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Stephens, L.R.; Anderson, K.; Stokoe, D.; Erdjument-Bromage, H.; Painter, G.F.; Holmes, A.B.; Gaffney, P.R.J.; Reese, C.B.; McCormick, F.; Tempst, P.; Coadwell, J.; Hawkins, P.T. (1998). "Protein Kinase B Kinases That
Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein
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Stokoe, D; Stephens, L. R.; Copeland, T; Gaffney, P. R.; Reese, C. B.; Painter, G. F.; Holmes, A. B.; McCormick, F; Hawkins, P. T. (1997). "Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B".
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Stephens, L.; Smrcka, A.; Cooke, F.T.; Jackson, T.R.; Sternweis, P.C.; Hawkins, P.T. (1994). "A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits".
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and survival. Later, they showed that PtdIns(3,4,5)P3 was responsible for the recruitment of both PKB and PDK1 to the membrane, and therefore the activation of the former by the latter.
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Hawkins, P.T.; Jackson, T.R.; Stephens, L.R. (1992). "Platelet-derived growth factor stimulates synthesis of Ptdlns(3,4,5)P3 by activating a Ptdlns(4,5)P2 3-OH kinase".
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188:). He became a staff scientist in the Inositide laboratory in 1992 and took the leadership of the laboratory in 1996. In 2008, he became associate director of the
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129:-activated Type 1B PI3K (PI3KΥ) and, in a sustained body of work, defined its structure, explained its complex pattern of regulation by GβΥ and
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Stephens, L.R.; Hughes, K.T.; Irvine, R.F. (1991). "Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils".
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109:. Early highlights were the mapping of new pathways of inositol phosphate synthesis. Together with his long-time collaborator
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as the key output signal produced by this enzyme. They identified and isolated the
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activation, a key pathway through which PtdIns(3,4,5)P3 formation regulates
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as the PtdIns(3,4,5)P3-activated link between PI3K-1 activation and
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Len
Stephens has contributed much to the understanding of
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Members of the
European Molecular Biology Organization
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Len
Stephens has received several awards, including:
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is the main substrate of receptor-controlled Type 1
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functions in eukaryotic cells, and in particular in
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206:Fellow of the Royal Society of London
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146:phosphoinositide-dependent kinase-1
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893:Fellows of the Royal Society
873:British molecular biologists
482:10.1126/science.277.5325.567
446:10.1126/science.279.5351.710
394:10.1016/0092-8674(94)90237-2
210:2009, elected member of the
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140:. They – in parallel with
121:(PI3Ks), thus identifying
119:phosphoinositide 3-kinases
133:, and proved its role in
90:(born 18 June 1960) is a
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182:University of Birmingham
164:Len Stephens received a
85:Leonard (Len) R Stephens
42:University of Birmingham
196:Awards and recognition
113:, he established that
111:Phillip Thomas Hawkins
740:Konstantin Novoselov
507:Len Stephens's group
830:Phillip Allen Sharp
438:1998Sci...279..710S
342:1992Natur.358..157H
291:1991Natur.351...33S
135:inflammatory events
92:molecular biologist
63:signal transduction
686:David Manolopoulos
511:Babraham Institute
190:Babraham Institute
186:Babraham Institute
154:cell proliferation
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73:Babraham Institute
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239:. Retrieved
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69:Institutions
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22:Len Stephens
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883:1960 births
774:Patrick Tam
751:John Parkes
735:Werner Nahm
725:John Morton
701:Tom McLeish
680:Ian Manners
634:Alan Grafen
629:John Goodby
609:Alun Davies
604:Alan Cowman
599:Stan Cowley
107:neutrophils
28:Nationality
862:Categories
745:Mark Pagel
730:Sean Munro
639:Clare Grey
619:Ian Frazer
241:12 January
219:References
178:Physiology
59:immunology
674:Dennis Lo
553:elected
410:53255676
315:12322154
251:cite web
803:Foreign
562:Fellows
555:in 2011
549:of the
547:Fellows
509:at the
490:9228007
470:Science
454:9445477
434:Bibcode
426:Science
402:8156600
366:4310878
358:1319558
338:Bibcode
307:1851250
287:Bibcode
170:Biology
138:in vivo
32:British
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330:Nature
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279:Nature
214:(EMBO)
55:Fields
406:S2CID
362:S2CID
311:S2CID
486:PMID
450:PMID
398:PMID
382:Cell
354:PMID
303:PMID
264:help
243:2014
160:Life
127:GPCR
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176:in
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