Knowledge (XXG)

Pericentriolar material

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Atypical centrioles during sexual reproduction Tomer Avidor-Reiss*, Atul Khire, Emily L. Fishman and Kyoung H. Jo Curr Biol. 2015 Nov 16;25(22):2956-63. doi: 10.1016/j.cub.2015.09.045. Epub 2015 Oct 17.
74:. Some PCM proteins are organized such that one end of the protein is found near the centriole and the other end is farther away from the centriole. The PCM size is dynamic during the 632: 328: 625: 656: 67: 254:
Eddé, B.; Rossier; Le Caer; Desbruyères; Gros; Denoulet (1990). "Posttranslational glutamylation of alpha-tubulin".
618: 321: 201:"Subdiffraction imaging of centrosomes reveals higher-order organizational features of pericentriolar material" 36: 32: 651: 298: 263: 314: 63: 236: 70:
finds that it is highly organized. The PCM have 9-fold symmetry that mimics the symmetry of the
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Lawo, Steffen; Hasegan, Monica; Gupta, Gagan D.; Pelletier, Laurence (November 2012).
645: 90: 306: 240: 598: 19:(PCM, sometimes also called pericent matrix) is a highly structured, dense mass of 169: 82:. During the G2 phase of the cell cycle, the PCM grows in size in a process named 40: 158: 44: 565: 338: 75: 24: 224: 347: 275: 200: 71: 28: 232: 283: 545: 505: 375: 150: 452: 154: 138: 20: 590: 555: 550: 540: 535: 530: 525: 520: 515: 460: 370: 365: 48: 299:
http://journal.frontiersin.org/article/10.3389/fcell.2015.00021/full
216: 560: 510: 500: 495: 490: 485: 480: 475: 470: 465: 441: 436: 387: 383: 379: 360: 355: 163: 134: 128: 94: 78:. After cell division, the PCM size is reduced in a process named 53: 570: 431: 426: 421: 411: 393: 144: 122: 116: 104: 310: 153:, cyclin dependant kinase receptor associated protein 2, binds 416: 110: 58:
The purple mesh represents pericentriolar material (PCM)
606: 450: 402: 346: 626: 322: 8: 113:, Proto-oncogene tyrosine-protein kinase LCK 31:. The PCM contains proteins responsible for 166:, binds gTubRCs that stabilise microtubules 633: 619: 329: 315: 307: 147:, pericentrin, a matrix scaffold protein 182: 62:Although the PCM appears amorphous by 23:which makes up the part of the animal 97:proteins are associated with the PCM 7: 587: 585: 194: 192: 190: 188: 186: 119:, Pericentriolar material 1 protein 605:. You can help Knowledge (XXG) by 14: 107:, Bardet-Biedl syndrome 4 protein 589: 1: 68:super-resolution microscopy 673: 584: 172:, nucleates microtubules 404:Pericentriolar material 276:10.1126/science.1967194 27:that surrounds the two 17:Pericentriolar material 59: 33:microtubule nucleation 84:centrosome maturation 57: 80:centrosome reduction 268:1990Sci...247...83E 205:Nature Cell Biology 64:electron microscopy 657:Cell biology stubs 341:and its components 60: 614: 613: 579: 578: 211:(11): 1148–1158. 89:According to the 664: 635: 628: 621: 593: 586: 331: 324: 317: 308: 301: 294: 288: 287: 251: 245: 244: 196: 93:, the following 672: 671: 667: 666: 665: 663: 662: 661: 642: 641: 640: 639: 582: 580: 575: 446: 398: 342: 335: 305: 304: 295: 291: 262:(4938): 83–85. 