalonate kinase
3237:Medical Subject Headings
2981:Biochemical Pharmacology
1607:Methylococcus capsulatus
1198:Chr 10: 76.37 – 76.39 Mb
1191:Chr 21: 46.19 – 46.23 Mb
4007:Phosphoglycerate mutase
3983:Lysolecithin acylmutase
3066:10.1126/science.1108625
2726:(inactive 2024-04-03).
2617:10.1073/pnas.2536559100
1667:function by inhibiting
1521:squalene-hopene cyclase
1434:X-ray crystal structure
1408:residue (D455) and two
1398:X-ray crystal structure
3542:Squalene monooxygenase
2836:10.1074/jbc.M803702200
2801:10.1074/jbc.M611063200
2025:10.1006/bbrc.1995.2110
1740:oxidosqualene cyclases
1444:Ring formation cascade
1424:attack by the nearest
1359:
1259:) is an oxidosqualene
4247:Eadie–Hofstee diagram
4180:Allosteric regulation
4058:Cycloartenol synthase
3623:Sterol 27-hydroxylase
3504:Geranyl pyrophosphate
3091:Toxicologic Pathology
2724:10.1007/s004390051135
2151:10.1093/molbev/msm090
1979:10.1073/pnas.63.1.110
1659:. The widely popular
1646:Clinical significance
1590:endoplasmic reticulum
1354:
1311:endoplasmic reticulum
832:endoplasmic reticulum
536:10 C1|10 39.1 cM
497:Chromosome 10 (mouse)
395:Chromosome 21 (human)
4257:Lineweaver–Burk plot
3557:7-Dehydrocholesterol
1738:It is believed that
1490:protein conformation
1305:associated with the
694:skin of external ear
268:List of PDB id codes
241:Available structures
4063:Lanosterol synthase
3547:Lanosterol synthase
3233:Lanosterol+synthase
3058:2005Sci...308.1149C
2925:10.1248/bpb.18.1459
2663:1999Sci...285.1033B
2608:2003PNAS..10015352P
2411:10.1021/ja00993a079
2206:10.1038/nature02993
2198:2004Natur.432..118T
1970:1969PNAS...63..110Y
1677:)-2,3-epoxysqualene
1546:)-2,3-epoxysqualene
1464:intermediates (see
1458:)-2,3-oxidosqualene
1273:)-2,3-oxidosqualene
1250:Lanosterol synthase
24:lanosterol synthase
4216:Enzyme superfamily
4149:Enzyme promiscuity
4022:Phosphomannomutase
4017:Phosphoglucomutase
3862:Steroid metabolism
3378:Mevalonate pathway
3370:steroid metabolism
3145:10.1101/gr.6.9.791
2955:10.1007/BF02281872
2881:10.1101/gr.4039406
2060:10.1007/BF02281872
1748:Phylogenetic trees
1574:mineralocorticoids
1364:suicide inhibitors
1360:
1317:is a soluble, non-
1012:ENSMUSG00000033105
846:Biological process
815:Cellular component
791:isomerase activity
784:Molecular function
4372:
4371:
4081:
4080:
3923:
3922:
3919:
3918:
3873:Steroid sulfatase
3850:
3849:
3603:
3602:
3512:
3511:
3468:Mevalonate kinase
3449:HMG-CoA reductase
3316:
3315:
3052:(5725): 1149–54.
2370:(5333): 1811–15.
2349:10.1021/ja963227w
2313:10.1021/ol9912940
2278:10.1021/ol802036c
2250:10.1021/ja963228o
2192:(7013): 118–122.
1728:HMG-CoA reductase
1712:HMG-CoA reductase
1693:HMG-CoA reductase
1679:and cholesterol,
1669:HMG-CoA reductase
1592:membrane. While
1372:homology modeling
1328:that produce it.
