1205:
902:
339:
Imogam Rabies-HT and Kedrab have a nominal potency of 150 IU/mL while
Hyperrab has a nominal potency of 300 IU/mL and requires smaller dosing. All three versions are used for post-exposure and indicate local infusion at the wound site with additional amount intramuscularly at a site distant from
321:
Rabies immunoglobulin (RIG) is indicated for the passive, transient post-exposure prophylaxis of rabies infection, when given immediately after contact with a rabid or possibly rabid animal and in combination with a rabies vaccine.
335:
There are three versions of rabies immunoglobulin licensed and available in the US. Imogam Rabies-HT is produced by Sanofi
Pasteur. Kedrab is produced by Kedrion Biopharma. Hyperrab is produced by Grifols.
147:
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of people or horses who have high levels of the antibody in their blood. The horse version is less expensive but has a higher rate of side effects.
825:
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The use of rabies immunoglobulin in the form of blood serum dates from 1891. Use became common within medicine in the 1950s. It is on the
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Common side effects include pain at the site of injection, fever, and headache. Severe allergic reactions such as
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309:. In the United States it is estimated to be more than US$ 1,000.00 per dose. It is made from the
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is not known to harm the baby. It works by binding to the rabies virus before it can enter
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following exposure. It is given after the wound is cleaned with soap and water or
818:
Emergency
Medicine: A Comprehensive Study Guide (Emergency Medicine (Tintinalli))
279:. It is not needed in people who have been previously vaccinated against rabies.
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World Health
Organization model list of essential medicines: 21st list 2019
503:"Imogam Rabies-HT - human rabies virus immune globulin injection, solution"
187:
801:
196:
664:
260:
967:"WHO Guide for Rabies Pre and Post Exposure Prophylaxis in Humans"
272:
905:
This article incorporates text from this source, which is in the
531:"Kedrab- human rabies virus immune globulin injection, solution"
305:. Rabies immunoglobulin is expensive and hard to come by in the
1038:
692:(69 ed.). British Medical Association. 2015. p. 869.
166:
923:
820:(7 ed.). New York: McGraw-Hill Companies. p. 1054.
559:"Hyperrab (rabies immune globulin- human injection, solution"
497:
495:
141:
73:
16:
Medication made up of antibodies against the rabies virus
805:. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
154:
584:"Hyperrab S/D (rabies immune globulin- human injection"
303:
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1021:
628:. The American Society of Health-System Pharmacists.
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729:(6th ed.). : Elsevier/Saunders. p. 659.
525:
523:
343:Kamrab is approved for medical use in Australia.
271:. It is given by injection into the site of the
654:(2009). Stuart MC, Kouimtzi M, Hill SR (eds.).
920:"Summary Basis for Regulatory Action - Kedrab"
1226:World Health Organization essential medicines
1050:
874:
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298:, rabies immunoglobulin is no longer useful.
8:
21:
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991:"Rabies Biologics | Specific Groups | CDC"
943:Centers for Disease Control and Prevention
938:"Vaccine and Immune Globulin Availability"
752:
750:
658:. World Health Organization. p. 398.
39:Imogam Rabies-HT, Kedrab, Hyperrab, others
841:
839:
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800:
663:
231:
690:British national formulary : BNF 69
1200:
352:
195:
372:Therapeutic Goods Administration (TGA)
20:
851:. Academic Press. 2011. p. 351.
795:. Geneva: World Health Organization.
53:
7:
865:from the original on 9 January 2017.
777:from the original on 9 January 2017.
743:from the original on 9 January 2017.
114:
632:from the original on 18 March 2011
294:. After the virus has entered the
14:
1065:Immune sera and immunoglobulins (
1203:
900:
267:and is followed by a course of
757:Jong EC, Zuckerman JN (2004).
1:
286:may rarely occur. Use during
251:) is a medication made up of
1028:Food and Drug Administration
886:Food and Drug Administration
1103:Hepatitis B immune globulin
848:Research Advances in Rabies
1242:
1026:(Briefing Document). U.S.
