Knowledge (XXG)

Retinoid

Source πŸ“

524: 33: 436:. Retinoids are further shown to worsen many metabolic diseases, such as diabetes and congestive heart failure. Large-scale randomized, controlled clinical trials have conclusively shown that vitamin A, retinol and other retinoids increase mortality and cancer rates. In addition to the harmful effects shared by other retinoids, 447:
The Pharmacovigilance Risk Assessment Committee (PRAC), based on its review, confirmed that taking oral retinoids during pregnancy can have harmful effects on the baby as they may cause CNS, cranio-facial, cardiovascular and other defects. The use of acitretin, alitretinoin and isotretinoin should be
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Many lotions that claim to prevent or treat stretch marks contain retinol, which is not an ingredient that is safe for pregnant women. The Association of the American Academy of Dermatology (AAD) recommends that pregnant women consult a health care provider before trying any lotions or oils for
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Goodman GE, Thornquist MD, Balmes J, Cullen MR, Meyskens FL, Omenn GS, et al. (December 2004). "The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements".
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Goodman GE, Thornquist MD, Balmes J, Cullen MR, Meyskens FL, Omenn GS, et al. (December 2004). "The Beta-Carotene and Retinol Efficacy Trial: incidence of lung cancer and cardiovascular disease mortality during 6-year follow-up after stopping beta-carotene and retinol supplements".
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Laosakul K, Chiewchanvit S, Chuamanochan M, Tovanabutra N (April 2022). "Acitretin treatment in antimalarial-refractory/intolerant discoid lupus erythematosus: A prospective, open-label, uncontrolled study".
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Retinoids have many important functions throughout the body, including roles in vision, regulation of skin proliferation and differentiation, growth of bone tissue, immune function, and male fertility.
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Toxic effects of retinoids occur with both acute or prolonged intake, depending on which retinoid is considered. The specific toxicity is related to the mechanism of action as well as exposure. A
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prohibited in women of childbearing age unless they take measures to prevent pregnancy. The use of topical retinoids should also be excluded during pregnancy and in women planning pregnancy.
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Sherman SI (March 2003). "Etiology, diagnosis, and treatment recommendations for central hypothyroidism associated with bexarotene therapy for cutaneous T-cell lymphoma".
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formed by alternating C=C double bonds in the polyene side chain are responsible for the color of retinoids (typically yellow, orange, or red). Hence, many retinoids are
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for storage. Most synthetic retinoids are absorbed when taken orally while topical retinoids cannot diffuse through the skin barrier unless it is compromised.
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treatment although it is not approved in other countries due a lack of consistent effects. Oral retinoids show considerable toxicity if they interact with
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Alpha-Tocopherol BC (April 1994). "The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers".
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The only fourth generation retinoid, Trifarotene, binds selectively to the RAR-y receptor. It was approved for use in the US in 2019.
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Third generation retinoids have narrow biological roles due to their constrained structure, with adapalene mimicking the effects of
1812:"Oral retinoid medicines: revised and simplified pregnancy prevention educational materials for healthcare professionals and women" 1860: 279: 4436: 201:
First generation retinoids are produced naturally in the body and interact with their normal biological counterparts, such as
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Synthetic analogs formulated for oral dosing. There are no topically available second generation formulations of retinoids.
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while synthetic retinoids likely bind to these and other proteins. First generation retinoids are rapidly metabolized by
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Burri BJ, Clifford AJ (October 2004). "Carotenoid and retinoid metabolism: insights from isotope studies".
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Burri BJ, Clifford AJ (October 2004). "Carotenoid and retinoid metabolism: insights from isotope studies".
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or are chemically related to it. Synthetic retinoids are used in medicine where they regulate skin health,
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Retinoids are divided into four generations based on their molecular structure and receptor selectivity.
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The biology of retinoids is complex and their use in medicine has well-known benefits in diseases like
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Makimoto A, Fujisaki H, Matsumoto K, Takahashi Y, Cho Y, Morikawa Y, et al. (January 2024).
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Makimoto A, Fujisaki H, Matsumoto K, Takahashi Y, Cho Y, Morikawa Y, et al. (January 2024).
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Second generation retinoids have a mixed effect and interact mainly with signaling in the skin.
