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Rate of infusion

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be administered to achieve a steady state of a fixed dose which has been demonstrated to be therapeutically effective.
1222: 775: 220: 510: 329: 208: 72: 32: 1212: 1186: 1022: 770: 764: 1087: 789: 54: 1217: 838: 600: 595: 505: 423: 974: 735: 710: 645: 534: 418: 1082: 874: 676: 353: 322: 1179: 1117: 979: 889: 730: 610: 378: 212: 185:) refers not just to the rate at which a drug is administered, but the desired rate at which a drug 1027: 915: 884: 530: 490: 413: 997: 947: 848: 661: 640: 540: 461: 373: 992: 853: 843: 671: 665: 500: 79: 1163: 1037: 925: 920: 690: 476: 456: 438: 174: 1077: 952: 780: 740: 725: 433: 383: 1067: 1047: 966: 808: 550: 495: 1206: 1072: 559: 466: 1159: 1042: 1002: 903: 827: 705: 388: 345: 1127: 614: 590: 21: 1007: 939: 831: 606: 785: 304: 1151: 907: 879: 866: 635: 555: 368: 760: 653: 649: 451: 318: 314: 117: 15: 1167: 138: 305:"Chapter 15.2 - Continuous IV Infusion - Steady State" 224: 223: 1100: 1060: 1016: 965: 938: 902: 865: 826: 817: 753: 698: 689: 628: 573: 522: 484: 475: 406: 361: 352: 133:
may be too technical for most readers to understand
46:. Unsourced material may be challenged and removed. 266: 267:{\displaystyle \textstyle K_{in}=C_{ss}\cdot CL} 1187: 330: 8: 1194: 1180: 1097: 1057: 962: 935: 899: 862: 823: 750: 695: 625: 570: 519: 481: 403: 358: 337: 323: 315: 245: 229: 222: 161:Learn how and when to remove this message 145:, without removing the technical details. 106:Learn how and when to remove this message 282: 143:make it understandable to non-experts 7: 1148: 1146: 44:adding citations to reliable sources 1166:. You can help Knowledge (XXG) by 1123:Minimum bactericidal concentration 14: 1150: 1113:Minimum inhibitory concentration 211:in the plasma multiplied by the 122: 20: 1053:WHO list of essential medicines 546:Non-specific effect of vaccines 31:needs additional citations for 1108:Antimicrobial pharmacodynamics 1: 1033:Functional analog (chemistry) 586:Hill equation (biochemistry) 207:It can be calculated as the 1239: 1145: 1101:Antimicrobial pharmacology 581:Dose–response relationship 511:Desensitization (medicine) 291:"Cp vs time - iv infusion" 209:steady-state concentration 1023:Coinduction (anesthetics) 1088:Multiple drug resistance 1061:Tolerance and resistance 429:Physiological antagonist 839:Neuropsychopharmacology 601:Cheng-Prussoff Equation 596:Del Castillo Katz model 523:Other effects of ligand 506:Receptor (biochemistry) 424:Irreversible antagonist 192:Abbreviations include K 1162:-related article is a 975:Classical pharmacology 736:Plasma protein binding 711:Volume of distribution 419:Competitive antagonist 268: 1083:Antibiotic resistance 875:Clinical pharmacology 394:Physiological agonist 354:Ligand (biochemistry) 269: 980:Reverse pharmacology 890:Pharmacoepidemiology 731:Biological half-life 611:Ligand binding assay 485:Activity at receptor 379:Irreversible agonist 221: 40:improve this article 1028:Combination therapy 916:Pharmacoinformatics 885:Medicinal chemistry 491:Mechanism of action 1223:Pharmacology stubs 998:Immunopharmacology 948:Pharmacotoxicology 849:Psychopharmacology 641:Intrinsic activity 541:Pleiotropy (drugs) 462:Agonist-antagonist 374:Endogenous agonist 264: 263: 55:"Rate of infusion" 1175: 1174: 1140: 1139: 1136: 1135: 