253: 252: 248: 217:10.1038/ncb2591 198: 197: 184: 179: 12: 11: 5: 670: 668: 660: 659: 654: 644: 643: 638: 637: 630: 623: 615: 612: 611: 594: 577: 576: 574: 573: 568: 563: 558: 553: 548: 543: 538: 533: 528: 523: 518: 513: 508: 503: 498: 493: 488: 483: 478: 473: 468: 463: 457: 455: 448: 447: 445: 444: 439: 434: 429: 424: 419: 414: 408: 406: 400: 399: 397: 396: 391: 373: 368: 363: 358: 352: 350: 344: 343: 336: 334: 333: 326: 319: 311: 303: 302: 289: 246: 181: 180: 178: 175: 174: 173: 167: 161: 157:that nucleate 148: 142: 132: 126: 120: 114: 108: 13: 10: 9: 6: 4: 3: 2: 669: 658: 655: 653: 650: 649: 647: 636: 631: 629: 624: 622: 617: 616: 610: 608: 604: 601:article is a 600: 595: 592: 588: 583: 572: 569: 567: 564: 562: 559: 557: 554: 552: 549: 547: 544: 542: 539: 537: 534: 532: 529: 527: 524: 522: 519: 517: 514: 512: 509: 507: 504: 502: 499: 497: 494: 492: 489: 487: 484: 482: 479: 477: 474: 472: 469: 467: 464: 462: 459: 458: 456: 454: 449: 443: 440: 438: 435: 433: 430: 428: 425: 423: 420: 418: 415: 413: 410: 409: 407: 405: 401: 395: 392: 389: 385: 381: 377: 374: 372: 369: 367: 364: 362: 359: 357: 354: 353: 351: 349: 345: 340: 332: 327: 325: 320: 318: 313: 312: 309: 300: 293: 290: 285: 281: 277: 273: 269: 265: 261: 257: 250: 247: 242: 238: 234: 230: 226: 222: 218: 214: 210: 206: 202: 195: 193: 191: 189: 187: 183: 176: 171: 170:Gamma Tubulin 168: 165: 162: 160: 156: 152: 149: 146: 143: 141:epsilon chain 140: 136: 133: 131:, Tankyrase-2 130: 127: 125:, Tankyrase-1 124: 121: 118: 115: 112: 109: 106: 103: 102: 101: 99: 96: 92: 91:Gene Ontology 87: 85: 81: 77: 73: 69: 65: 56: 52: 50: 46: 42: 38: 34: 30: 26: 22: 18: 652:Cell biology 607:expanding it 599:cell biology 596: 581: 403: 292: 259: 255: 249: 208: 204: 159:microtubules 88: 61: 16: 15: 45:pericentrin 646:Categories 348:Centrioles 339:centrosome 177:References 76:cell cycle 39:including 29:centrioles 25:centrosome 225:1476-4679 72:centriole 41:γ-tubulin 37:anchoring 453:proteins 376:Centrins 241:11286303 233:23086237 151:CDK5RAP2 284:1967194 264:Bibcode 256:Science 155:gTubRCs 139:Tubulin 21:protein 556:CEP350 551:CEP250 546:CEP215 541:CEP192 536:CEP170 531:CEP164 526:CEP152 521:CEP135 516:CEP120 461:CCP110 451:other 371:CEP104 366:CNTROB 282:  239:  231:  223:  49:ninein 597:This 561:CNTRL 511:CEP97 506:CEP90 501:CEP78 496:CEP76 491:CEP72 486:CEP70 481:CEP68 476:CEP63 471:CEP57 466:CEP55 442:TUBE1 437:TNKS2 388:CETN3 384:CETN2 380:CETN1 361:CENPJ 356:SASS6 237:S2CID 164:NEDD1 135:TUBE1 129:TNKS2 95:human 603:stub 571:NINL 432:TNKS 427:PCNT 422:PCM1 412:BBS4 394:SFI1 386:and 337:The 280:PMID 229:PMID 221:ISSN 145:PCNT 123:TNKS 117:PCM1 105:BBS4 47:and 35:and 566:NIN 417:Lck 272:doi 260:247 213:doi 111:Lck 648:: 382:, 278:. 270:. 258:. 235:. 227:. 219:. 209:14 207:. 203:. 185:^ 137:, 100:: 86:. 66:, 51:. 43:, 634:e 627:t 620:v 609:. 390:) 378:( 330:e 323:t 316:v 286:. 274:: 266:: 243:. 215::

Index

protein
centrosome
centrioles
microtubule nucleation
anchoring
γ-tubulin
pericentrin
ninein

electron microscopy
super-resolution microscopy
centriole
cell cycle
centrosome reduction
centrosome maturation
Gene Ontology
human

BBS4
Lck
PCM1
TNKS
TNKS2
TUBE1
Tubulin
PCNT
CDK5RAP2
gTubRCs
microtubules
NEDD1

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