71:. On the other hand, retinoids are known to have many harmful effects on metabolism and cancer. 5882: 5837: 5648: 5594: 5579: 5428: 5139: 5087: 4972: 4820: 4765: 4735: 4710: 4660: 4655: 4645: 4630: 4579: 4574: 4531: 4466: 4456: 4426: 4370: 4340: 4297: 4287: 4136: 4060: 3912: 3825: 3622: 3354: 3314: 3309: 3304: 3056: 1469:"Retinoid Therapy for Neuroblastoma: Historical Overview, Regulatory Challenges, and Prospects" 1418:"Retinoid Therapy for Neuroblastoma: Historical Overview, Regulatory Challenges, and Prospects" 5887: 5862: 5852: 5703: 5678: 5663: 5628: 5604: 5599: 5350: 5281: 4950: 4920: 4800: 4620: 4554: 4526: 4511: 4506: 4481: 4097: 4065: 4045: 3988: 3873: 3796: 3791: 3786: 3781: 3617: 3612: 3364: 3334: 3220: 3210: 3061: 3015: 2405: 2390: 1741: 1706: 1671: 1635: 1604:"The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes" 1578: 1551: 1520:"The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes" 1500: 1449: 1398: 1347: 1311: 1270: 1167: 1136:"The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes" 1116: 1081: 1046: 967: 928: 845: 804: 755: 706: 670: 639:"The pathogenic role of retinoid nuclear receptor signaling in cancer and metabolic syndromes" 619: 568: 512: 334: 191: 32: 5907: 5623: 5569: 5564: 4599: 4446: 4355: 4312: 3863: 3776: 3662: 3642: 3637: 3632: 3284: 3205: 3200: 3110: 3105: 3100: 3095: 3090: 5963: 5955: 5950: 5769: 5673: 5668: 5254: 4840: 4476: 4441: 4331: 4317: 4277: 4210: 4036: 4027: 3959: 3950: 3942: 3844: 3835: 3757: 3748: 3599: 3537: 3404: 3399: 3394: 3389: 3384: 3379: 3369: 3359: 3349: 3344: 3215: 3115: 3085: 2542: 2395: 2347: 1990: 1733: 1698: 1663: 1625: 1615: 1541: 1531: 1490: 1480: 1439: 1429: 1388: 1378: 1339: 1301: 1260: 1250: 1157: 1147: 1108: 1073: 1036: 1028: 959: 918: 908: 835: 794: 786: 745: 737: 698: 660: 650: 609: 599: 558: 550: 502: 494: 329:, and skin wrinkles. In addition, retinoids are used to treat rare skin disorders including 4559: 4408: 3185: 3125: 3120: 278:
are transported from the enterocytes to the liver and are processed into retinyl esters by
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and retinyl esters derived from animal sources. Retinyl esters are transported through the
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The basic structure of the hydrophobic retinoid molecule consists of a cyclic end group, a
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Kafi R, Kwak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA, et al. (May 2007).
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Topical retinoid with selectivity towards the RAR receptor located in the epidermis.
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6-(N-ethyl-N-(5-isobutoxy-4-isopropyl-2-(E)-styrylphenyl)amino)nicotinic acid
2290: 971: 377:, which includes the presence of painful tender swellings on the long bones. 5902: 5842: 5574: 5532: 5517: 5512: 5502: 5492: 5487: 5482: 5477: 5392: 5375: 5370: 5365: 5249: 5229: 5224: 5189: 5184: 5144: 5117: 5072: 5067: 5062: 5042: 4997: 4992: 4955: 4945: 4870: 4589: 4496: 4345: 4282: 4195: 4112: 3917: 3902: 3723: 3718: 3328: 3270: 3230: 3159: 3076: 3071: 3066: 2932: 2909: 2846: 2801: 2623: 2582: 2562: 2537: 2519: 2418: 2274: 2234: 2186: 1485: 1434: 418: 386: 322: 152: 139: 110: 49: 1745: 1737: 1675: 1639: 1582: 1555: 1504: 1453: 1402: 1351: 1315: 1274: 1171: 1120: 1085: 1050: 932: 864:"Soriatane (Acitretin): Side Effects, Uses, Dosage, Interactions, Warnings" 863: 849: 808: 759: 710: 674: 623: 572: 516: 1710: 1667: 702: 5735: 5559: 5421: 5416: 5355: 5345: 5323: 5318: 5239: 5214: 5164: 5107: 5097: 5032: 5027: 4987: 4302: 3922: 3728: 2811: 2783: 2613: 2608: 2532: 2171: 2020: 2010: 2000: 1957: 1620: 1536: 1237:
Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G (2006).
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Mukherjee S, Date A, Patravale V, Korting HC, Roeder A, Weindl G (2006).
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All classes of retinoid bind to many proteins. Natural retinoids such as
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has an unknown biological pathway but appears to act as a growth factor.