1096: 1095: 993:Photopharmacology 988: 987: 961: 960: 934: 933: 898: 897: 861: 860: 854:Electrophysiology 844:Neuropharmacology 799: 798: 749: 748: 685: 684: 672:Therapeutic index 624: 623: 569: 568: 518: 517: 447: 446: 402: 401: 171: 170: 163: 116: 115: 108: 90: 1230: 1213:Pharmacokinetics 1196: 1189: 1182: 1154: 1147: 1098: 1058: 1038:Polypharmacology 963: 936: 926:Pharmacogenomics 921:Pharmacogenetics 900: 863: 824: 751: 721:Rate of infusion 696: 691:Pharmacokinetics 626: 571: 520: 482: 477:Pharmacodynamics 457:Neurotransmitter 439:Enzyme inhibitor 404: 359: 339: 332: 325: 316: 309: 308: 301: 295: 294: 287: 273: 271: 270: 265: 253: 252: 237: 236: 179:rate of infusion 175:pharmacokinetics 166: 159: 155: 152: 146: 126: 125: 118: 111: 104: 100: 97: 91: 89: 48: 24: 16: 1238: 1237: 1233: 1232: 1231: 1229: 1228: 1227: 1203: 1202: 1201: 1200: 1143: 1141: 1132: 1092: 1078:Drug resistance 1056: 1012: 984: 957: 953:Neurotoxicology 930: 894: 857: 819: 813: 795: 745: 741:Bioavailability 726:Onset of action 681: 620: 565: 514: 471: 443: 434:Inverse agonist 398: 384:Partial agonist 348: 343: 313: 312: 303: 302: 298: 289: 288: 284: 279: 241: 225: 219: 218: 203: 199: 195: 167: 156: 150: 147: 139:help improve it 136: 127: 123: 112: 101: 95: 92: 49: 47: 37: 25: 12: 11: 5: 1236: 1234: 1226: 1225: 1220: 1218:Temporal rates 1215: 1205: 1204: 1199: 1198: 1191: 1184: 1176: 1173: 1172: 1155: 1138: 1137: 1134: 1133: 1131: 1130: 1125: 1120: 1118:Bacteriostatic 1115: 1110: 1104: 1102: 1094: 1093: 1091: 1090: 1085: 1080: 1075: 1070: 1068:Drug tolerance 1064: 1062: 1055: 1050: 1048:Lists of drugs 1045: 1040: 1035: 1030: 1025: 1020: 1018: 1014: 1013: 1011: 1010: 1005: 1000: 995: 989: 986: 985: 983: 982: 977: 971: 969: 967:Drug discovery 959: 958: 956: 955: 950: 944: 942: 932: 931: 929: 928: 923: 918: 912: 910: 896: 895: 893: 892: 887: 882: 877: 871: 869: 859: 858: 856: 851: 846: 841: 836: 834: 821: 815: 814: 812: 811: 809:Bioequivalence 806: 800: 797: 796: 794: 793: 783: 778: 773: 768: 757: 755: 747: 746: 744: 743: 738: 733: 728: 723: 718: 708: 702: 700: 693: 687: 686: 683: 682: 680: 679: 674: 669: 643: 638: 632: 630: 622: 621: 619: 618: 603: 598: 593: 588: 583: 577: 575: 567: 566: 564: 563: 553: 551:Adverse effect 548: 543: 538: 526: 524: 516: 515: 513: 508: 503: 498: 496:Mode of action 493: 488: 486: 479: 473: 472: 470: 469: 464: 459: 454: 448: 445: 444: 442: 441: 436: 431: 426: 421: 416: 410: 408: 400: 399: 397: 396: 391: 386: 381: 376: 371: 365: 363: 356: 350: 349: 344: 342: 341: 334: 327: 319: 311: 310: 296: 281: 280: 278: 275: 262: 259: 256: 251: 248: 244: 240: 235: 232: 228: 201: 197: 193: 169: 168: 130: 128: 121: 114: 113: 28: 26: 19: 13: 10: 9: 6: 4: 3: 2: 1235: 1224: 1221: 1219: 1216: 1214: 1211: 1210: 1208: 1197: 1192: 1190: 1185: 1183: 1178: 1177: 1171: 1169: 1165: 1161: 1156: 1153: 1149: 1144: 1129: 1126: 1124: 1121: 1119: 1116: 1114: 1111: 1109: 1106: 1105: 1103: 1099: 1089: 1086: 1084: 1081: 1079: 1076: 1074: 1073:Tachyphylaxis 1071: 1069: 1066: 1065: 1063: 1059: 1054: 1051: 1049: 1046: 1044: 1041: 1039: 1036: 1034: 1031: 1029: 1026: 1024: 1021: 1019: 1015: 1009: 1006: 1004: 1001: 999: 996: 994: 991: 990: 981: 978: 976: 973: 972: 970: 968: 964: 954: 951: 949: 946: 945: 943: 941: 937: 927: 924: 922: 919: 917: 914: 913: 911: 909: 905: 901: 891: 888: 886: 883: 881: 878: 876: 873: 872: 870: 868: 864: 855: 852: 850: 847: 845: 842: 