1247:
1246:
1243:
1242:
1216:
1215:
1181:
1180:
1160:
1159:
1122:
1121:
1101:
1100:
1063:
1062:
1044:
1043:
1018:
1017:
999:
998:
969:
968:
950:
949:
898:
897:
768:
767:
764:
763:
742:
741:
729:
728:
667:
666:
565:
564:
464:
463:
291:
290:
287:
286:
251:Ortholog search:
218:
217:
214:
213:
117:metabolic pathway
4424:
4389:
4388:
4380:
4252:Hanes–Woolf plot
4195:Enzyme activator
4190:Enzyme inhibitor
4164:Enzyme catalysis
4108:
4101:
4094:
4085:
3950:
3943:
3936:
3927:
3881:sulfotransferase
3842:
3798:
3790:
3764:
3726:
3701:
3638:
3524:
3403:(regulated step)
3401:HMG-CoA synthase
3383:
3354:lipid metabolism
3343:
3336:
3329:
3320:
3302:
3287:
3267:
3260:
3253:
3244:
3221:
3211:
3186:
3157:
3147:
3122:
3085:
3039:
3029:
3004:
2974:
2937:
2927:
2902:
2892:
2858:
2848:
2838:
2813:
2803:
2778:
2749:
2743:
2735:
2693:
2692:
2674:
2657:(5430): 1033–6.
2646:
2640:
2639:
2629:
2619:
2587:
2581:
2580:
2570:
2561:(30): 14435–40.
2546:
2540:
2539:
2529:
2505:
2499:
2498:
2470:
2464:
2463:
2453:
2429:
2423:
2422:
2394:
2388:
2387:
2359:
2353:
2352:
2337:J. Am. Chem. Soc
2331:
2325:
2324:
2296:
2290:
2289:
2260:
2254:
2253:
2238:J. Am. Chem. Soc
2232:
2226:
2225:
2181:
2164:
2163:
2153:
2144:(8): 1714–1721.
2129:
2120:
2119:
2091:
2080:
2079:
2043:
2037:
2036:
2008:
2002:
2001:
1991:
1981:
1949:
1940:
1939:
1907:
1896:
1895:
1885:
1861:
1855:
1854:
1843:
1837:
1836:
1825:
1819:
1809:
1798:
1788:
1766:, suggests that
1430:hydrogen bonding
1229:
1228:
1200:
1193:
1176:
1164:
1155:
1131:
1127:RefSeq (protein)
1117:
1105:
1096:
1072:
1048:
1029:
1003:
980:
954:
935:
904:
858:lipid metabolism
774:
753:
738:
698:Ileal epithelium
678:
676:Top expressed in
671:
656:ventricular zone
616:
614:Top expressed in
609:
588:
571:
561:
548:
537:
522:
515:
509:
498:
486:
470:
460:
447:
436:
421:
414:
408:
397:
383:
367:
361:
312:
305:
282:
265:
259:
238:
237:
232:
220:
171:
21:
4432:
4431:
4427:
4426:
4425:
4423:
4422:
4421:
4397:
4396:
4395:
4383:
4375:
4373:
4368:
4280:Oxidoreductases
4266:
4242:Enzyme kinetics
4230:
4226:List of enzymes
4199:
4168:
4139:Catalytic triad
4117:
4112:
4082:
4077:
4068:Lupeol synthase
4043:
3992:
3968:
3954:
3924:
3915:
3855:Other/ungrouped
3846:
3819:
3777:17α-Hydroxylase
3752:
3748:11β-Hydroxylase
3693:17α-Hydroxylase
3662:corticosteroids
3655:
3633:Steroidogenesis
3627:
3599:
3580:
3551:
3508:
3487:
3453:
3434:
3406:
3372:
3347:
3317:
3312:
3309:
3303:
3294:
3288:
3274:
3271:
3229:
3224:
3189:
3160:
3132:Genome Research
3125:
3088:
3042:
3007:
2977:
2940:
2918:(10): 1459–61.
2905:
2869:Genome Research
2861:
2829:(10): 6218–26.
2816:
2781:
2755:Atherosclerosis
2752:
2736:
2705:
2701:
2699:Further reading
2696:
2672:10.1.1.516.9123
2648:
2647:
2643:
2602:(26): 15352–7.
2589:
2588:
2584:
2548:
2547:
2543:
2520:(12): 2608–14.
2507:
2506:
2502:
2472:
2471:
2467:
2431:
2430:
2426:
2396:
2395:
2391:
2361:
2360:
2356:
2333:
2332:
2328:
2301:Organic Letters
2298:
2297:
2293:
2272:(21): 4959–62.