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may also occur. Similar effects occur with other retinoids, except for
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The major source of retinoids in human diet are plant pigments such as
187: 106: 102: 1861:"Is Vitamin A, Retinyl Palmitate and Retinol Safe for Pregnant Women?" 840: 823: 498: 5633: 4834: 2181: 2103: 1367:"The utility of bexarotene in mycosis fungoides and SΓ©zary syndrome" 5445: 2166: 775:"Retinoic acid synthesis and signaling during early organogenesis" 410: 31: 824:"Adverse effects of isotretinoin: A large, retrospective review" 345:
and thus are only approved in several severe diseases including
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Brzezinski P, Borowska K, Chiriac A, Smigielski J (July 2017).
2779: 1918: 1290:"Improvement of naturally aged skin with vitamin A (retinol)" 1784:"PRAC Seeks New Pregnancy Prevention Measures For Retinoids" 946:
Duvic M, Nagpal S, Asano AT, Chandraratna RA (August 1997).
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Common skin conditions treated by topical retinoids include
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Motamedi M, Chehade A, Sanghera R, Grewal P (2021-07-22).
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Hall JA, Grainger JR, Spencer SP, Belkaid Y (July 2011).
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Hall JA, Grainger JR, Spencer SP, Belkaid Y (July 2011).
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and retinyl esters bind to carrier proteins such as
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Medicines and Healthcare products Regulatory Agency
4857: 3999: 3884: 3807: 3700: 481:Kiser PD, Golczak M, Palczewski K (January 2014). 3682: 3501: 890: 888: 424:Retinoids provoke rapid elevation of circulating 5778: 5759: 5714: 4156: 1602:Esposito M, Amory JK, Kang Y (September 2024). 1518:Esposito M, Amory JK, Kang Y (September 2024). 1188:. National Psoriasis Foundation. Archived from 1134:Esposito M, Amory JK, Kang Y (September 2024). 637:Esposito M, Amory JK, Kang Y (September 2024). 5820: 3027: 952:Journal of the American Academy of Dermatology 5797: 4253: 3454: 3000: 2738: 2306: 1934: 1186:"Systemic medications: Soriatane (acitretin)" 8: 4381: 36:1st, 2nd, 3rd-generation retinoid compounds. 3241: 4847: 3695: 3514: 3496: 3461: 3447: 3439: 3007: 2993: 2985: 2889: 2769: 2745: 2731: 2723: 2313: 2299: 2291: 1941: 1927: 1919: 726:"A Clinician's Guide to Topical Retinoids" 483:"Chemistry of the retinoid (visual) cycle" 337:. In Japan, isotretinoin may be used for 1911:at the U.S. National Library of Medicine 1629: 1619: 1545: 1535: 1494: 1484: 1443: 1433: 1392: 1382: 1365:Panchal MR, Scarisbrick JJ (2015-02-03). 1305: 1264: 1254: 1161: 1151: 1040: 922: 912: 839: 798: 749: 730:Journal of Cutaneous Medicine and Surgery 664: 654: 613: 603: 562: 506: 270:pathway to the liver or fat tissue while 99:Isomers and naturally occurring compounds 1656:Journal of the National Cancer Institute 691:Journal of the National Cancer Institute 81: 1101:Archives of Biochemistry and Biophysics 1066:Archives of Biochemistry and Biophysics 473: 4852: 2645:Clindamycin/adapalene/benzoyl peroxide 190:side chain and a polar end group. The 1212:"Psoriasis - Diagnosis and treatment" 996:from the original on 19 November 2019 586:Topping T, Griswold MD (2022-04-28). 7: 5475:Selective COX-2 inhibitors (coxibs): 3228:Retinoic acid metabolism inhibitors: 1608:The Journal of Experimental Medicine 1577:. Treasure Island (FL): StatPearls. 1569:Olson JM, Ameer MA, Goyal A (2024). 