268:
methodology, PRRSV type 2 was sub-divided into 9 lineages, which are present with different prevalence across the world. Despite type 2 PRRSV being named the North
American PRRSV, there are two lineages that are restricted to Asia. The other lineages had what is assumed introductions into other geographic locations such as Thailand, Canada, China and Italy. Within the U.S., the prevalence of different lineages of PRRSV change over time. It is presumed that Type 2 PRRSV was first seen in Canada after analyzing serological evidence. By 2010, of the top ten swine production states in the United States, viruses in 3 of the 9 major lineages were present. Two of the three lineages were considered major lineages because of their sample size. By 2019, at least 5 different lineages circulate in a single U.S. region, and certain lineages display complex intra-lineage variability, which has been sometimes referred to as sub-lineages. The occurrence of specific lineages in the United States are not homogeneous, certain lineages are more prevalent in specific parts of the country.
302:
ORF2a, 3, 4, 5, encode glycoprotein 2,2a, 3, 4, and 5. ORF2b encodes the envelope protein. There is a newly discovered protein encoded in ORF5a that overlaps ORF5. ORF6 encodes the membrane protein. The nucleocapsid (N) protein is encoded by ORF7. The N protein is composed of 123 amino acids, produces an immune response within the cell, and is thought to be multifunctional. This protein also has five antigenic regions. A cryptic nuclear localization signal (NLS), a functional nuclear localization signal (NLS-2), and a nucleolar localization signal (NoLS) are all located on this protein as well.
332:
has been shown that mutations within the leader transcription regulating sequence (TRS) of the type 2 PRRSV genome may inhibit proper sgmRNA translation. Intact leader TRS is required for proper sgmRNA transcription. PRSSV uses different non-conical (non-structural) body translation regulating sequences (TRS-B) to produce different sg mRNA species. Different strains have and use different TRS-Bs depending on genotype changes that have occurred. The 3' terminal C5 and C6 are conserved within different species' TRS-Bs.
365:
KB-driven inflammatory cytokine response. This response activates the DHX36-MyD88-P65 signaling cascade. When researchers knocked out DHX36, the activation of NF-ÎșB signaling by PRSSV and nucleocapsid (N) protein was inhibited. Because of this experiment it is now known that type 2 PRSSV using its N protein to induce the NF-ÎșB response. Type 2 PRSSV is able to induce this response through the interaction between the N protein and DHX36. This interaction is made possible through the N-terminal of the DHX36.
290:
who have been infected. Without a strong neutralizing vaccination, the host cells are able to attach strongly and then with weak neutralizing effects, end up getting infected easier. The live attenuated vaccine works through an unknown mechanism and only helps clinical symptoms; it does not prevent infection. It is thought that the live attenuated vaccination may also revert to the virulent form of the virus. These two vaccinations are currently not effective.
35:
227:(ORFs) with a 5' untranslated region (UTR) and a 3' UTR. PRRSV causes porcine reproductive and respiratory syndrome in swine. This syndrome results in failure during breeding and respiratory problems. Type 2 PRRSV was first seen in the United States in 1987. However, it has now spread worldwide to commercial swine facilities.
316:
kDa protein out of solution. However, this does not completely block attachment to the PAMs. It has been shown previously that heparin can reduce infection of Marc-145 cells (a derived cell line from the
African green monkey kidney cell line). It has now been shown that binding of type 2 PRRSV binds to heparin sulfate
331:
PRSSV is assumed to transcribe like other nidoviruses that transcribe in a discontinuous fashion. The structural proteins are translated from the 5' ends of the sub genomic (sg) mRNA 2 to 7. The 5' UTR in PRRSV consists of its 5' leader sequence. The PRSSV generates a 3' coterminal set of sgmRNAs. It
301:
Type 2 PRRSV is an enveloped virus with a non-isometric nucleocapsid core. The Type 2 PRRSV genome has 10 open reading frames (ORFs) present. There are two large ORFs (ORF1a and ORF1b) that encode non-structural proteins. The remaining eight ORFs create the six main structural proteins for the virus.
289:
Currently, inactivated and live attenuated viruses are used to try to eliminate porcine reproductive and respiratory syndrome (PRRS). It has been found that the inactivated vaccination only induces weak neutralizing antibodies against PRRS. This type of response can create a worse infection for those
230:
Within the swine industry, porcine reproductive and respiratory syndrome causes interstitial pneumonia of grown swine and fetal death. Early gestation infection of a maternal swine can lead to embryonic infection. During mid-gestation, the fetuses are protected as the virus can not pass the placenta.