975:World Health Organization
789:World Health Organization
763:. PMPH-USA. p. 205.
652:World Health Organization
656:WHO Model Formulary 2008
626:"Rabies Immune Globulin"
340:vaccine administration.
259:. It is used to prevent
1093:Anthrax immune globulin
162: / Schedule D
96:Intramuscular injection
1183:Tixagevimab/cilgavimab
1108:Zoster-immune globulin
1098:Rho(D) immune globulin
816:Tintinalli JE (2010).
296:central nervous system
1140:Monoclonal antibodies
1076:Polyclonal antibodies
1030:(FDA). 25 April 2019.
245:Rabies immunoglobulin
23:Rabies immunoglobulin
760:Travelers' Vaccines
725:, Offit PA (eds.).
326:Society and culture
150:(Prescription only)
25:
947:. 26 February 2020
1191:
1190:
1134:
1133:
997:. 15 January 2021
926:. 23 August 2017.
827:978-0-07-148480-0
721:. In Plotkin SA,
719:"Rabies Vaccines"
480:. 14 October 2020
446:"Hyperrab S/D PI"
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374:. 23 August 2021
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890:. 21 March 2018
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452:. 25 April 2012
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400:. 25 April 2012
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1168:Obiltoxaximab
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29:Clinical data
27:
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1148:Bezlotoxumab
999:. Retrieved
994:
985:
973:
961:
949:. Retrieved
941:
932:
914:
892:. Retrieved
883:
847:
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811:
802:10665/325771
792:
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759:
726:
723:Orenstein WA
708:
689:
684:
655:
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634:. Retrieved
593:10 September
591:. Retrieved
587:
578:
566:. Retrieved
562:
538:. Retrieved
534:
510:. Retrieved
506:
482:. Retrieved
475:
466:
456:10 September
454:. Retrieved
449:
440:
430:10 September
428:. Retrieved
423:
414:
404:10 September
402:. Retrieved
397:
388:
378:10 September
376:. Retrieved
371:
342:
338:
334:
320:
317:Medical uses
311:blood plasma
300:
292:nerve tissue
281:
257:rabies virus
255:against the
248:
244:
243:
133:Legal status
127:Legal status
18:
1178:Raxibacumab
1173:Palivizumab
1153:Motavizumab
1001:18 November
995:www.cdc.gov
665:10665/44053
420:"Imogam PI"
394:"Kamrab PI"
284:anaphylaxis
182:Identifiers
35:Trade names
1163:Nirsevimab
715:Plotkin SA
347:References
253:antibodies
233:95F619ATQ2
208:ChemSpider
1158:Nebacumab
1126:Antivenom
1118:Antiserum
636:8 January
288:pregnancy
89:Routes of
63:Pregnancy
55:Monograph
49:Drugs.com
1220:Category
1210:Medicine
951:24 March
880:"Kedrab"
863:Archived
791:(2019).
775:Archived
741:Archived
727:Vaccines
717:(2013).
630:Archived
588:DailyMed
568:24 March
563:DailyMed
540:24 March
535:DailyMed
512:24 March
507:DailyMed
484:17 April
368:"Kamrab"
188:DrugBank
103:ATC code
78: B2
65:category
979:. 2014.
197:DB11603
158::
119:)
113: (
111:J06BB05
1196:Portal
894:7 June
855:
824:
767:
733:
696:
672:
261:rabies
173:℞-only
171:
160:℞-only
146:
1024:(PDF)
977:(WHO)
970:(PDF)
945:(CDC)
888:(FDA)
884:U.S.
331:Names
273:wound
1085:IVIG
1003:2022
953:2020
896:2020
853:ISBN
822:ISBN
765:ISBN
731:ISBN
694:ISBN
670:ISBN
638:2017
595:2021
570:2020
542:2020
514:2020
486:2024
458:2021
432:2021
406:2021
380:2021
275:and
224:UNII
215:none
45:AHFS
1067:J06
924:FDA
797:hdl
660:hdl
249:RIG
116:WHO
1222::
993:.
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355:^
167:US
155:CA
148:S4
142:AU
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Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.