69:
4394:
211:, such as in prostate cancer. There are many mechanisms by which Rab protein dysfunction has been shown to cause cancer. To name a few, elevated expression of the oncogenic Rab1, along with Rab1A proteins, promote the growth of tumors, often with a poor prognosis. The overexpression of Rab23 has been linked to
235:
There are approximately 70 different Rabs that have been identified in humans thus far. They are mostly involved in vesicle trafficking. Their complexity can be understood if thought of as address labels for vesicle trafficking, defining the identity and routing of vesicles. Shown in parentheses are
59:
networks, and membrane fusion. These processes make up the route through which cell surface proteins are trafficked from the Golgi to the plasma membrane and are recycled. Surface protein recycling returns proteins to the surface whose function involves carrying another protein or substance inside
103:
Rabs switch between two conformations, an inactive form bound to GDP (guanosine diphosphate), and an active form bound to GTP (guanosine triphosphate). A guanine nucleotide exchange factor (GEF) catalyzes the conversion from GDP-bound to GTP-bound form, thereby activating the Rab. The inherent GTP
108:
leading to Rab inactivation. REPs carry only the GDP-bound form of Rab, and Rab effectors, proteins with which Rab interacts and through which it functions, only bind the GTP-bound form of Rab. Rab effectors are very heterogeneous, and each Rab isoform has many effectors through which it carries
109:
out multiple functions. The specific binding of the effector to the Rab protein allows the Rab protein to be effective, and conversely, the conformation shift of the Rab protein to the inactive state leads to effector dissociation from the Rab protein.
99:
can then insert into the membrane, anchoring Rab at the cytoplasmic face of a vesicle or the plasma membrane. Because Rab proteins are anchored to the membrane through a flexible C-terminal region, they can be thought of as a 'balloon on a string'.
164:(REP-1). REP-1 and REP-2 (a REP-1 like protein) both help with the prenylation and transport of Rab proteins. Rab27 has been found to preferentially depend on REP-1 for prenylation, which could be the underlying cause of choroideremia.
194:
formation and social interaction patterns. It is noted that the social and behavioral patterns exhibited in mice that are carriers of the GDI1 protein are similar to those observed in humans with the same deletion. The loss of the
2162:
3189:
2155:
991:
Lesage S, Bras J, Cormier-Dequaire F, Condroyer C, Nicolas A, Darwent L, Guerreiro R, Majounie E, Federoff M, Heutink P, Wood NW, Gasser T, Hardy J, Tison F, Singleton A, Brice A (June 2015).
133:(GDI) binds the prenyl groups of the inactive, GDP-bound form of Rab, inhibits the exchange of GDP for GTP (which would reactivate the Rab) and delivers Rab to its original membrane.
2148:
1148:
3221:
1926:
215:. In addition to directly causing cancer, dysregulation of Rab proteins has also been linked to progression of already existent tumors, and contributing to their malignancy.
3063:
2129:
2171:
1787:
1141:
199:
gene has been shown through brain extracts of the mutant mice to lead to the accumulation of the Rab4 and Rab5 proteins, thus inhibiting their function.
2214:
2659:
3914:
3166:
2802:
2710:
2607:
2321:
2277:
3214:
3124:
60:
the cell, such as the transferrin receptor, or serves as a means of regulating the number of a certain type of protein molecules on the surface.
3444:
2204:
4419:
1134:
647:
3413:
3103:
3026:
1352:
1165:
88:
in the C-terminus. Rab escort proteins (REPs) deliver newly synthesized and prenylated Rab to its destination membrane by binding the
3207:
3146:
4113:
2555:
2685:
3058:
4004:
1916:
130:
3999:
3114:
2316:
2292:
2272:
628:"Chapter 10 - Mycobacterial Survival in Alveolar Macrophages as a Result of Coronin-1a Inhibition of Autophagosome Formation"
4269:
2921:
4021:
2873:
2326:
1640:
4384:
4069:
3386:
3079:
3054:
3045:
2907:
2560:
3991:
2187:
1161:
145:
function, and as such, when any deviation is introduced to the Rab protein cycle, physiological disease states ensue.
77:
2938:
942:
Johnson IR, Parkinson-Lawrence EJ, Keegan H, Spillane CD, Barry-O'Crowley J, Watson WR, et al. (November 2015).
80:, anchored to a membrane via a lipid group covalently linked to an amino acid. Specifically, Rabs are anchored via
1315:
1310:
4254:
4370:
4357:
4344:
4331:
4318:
4305:
4292:
4050:
3591:
3489:
3314:
3310:
3287:
3260:
3247:
3234:
105:
4264:
223:
Mutations of the Rab39b protein have been linked to X-linked intellectual disability and also to a rare form of
4218:
4161:
3605:
3300:
3265:
3238:
3161:
2748:
2251:
2233:
2096:
1120:
51:. Rab GTPases regulate many steps of membrane trafficking, including vesicle formation, vesicle movement along
4166:
3975:
3938:
3277:
2954:
2664:
2634:
2619:
2582:
1581:
183:
3705:
3345:
2242:
224:
1126:
4187:
4106:
3835:
3743:
3035:
2846:
2614:
627:
4259:
2438:
1652:
4414:
4223:
4040:
3017:
2890:
1866:
1817:
1778:
1719:
626:
Seto, Shintaro; Tsujimura, Kunio; Horii, Toshinobu; Koide, Yukio (2014-01-01), Hayat, M. A. (ed.),
129:
After membrane fusion and effector dissociation, Rab is recycled back to its membrane of origin. A
4156:
4055:
3621:
3199:
2423:
2388:
2063:
161:
2140:
993:"Loss-of-function mutations in RAB39B are associated with typical early-onset Parkinson disease"
893:
Johnson IR, Parkinson-Lawrence EJ, Shandala T, Weigert R, Butler LM, Brooks DA (December 2014).
68:
722:
Seabra MC, Mules EH, Hume AN (January 2002). "Rab GTPases, intracellular traffic and disease".
3295:
2311:
2267:
1095:
1022:
973:
924:
875:
834:
793:
739:
699:
643:
605:
191:
178:
gene, which encodes a guanosine nucleotide dissociation inhibitor, have been shown to lead to
1940:
4202:
4197:
4171:
4099:
3685:
3631:
3613:
3479:
3469:
3423:
2282:
2260:
2256:
1330:
1320:
1174:
1157:
1085:
1012:
1004:
963:
955:
914:
906:
865:
824:
783:
773:
731:
689:
681:
635:
595:
585:
535:
3498:
2979:
2520:
2112:
1846:
1768:
1568:
1468:
1463:
1458:
1443:
1433:
1292:
1287:
525:
485:
425:
376:
4249:
4233:
4146:
4032:
3735:
3435:
3255:
3002:
2997:
2758:
2753:
2729:
2724:
2690:
2515:
2339:
1423:
1340:
1192:
1183:
1116:
1074:"The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration"
28:
4398:
4287:
4228:
3355:
2701:
1017:
992:
968:
943:
919:
894:
788:
761:
694:
669:
639:
212:
208:
829:
812:
735:
600:
4408:
4192:
4151:
3899:
3509:
2780:
2719:
2592:
2089:
1484:
1380:
1348:
153:
48:
590:
207:
Evidence shows that overexpression of Rab GTPases have a striking relationship with
4141:
3884:
3857:
3786:
3779:
3762:
3757:
3731:
2736:
2574:
2022:
1626:
1577:
1497:
944:"Endosomal gene expression: a new indicator for prostate cancer patient prognosis?"