263:
patterns. These are characterized by displaying a cut pattern of three different enzymes (MluI, HincII and SacII) in the ORF5 portion of the PRRSV genome. Common RFLP types for are 1-7-4, 1-8-4, 2-5-2, among thousands of others. Criticism to this way of classifying the virus range from the multitude
339:
ORF1a and ORF1b are translated to create two large proteins. Processing of these precursor proteins creates at least 14 nonstructural proteins. The processing is regulated by four main viral proteases. Most of the nonstructural protein (NSPs) assemble and create a complex called the replication and
315:
It has been found that a 210-kDa membrane protein expressed on porcine alveolar macrophages (PAMS) allows PRRSV to attach to the membrane. The exact nature of this protein has not yet been identified. Infection by PRRSV can be completely blocked using monoclonal antibodies that precipitate the 210-
271:
Since the 1987 classification of type 2 (North
American-like) PRRSV, the virus has greatly diversified. There are three main epidemiological events that have occurred. There has been the introduction of the MN184-related cluster, acute PRRS/abortion storm, and highly pathogenic Chinese strains. The
351:
At the end of replication, the nucleocapsid proteins surround the newly made genome. The new nucleocapsid complex buds from the smooth endoplasmic reticulum and the golgi complex. Through this process the new capsid obtains the required six viral envelope proteins. The new virions then go into the
355:
The type 2 PRRSV infection induces the unfolded protein response (UPR) within the cell, also known as the endoplasmic reticulum (ER) stress response. This response triggers the function of c-Jun N-terminal kinases (JNK). The activation of JNK leads to p53 and Akt activation which in turn lead to
335:
It has been suggested that despite the normal anti-viral role
Protein Kinase R (PKR) plays in cells, type 2 PRRSV uses PKR as a pro-viral kinase within the cell. When PKR was knocked out in Marc-145 cells, Type-2 PRRSV strain 23983 replication decreased. Therefore, it is assumed that PKR plays a
364:
One main way that Type 2 PRSSV modulates the host cell is through the activation of the inflammatory response. This pro-inflammatory response in host cells oftentimes most visibly results in interstitial pneumonia of the infected swine. It has now been found that type 2 PRRSV increases the NF -
1272:
Zheng, Haihong; Zhang, Keyu; Zhu, Xing-Quan; Liu, Changlong; Lu, Jiaqi; Gao, Fei; Zhou, Yan; Zheng, Hao; Lin, Tao (2014-08-01). "Genetic manipulation of a transcription-regulating sequence of porcine reproductive and respiratory syndrome virus reveals key nucleotides determining its activity".
280:
The genetic diversity of Type 2 PRRSV continues to grow. Canada and the United States have shown the highest degree of continued diversity. In Canada, the diversity is more localized in certain areas and thought to be due to the introduction of vaccination diversity. The United States genetic
267:
Because of those limitations, PRRSV type 2 has been recently classified according to phylogenetic characteristics of the ORF5 portion of the viral genome, which aggregates isolates into phylogenetic lineages based on the ancestral relationships and genetic distance among isolates. Using this
264:
of possible combinations of different cut pattern of the three enzymes (leading to tens of thousands of different PRRSV RFLP patterns, with unknown epidemiological significance) to the quick change in RFLP types of a single virus in as few as 10 animal passages.
1324:
Wang, Xiuqing; Zhang, Hanmo; Abel, Alex M.; Nelson, Eric (2016-02-01). "Protein kinase R (PKR) plays a pro-viral role in porcine reproductive and respiratory syndrome virus (PRRSV) replication by modulating viral gene transcription".
382:
281:
diversity has increased in all geographic areas. However, Mexico contains the greatest number of genetic outliers. Researchers believe this is due to multiple reintroductions of the virus to the areas.
320:
on the PAMs is vital to entry. PRRSV then binds to CD169 on the PAM. This binding activates receptor-mediated clathrin-dependent endocytosis. The genome enters the cytoplasm using a reaction by CD163.
936:"Recognition of Highly Diverse Type-1 and -2 Porcine Reproductive and Respiratory Syndrome Viruses (PRRSVs) by T-Lymphocytes Induced in Pigs after Experimental Infection with a Type-2 PRRSV Strain"
1419:"DExD/H-Box Helicase 36 Signaling via Myeloid Differentiation Primary Response Gene 88 Contributes to NF-ÎșB Activation to Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection"
293:
There have been many new attempts to find effective vaccinations. Researchers are currently trying to identify neutralizing antibodies that will provide true immunity against type 2 PRRSV.
