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sites but also to adjacent nonspecific DNA, a behavior known as "spreading". The ParB-DNA complex is thought to be translocated by a
Brownian ratchet mechanism involving the ParA ATPase: ParA binds DNA nonspecifically in its ATP-bound state but much more weakly in its ADP-bound state. The ParB-DNA
74:
complex binds to ATP-bound ParA, stimulating its ATPase activity and its dissociation from DNA. In this way, the ParB-DNA complex can be translocated by chasing a receding wave. This translocation mechanism has been observed by fluorescence microscopy both
56:
elements located within or adjacent to this operon. Collectively, these components function to ensure accurate partitioning of plasmids or whole chromosomes between bacterial daughter cells prior to cell division.
481:
Walter, JC; Dorignac, J; Lorman, V; Rech, J; Bouet, JY; Nollmann, M; Palmeri, J; Parmeggiani, A; Geniet, F (2017). "Surfing on protein waves: proteophoresis as a mechanism for bacterial genome partitioning".
262:"Whole-genome analysis of the chromosome partitioning and sporulation protein Spo0J (ParB) reveals spreading and origin-distal sites on the Bacillus subtilis chromosome"
803:
32:. Originally identified as a genetic element required for faithful partitioning of low-copy-number plasmids, it consists of three components: the ParA
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Murray, H; Ferreira, H; Errington, J (Sep 2006). "The bacterial chromosome segregation protein Spo0J spreads along DNA from parS nucleation sites".
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66:
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702:"Cell-free study of F plasmid partition provides evidence for cargo transport by a diffusion-ratchet mechanism"
25:
434:"P1 ParA interacts with the P1 partition complex at parS and an ATP-ADP switch controls ParA activities"
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Hwang, LC; Vecchiarelli, AG; Han, YW; Mizuuchi, M; Harada, Y; Funnell, BE; Mizuuchi, K (May 2, 2013).
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Ptacin, JL; Lee, SF; Garner, EC; Toro, E; Eckart, M; Comolli, LR; Moerner, WE; Shapiro, L (Aug 2010).
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Sanchez, A; Cattoni, DI; Walter, JC; Rech, J; Parmeggiani, A; Nollmann, M; Bouet, JY (2015).
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303:"Stochastic Self-Assembly of ParB Proteins Builds the Bacterial DNA Segregation Apparatus"
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Proceedings of the
National Academy of Sciences of the United States of America
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Proceedings of the
National Academy of Sciences of the United States of America
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653:"ParA-mediated plasmid partition driven by protein pattern self-organization"
344:"Polymerization of SopA partition ATPase: regulation by DNA binding and SopB"
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69:(ChIP) experiments, ParB has the ability to bind not only to high-affinity
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385:"F plasmid partition depends on interaction of SopA with non-specific DNA"
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Plasmid and chromosome traffic control: how ParA and ParB drive partition
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594:"Movement and equipositioning of plasmids by ParA filament disassembly"
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545:"A spindle-like apparatus guides bacterial chromosome segregation"
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Ringgaard, S; van Zon, J; Howard, M; Gerdes, K (Nov 17, 2009).
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Vecchiarelli, AG; Hwang, LC; Mizuuchi, K (Apr 9, 2013).
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Rodionov, O; Lobocka, M; Yarmolinsky, M (Jan 22, 1999).
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162:"Silencing of genes flanking the P1 plasmid centromere"
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system is a broadly conserved molecular mechanism for
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Bouet, JY; Ah-Seng, Y; Benmeradi, N; Lane, D (2007).
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48:genes are typically found in the same
260:Breier, AM; Grossman, AD (May 2007).
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776:. You can help Knowledge (XXG) by
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103:. Vol. 56. pp. 145–80.
99:Surtees, JA; Funnell, BE (2003).
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402:10.1111/j.1365-2958.2008.06465.x
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279:10.1111/j.1365-2958.2007.05690.x
221:10.1111/j.1365-2958.2006.05316.x
432:Bouet, JY; Funnell, BE (1999).
514:10.1103/PhysRevLett.119.028101
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109:10.1016/s0070-2153(03)01010-x
67:chromatin immunoprecipitation
186:10.1126/science.283.5401.546
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320:10.1016/j.cels.2015.07.013
82:with purified components.
727:10.1073/pnas.1302745110
619:10.1073/pnas.0908347106
484:Physical Review Letters
450:10.1093/emboj/18.5.1415
772:-related article is a
389:Molecular Microbiology
348:Molecular Microbiology
266:Molecular Microbiology
209:Molecular Microbiology
26:chromosome segregation
669:10.1038/emboj.2013.34
718:2013PNAS..110E1390V
610:2009PNAS..10619369R
549:Nature Cell Biology
506:2017PhRvL.119b8101W
178:1999Sci...283..546R
828:Microbiology stubs
78:and more recently
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