96:
1072:
Kessler D, Gruen GC, Heider D, Morgner J, Reis H, Schmid KW, Jendrossek V (2012).
910:
632:
Autophagy: Cancer, Other
Pathologies, Inflammation, Immunity, Infection, and Aging
1008:
573:
4365:
4300:
4136:
3980:
2639:
2209:
1548:
1528:
89:
4393:
685:
3965:
3654:
2829:
2624:
2301:
1694:
1689:
1684:
1232:
778:
44:
32:
3151:
959:
870:
853:
4339:
4313:
3671:
3230:
3093:
2306:
2224:
1935:
811:
Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL (January 1994).
142:
1099:
1026:
977:
928:
797:
743:
703:
609:
879:
838:
2003:
1680:
1672:
1644:
1599:
1523:
1489:
1212:
179:
85:
895:"Altered endosome biogenesis in prostate cancer has biomarker potential"
4076:
4045:
3823:
3818:
3577:
3567:
3542:
3537:
3272:
3171:
2895:
2741:
2030:
2008:
1543:
1301:
92:, insoluble prenyl groups and carrying Rab through the cytoplasm. The
56:
24:
1090:
1073:
4352:
4122:
3953:
3595:
3572:
3562:
3532:
3527:
3522:
3517:
3474:
3464:
3459:
3454:
3449:
3418:
3406:
3401:
3396:
3391:
3379:
3374:
3369:
3318:
3176:
2964:
2959:
2669:
2105:
2100:
1608:
1604:
1325:
1305:
1205:
1200:
434:
81:
40:
813:"REP-2, a Rab escort protein encoded by the choroideremia-like gene"
4326:
4009:
3948:
3931:
3926:
3774:
3752:
3718:
3713:
3698:
3676:
3664:
3659:
3649:
3644:
3639:
3364:
3340:
2974:
2969:
2931:
2916:
2883:
2878:
2839:
2834:
2822:
2817:
2812:
2807:
2795:
2773:
2768:
2763:
2540:
2535:
2530:
2525:
2485:
2480:
2418:
2413:
2408:
2403:
2378:
2373:
2368:
2363:
2358:
2353:
2348:
1903:
1890:
1885:
1880:
1875:
1856:
1851:
1841:
1836:
1831:
1826:
1807:
1802:
1797:
1792:
1763:
1758:
1753:
1748:
1743:
1738:
1733:
1728:
1630:
1617:
1613:
1591:
1563:
1558:
1538:
1533:
1501:
1453:
1448:
1438:
1366:
1361:
1356:
1282:
1277:
1272:
1267:
1262:
1222:
1217:
552:
515:
505:
495:
475:
465:
455:
445:
415:
406:
396:
367:
358:
347:
336:
326:
317:
307:
298:
288:
279:
269:
93:
52:
36:
4014:
3970:
3958:
3943:
3909:
3904:
3889:
3872:
3867:
3862:
3850:
3845:
3840:
3830:
3806:
3801:
3796:
3791:
3693:
3156:
3141:
2926:
2866:
2861:
2856:
2851:
2790:
2785:
2629:
2602:
2597:
2510:
2505:
2500:
2495:
2490:
2467:
2462:
2457:
2452:
2447:
2398:
2393:
2383:
2082:
2077:
2072:
2067:
2045:
2040:
2035:
1987:
1982:
1966:
1961:
1956:
1662:
1657:
1553:
1515:
1428:
1418:
1413:
1408:
1403:
1398:
1393:
1388:
1257:
1252:
1247:
1242:
1237:
1227:
385:
258:
174:
72:
The four steps of Rab protein vesicle transport (listed in text)
4095:
3203:
2144:
1130:
4064:
4060:
3190:
deficiencies of intracellular signaling peptides and proteins
1040:
854:"Deficient Geranylgeranylation of Ram/Rab27 in Choroideremia"
670:"Role of Rab GTPases in membrane traffic and cell physiology"
35:. Approximately 70 types of Rabs have now been identified in
4091:
186:. In a study done on mice, carriers for a deletion of the
141:
Rab proteins and their functions are essential to proper
112:
Effector proteins have one of four different functions.
1058:
510:
Small-scale transport, promoter for tumor development
4382:
490:
Golgi, mitochondria, early phagosome, early endosome
4278:
4242:
4211:
4180:
4129:
4030:
3989:
3729:
3603:
3590:
3555:
3507:
3488:
3434:
3354:
3333:
3326:
3309:
3286:
3246:
3134:
3113:
3092:
3072:
3044:
3025:
3015:
2990:
2947:
2906:
2709:
2699:
2678:
2652:
2573:
2291:
2241:
2232:
2223:
2197:
2178:
2056:
2021:
1996:
1975:
1949:
1925:
1865:
1816:
1777:
1718:
1711:
1704:
1671:
1639:
1590:
1514:
1477:
1379:
1339:
1191:
1182:
1173:
3064:Sh2 domain-containing protein tyrosine phosphatase
440:Recycling endosomes, post-Golgi exocytic carriers
156:is caused by a loss-of-function mutation in the
852:Seabra MC, Ho YK, Anant JS (October 13, 1995).
634:, Amsterdam: Academic Press, pp. 161–170,
4107:
3215:
2172:Intracellular signaling peptides and proteins
2156:
1142:
480:Lipid droplets, golgi, endoplasmic reticulum
8:
762:"Rab-mediated vesicle trafficking in cancer"
236:the equivalent names in the model organisms
331:Clathrin-coated vesicles, plasma membranes
4114:
4100:
4092:
3600:
3330:
3323:
3222:
3208:
3200:
3059:Receptor-like protein tyrosine phosphatase
3022:
2706:
2238:
2229:
2163:
2149:
2141:
1715:
1708:
1188:
1179:
1149:
1135:
1127:
450:Golgi, endosome, cytosol, plasma membrane
2660:Cyclin-dependent kinase inhibitor protein
1119:at the U.S. National Library of Medicine
1089:
1016:
967:
918:
869:
828:
787:
777:
693:
668:Hutagalung AH, Novick PJ (January 2011).