779:"Instability of the Restriction Fragment Length Polymorphism Pattern of Open Reading Frame 5 of Porcine Reproductive and Respiratory Syndrome Virus during Sequential Pig-to-Pig Passages"
328:
Despite the genetic variation that occurs in type 2 PRRSV, a conserved stem loop in the genome has been identified. This is believed to play a role in viral replication and translation.
208:(PRRSV). The two types of PRRSV are distinguished by which genomic cluster they are associated with. Type 1 is associated with a LV cluster. Type 2 is associated with a VR2332 cluster.
205:
1220:"Replacement of the heterologous 5âČ untranslated region allows preservation of the fully functional activities of type 2 porcine reproductive and respiratory syndrome virus"
340:
transcription complex (RTC). The complexes then accumulate in the endoplasmic reticulum double membrane vesicles. These complexes direct both replication and transcription.
934:
Chung, Chungwon J.; Cha, Sang-Ho; Grimm, Amanda L.; Chung, Grace; Gibson, Kathleen A.; Yoon, Kyoung-Jin; Parish, Steven M.; Ho, Chak-Sum; Lee, Stephen S. (2016-10-31).
554:
Shi, Mang; Lam, Tommy Tsan-Yuk; Hon, Chung-Chau; Murtaugh, Michael P.; Davies, Peter R.; Hui, Raymond Kin-Hei; Li, Jun; Wong, Lina Tik-Wim; Yip, Chi-Wai (2010-09-01).
251:
tropism for cells like macrophages or monocytes. PRRSV can then infect a subpopulation of macrophages. These can then be identified by the expression of sialoadhesin
617:"Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts"
1160:"Involvement of the matrix protein in attachment of porcine reproductive and respiratory syndrome virus to a heparinlike receptor on porcine alveolar macrophages"
1003:"The N-N non-covalent domain of the nucleocapsid protein of type 2 porcine reproductive and respiratory syndrome virus enhances induction of IL-10 expression"
1107:
Jusa, E. R.; Inaba, Y.; Kouno, M.; Hirose, O. (May 1997). "Effect of heparin on infection of cells by porcine reproductive and respiratory syndrome virus".
828:"Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses"
676:"Analysis of porcine reproductive and respiratory syndrome virus attachment and internalization: distinctive roles for heparan sulphate and sialoadhesin"
556:"Phylogeny-Based Evolutionary, Demographical, and Geographical Dissection of North American Type 2 Porcine Reproductive and Respiratory Syndrome Viruses"
356:
apoptosis of the cell. It is thought that this apoptosis of the host cell plays a significant role in the pathogenesis of the type 2 PRRSV infection.
1378:"Involvement of unfolded protein response, p53 and Akt in modulation of porcine reproductive and respiratory syndrome virus-mediated JNK activation"
260:
231:
However, in late state gestation transplacental infection to and from fetuses can occur and large scale reproductive failure may occur.
1052:"Identification of a Putative Receptor for Porcine Reproductive and Respiratory Syndrome Virus on Porcine Alveolar Macrophages"
34:
1218:
Gao, Fei; Yao, Huochun; Lu, Jiaqi; Wei, Zuzhang; Zheng, Haihong; Zhuang, Jinshan; Tong, Guangzhi; Yuan, Shishan (2013).
1417:
Jing, Huiyuan; Zhou, Yanrong; Fang, Liurong; Ding, Zhen; Wang, Dang; Ke, Wenting; Chen, Huanchun; Xiao, Shaobo (2017).
193:
826:
Shi M, Lam TT, Hon CC, Murtaugh MP, Davies PR, Hui RK, Li J, Wong LT, Yip CW, Jiang JW, Leung FC (Sep 2010).
1487:
726:
Paploski IA, Corzo C, Rovira A, Murtaugh MP, Sanhueza JM, Vilalta C, Schroeder DC, VanderWaal K (Nov 2019).
1482:
947:
728:"Temporal Dynamics of Co-circulating Lineages of Porcine Reproductive and Respiratory Syndrome Virus"
29:
1376:
Huo, Yazhen; Fan, Lihong; Yin, Shutao; Dong, Yinhui; Guo, Xiao; Yang, Hanchun; Hu, Hongbo (2013).
