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171:. It encompasses 27 faculty-led teams from 13 schools and departments throughout U-M. The LSI brings together leading scientists from a variety of life science disciplines, working with a range of models systems and cutting-edge research tools, to accelerate breakthroughs and discoveries that will broaden understanding of the basic processes of life and lead to new treatments to improve human health.
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Center for
Structural Biology and the Center for Chemical Genomics. The cryo-electron microscopy facility opened in 2009, expanding the institute's structural biology capabilities. In 2018, with support from the U-M Biosciences Initiative, the institute began expanding the cryo-EM program and also launched its Natural Products Discovery Core.
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The LSI is a 235,000 square feet building with six floors, located between U-M's central campus and the university's medical campus in Ann Arbor. Completed in 2003, the building includes housing for wet lab and laboratory support spaces, administration offices, PI offices, interaction spaces, core
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began his tenure as the Mary Sue
Coleman Director of the University of Michigan Life Sciences Institute in September 2016. A leading researcher in brain regulation of body weight, Cone also serves as vice provost and director of U-M's biosciences initiative. The managing director is Anna Schork.
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The LSI Annual
Symposium invites leading scientists from different disciplines to converge around a single topic. Past symposia have been designed to explore genetic insights into biology and disease, cancer, stem cell biology, evolutionary biology, autophagy and diseases of the nervous system.
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The first faculty members moved into the building and opened their labs in
September 2003, and the institute celebrated its grand opening in May 2004. That same year, the institute's first two research cores opened, supporting high-throughput screening and structural biology research : the
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A high-throughput screening (HTS) facility is a central component of the Center for
Chemical Genomics (CCG). This core facility is designed to assist academic researchers in carrying out high-throughput screens of chemical libraries and to identify new tools for biological research.
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In 1998, the
University of Michigan formed a commission to create a vision for the future of the life sciences at the university. In response to the commission's recommendations, in 1999, the Regents of the University of Michigan unanimously approved the construction of the
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The Center for
Structural Biology (CSB) is a "collaboratory" for X-ray crystallography, crystallization and protein engineering, and is a comprehensive structural biology resource for researchers at the University of Michigan and surrounding area. The center includes:
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The Life
Sciences Institute is a multidisciplinary basic science research institute, with focal strengths in chemical and structural biology. Its 23 faculty members lead labs specializing in a wide range of life sciences disciplines, including:
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Of the university's $ 823 million in research expenditures, more than half is allocated for research in the life sciences, and the LSI is a cornerstone of this effort.
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The exterior design of the building is intended to harmonize with other campus loft-style structures, while also meeting the needs of a modern research institute.
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In addition to faculty labs, the institute is home to research cores that provide services to the institute, the university, and external partners:
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as director. Saltiel served as the director until 2015, followed by interim director
Stephen Weiss, who led the institute from 2015 to 2016.
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In 2021, the building that houses the institute was renamed Mary Sue
Coleman Hall, in honor of President Emerita Mary Sue Coleman.
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Macromolecular Crystallization & Crystallography Laboratories for solving crystal structures of biological molecules
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The cryo-EM facility at the Life Sciences Institute offers a wide range of advanced microscopes and technologies for
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The Natural Products Discovery Core is home to a library of more than 45,000
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Protein Purification Facilities for small- and large-scale protein production
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space, in addition to the $ 130 million for the endowment and startup costs.
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laboratory areas, a combined gallery/lobby space and a small library.
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Research institution in campus of University of Michigan in Ann Arbor
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through the Life Science Collaborative Access Team (LS-CAT)
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The institute's first director was Jack E. Dixon. In 2002,
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High-Throughput Protein Laboratory for protein engineering
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Regents of the University of Michigan (May 20, 1999).
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The Life Sciences Institute building in August 2013
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246:neuroscience and neurodegeneration
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442:"Meeting Minutes, May 20, 1999"
321:Natural Products Discovery Core
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619:University of Michigan campus
503:"X-ray facilities and LS-CAT"
275:Center for Structural Biology
266:Center for Chemical Genomics
298:Argonne National Laboratory
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327:natural product extracts
315:cryo-electron tomography
311:cryo-electron microscopy
580:42.279700°N 83.734091°W
185:Life Sciences Institute
161:Life Sciences Institute
20:Life Sciences Institute
609:University of Michigan
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293:On-site X-ray facility
243:metabolism and obesity
165:University of Michigan
134:University of Michigan
57:Field of research
585:42.279700; -83.734091
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37:Established
598:Categories
571:83°44′03″W
568:42°16′47″N
539:2008-10-23
485:2022-07-27
395:References
202:Leadership
462:"History"
258:chemistry
169:Ann Arbor
425:Archived
333:Facility
237:genetics
225:Research
120:Location
101:Director
94:Medicine
78:Genetics
189:wet lab
178:History
140:Website
112:Address
149:.umich
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