198:. PBSC donors are given a course of GCSF prior to PBSC collection. The increase in white blood cell proliferation as a result of the Filgrastim ensures a better results from the donation. The course is usually given over a 4-day period prior to PBSC collection. The most common side effects of Filgrastim are bone, joint, back, arm, leg, mouth, throat, and muscle pain. Additionally, headache, nausea, vomiting, dizziness, fatigue, rash, loss of appetite, and difficulty falling or staying asleep are common.
29:
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Singhal, S; Powles, R; Kulkarni, S; Treleaven, J; Sirohi, B; Millar, B; Shepherd, V; Saso, R; Rowland, A; Long, S; Cabral, S; Horton, C; Mehta, J (March 2000). "Comparison of marrow and blood cell yields from the same donors in a double-blind, randomized study of allogeneic marrow vs blood stem cell
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PBSCT. For example, calculations must be made to ensure consistency in the amount of total blood volume between the donor and recipient. If the total blood volume of the donor is less than that of the recipient (such as when a child is donating to an adult), multiple PBSCT sessions may be required
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Nagayama, Hitomi; Ooi, Jun; Tomonari, Akira; Iseki, Tohru; Arinobu, Tojo; Tani, Kenzaburo; Takahashi, Tsuneo A.; Yamashita, Naohide; Asano, Shigetaka (2002). "Severe Immune
Dysfunction after Lethal Neutron Irradiation in a JCO Nuclear Facility Accident Victim".
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was treated with PBSCT in an attempt to restore his destroyed immune system. Cells from the patient's sister's bone marrow were administered, and in the following weeks successfully began dividing and differentiating into
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Sevilla, J; Plaza, SF; González-Vicent, M; Lassaletta, A; Ramírez, M; Madero, L; Díaz, MA (2007). "PBSC collection in extremely low weight infants: a single-center experience".
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248:. However, several weeks later, the cells were found to have been mutated by the radiation still present within the patient's body, and were observed carrying out
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equivalent due to the ease and less invasive nature of the procedure. Studies suggest that PBSCT has a better outcome in terms of the number of
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75:. Stem cells can be destroyed through cancer treatments such as chemotherapy or radiation, as well as any blood-related diseases, such as
621:"Neoendothelialization after peripheral blood stem cell transplantation in humans: a case report of a Tokaimura nuclear accident victim"
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Suzuki, T.; Nishida, M.; Futami, S.; Fukino, K.; Amaki, T.; Aizawa, K.; Chiba, S.; Hirai, H.; Maekawa, K.; Nagai, R. (2003).
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PBSCT involves transformation of blood between different individuals, this naturally carries more complications than
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and death. Health care providers must exercise careful precaution when considering donor-recipient matching in
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for adequate collection. Performing such a collection in a single setting could result in risks such as
252:. Later studies on the incident and subsequent use of PBSCT found that the transplant had also induced
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An early example of a successful peripheral stem cell transplant was carried out in the wake of the
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324:"Stem Cell Transplant (Peripheral Blood, Bone Marrow, and Cord Blood Transplants)"
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Welte, K; Gabrilove, J; Bronchud, MH; Platzer, E; Morstyn, G (Sep 15, 1996).
402:"Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation"
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169:). The apheresis procedure typically lasts for 4–6 hours, depending on the
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then migrate to the recipient's bone marrow, through a process known as
68:), also called "Peripheral stem cell support", is a method of replacing
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499:"Peripheral blood stem cells for allogeneic transplantation: a review"
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from a donor (PBSC collection). The product is then administered
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entry in the public domain NCI Dictionary of Cancer Terms
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A bag of freshly transplanted peripheral blood stem cells
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to recover, proliferate and continue producing healthy
300:"Frequently asked questions about stem cell research"
134:, where the transplanted cells override the previous
91:. PBSCT is now a much more common procedure than its
474:"Filgrastim Injection: MedlinePlus Drug Information"
157:(blood cells donated by someone else with matching
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239:. Hisashi Ouchi, who received the highest dose of
126:to the patient after treatment. The administered
417:"Filgrastim (r-metHuG-CSF): the first 10 years"
188:that stimulate white blood cell proliferation.
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434:10.1182/blood.V88.6.1907.bloodjournal8861907
16:Method of replacing blood-forming stem cells
62:Peripheral blood stem cell transplantation
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192:is a synthetic form of GCSF produced in
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182:Granulocyte colony stimulating factor
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664:Peripheral stem cell transplantation
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345:"Peripheral Blood Stem Cell Harvest"
177:Preparation prior to PBSC Collection
22:Peripheral stem cell transplantation
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153:(an individual's own blood cells),
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114:that are similar to those in the
675: This article incorporates
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237:1999 Tokaimura nuclear accident
184:(GCSF) are naturally occurring
688:U.S. National Cancer Institute
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638:10.1016/s0008-6363(02)00780-0
497:Cutler, C; Antin, JH (2001).
278:"Dictionary of Cancer Terms"
368:Bone Marrow Transplantation
165:(blood cells donated by an
149:The transplantation may be
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683:Dictionary of Cancer Terms
516:10.1634/stemcells.19-2-108
552:10.1080/14653240701320270
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704:Transplantation medicine
128:hematopoietic stem cells
108:hematopoietic stem cells
625:Cardiovascular Research
97:hematopoietic stem cell
677:public domain material
457:"G-CSF Administration"
380:10.1038/sj.bmt.1702173
219:, which could lead to
254:neoendothelialization
250:autoimmune responses
631:(2). NCBI: 487–92.
110:in the circulating
93:bone marrow harvest
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366:transplantation".
138:. This allows the
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540:Cytotherapy
304:Mayo Clinic
258:endothelium
217:hypovolemia
144:blood cells
140:bone marrow
136:bone marrow
116:bone marrow
101:CD34+ cells
724:Stem cells
714:Hematology
709:Lymphology
698:Categories
503:Stem Cells
483:2021-04-15
309:2021-04-15
264:References
225:allogeneic
212:autologous
208:allogeneic
190:Filgrastim
155:allogeneic
151:autologous
73:stem cells
44:hematology
241:radiation
163:syngeneic
120:apheresis
106:Immature
103:) yield.
40:Specialty
647:12757883
598:12215015
560:17573611
525:11239165
388:10713626
81:lymphoma
77:leukemia
606:9152173
443:8822908
350:4 March
329:4 March
284:2 March
231:History
227:PBSCT.
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206:Since
195:E.coli
161:), or
679:from
602:S2CID
421:Blood
112:blood
66:PBSCT
50:[
643:PMID
594:PMID
556:PMID
521:PMID
439:PMID
384:PMID
352:2012
331:2012
286:2012
87:and
633:doi
586:doi
548:doi
511:doi
429:doi
376:doi
159:HLA
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