1358:
1306:
1140:
1032:
911:
466:
224:
166:
1458:
1440:
1399:
1350:
1342:
1298:
1290:
1251:
1197:
1179:
1132:
1124:
1089:
1071:
1024:
983:
965:
903:
857:
808:
759:
697:
656:
638:
593:
575:
536:
518:
458:
317:
1448:
1430:
1389:
1334:
1282:
1241:
1231:
1187:
1171:
1116:
1079:
1063:
1014:
973:
955:
893:
882:"Evolutionary diversification of type 2 porcine reproductive and respiratory syndrome virus"
847:
839:
798:
790:
749:
739:
687:
646:
628:
583:
567:
526:
510:
448:
437:"Evolutionary diversification of type 2 porcine reproductive and respiratory syndrome virus"
435:
Brar, Manreetpal Singh; Shi, Mang; Murtaugh, Michael P.; Leung, Frederick Chi-Ching (2015).
406:
131:
95:
1050:
Duan, Xiaobo; Nauwynck, Hans J.; Favoreel, Herman W.; Pensaert, Maurice B. (1998-05-01).
951:
1453:
1418:
1246:
1219:
978:
935:
852:
827:
754:
727:
651:
616:
588:
555:
531:
498:
343:
Besides these hints, the exact way in which type 2 PRRSV translates remains a mystery.
189:
143:
1192:
1159:
1084:
1051:
803:
778:
1476:
794:
223:. It has a positive sense RNA genome that is 15 kb long. This genome consists of ten
213:
119:
71:
1362:
1175:
1144:
1067:
1036:
915:
470:
1310:
197:
83:
1001:
Liu, Xing; Fan, Baochao; Bai, Juan; Wang, Haiyan; Li, Yufeng; Jiang, Ping (2015).
1158:
Delputte, P. L.; Vanderheijden, N.; Nauwynck, H. J.; Pensaert, M. B. (May 2002).
960:
1394:
1377:
1236:
1120:
612:
219:
107:
1338:
1286:
633:
514:
499:"Overview: Replication of porcine reproductive and respiratory syndrome virus"
1444:
1435:
1346:
1294:
1183:
1128:
1075:
969:
744:
642:
579:
522:
59:
1462:
1403:
1354:
1302:
1255:
1201:
1028:
987:
907:
861:
812:
763:
701:
660:
597:
540:
462:
1136:
1093:
692:
675:
1019:
1002:
898:
881:
843:
611:
Ladinig, Andrea; Ashley, Carolyn; Detmer, Susan E.; Wilkinson, Jamie M.;
571:
453:
436:
46:
259:
PRRSV type 2 has been historically classified according to
674:
Delputte, P. L.; Costers, S.; Nauwynck, H. J. (2005).
206:
porcine reproductive and respiratory syndrome viruses
202:
porcine reproductive and respiratory syndrome virus 2
175:
Porcine reproductive and respiratory syndrome virus 2
880:Brar MS, Shi M, Murtaugh MP, Leung FC (Jul 2015).
615:; Plastow, Graham; Harding, John CS (2015-09-25).
336:pro-viral role by affecting PRRSV transcription.
875:
873:
871:
261:RFLP (restriction fragment length polymorphism)
721:
719:
717:
715:
713:
711:
272:history of their incidences remain a mystery.
1267:
1265:
929:
927:
925:
8:
1213:
1211:
497:Yun, Sang-Im; Lee, Young-Min (2013-12-01).
430:
428:
426:
200:. Members of the species are also known as
492:
490:
488:
486:
484:
482:
480:
18:
1452:
1434:
1393:
1245:
1235:
1191:
1083:
1018:
977:
959:
897:
851:
802:
753:
743:
691:
650:
632:
587:
530:
452:
1109:American Journal of Veterinary Research
374:
7:
383:"Taxonomy browser (Betaarterivirus)"
352:extracellular space via exocytosis.
204:. Member viruses are a type of the
777:Cha S, Chang C, Yoon K (Oct 2004).