599:
589:
3167:Phosphatidylethanolamine binding protein
2803:Interleukin-1 receptor associated kinase
2215:Ca2+/calmodulin-dependent protein kinase
246:
190:gene have shown marked abnormalities in
104:hydrolysis of Rabs can be enhanced by a
67:
4389:
564:
43:fold, which consists of a six-stranded
2922:Focal adhesion protein-tyrosine kinase
2205:Intracellular calcium-sensing proteins
2130:vesicular transport protein disorders
1059:"Aspergillus Genome Database (AspGD)"
1041:"Saccharomyces Genome Database (SGD)"
116:Cargo budding, selection, and coating
7:
1078:Cellular Physiology and Biochemistry
755:
753:
717:
715:
713:
621:
619:
858:The Journal of Biological Chemistry
817:The Journal of Biological Chemistry
420:Late endosome, trans-golgi network
39:. Rab proteins generally possess a
3147:Signal transducing adaptor protein
2322:3',5'-cyclic-GMP phosphodiesterase
2278:3',5'-cyclic-AMP phosphodiesterase
760:Tzeng HT, Wang YC (October 2016).
640:10.1016/b978-0-12-405877-4.00010-x
14:
3142:Activating transcription factor 6
2556:G protein-coupled receptor kinase
520:Extracellular vesicles, endosome
4392:
2686:Phosphoinositide phospholipase C
572:Stenmark H, Olkkonen VM (2001).
540:Binds Caspase-1 in inflammasome
293:Secretory and synaptic vesicles
591:10.1186/gb-2001-2-5-reviews3007
401:Basolateral secretory vesicles
122:Vesicle uncoating and tethering
106:GTPase-activating protein (GAP)
3125:GTP-binding protein regulators
3115:GTP-binding protein regulators
353:Golgi and trans-Golgi network
16:Family of GTP-binding proteins
1:
2874:Rho-associated protein kinase
911:10.1158/1541-7786.MCR-14-0074
830:10.1016/S0021-9258(17)42142-9
766:Journal of Biomedical Science
736:10.1016/s1471-4914(01)02227-4
4420:Peripheral membrane proteins
3080:Dual-specificity phosphatase
3055:protein tyrosine phosphatase
2561:AMP-activated protein kinase
1162:vesicular transport proteins
1009:10.1212/NXG.0000000000000009
724:Trends in Molecular Medicine
78:peripheral membrane proteins
3992:Protein-synthesizing GTPase
3104:apoptosis signaling pathway
4436:
686:10.1152/physrev.00059.2009
131:GDP dissociation inhibitor
4270:Michaelis–Menten kinetics
4051:Guanylate-binding protein
3235:acid anhydride hydrolases
3185:
2948:Serine/threonine/tyrosine
2551:
2434:
2335:
2125:
1912:
1899:
1867:Adaptor protein complex 4
1818:Adaptor protein complex 3
1779:Adaptor protein complex 2
1720:Adaptor protein complex 1
899:Molecular Cancer Research
779:10.1186/s12929-016-0287-7
391:Late endosomes, vacuoles
47:which is flanked by five
4162:Diffusion-limited enzyme
3606:Heterotrimeric G protein
3301:Phosphoadenylylsulfatase
3162:Olfactory marker protein
2749:Glycogen synthase kinase
2252:Heterotrimeric G protein
2097:Vacuolar protein sorting
1121:Medical Subject Headings
960:10.18632/oncotarget.6114
871:10.1074/jbc.270.41.24420
238:Saccharomyces cerevisiae
3278:Thiamine-triphosphatase
2955:Dual-specificity kinase
2665:Cyclin-dependent kinase
574:"The Rab GTPase family"
218:
184:intellectual disability
168:Intellectual disability
1061:. Stanford University.
1047:. Stanford University.
530:Recruits LRRK2 to TGN
274:ER, cis-Golgi network
73:
4255:Eadie–Hofstee diagram
4188:Allosteric regulation
4033:Polymerization motors
3744:Rho family of GTPases
3036:Protein phosphatase 2
2847:p21-activated kinases
674:Physiological Reviews
253:Subcellular location
231:Types of Rab proteins
203:Cancer/carcinogenesis
160:gene which codes for
137:Clinical significance
71:
4265:Lineweaver–Burk plot
2439:G beta-gamma complex
312:Recycling endosomes
242:Aspergillus nidulans
4041:dynamin superfamily
3018:protein phosphatase
2891:Ribosomal s6 kinase
997:Neurology. Genetics
864:(41): 24420–24427.
225:Parkinson's disease
219:Parkinson's disease
27:is a member of the
4224:Enzyme superfamily
4157:Enzyme promiscuity
2188:MAP kinase pathway
2064:EHD protein family
584:(5): REVIEWS3007.
547:Other Rab proteins
162:Rab escort protein
74:
4380:
4379:
4089:
4088:
4085:
4084:
3586:
3585:
3551:
3550:
3296:Adenylylsulfatase
3197:
3196:
3152:I-kappa B protein
3088:
3087:
3011:
3010:
2648:
2647:
2569:
2568:
2312:Guanylate cyclase
2268:Adenylate cyclase
2138:
2137:
2121:
2120:
2017:
2016:
1712:Vesicle formation
1510:
1509:
1375:
1374:
1091:10.1159/000295249
649:978-0-12-405877-4
544:
543:
192:short-term memory
172:Mutations in the
119:Vesicle transport
76:Rab proteins are
4427:
4397:
4396:
4388:
4260:Hanes–Woolf plot
4203:Enzyme activator
4198:Enzyme inhibitor
4172:Enzyme catalysis
4116:
4109:
4102:
4093:
3601:
3331:
3324:
3224:
3217:
3210:
3201:
3027:Serine/threonine
3023:
2711:Serine/threonine
2707:
2327:Protein kinase G
2283:Protein kinase A
2239:
2230:
2165:
2158:
2151:
2142:
1716:
1709:
1189:
1180:
1175:Synaptic vesicle
1158:Membrane protein
1151:
1144:
1137:
1128:
1104:
1103:
1093:
1069:
1063:
1062:
1055:
1049:
1048:
1045:Yeast Genome Org
1037:
1031:
1030:
1020:
988:
982:
981:
971:
954:(35): 37919–29.
939:
933:
932:
922:
890:
884:
883:
873:
849:
843:
842:
832:
808:
802:
801:
791:
781:
757:
748:
747:
719:
708:
707:
697:
665:
659:
658:
657:
656:
623:
614:
613:
603:
593:
569:
500:Plasma membrane
460:Early endosomes
342:Early endosomes
247:
4435:
4434:
4430:
4429:
4428:
4426:
4425:
4424:
4405:
4404:
4403:
4391:
4383:
4381:
4376:
4288:Oxidoreductases
4274:
4250:Enzyme kinetics
4238:
4234:List of enzymes
4207:
4176:
4147:Catalytic triad
4125:
4120:
4090:
4081:
4026:
3985:
3736:Ras superfamily
3725:
3709:
3689:
3635:
3625:
3617:
3582:
3547:
3503:
3484:
3430:
3387:Plasma membrane
3350:
3305:
3282:
3256:Pyrophosphatase
3242:
3228:
3198:
3193:
3181:
3130:
3109:
3084:
3068:
3040:
3007:
2998:Arginine kinase
2986:
2943:
2902:
2695:
2691:Phospholipase C
2674:
2644:
2565:
2547:
2477:
2444:
2430:
2345:
2340:G alpha subunit
2331:
2287:
2219:
2193:
2174:
2169:
2139:
2134:
2133:
2117:
2052:
2013:
1992:
1971:
1945:
1921:
1908:
1895:
1861:
1812:
1773:
1705:Other/ungrouped
1700:
1667:
1635:
1586:
1506:
1492:
1473:
1371:
1335:
1169:
1155:
1113:
1108:
1107:
1084:(5–6): 647–56.