2266:Organic Letters
2262:
2261:
2257:
2234:
2233:
2229:
2183:
2182:
2167:
2131:
2130:
2123:
2093:
2092:
2083:
2045:
2044:
2040:
2010:
2009:
2005:
1951:
1950:
1943:
1909:
1908:
1899:
1863:
1862:
1858:
1845:
1844:
1840:
1827:
1826:
1822:
1810:
1801:
1789:
1780:
1776:
1736:
1657:atherosclerosis
1653:
1648:
1616:
1570:glucocorticoids
1538:
1533:
1474:
1446:
1394:
1388:
1349:
1238:View/Edit Mouse
1233:View/Edit Human
1196:
1189:
1186:Location (UCSC)
1172:
1151:
1147:
1143:
1139:
1113:
1092:
1088:
1084:
1080:
993:ENSG00000281289
991:
989:ENSG00000160285
882:
841:
810:
734:
725:
720:
716:
712:
708:
704:
700:
696:
692:
688:
674:
663:
658:
654:
650:
648:pituitary gland
646:
644:corpus callosum
642:
640:skin of abdomen
638:
634:
630:
626:
612:
556:
543:
535:
525:
524:
523:
516:
496:
473:Gene location (
455:
442:
434:
424:
423:
422:
415:
393:
370:Gene location (
359:LSS - orthologs
321:
308:
301:
274:
252:
17:
12:
11:
5:
4430:
4428:
4420:
4419:
4414:
4409:
4399:
4398:
4394:
4393:
4370:
4369:
4367:
4366:
4353:
4340:
4327:
4314:
4301:
4288:
4274:
4272:
4268:
4267:
4265:
4264:
4259:
4254:
4249:
4244:
4238:
4236:
4232:
4231:
4229:
4228:
4223:
4218:
4213:
4207:
4205:
4204:Classification
4201:
4200:
4198:
4197:
4192:
4187:
4182:
4176:
4174:
4170:
4169:
4167:
4166:
4161:
4156:
4151:
4146:
4141:
4136:
4131:
4125:
4123:
4119:
4118:
4113:
4111:
4110:
4103:
4096:
4088:
4079:
4078:
4076:
4075:
4070:
4065:
4060:
4054:
4052:
4045:
4044:
4042:
4041:
4036:
4035:
4034:
4029:
4019:
4014:
4009:
4003:
4001:
4000:Phosphomutases
3994:
3993:
3991:
3990:
3985:
3979:
3977:
3970:
3969:
3955:
3953:
3952:
3945:
3938:
3930:
3921:
3920:
3917:
3916:
3914:
3913:
3908:
3903:
3897:
3896:
3895:
3894:
3889:
3877:
3876:
3875:
3858:
3856:
3852:
3851:
3848:
3847:
3845:
3844:
3836:
3830:
3828:
3821:
3820:
3818:
3817:
3816:
3815:
3810:
3800:
3792:
3784:
3779:
3773:
3771:
3761:
3754:
3753:
3751:
3750:
3745:
3743:21-Hydroxylase
3740:
3739:
3738:
3733:
3716:
3715:
3714:
3713:
3708:
3695:
3679:
3678:
3676:18-Hydroxylase
3666:
3664:
3657:
3656:
3654:
3653:
3647:
3645:
3635:
3629:
3628:
3626:
3625:
3620:
3614:
3612:
3605:
3604:
3601:
3600:
3598:
3597:
3591:
3589:
3582:
3581:
3579:
3578:
3573:
3568:
3562:
3560:
3553:
3552:
3550:
3549:
3544:
3539:
3533:
3531:
3521:
3514:
3513:
3510:
3509:
3507:
3506:
3501:
3495:
3493:
3489:
3488:
3486:
3485:
3480:
3475:
3470:
3464:
3462:
3455:
3454:
3452:
3451:
3445:
3443:
3441:Mevalonic acid
3436:
3435:
3433:
3432:
3427:
3422:
3416:
3414:
3408:
3407:
3405:
3404:
3398:
3392:
3390:
3380:
3374:
3373:
3348:
3346:
3345:
3338:
3331:
3323:
3314:
3313:
3311:
3310:
3304:
3297:
3295:
3289:
3282:
3279:
3276:
3275:
3272:
3270:
3269:
3262:
3255:
3247:
3241:
3240:
3228:
3227:External links
3225:
3223:
3222:
3187:
3158:
3138:(9): 791–806.
3123:
3086:
3040:
3020:(12): 2582–9.
3005:
2975:
2943:Human Genetics
2938:
2903:
2859:
2814:
2794:(8): 5207–16.