14:
795:10.1128/JCM.42.10.4462-4467.2004
783:Journal of Clinical Microbiology
33:
1176:10.1128/JVI.76.9.4312-4320.2002
1068:10.1128/JVI.72.5.4520-4523.1998
886:The Journal of General Virology
1:
407:"Betaarterivirus ~ ViralZone"
324:Replication and transcription
961:10.1371/journal.pone.0165450
360:Modulation of host processes
1395:10.1016/j.virol.2013.06.015
1237:10.1016/j.virol.2012.12.013
1121:10.2460/ajvr.1997.58.05.488
1007:Journal of General Virology
680:Journal of General Virology
441:Journal of General Virology
194:positive-strand RNA viruses
1504:
239:As a member of the family
1339:10.1007/s00705-015-2671-0
1287:10.1007/s00705-014-2018-2
732:Frontiers in Microbiology
634:10.1186/s13567-015-0251-7
515:10.1007/s12275-013-3431-z
172:
165:
28:
21:
1436:10.3389/fimmu.2017.01365
745:10.3389/fmicb.2019.02486
306:Genome replication cycle
1423:Frontiers in Immunology
503:Journal of Microbiology
185:Betaarterivirus suid 2
158:Betaarterivirus suid 2
23:Betaarterivirus suid 2
693:10.1099/vir.0.80675-0
217:family and the order
1327:Archives of Virology
1275:Archives of Virology
1020:10.1099/vir.0.000061
899:10.1099/vir.0.000104
844:10.1128/JVI.02551-09
572:10.1128/jvi.02551-09
454:10.1099/vir.0.000104
411:viralzone.expasy.org
387:www.ncbi.nlm.nih.gov
347:Assembly and release
311:Attachment and entry
255:Viral classification
30:Virus classification
1164:Journal of Virology
1056:Journal of Virology
952:2016PLoSO..1165450C
832:Journal of Virology
621:Veterinary Research
560:Journal of Virology
225:open reading frames
318:glycosaminoglycans
838:(17): 8700â8711.
789:(10): 4462â4467.
566:(17): 8700â8711.
276:Genomic diversity
181:
180:
1495:
1467:
1466:
1456:
1438:
1414:
1408:
1407:
1397:
1388:(1â2): 233â240.
1373:
1367:
1366:
1321:
1315:
1314:
1281:(8): 1927â1940.
1269:
1260:
1259:
1249:
1239:
1215:
1206:
1205:
1195:
1170:(9): 4312â4320.
1155:
1149:
1148:
1104:
1098:
1097:
1087:
1062:(5): 4520â4523.
1047:
1041:
1040:
1022:
1013:(6): 1276â1286.
998:
992:
991:
981:
963:
946:(10): e0165450.
931:
920:
919:
901:
892:(7): 1570â1580.
877:
866:
865:
855:
823:
817:
816:
806:
774:
768:
767:
757:
747:
723:
706:
705:
695:
686:(5): 1441â1445.
671:
665:
664:
654:
636:
608:
602:
601:
591:
551:
545:
544:
534:
494:
475:
474:
456:
447:(7): 1570â1580.
432:
421:
420:
418:
417:
403:
397:
396:
394:
393:
379:
211:PRRSV is in the
188:is a species of
38:
37:
19:
16:Species of virus
1503:
1502:
1498:
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995:
933:
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923:
879:
878:
869:
825:
824:
820:
776:
775:
771:
725:
724:
709:
673:
672:
668:
613:Lunney, Joan K.
610:
609:
605:
553:
552:
548:
496:
495:
478:
434:
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389:
381:
380:
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371:
362:
349:
326:
313:
308:
299:
287:
278:
257:
243:, PRRSV has an
237:
161:
133:Betaarterivirus
97:Pisoniviricetes
32:
17:
12:
11:
5:
1501:
1499:
1491:
1490:
1488:Swine diseases
1485:
1475:
1474:
1469:
1468:
1409:
1368:
1333:(2): 327â333.
1316:
1261:
1207:
1150:
1115:(5): 488â491.
1099:
1042:
993:
921:
867:
818:
769:
707:
666:
603:
546:
509:(6): 711â723.
476:
422:
398:
373:
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236:
233:
179:
178:
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170:
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163:
162:
155:
153:
149:
148:
145:Ampobartevirus
141:
137:
136:
129:
125:
124:
117:
113:
112:
105:
101:
100:
93:
89:
88:
81:
77:
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69:
65:
64:
57:
50:
49:
44:
40:
39:
26:
25:
15:
13:
10:
9:
6:
4:
3:
2:
1500:
1489:
1486:
1484:
1483:Arteriviridae
1481:
1480:
1478:
1464:
1460:
1455:
1450:
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1437:
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1428:
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