1071:
1070:
1066:
1057:
1056:
1052:
1039:
1038:
1034:
990:
989:
985:
941:
940:
936:
905:(12): 1851–62.
892:
891:
887:
851:
850:
846:
810:
809:
805:
759:
758:
751:
721:
720:
711:
667:
666:
662:
654:
652:
650:
625:
624:
617:
571:
570:
566:
561:
549:
233:
221:
205:
170:
151:
139:
66:
29:Ras superfamily
17:
12:
11:
5:
4433:
4431:
4423:
4422:
4417:
4407:
4406:
4402:
4401:
4378:
4377:
4375:
4374:
4361:
4348:
4335:
4322:
4309:
4296:
4282:
4280:
4276:
4275:
4273:
4272:
4267:
4262:
4257:
4252:
4246:
4244:
4240:
4239:
4237:
4236:
4231:
4226:
4221:
4215:
4213:
4212:Classification
4209:
4208:
4206:
4205:
4200:
4195:
4190:
4184:
4182:
4178:
4177:
4175:
4174:
4169:
4164:
4159:
4154:
4149:
4144:
4139:
4133:
4131:
4127:
4126:
4121:
4119:
4118:
4111:
4104:
4096:
4087:
4086:
4083:
4082:
4080:
4079:
4074:
4073:
4072:
4067:
4058:
4053:
4048:
4037:
4035:
4028:
4027:
4025:
4024:
4019:
4018:
4017:
4012:
4007:
3996:
3994:
3987:
3986:
3984:
3983:
3978:
3973:
3968:
3963:
3962:
3961:
3956:
3951:
3946:
3936:
3935:
3934:
3929:
3919:
3918:
3917:
3912:
3907:
3895:
3894:
3893:
3892:
3887:
3877:
3876:
3875:
3870:
3865:
3855:
3854:
3853:
3848:
3843:
3833:
3828:
3827:
3826:
3821:
3811:
3810:
3809:
3804:
3799:
3794:
3784:
3783:
3782:
3777:
3767:
3766:
3765:
3760:
3755:
3740:
3738:
3727:
3726:
3724:
3723:
3722:
3721:
3716:
3707:
3703:
3702:
3701:
3696:
3687:
3683:
3682:
3681:
3680:
3679:
3669:
3668:
3667:
3662:
3652:
3647:
3642:
3633:
3629:
3628:
3627:
3623:
3615:
3610:
3608:
3598:
3588:
3587:
3584:
3583:
3581:
3580:
3575:
3570:
3565:
3559:
3557:
3553:
3552:
3549:
3548:
3546:
3545:
3540:
3535:
3530:
3525:
3520:
3514:
3512:
3505:
3504:
3502:
3501:
3495:
3493:
3486:
3485:
3483:
3482:
3477:
3472:
3467:
3462:
3457:
3452:
3447:
3441:
3439:
3432:
3431:
3429:
3428:
3427:
3426:
3421:
3411:
3410:
3409:
3404:
3399:
3394:
3384:
3383:
3382:
3377:
3372:
3361:
3359:
3352:
3351:
3349:
3348:
3343:
3337:
3335:
3334:Cu++ (3.6.3.4)
3328:
3321:
3307:
3306:
3304:
3303:
3298:
3292:
3290:
3284:
3283:
3281:
3280:
3275:
3270:
3269:
3268:
3263:
3252:
3250:
3244:
3243:
3229:
3227:
3226:
3219:
3212:
3204:
3195:
3194:
3186:
3183:
3182:
3180:
3179:
3174:
3169:
3164:
3159:
3154:
3149:
3144:
3138:
3136:
3132:
3131:
3129:
3128:
3119:
3117:
3111:
3110:
3108:
3107:
3098:
3096:
3090:
3089:
3086:
3085:
3083:
3082:
3076:
3074:
3070:
3069:
3067:
3066:
3061:
3051:
3049:
3042:
3041:
3039:
3038:
3032:
3030:
3020:
3013:
3012:
3009:
3008:
3006:
3005:
3000:
2994:
2992:
2988:
2987:
2985:
2984:
2983:
2982:
2977:
2972:
2967:
2962:
2951:
2949:
2945:
2944:
2942:
2941:
2936:
2935:
2934:
2929:
2919:
2913:
2911:
2904:
2903:
2901:
2900:
2899:
2898:
2888:
2887:
2886:
2881:
2871:
2870:
2869:
2864:
2859:
2854:
2844:
2843:
2842:
2837:
2827:
2826:
2825:
2820:
2815:
2810:
2800:
2799:
2798:
2793:
2788:
2778:
2777:
2776:
2771:
2766:
2761:
2756:
2746:
2745:
2744:
2734:
2733:
2732:
2727:
2716:
2714:
2704:
2702:protein kinase
2697:
2696:
2694:
2693:
2688:
2682:
2680:
2676:
2675:
2673:
2672:
2667:
2662:
2656:
2654:
2650:
2649:
2646:
2645:
2643:
2642:
2637:
2632:
2627:
2622:
2617:
2612:
2611:
2610:
2605:
2600:
2590:
2585:
2579:
2577:
2571:
2570:
2567:
2566:
2564:
2563:
2558:
2552:
2549:
2548:
2546:
2545:
2544:
2543:
2538:
2533:
2528:
2523:
2518:
2513:
2508:
2503:
2498:
2493:
2488:
2483:
2475:
2472:
2471:
2470:
2465:
2460:
2455:
2450:
2442:
2435:
2432:
2431:
2429:
2428:
2427:
2426:
2421:
2416:
2411:
2406:
2401:
2396:
2391:
2386:
2381:
2376:
2371:
2366:
2361:
2356:
2351:
2343:
2336:
2333:
2332:
2330:
2329:
2324:
2319:
2314:
2309:
2304:
2298:
2296:
2289:
2288:
2286:
2285:
2280:
2275:
2270:
2265:
2264:
2263:
2248:
2246:
2236:
2234:Heterotrimeric
2227:
2221:
2220:
2218:
2217:
2212:
2207:
2201:
2199:
2195:
2194:
2192:
2191:
2182:
2180:
2176:
2175:
2170:
2168:
2167:
2160:
2153:
2145:
2136:
2135:
2126:
2123:
2122:
2119:
2118:
2116:
2115:
2109:
2108:
2103:
2093:
2092:
2090:Sorting nexins
2086:
2085:
2080:
2075:
2070:
2060:
2058:
2054:
2053:
2051:
2050:
2049:
2048:
2043:
2038:
2027:
2025:
2019:
2018:
2015:
2014:
2012:
2011:
2006:
2000:
1998:
1994:
1993:
1991:
1990:
1985:
1979:
1977:
1973:
1972:
1970:
1969:
1964:
1959:
1953:
1951:
1947:
1946:
1944:
1943:
1938:
1932:
1930:
1923:
1922:
1920:
1919:
1913:
1910:
1909:
1907:
1906:
1900:
1897:
1896:
1894:
1893:
1888:
1883:
1878:
1872:
1870:
1863:
1862:
1860:
1859:
1854:
1849:
1844:
1839:
1834:
1829:
1823:
1821:
1814:
1813:
1811:
1810:
1805:
1800:
1795:
1790:
1784:
1782:
1775:
1774:
1772:
1771:
1766:
1761:
1756:
1751:
1746:
1741:
1736:
1731:
1725:
1723:
1713:
1706:
1702:
1701:
1699:
1698:
1692:
1687:
1677:
1675:
1669:
1668:
1666:
1665:
1660:
1655:
1649:
1647:
1637:
1636:
1634:
1633:
1623:
1622:
1621:
1620:
1611:
1596:
1594:
1588:
1587:
1585:
1584:
1574:
1573:
1572:
1571:
1566:
1561:
1556:
1551:
1546:
1541:
1536:
1531:
1520:
1518:
1512:
1511:
1508:
1507:
1505:
1504:
1494:
1493:
1487:
1481:
1479:
1475:
1474:
1472:
1471:
1466:
1461:
1456:
1451:
1446:
1441:
1436:
1431:
1426:
1421:
1416:
1411:
1406:
1401:
1396:
1391:
1385:
1383:
1377:
1376:
1373:
1372:
1370:
1369:
1364:
1359:
1345:
1343:
1337:
1336:
1334:
1333:
1328:
1323:
1318:
1313:
1308:
1298:
1297:
1296:
1295:
1290:
1285:
1280:
1275:
1270:
1265:
1260:
1255:
1250:
1245:
1240:
1235:
1230:
1225:
1220:
1209:
1208:
1203:
1197:
1195:
1186:
1177:
1171:
1170:
1156:
1154:
1153:
1146:
1139:
1131:
1125:
1124:
1117:rab+G-Proteins
1112:
1111:External links
1109:
1106:
1105:
1064:
1050:
1032:
983:
934:
885:
844:
803:
749:
709:
660:
648:
615:
578:Genome Biology
563:
562:
560:
557:
556:
555:
548:
545:
542:
541:
538:
532:
531:
528:
522:
521:
518:
512:
511:
508:
502:
501:
498:
492:
491:
488:
482:
481:
478:
472:
471:
468:
462:
461:
458:
452:
451:
448:
442:
441:
438:
437:(Ypt31, RabE)
431:
430:
428:
422:
421:
418:
412:
411:
409:
403:
402:
399:
393:
392:
389:
382:
381:
379:
373:
372:
370:
364:
363:
361:
355:
354:
351:
344:
343:
340:
339:(Vps21, RabB)
333:
332:
329:
323:
322:
320:
314:
313:
310:
304:
303:
301:
295:
294:
291:
285:
284:
282:
276:
275:
272:
266:
265:
264:Golgi complex
262:
255:
254:
251:
232:
229:
220:
217:
213:gastric cancer
209:carcinogenesis
204:
201:
169:
166:
150:
147:
138:
135:
127:
126:
125:Vesicle fusion
123:
120:
117:
84:groups on two
65:
62:
15:
13:
10:
9:
6:
4:
3:
2:
4432:
4421:
4418:
4416:
4413:
4412:
4410:
4400:
4395:
4390:
4386:
4372:
4368:
4367:
4362:
4359:
4355:
4354:
4349:
4346:
4342:
4341:
4336:
4333:
4329:
4328:
4323:
4320:
4316:
4315:
4310:
4307:
4303:
4302:
4297:
4294:
4290:
4289:
4284:
4283:
4281:
4277:
4271:
4268:
4266:
4263:
4261:
4258:
4256:
4253:
4251:
4248:
4247:
4245:
4241:
4235:
4232:
4230:
4229:Enzyme family
4227:
4225:
4222:
4220:
4217:
4216:
4214:
4210:
4204:
4201:
4199:
4196:
4194:
4193:Cooperativity
4191:
4189:
4186:
4185:
4183:
4179:
4173:
4170:
4168:
4165:
4163:
4160:
4158:
4155:
4153:
4152:Oxyanion hole
4150:
4148:
4145:
4143:
4140:
4138:
4135:
4134:
4132:
4128:
4124:
4117:
4112:
4110:
4105:
4103:
4098:
4097:
4094:
4078:
4075:
4071:
4068:
4066:
4062:
4059:
4057:
4054:
4052:
4049:
4047:
4044:
4043:
4042:
4039:
4038:
4036:
4034:
4029:
4023:
4020:
4016:
4013:
4011:
4008:
4006:
4003:
4002:
4001:
3998:
3997:
3995:
3993:
3988:
3982:
3979:
3977:
3974:
3972:
3969:
3967:
3964:
3960:
3957:
3955:
3952:
3950:
3947:
3945:
3942:
3941:
3940:
3937:
3933:
3930:
3928:
3925:
3924:
3923:
3920:
3916:
3913:
3911:
3908:
3906:
3903:
3902:
3901:
3897:
3896:
3891:
3888:
3886:
3883:
3882:
3881:
3878:
3874:
3871:
3869:
3866:
3864:
3861:
3860:
3859:
3856:
3852:
3849:
3847:
3844:
3842:
3839:
3838:
3837:
3834:
3832:
3829:
3825:
3822:
3820:
3817:
3816:
3815:
3812:
3808:
3805:
3803:
3800:
3798:
3795:
3793:
3790:
3789:
3788:
3785:
3781:
3778:
3776:
3773:
3772:
3771:
3768:
3764:
3761:
3759:
3756:
3754:
3751:
3750:
3749:
3745:
3742:
3741:
3739:
3737:
3733:
3728:
3720:
3717:
3715:
3712:
3711:
3710:
3704:
3700:
3697:
3695:
3692:
3691:
3690:
3684:
3678:
3675:
3674:
3673:
3670:
3666:
3663:
3661:
3658:
3657:
3656:
3653:
3651:
3648:
3646:
3643:
3641:
3638:
3637:
3636:
3630:
3626:
3620:
3619:
3618:
3612:
3611:
3609:
3607:
3602:
3599:
3597:
3593:
3589:
3579:
3576:
3574:
3571:
3569:
3566:
3564:
3561:
3560:
3558:
3554:
3544:
3541:
3539:
3536:
3534:
3531:
3529:
3526:
3524:
3521:
3519:
3516:
3515:
3513:
3511:
3510:P-type ATPase
3506:
3500:
3497:
3496:
3494:
3491:
3487:
3481:
3478:
3476:
3473:
3471:
3468:
3466:
3463:
3461:
3458:
3456:
3453:
3451:
3448:
3446:
3443:
3442:
3440:
3437:
3433:
3425:
3422:
3420:
3417:
3416:
3415:
3412:
3408:
3405:
3403:
3400:
3398:
3395:
3393:
3390:
3389:
3388:
3385:
3381:
3378:
3376:
3373:
3371:
3368:
3367:
3366:
3363:
3362:
3360:
3357:
3353:
3347:
3344:
3342:
3339:
3338:
3336:
3332:
3329:
3325:
3322:
3320:
3316:
3312:
3308:
3302:
3299:
3297:
3294:
3293:
3291:
3289:
3285:
3279:
3276:
3274:
3271:
3267:
3264:
3262:
3259:
3258:
3257:
3254:
3253:
3251:
3249:
3245:
3240:
3236:
3232:
3225:
3220:
3218:
3213:
3211:
3206:
3205:
3202:
3192:
3191:
3184:
3178:
3175:
3173:
3170:
3168:
3165:
3163:
3160:
3158:
3155:
3153:
3150:
3148:
3145:
3143:
3140:
3139:
3137:
3133:
3127:
3126:
3121:
3120:
3118:
3116:
3112:
3106:
3105:
3100:
3099:
3097:
3095:
3091:
3081:
3078:
3077:
3075:
3071:
3065:
3062:
3060:
3056:
3053:
3052:
3050:
3047:
3043:
3037:
3034:
3033:
3031:
3028:
3024:
3021:
3019:
3014:
3004:
3001:
2999:
2996:
2995:
2993:
2989:
2981:
2978:
2976:
2973:
2971:
2968:
2966:
2963:
2961:
2958:
2957:
2956:
2953:
2952:
2950:
2946:
2940:
2937:
2933:
2930:
2928:
2925:
2924:
2923:
2920:
2918:
2915:
2914:
2912:
2909:
2905:
2897:
2894:
2893:
2892:
2889:
2885:
2882:
2880:
2877:
2876:
2875:
2872:
2868:
2865:
2863:
2860:
2858:
2855:
2853:
2850:
2849:
2848:
2845:
2841:
2838:
2836:
2833:
2832:
2831:
2828:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2805:
2804:
2801:
2797:
2794:
2792:
2789:
2787:
2784:
2783:
2782:
2779:
2775:
2772:
2770:
2767:
2765:
2762:
2760:
2757:
2755:
2752:
2751:
2750:
2747:
2743:
2740:
2739:
2738:
2735:
2731:
2728:
2726:
2723:
2722:
2721:
2720:Casein kinase
2718:
2717:
2715:
2712:
2708:
2705:
2703:
2698:
2692:
2689:
2687:
2684:
2683:
2681:
2677:
2671:
2668:
2666:
2663:
2661:
2658:
2657:
2655:
2651:
2641:
2638:
2636:
2633:
2631:
2628:
2626:
2623:
2621:
2618:
2616:
2613:
2609:
2606:
2604:
2601:
2599:
2596:
2595:
2594:
2591:
2589:
2586:
2584:
2581:
2580:
2578:
2576:
2572:
2562:
2559:
2557:
2554:
2553:
2550:
2542:
2539:
2537:
2534:
2532:
2529:
2527:
2524:
2522:
2519:
2517:
2514:
2512:
2509:
2507:
2504:
2502:
2499:
2497:
2494:
2492:
2489:
2487:
2484:
2482:
2479:
2478:
2473:
2469:
2466:
2464:
2461:
2459:
2456:
2454:
2451:
2449:
2446:
2445:
2440:
2437:
2436:
2433:
2425:
2422:
2420:
2417:
2415:
2412:
2410:
2407:
2405:
2402:
2400:
2397:
2395:
2392:
2390:
2387:
2385:
2382:
2380:
2377:
2375:
2372:
2370:
2367:
2365:
2362:
2360:
2357:
2355:
2352:
2350:
2347:
2346:
2341:
2338:
2337:
2334:
2328:
2325:
2323:
2320:
2318:
2315:
2313:
2310:
2308:
2305:
2303:
2300:
2299:
2297:
2294:
2290:
2284:
2281:
2279:
2276:
2274:
2271:
2269:
2266:
2262:
2258:
2255:
2254:
2253:
2250:
2249:
2247:
2244:
2240:
2237:
2235:
2231:
2228:
2226:
2222:
2216:
2213:
2211:
2208:
2206:
2203:
2202:
2200:
2196:
2190:
2189:
2184:
2183:
2181:
2177:
2173:
2166:
2161:
2159:
2154:
2152:
2147:
2146:
2143:
2132:
2131:
2124:
2114:
2111:
2110:
2107:
2104:
2102:
2098:
2095:
2094:
2091:
2088:
2087:
2084:
2081:
2079:
2076:
2074:
2071:
2069:
2065:
2062:
2061:
2059:
2055:
2047:
2044:
2042:
2039:
2037:
2034:
2033:
2032:
2029:
2028:
2026:
2024:
2020:
2010:
2007:
2005:
2002:
2001:
1999:
1995:
1989:
1986:
1984:
1981:
1980:
1978:
1974:
1968:
1965:
1963:
1960:
1958:
1955:
1954:
1952:
1948:
1942:
1939:
1937:
1934:
1933:
1931:
1928:
1924:
1918:
1915:
1914:
1911:
1905:
1902:
1901:
1898:
1892:
1889:
1887:
1884:
1882:
1879:
1877:
1874:
1873:
1871:
1868:
1864:
1858:
1855:
1853:
1850:
1848:
1845:
1843:
1840:
1838:
1835:
1833:
1830:
1828:
1825:
1824:
1822:
1819:
1815:
1809:
1806:
1804:
1801:
1799:
1796:
1794:
1791:
1789:
1786:
1785:
1783:
1780:
1776:
1770:
1767:
1765:
1762:
1760:
1757:
1755:
1752:
1750:
1747:
1745:
1742:
1740:
1737:
1735:
1732:
1730:
1727:
1726:
1724:
1721:
1717:
1714:
1710:
1707:
1703:
1696:
1693:
1691:
1688:
1686:
1682:
1679:
1678:
1676:
1674:
1670:
1664:
1661:
1659:
1656:
1654:
1651:
1650:
1648:
1646:
1642:
1638:
1632:
1628:
1625:
1624:
1619:
1615:
1612:
1610:
1606:
1603:
1602:
1601:
1598:
1597:
1595:
1593:
1589:
1583:
1579:
1576:
1575:
1570:
1567:
1565:
1562:
1560:
1557:
1555:
1552:
1550:
1547:
1545:
1542:
1540:
1537:
1535:
1532:
1530:
1527:
1526:
1525:
1522:
1521:
1519:
1517:
1513:
1503:
1499:
1496:
1495:
1491:
1488:
1486:
1485:Synaptophysin
1483:
1482:
1480:
1476:
1470:
1467:
1465:
1462:
1460:
1457:
1455:
1452:
1450:
1447:
1445:
1442:
1440:
1437:
1435:
1432:
1430:
1427:
1425:
1422:
1420:
1417:
1415:
1412:
1410:
1407:
1405:
1402:
1400:
1397:
1395:
1392:
1390:
1387:
1386:
1384:
1382:
1381:Synaptotagmin
1378:
1368:
1365:
1363:
1360:
1358:
1354:
1350:
1349:Synaptobrevin
1347:
1346:
1344:
1342:
1338:
1332:
1329:
1327:
1324:
1322:
1319:
1317:
1314:
1312:
1309:
1307:
1303:
1300:
1299:
1294:
1291:
1289:
1286:
1284:
1281:
1279:
1276:
1274:
1271:
1269:
1266:
1264:
1261:
1259:
1256:
1254:
1251:
1249:
1246:
1244:
1241:
1239:
1236:
1234:
1231:
1229:
1226:
1224:
1221:
1219:
1216:
1215:
1214:
1211:
1210:
1207:
1204:
1202:
1199:
1198:
1196:
1194:
1190:
1187:
1185:
1181:
1178:
1176:
1172:
1167:
1163:
1159:
1152:
1147:
1145:
1140:
1138:
1133:
1132:
1129:
1122:
1118:
1115:
1114:
1110:
1101:
1097:
1092:
1087:
1083:
1079:
1075:
1068:
1065:
1060:
1054:
1051:
1046:
1042:
1036:
1033:
1028:
1024:
1019:
1014:
1010:
1006:
1002:
998:
994:
987:
984:
979:
975:
970:
965:
961:
957:
953:
949:
945:
938:
935:
930:
926:
921:
916:
912:
908:
904:
900:
896:
889:
886:
881:
877:
872:
867:
863:
859:
855:
848:
845:
840:
836:
831:
826:
823:(3): 2111–7.