2779:
2750:
2712:Human Genetics
2702:
2700:
2697:
2695:
2694:
2641:
2582:
2541:
2500:
2481:(2): 898–904.
2465:
2424:
2405:(17): 4561–2.
2389:
2354:
2343:(6): 1277–88.
2326:
2291:
2255:
2244:(6): 1289–96.
2227:
2165:
2121:
2102:(2): 247–254.
2081:
2054:(5): 620–624.
2048:Human Genetics
2038:
2019:(1): 154–160.
2003:
1941:
1922:(7): 335–340.
1897:
1876:(12): 3014–5.
1856:
1838:
1820:
1799:
1777:
1775:
1772:
1760:Pilbara Craton
1735:
1732:
1714:activity. The
1652:
1649:
1647:
1644:
1615:
1612:
1537:
1534:
1532:
1529:
1473:
1470:
1445:
1442:
1422:intramolecular
1387:
1384:
1348:
1345:
1319:membrane bound
1267:that converts
1245:
1244:
1241:
1240:
1235:
1225:
1224:
1218:
1217:
1214:
1213:
1211:
1209:
1202:
1201:
1194:
1187:
1183:
1182:
1179:
1178:
1168:
1167:
1161:
1158:
1157:
1135:
1134:
1128:
1124:
1123:
1120:
1119:
1109:
1108:
1102:
1099:
1098:
1076:
1075:
1069:
1065:
1064:
1061:
1060:
1052:
1051:
1045:
1042:
1041:
1033:
1032:
1026:
1020:
1019:
1016:
1015:
1007:
1006:
1000:
997:
996:
984:
983:
977:
971:
970:
967:
966:
958:
957:
951:
948:
947:
939:
938:
932:
926:
925:
920:
915:
911:
910:
900:
899:
896:
895:
884:
883:
881:
880:
875:
870:
865:
860:
855:
849:
847:
843:
842:
840:
839:
834:
829:
824:
818:
816:
812:
811:
809:
808:
803:
798:
793:
787:
785:
781:
780:
770:
769:
766:
765:
762:
761:
758:
757:
750:
744:
743:
740:
739:
731:
730:
727:
726:
724:
723:
719:
715:
711:
707:
703:
699:
695:
691:
687:
683:
680:
679:
668:
665:
664:
662:
661:
657:
653:
649:
645:
641:
637:
633:
629:
625:
624:gastric mucosa
621:
618:
617:
605:
604:
596:
585:
579:
578:
575:RNA expression
567:
566:
563:
562:
554:
550:
549:
541:
538:
533:
527:
526:
517:
510:
504:
500:
499:
494:
488:
487:
479:
478:
466:
465:
462:
461:
453:
449:
448:
440:
437:
432:
426:
425:
416:
409:
403:
399:
398:
391:
385:
384:
376:
375:
363:
362:
319:
315:
314:
306:
298:
297:
293:
292:
289:
288:
285:
284:
270:
269:
261:
260:
249:
243:
242:
234:
233:
225:
224:
216:
215:
212:
211:
206:
200:
199:
194:
188:
187:
182:
176:
175:
167:
166:
157:
151:
150:
139:
132:
131:
126:
120:
119:
114:
108:
107:
102:
96:
95:
90:
84:
83:
78:
72:
71:
66:
60:
59:
55:
54:
49:
43:
42:
37:
31:
30:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
4429:
4418:
4415:
4413:
4410:
4408:
4405:
4404:
4402:
4392:
4387:
4382:
4378:
4364:
4360:
4359:
4354:
4351:
4347:
4346:
4341:
4338:
4334:
4333:
4328:
4325:
4321:
4320:
4315:
4312:
4308:
4307:
4302:
4299:
4295:
4294:
4289:
4286:
4282:
4281:
4276:
4275:
4273:
4269:
4263:
4260:
4258:
4255:
4253:
4250:
4248:
4245:
4243:
4240:
4239:
4237:
4233:
4227:
4224:
4222:
4221:Enzyme family
4219:
4217:
4214:
4212:
4209:
4208:
4206:
4202:
4196:
4193:
4191:
4188:
4186:
4185:Cooperativity
4183:
4181:
4178:
4177:
4175:
4171:
4165:
4162:
4160:
4157:
4155:
4152:
4150:
4147:
4145:
4144:Oxyanion hole
4142:
4140:
4137:
4135:
4132:
4130:
4127:
4126:
4124:
4120:
4116:
4109:
4104:
4102:
4097:
4095:
4090:
4089:
4086:
4074:
4071:
4069:
4066:
4064:
4061:
4059:
4056:
4055:
4053:
4050:
4046:
4040:
4037:
4033:
4030:
4028:
4025:
4024:
4023:
4020:
4018:
4015:
4013:
4010:
4008:
4005:
4004:
4002:
3999:
3995:
3989:
3986:
3984:
3981:
3980:
3978:
3975:
3971:
3966:
3962:
3958:
3951:
3946:
3944:
3939:
3937:
3932:
3931:
3928:
3912:
3909:
3907:
3904:
3902:
3899:
3898:
3893:
3890:
3888:
3885:
3884:
3883:
3882:
3878:
3874:
3871:
3870:
3869:
3868:
3863:
3860:
3859:
3857:
3853:
3843:
3837:
3835:
3832:
3831:
3829:
3827:
3822:
3814:
3811:
3809:
3806:
3805:
3804:
3801:
3799:
3793:
3791:
3785:
3783:
3780:
3778:
3775:
3774:
3772:
3770:
3765:
3762:
3760:
3755:
3749:
3746:
3744:
3741:
3737:
3734:
3732:
3729:
3728:
3727:
3721:
3718:
3717:
3712:
3709:
3707:
3704:
3703:
3702:
3696:
3694:
3691:
3689:
3685:
3681:
3680:
3677:
3674:
3672:
3668:
3667:
3665:
3663:
3658:
3652:
3649:
3648:
3646:
3644:
3639:
3636:
3634:
3630:
3624:
3621:
3619:
3616:
3615:
3613:
3611:
3606:
3596:
3593:
3592:
3590:
3587:
3583:
3577:
3574:
3572:
3569:
3567:
3564:
3563:
3561:
3558:
3554:
3548:
3545:
3543:
3540:
3538:
3535:
3534:
3532:
3530:
3525:
3522:
3520:
3515:
3505:
3502:
3500:
3497:
3496:
3494:
3490:
3484:
3481:
3479:
3476:
3474:
3471:
3469:
3466:
3465:
3463:
3461:
3456:
3450:
3447:
3446:
3444:
3442:
3437:
3431:
3428:
3426:
3423:
3421:
3420:HMG-CoA lyase
3418:
3417:
3415:
3413:
3409:
3402:
3399:
3397:
3394:
3393:
3391:
3389:
3384:
3381:
3379:
3375:
3371:
3367:
3363:
3359:
3355:
3351:
3344:
3339:
3337:
3332:
3330:
3325:
3324:
3321:
3307:
3301:
3296:
3292:
3286:
3281:
3277:
3268:
3263:
3261:
3256:
3254:
3249:
3248:
3245:
3238:
3234:
3231:
3230:
3226:
3219:
3215:
3210:
3205:
3202:(1): 148–58.
3201:
3197:
3193:
3188:
3184:
3180:
3176:
3172:
3169:(2): 247–54.
3168:
3164:
3159:
3155:
3151:
3146:
3141:
3137:
3133:
3129:
3124:
3120:
3116:
3112:
3108:
3104:
3100:
3096:
3092:
3087:
3083:
3079:
3075:
3071:
3067:
3063:
3059:
3055:
3051:
3047:
3041:
3037:
3033:
3028:
3023:
3019:
3015:
3011:
3006:
3002:
2998:
2994:
2990:
2987:(4): 439–49.
2986:
2982:
2976:
2972:
2968:
2964:
2960:
2956:
2952:
2948:
2944:
2939:
2935:
2931:
2926:
2921:
2917:
2913:
2909:
2904:
2900:
2896:
2891:
2886:
2882:
2878:
2874:
2870:
2866:
2860:
2856:
2852:
2847:
2842:
2837:
2832:
2828:
2824:
2820:
2815:
2811:
2807:
2802:
2797:
2793:
2789:
2785:
2780:
2776:
2772:
2768:
2764:
2760:
2756:
2751:
2747:
2741:
2733:
2729:
2725:
2721:
2718:(5): 489–95.