840: 837: 835: 833: 829: 825: 822: 816: 810: 807: 805: 802: 801: 791: 787: 784: 782: 779: 777: 774: 772: 769: 766: 762: 759: 758: 756: 752: 742: 739: 737: 734: 732: 729: 727: 724: 722: 719: 716: 712: 709: 707: 704: 703: 701: 697: 694: 692: 688: 678: 675: 673: 670: 667: 663: 659: 655: 651: 647: 644: 642: 639: 637: 634: 633: 631: 627: 616: 612: 608: 604: 602: 599: 597: 594: 592: 589: 587: 584: 582: 579: 578: 576: 572: 561: 560:Neurotoxicity 557: 554: 552: 549: 547: 544: 542: 539: 536: 532: 529:Selectivity ( 528: 527: 525: 521: 512: 509: 507: 504: 502: 499: 497: 494: 492: 489: 487: 483: 480: 478: 474: 468: 467:Pharmacophore 465: 463: 460: 458: 455: 453: 450: 449: 440: 437: 435: 432: 430: 427: 425: 422: 420: 417: 415: 412: 411: 409: 405: 395: 392: 390: 387: 385: 382: 380: 377: 375: 372: 370: 367: 366: 364: 360: 357: 355: 351: 347: 340: 335: 333: 328: 326: 321: 320: 317: 306: 300: 297: 292: 286: 283: 276: 274: 260: 257: 254: 249: 246: 242: 238: 233: 230: 226: 216: 214: 210: 205: 190: 188: 184: 180: 176: 165: 162: 154: 151:February 2021 144: 140: 134: 131:This article 129: 120: 119: 110: 107: 99: 96:February 2021 88: 85: 81: 78: 74: 71: 67: 64: 60: 57: –  56: 52: 51:Find sources: 45: 41: 35: 34: 29:This article 27: 23: 18: 17: 1168:expanding it 1160:pharmacology 1157: 1142: 1043:Chemotherapy 1003:Cell biology 904:Biochemistry 828:Neuroscience 776:Distribution 720: 706:Loading dose 389:Superagonist 346:Pharmacology 299: 285: 217: 206: 191: 186: 182: 178: 172: 157: 148: 132: 102: 93: 83: 76: 69: 62: 50: 38:Please help 33:verification 30: 1128:Bactericide 804:Compartment 615:Patch clamp 591:Schild plot 183:dosing rate 1207:Categories 1008:Physiology 940:Toxicology 832:psychology 781:Metabolism 771:Absorption 765:Liberation 607:Organ bath 535:Functional 414:Antagonist 407:Inhibitory 362:Excitatory 277:References 66:newspapers 790:Clearance 786:Excretion 605:Methods ( 255:⋅ 213:clearance 908:genetics 880:Pharmacy 867:Medicine 677:Affinity 636:Efficacy 574:Analysis 556:Toxicity 818:Related 761:(L)ADME 715:Initial 699:Metrics 646:Potency 629:Metrics 531:Binding 501:Binding 369:Agonist 137:Please 80:scholar 820:fields 200:, or R 187:should 177:, the 82:  75:  68:  61:  53:  1158:This 1017:Other 754:LADME 87:JSTOR 73:books 1164:stub 906:and 830:and 666:TD50 662:LD50 658:ED50 654:IC50 650:EC50 452:Drug 181:(or 59:news 763:: ( 196:, K 173:In 141:to 42:by 1209:: 664:, 660:, 656:, 652:, 613:, 609:, 533:, 215:: 204:. 194:in 1195:e 1188:t 1181:v 1170:. 792:) 788:( 767:) 717:) 713:( 668:) 648:( 617:) 562:) 558:( 537:) 338:e 331:t 324:v 307:. 293:. 261:L 258:C 250:s 247:s 243:C 239:= 234:n 231:i 227:K 202:0 198:0 164:) 158:( 153:) 149:( 135:. 109:) 103:( 98:) 94:( 84:· 77:· 70:· 63:· 36:.

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"Rate of infusion"
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scholar
JSTOR
Learn how and when to remove this message
help improve it
make it understandable to non-experts
Learn how and when to remove this message
pharmacokinetics
steady-state concentration
clearance
"Cp vs time - iv infusion"
"Chapter 15.2 - Continuous IV Infusion - Steady State"
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t
e
Pharmacology
Ligand (biochemistry)
Agonist
Endogenous agonist
Irreversible agonist
Partial agonist
Superagonist
Physiological agonist

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