822:
818:
814:
807:
804:
799:
795:
790:
785:
780:
775:
771:
767:
763:
756:
754:
750:
745:
741:
737:
733:
729:
725:
718:
716:
714:
710:
705:
701:
696:
691:
687:
683:
680:(1): 119–49.
679:
675:
671:
664:
661:
651:
645:
641:
637:
633:
629:
622:
620:
616:
611:
607:
602:
597:
592:
587:
583:
579:
575:
568:
565:
558:
554:
551:
550:
546:
539:
537:
534:
533:
529:
527:
524:
523:
519:
517:
514:
513:
509:
507:
504:
503:
499:
497:
494:
493:
489:
487:
484:
483:
479:
477:
474:
473:
469:
467:
464:
463:
459:
457:
454:
453:
449:
447:
444:
443:
439:
436:
433:
432:
429:
427:
424:
423:
419:
417:
414:
413:
410:
408:
405:
404:
400:
398:
395:
394:
390:
388:(Ypt7, RabS)
387:
384:
383:
380:
378:
375:
374:
371:
369:
366:
365:
362:
360:
357:
356:
352:
350:(Ypt6, RabC)
349:
346:
345:
341:
338:
335:
334:
330:
328:
325:
324:
321:
319:
316:
315:
311:
309:
306:
305:
302:
300:
297:
296:
292:
290:
287:
286:
283:
281:
278:
277:
273:
271:
268:
267:
263:
261:(Ypt1, RabO)
260:
257:
256:
252:
249:
248:
245:
243:
239:
230:
228:
226:
216:
214:
210:
202:
200:
198:
193:
189:
185:
181:
177:
176:
167:
165:
163:
159:
155:
154:Choroideremia
149:Choroideremia
148:
146:
144:
136:
134:
132:
124:
121:
118:
115:
114:
113:
110:
107:
101:
98:
97:prenyl groups
95:
91:
87:
83:
79:
70:
63:
61:
58:
54:
50:
49:alpha helices
46:
42:
38:
34:
30:
26:
22:
4366:Translocases
4363:
4350:
4337:
4324:
4311:
4301:Transferases
4298:
4285:
4142:Binding site
3921:
3879:
3813:
3769:
3747:
3732:Small GTPase
3346:Wilson/ATP7B
3341:Menkes/ATP7A
3187:
3122:
3101:
2737:eIF-2 kinase
2587:
2185:
2127:
2023:Small GTPase
1627:Small GTPase
1578:Small GTPase
1544:COPD/Archain
1498:Small GTPase
1081:
1077:
1067:
1053:
1044:
1035:
1000:
996:
986:
951:
947:
937:
902:
898:
888:
861:
857:
847:
820:
816:
806:
769:
765:
730:(1): 23–30.
727:
723:
677:
673:
663:
653:, retrieved
631:
581:
577:
567:
241:
237:
234:
222:
206:
196:
187:
182:nonspecific
173:
171:
157:
152:
140:
128:
111:
102:
75:
20:
18:
4137:Active site
4056:Mitofusin-1
4031:3.6.5.5-6:
4000:Prokaryotic
2424:GNA15/GNA16
2210:Calcineurin
90:hydrophobic
4415:G proteins
4409:Categories
4340:Isomerases
4314:Hydrolases
4181:Regulation
4022:Eukaryotic
3655:Transducin
3492:(3.6.3.10)
3231:Hydrolases
2830:Lim kinase
2781:IκB kinase
2302:Transducin
948:Oncotarget
655:2020-11-19
559:References
45:beta sheet
33:G proteins
23:family of
4219:EC number
3990:3.6.5.3:
3730:3.6.5.2:
3672:Gustducin
3604:3.6.5.1:
3438:(3.6.3.9)
3358:(3.6.3.8)
3261:Inorganic
3188:see also
3094:Apoptosis
2575:Monomeric
2307:Gustducin
2225:G protein
2128:See also
1003:(1): e9.
772:(1): 70.