2717:
2713:
2709:
2704:
2703:
2698:
2690:
2686:
2682:
2678:
2673:
2668:
2664:
2660:
2656:
2652:
2645:
2642:
2637:
2633:
2628:
2623:
2618:
2613:
2609:
2605:
2601:
2597:
2593:
2586:
2583:
2578:
2574:
2569:
2564:
2560:
2556:
2552:
2545:
2542:
2537:
2533:
2528:
2523:
2519:
2515:
2511:
2504:
2501:
2496:
2492:
2488:
2484:
2480:
2476:
2469:
2466:
2461:
2457:
2452:
2447:
2444:(3): 1067–8.
2443:
2439:
2435:
2428:
2425:
2420:
2416:
2412:
2408:
2404:
2400:
2393:
2390:
2385:
2381:
2377:
2373:
2369:
2365:
2358:
2355:
2350:
2346:
2342:
2338:
2330:
2327:
2322:
2318:
2314:
2310:
2307:(3): 339–41.
2306:
2302:
2295:
2292:
2287:
2283:
2279:
2275:
2271:
2267:
2259:
2256:
2251:
2247:
2243:
2239:
2231:
2228:
2223:
2219:
2215:
2211:
2207:
2203:
2199:
2195:
2191:
2187:
2180:
2178:
2176:
2174:
2172:
2170:
2166:
2161:
2157:
2152:
2147:
2143:
2139:
2135:
2128:
2126:
2122:
2117:
2113:
2109:
2105:
2101:
2097:
2090:
2088:
2086:
2082:
2077:
2073:
2069:
2065:
2061:
2057:
2053:
2049:
2042:
2039:
2034:
2030:
2026:
2022:
2018:
2014:
2007:
2004:
1999:
1995:
1990:
1985:
1980:
1975:
1971:
1967:
1963:
1959:
1955:
1948:
1946:
1942:
1937:
1933:
1929:
1925:
1921:
1917:
1913:
1906:
1904:
1902:
1898:
1893:
1889:
1884:
1879:
1875:
1871:
1867:
1860:
1857:
1852:
1848:
1842:
1839:
1834:
1830:
1824:
1821:
1817:
1813:
1808:
1806:
1804:
1800:
1796:
1792:
1787:
1785:
1783:
1779:
1773:
1771:
1769:
1765:
1761:
1757:
1753:
1749:
1745:
1741:
1733:
1731:
1729:
1725:
1721:
1717:
1713:
1709:
1705:
1701:
1696:
1694:
1690:
1686:
1682:
1678:
1676:
1670:
1666:
1662:
1658:
1650:
1645:
1643:
1641:
1637:
1633:
1629:
1625:
1621:
1613:
1611:
1609:
1608:
1603:
1599:
1595:
1591:
1587:
1583:
1579:
1578:neurosteroids
1575:
1571:
1567:
1563:
1559:
1555:
1551:
1547:
1545:
1535:
1530:
1528:
1526:
1522:
1518:
1514:
1509:
1507:
1503:
1499:
1495:
1491:
1487:
1483:
1480:. The enzyme
1479:
1471:
1469:
1467:
1463:
1459:
1457:
1451:
1443:
1441:
1439:
1435:
1431:
1427:
1423:
1419:
1415:
1411:
1407:
1406:aspartic acid
1403:
1399:
1393:
1385:
1383:
1381:
1377:
1373:
1370:studies, and
1369:
1365:
1357:
1353:
1346:
1344:
1342:
1338:
1334:
1329:
1327:
1323:
1320:
1316:
1312:
1308:
1304:
1300:
1295:
1293:
1290:
1286:
1282:
1278:
1274:
1272:
1266:
1262:
1258:
1255:
1251:
1239:
1234:
1230:
1226:
1223:
1219:
1212:
1210:
1207:
1203:
1199:
1195:
1192:
1188:
1184:
1177:
1175:
1169:
1165:
1162:
1156:
1154:
1150:
1146:
1142:
1136:
1132:
1129:
1125:
1118:
1116:
1110:
1106:
1103:
1097:
1095:
1091:
1087:
1083:
1077:
1073:
1070:
1068:RefSeq (mRNA)
1066:
1059:
1058:
1053:
1049:
1046:
1040:
1039:
1034:
1030:
1027:
1025:
1021:
1014:
1013:
1008:
1004:
1001:
995:
994:
990:
985:
981:
978:
976:
972:
965:
964:
959:
955:
952:
946:
945:
940:
936:
933:
931:
927:
924:
921:
919:
916:
912:
909:
905:
901:
894:
890:
885:
879:
876:
874:
871:
869:
866:
864:
861:
859:
856:
854:
851:
850:
848:
845:
844:
838:
835:
833:
830:
828:
825:
823:
822:lipid droplet
820:
819:
817:
814:
813:
807:
804:
802:
799:
797:
794:
792:
789:
788:
786:
783:
782:
779:
778:Gene ontology
775:
771:
759:
754:
751:
749:
745:
737:
732:
721:
718:sciatic nerve
