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One of the most active areas of search for ligands to receptors, are in the field of brain receptors. In the hunt for psychopharmacologically active substances, psychoactive plant products are screened towards a receptorome array. Apart from finding new substances, discovering the molecular
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The human receptorome constitutes at least 5% of the human genome. It encodes receptors that mediate the physiological, pathological and therapeutic responses to both exogenous and endogenous ligands.
59:(on a chip) and physical screening methods have been devised to mine the receptorome efficiently and "mass-screening" substances towards a huge set of receptors to study effect and interaction.
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In analogy with the genome, where the genome is the total set of genes, the receptorome can be considered the total set of genes giving rise to
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mechanisms responsible for these substances' actions will likely give insights into the molecular underpinnings of human consciousness.
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or receptor molecules. It could also be seen as the total number of receptor proteins in a certain organism.
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112:(2006). "Screening the receptorome: an efficient approach for drug discovery and target validation".
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In practice, the receptorome now is considered to encompass not only traditional receptors but also
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in the human genome that are potential drug targets. Some of the most renowned types are the
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but also to other sets of structural or functional units such as the
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85:An article on screening the GPCR-receptorome is:
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207:- NIMH Psychoactive Drug Screening Program
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212:- Wiki-page for editing receptors
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153:Journal of Psychopharmacology
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149:"Screening the receptorome"
72:G protein-coupled receptors
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108:Strachan, RT; Ferrara, G;
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87:Mining the Receptorome
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