470:Endosome
143:organelle
86:cysteines
31:of small
4243:Kinetics
4167:Cofactor
4130:Activity
3266:Thiamine
3046:Tyrosine
2991:Arginine
2908:Tyrosine
2004:Retromer
1681:Caveolin
1673:Caveolae
1645:Clathrin
1600:Coatomer
1524:Coatomer
1490:Synapsin
1213:Syntaxin
1100:22613965
1027:27066548
978:26473288
929:25080433
798:27716280
744:11796263
704:21248164
610:11387043
180:X-linked
64:Function
25:proteins
4399:Biology
4353:Ligases
4123:Enzymes
4077:Tubulin
4046:Dynamin
3898:other:
3578:Katanin
3568:Kinesin
3543:ATP13A3
3538:ATP13A2
3273:Apyrase
3172:EDARADD
3157:Mucin-4
2896:RPS6KA1
2742:EIF2AK3
2198:Calcium
2031:Dynamin
1976:BLOC-3:
1950:BLOC-2:
1941:BLOC153
1341:R-SNARE
1302:Munc-18
1193:Q-SNARE
1018:4821081
969:4741974
920:4757910
880:7592656
839:8294464
789:5053131
695:3710122
57:tubulin
4385:Portal
4327:Lyases
3954:ARL13B
3814:RhoBTB
3708:α12/13
3596:GTPase
3573:Myosin
3563:Dynein
3533:ATP12A
3528:ATP11B
3523:ATP10A
3518:ATP8B1
3508:Other
3480:ATP1B4
3475:ATP1B3
3470:ATP1B2
3465:ATP1B1
3460:ATP1A4
3455:ATP1A3
3450:ATP1A2
3445:ATP1A1
3436:Na+/K+
3424:ATP2C2
3419:ATP2C1
3407:ATP2B4
3402:ATP2B3
3397:ATP2B2
3392:ATP2B1
3380:ATP2A3
3375:ATP2A2
3370:ATP2A1
3319:ATPase
3177:PRKCSH
3016:Other
2965:DYRK1B
2960:DYRK1A
2700:Other
2670:Cyclin
2653:Cyclin
2106:VPS33B
2101:VPS13B
1997:Coats:
1936:DTNBP1
1927:BLOC-1
1609:SEC24A
1605:SEC23A
1331:STXBP6
1326:STXBP5
1321:STXBP4
1316:STXBP3
1311:STXBP2
1306:STXBP1
1206:SNAP29
1201:SNAP25
1123:(MeSH)
1098:
1025:
1015:
976:
966:
927:
917:
878:
837:
796:
786:
742:
702:
692:
646:
608:
601:138937
598:
536:RAB39A
435:RAB11A
82:prenyl
41:GTPase
37:humans
4279:Types
4010:EF-Tu
3949:SAR1B
3932:RAB27
3927:RAB23
3880:RhoDF
3770:RhoUV
3753:CDC42
3748:Cdc42
3734:>
3719:GNA13
3714:GNA12
3699:GNA11
3688:αq/11
3677:GNAT3
3665:GNAT2
3660:GNAT1
3650:GNAI3
3645:GNAI2
3640:GNAI1
3592:3.6.5
3556:3.6.4
3499:ATP4A
3490:H+/K+
3365:SERCA
3327:3.6.3
3311:3.6.3
3288:3.6.2
3248:3.6.1
3135:Other
3073:both:
2980:DYRK4
2975:DYRK3
2970:DYRK2
2932:PTK2B
2917:ZAP70
2884:ROCK2
2879:ROCK1
2840:LIMK2
2835:LIMK1
2823:IRAK4
2818:IRAK3
2813:IRAK2
2808:IRAK1
2796:IKBKG
2774:GSK3B
2769:GSK3A
2764:GSK-3
2679:Lipid
2630:Rhebs
2541:BSCL2
2536:GNG13
2531:GNG12
2526:GNG11
2521:GNG10
2486:GNGT2
2481:GNGT1
2419:GNA14
2414:GNA13
2409:GNA12
2404:GNA11
2379:GNAT3
2374:GNAT2
2369:GNAT1
2364:GNAI3
2359:GNAI2
2354:GNAI1
2349:GNAO1
2113:SYNRG
2057:Other
2009:TIP47
1904:LMAN1
1891:AP4S1
1886:AP4M1
1881:AP4E1
1876:AP4B1
1857:AP3S2
1852:AP3S1
1847:AP3M2
1842:AP3M1
1837:AP3D1
1832:AP3B2
1827:AP3B1
1808:AP2S1
1803:AP2M1
1798:AP2B1
1793:AP2A2
1788:AP2A1
1769:AP1S3
1764:AP1S2
1759:AP1S1
1754:AP1M2
1749:AP1M1
1744:AP1G2
1739:AP1G1
1734:AP1B1
1729:AP1AR
1631:SAR1A
1618:SEC31
1614:SEC13
1592:COPII
1569:COPZ2
1564:COPZ1
1559:COPG2
1539:COPB2
1534:COPB1
1502:RAB3A
1478:Other
1469:SYT17
1464:SYT16
1459:SYT15
1454:SYT14
1449:SYT13
1444:SYT12
1439:SYT11
1434:SYT10
1367:VAMP3
1362:VAMP2
1357:VAMP1
1293:STX19
1288:STX18
1283:STX17
1278:STX16
1273:STX12
1268:STX11
1263:STX10
1223:STX1B
1218:STX1A
1184:SNARE
1166:TC 1F
553:RABIF
526:RAB29
516:RAB27
506:RAB25
496:RAB23
486:RAB20
476:RAB18
466:RAB17
456:RAB14
446:RAB13
426:RAB9B
416:RAB9A
407:RAB8B
397:RAB8A
377:RAB6D
368:RAB6C
359:RAB6B
348:RAB6A
337:RAB5C
327:RAB5A
318:RAB4B
308:RAB4A
299:RAB3B
289:RAB3A
280:RAB2B
270:RAB2A
250:Name
94:lipid
53:actin
4371:list
4364:EC7
4358:list
4351:EC6
4345:list
4338:EC5
4332:list
4325:EC4
4319:list
4312:EC3
4306:list
4299:EC2
4293:list
4286:EC1
4070:OPA1
4063:and
4015:EF-G
4005:IF-2
3971:Rheb
3959:ARL6
3944:ARF6
3915:NRAS
3910:KRAS
3905:HRAS
3890:RhoD
3885:RhoF
3831:RhoH
3807:RhoG
3792:Rac1
3780:RhoV
3775:RhoU
3758:TC10
3694:GNAQ
3414:SPCA
3241:3.6)
3123:see
3102:see
3003:McsB
2927:PTK2
2867:PAK4
2862:PAK3
2857:PAK2
2852:PAK1
2791:IKK2
2786:CHUK
2759:GSK2
2754:GSK1
2640:RGKs
2635:Raps
2620:Arfs
2615:Rhos
2608:NRAS
2603:KRAS
2598:HRAS
2588:Rabs
2583:ARFs
2516:GNG8
2511:GNG7
2506:GNG5
2501:GNG4
2496:GNG3
2491:GNG2
2468:GNB5
2463:GNB4
2458:GNB3
2453:GNB2
2448:GNB1
2399:GNAQ
2394:GNAL
2389:GNAS
2384:GNAZ
2317:cGMP
2293:cGMP
2273:cAMP
2243:cAMP
2186:see
2083:EHD4
2078:EHD3
2073:EHD2
2068:EHD1
2046:DNM3
2041:DNM2
2036:DNM1
1988:HPS4
1983:HPS1
1967:HPS6
1962:HPS5
1957:HPS3
1917:LYST
1695:CAV3
1690:CAV2
1685:CAV1
1663:CLTC
1658:CLTB
1653:CLTA
1554:COPG
1549:COPE
1529:COPA
1516:COPI
1429:SYT9
1424:SYT8
1419:SYT7
1414:SYT6
1409:SYT5
1404:SYT4
1399:SYT3
1394:SYT2
1389:SYT1
1353:VAMP
1258:STX8
1253:STX7
1248:STX6
1243:STX5
1238:STX4
1233:STX3
1228:STX2
1096:PMID
1023:PMID
974:PMID
925:PMID
876:PMID
835:PMID
794:PMID
740:PMID
700:PMID
644:ISBN
606:PMID
386:RAB7
259:RAB1
240:and
197:GDI1
188:GDI1
175:GDI1
55:and
19:The
4065:MX2
4061:MX1
3981:RGK
3976:Rap
3966:Ran
3939:Arf
3922:Rab
3900:Ras
3858:Rnd
3836:Rho
3787:Rac
3763:TCL
3624:olf
3356:Ca+
2939:BTK
2625:Ran
2593:Ras
2179:MAP
1641:RME
1582:ARF
1086:doi
1013:PMC
1005:doi
964:PMC
956:doi
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