717:
713:
709:
706:hair follicle
705:
701:
697:
693:
689:
685:
684:
681:
677:
672:
669:
659:
655:
651:
647:
643:
639:
635:
631:
627:
623:
622:
619:
615:
610:
607:
606:
603:
601:
597:
595:
594:
590:
589:
586:
584:
580:
576:
572:
568:
560:
555:
551:
547:
542:
532:
528:
521:
514:
508:
501:
493:
489:
485:
480:
476:
471:
467:
459:
454:
450:
446:
441:
431:
427:
420:
413:
407:
400:
396:
390:
386:
382:
377:
373:
368:
364:
360:
356:
352:
348:
344:
340:
336:
332:
328:
324:
316:
311:
304:
299:
294:
283:
281:
277:
271:
266:
263:
262:
258:
255:
248:
244:
239:
235:
231:
226:
221:
210:
207:
205:
201:
198:
195:
193:
189:
186:
183:
181:
177:
172:
168:
165:
161:
158:
156:
155:Gene Ontology
152:
149:
146:
143:
140:
137:
133:
130:
127:
125:
121:
118:
115:
113:
109:
106:
103:
101:
97:
94:
93:NiceZyme view
91:
89:
85:
82:
79:
77:
73:
70:
67:
65:
61:
56:
53:
50:
48:
44:
41:
38:
36:
32:
27:
22:
19:
4358:Translocases
4355:
4342:
4329:
4316:
4303:
4293:Transferases
4290:
4277:
4134:Binding site
4062:
4051:Other groups
3879:
3865:
3803:5α-Reductase
3759:sex hormones
3719:
3682:
3669:
3643:pregnenolone
3546:
3305:
3290:
3199:
3195:
3166:
3162:
3135:
3131:
3097:(2): 174–9.
3094:
3090:
3049:
3045:
3017:
3013:
2984:
2980:
2949:(5): 620–4.
2946:
2942:
2915:
2911:
2875:(1): 55–65.
2872:
2868:
2826:
2822:
2791:
2787:
2761:(1): 63–72.
2758:
2754:
2740:cite journal
2715:
2711:
2654:
2650:
2644:
2599:
2595:
2585:
2558:
2554:
2544:
2517:
2513:
2503:
2478:
2474:
2468:
2441:
2437:
2427:
2402:
2398:
2392:
2367:
2363:
2357:
2340:
2336:
2329:
2304:
2300:
2294:
2269:
2265:
2258:
2241:
2237:
2230:
2189:
2185:
2141:
2137:
2099:
2095:
2051:
2047:
2041:
2016:
2012:
2006:
1964:(1): 110–7.
1961:
1957:
1919:
1915:
1873:
1869:
1859:
1850:
1841:
1832:
1823:
1737:
1719:
1697:
1674:
1654:
1635:
1631:
1623:
1619:
1617:
1605:
1588:side of the
1566:progestogens
1543:
1539:
1510:
1505:
1485:
1478:β-structures
1475:
1465:
1455:
1447:
1414:Corey et al.
1413:
1395:
1361:
1355:
1330:
1309:side of the
1296:
1288:
1270:
1249:
1248:
1171:
1149:NP_001138909
1145:NP_001138908
1141:NP_001001438
1138:
1112:
1090:NM_001145437
1086:NM_001145436
1082:NM_001001438
1079:
1055:
1036:
1010:
987:
961:
942:
922:
917:
722:ciliary body
598:
591:
318:External IDs
273:
81:BRENDA entry
18:
4129:Active site
3976:Acyl Groups
3782:17,20-Lyase
3671:aldosterone
3586:Desmosterol
3519:cholesterol
3430:Thiophorase
3412:Ketogenesis
3362:cholesterol
3273:PDB gallery
1685:isoprenoids
1602:prokaryotes
1594:cholesterol
1554:cholesterol
1498:hydrophobic
1482:active site
1462:carbocation
1450:cholesterol
1426:double bond
1392:protonation
1368:mutagenesis
1333:cholesterol
1326:prokaryotes
1324:in the few
1285:cholesterol
702:Paneth cell
636:right ovary
632:skin of leg
557:76,392,972
544:76,367,422
456:46,228,824
443:46,188,141
296:Identifiers
69:IntEnz view
29:Identifiers
4401:Categories
4332:Isomerases
4306:Hydrolases
4173:Regulation
3610:Bile acids
3529:lanosterol
3364:synthesis
3350:Metabolism
1818:, May 2017
1797:, May 2017
1774:References
1768:eukaryotes
1756:cholestane
1754:including
1730:activity.
1724:lanosterol
1708:lanosterol
1689:coenzyme Q
1640:lanosterol
1598:eukaryotes
1582:eukaryotes
1550:lanosterol
1494:eukaryotes
1390:See also:
1380:lanosterol
1337:inhibitors
1299:eukaryotes
1281:Lanosterol
1277:lanosterol
660:left ovary
628:C1 segment
602:(ortholog)
339:HomoloGene
138:structures
105:KEGG entry
52:9032-71-7
4417:EC 5.4.99
4211:EC number
3957:Isomerase
3867:sulfatase
3834:Aromatase
3826:estrogens
3769:androgens
3688:cortisone
2667:CiteSeerX
1764:Australia
1744:hopanoids
1734:Evolution
1716:oxysterol
1628:substrate
1586:cytosolic
1562:androgens
1558:estrogens
1525:exergonic
1472:Structure
1410:histidine
1356:Figure 1:
1347:Mechanism
1307:cytosolic
1174:NP_666118
1153:NP_002331
1115:NM_146006
1094:NM_002340
908:Orthologs
347:GeneCards
58:Databases
4235:Kinetics
4159:Cofactor
4122:Activity
3684:cortisol
3492:Geranyl-
3183:14766201
3119:38721319
3111:11421484
3082:13047538
3074:15790807
3036:18660489
2971:21051816
2899:16344560
2855:19119143
2810:17186944
2775:16806233
2732:10598817
2689:10446042
2636:14660793
2536:16210564
2321:10814317
2286:18842050
2214:15525992
2160:17567593
2116:14766201
2076:21051816
1936:15951028
1814:–
1793:–
1752:steranes
1531:Function
1506:Figure 2
1466:Figure 1
1438:cysteine
1257:5.4.99.7
1222:Wikidata
887:Sources:
837:membrane
710:gastrula
209:proteins
197:articles
185:articles
142:RCSB PDB
40:5.4.99.7
4391:Biology
4345:Ligases
4115:Enzymes
3961:mutases
3892:SULT2A1
3887:SULT1A1
3388:HMG-CoA
3366:enzymes
3358:ketones
3218:8820110
3154:8889548
3054:Bibcode
3046:Science
3001:9763219
2963:8655142
2934:8593458
2890:1356129
2846:2649084
2659:Bibcode
2651:Science
2604:Bibcode
2577:3667583
2495:1445330
2460:7451488
2419:6046552
2384:9295270
2364:Science
2194:Bibcode
2068:8655142
2033:7639730
1998:5257956
1966:Bibcode
1892:6027261
1816:Ensembl
1795:Ensembl
1681:statins
1418:epoxide
1341:statins
1322:protein
1261:cyclase
1024:UniProt
975:Ensembl
914:Species
893:QuickGO
577:pattern
435:21q22.3
335:1336155
303:Aliases
164:QuickGO
129:profile
112:MetaCyc
47:CAS no.
4377:Portal
4319:Lyases
4049:5.4.99
3239:(MeSH)
3216:
3181:
3152:
3117:
3109:
3080:
3072:
3034:
2999:
2969:
2961:
2932:
2897:
2887:
2853:
2843:
2808:
2773:
2730:
2687:
2669:
2634:
2627:307571
2624:
2575:
2534:
2493:
2458:
2417:
2382:
2319:
2284:
2222:364281
2220:
2212:
2186:Nature
2158:
2114:
2074:
2066:
2031:
1996:
1989:534008
1986:
1934:
1890:
1661:statin
1600:, few
1576:, and
1376:enzyme
1315:enzyme
1265:enzyme
1263:(OSC)
1208:search
1206:PubMed
1057:Q8BLN5
1038:P48449
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