1524:The Journal of Experimental Medicine 1140:The Journal of Experimental Medicine 643:The Journal of Experimental Medicine 3584:Tooltip Prostaglandin D2 receptor 2 3527:Tooltip Prostaglandin D2 receptor 1 1691:The New England Journal of Medicine 432:as well as cholesterol, leading to 369:of chronic or acute poisoning with 149:Retinoidal benzoic acid derivatives 5446:AM-404 (N-arachidonoylaminophenol) 5264:Anthranilic acids (fenamic acids): 4916:Mesalazine (5-aminosalicylic acid) 4007:Tooltip Prostaglandin EP4 receptor 3892:Tooltip Prostaglandin EP3 receptor 3815:Tooltip Prostaglandin EP2 receptor 3708:Tooltip Prostaglandin EP1 receptor 1103:. Highlight issue on Carotenoids. 1068:. Highlight issue on Carotenoids. 25: 5936:Ξ³-Linolenic acid (gamolenic acid) 5282:Meclofenamic acid (meclofenamate) 3691:Tooltip Prostaglandin E2 receptor 3510:Tooltip Prostaglandin D2 receptor 5991:Leukotriene signaling modulators 5783:Tooltip Prostaglandin F synthase 5764:Tooltip Prostaglandin E synthase 5723:Tooltip Prostaglandin D synthase 4165:Tooltip Prostaglandin F receptor 522: 48:that are natural derivatives of 5302:Talinflumic acid (talinflumate) 5292:Morniflumic acid (morniflumate) 5272:Floctafenic acid (floctafenate) 5255:Tiaprofenic acid (tiaprofenate) 1243:Clinical Interventions in Aging 1218:from the original on 7 May 2017 990:US Food and Drug Administration 986:"Drug Approval Package: Aklief" 901:Clinical Interventions in Aging 874:from the original on 2013-12-02 736:(1). SAGE Publications: 71–78. 5825:Tooltip Thromboxane A synthase 4876:Aspirin (acetylsalicylic acid) 4090:16,16-Dimethyl Prostaglandin E 3032:Tooltip Retinoic acid receptor 1863:. Metrin Skincare. 26 May 2022 1: 5984:Receptor/signaling modulators 5806:Tooltip Prostacyclin synthase 5307:Tolfenamic acid (tolfenamate) 5277:Flufenamic acid (flufenamate) 5267:Etofenamic acid (etofenamate) 4323:Prostacyclin (prostaglandin I 4262:Tooltip Prostacyclin receptor 3427:Receptor/signaling modulators 3266:-Retinoic acid (alitretinoin) 3052:-Retinoic acid (alitretinoin) 2660:Erythromycin/benzoyl peroxide 964:10.1016/s0190-9622(97)80396-9 417:and its derivatives, such as 4390:Tooltip Thromboxane receptor 2650:Clindamycin/benzoyl peroxide 1033:10.1016/j.immuni.2011.07.002 773:Duester G (September 2008). 555:10.1016/j.immuni.2011.07.002 347:acute promyelocytic leukemia 249:Retinoic acid receptor gamma 65:acute promyelocytic leukemia 5456:Paracetamol (acetaminophen) 5287:Mefenamic acid (mefenamate) 4941:Salicylate (salicylic acid) 3246:Tooltip Retinoid X receptor 1765:. European Medicines Agency 1703:10.1056/NEJM199404143301501 245:Retinoic acid receptor beta 6029: 5135:Bucloxic acid (blucloxate) 5053:Indometacin (indomethacin) 3375:LE135 (RAR beta selective) 3275:-Retinoic acid (tretinoin) 3081:-Retinoic acid (tretinoin) 2857:Calcipotriol/betamethasone 2675:Tretinoin/benzoyl peroxide 2640:Adapalene/benzoyl peroxide 1307:10.1001/archderm.143.5.606 791:10.1016/j.cell.2008.09.002 592:Frontiers in Endocrinology 305:enzymes, typically of the 5975: 5297:Niflumic acid (niflumate) 4401:Carbocyclic thromboxane A 3418: 2945: 2683: 2665:Erythromycin/isotretinoin 1344:10.1177/09612033221086878 1256:10.2147/ciia.2006.1.4.327 1113:10.1016/j.abb.2004.04.028 1078:10.1016/j.abb.2004.04.028 914:10.2147/ciia.2006.1.4.327 742:10.1177/12034754211035091 605:10.3389/fendo.2022.871225 452:stretch mark prevention. 351:cutaneous T-cell lymphoma 203:retinol binding protein 4 5615:Menatetrenone (vitamin K 5438:Aminophenols (anilines): 2754:Drugs used for psoriasis 1913:Medical Subject Headings 355:heterotopic ossification 5941:Dihomo-Ξ³-linolenic acid 5338:Enolic acids (oxicams): 4881:Benorilate (benorylate) 1486:10.3390/cancers16030544 1435:10.3390/cancers16030544 1371:OncoTargets and Therapy 1294:Archives of Dermatology 211:all-trans-retinoic acid 5740:selenium tetrachloride 2196:Vitamin A retinoids (C 1738:10.3816/CLM.2003.n.006 37: 27:Group of tetraterpenes 5409:Aminonicotinic acids: 2655:Clindamycin/tretinoin 35: 5058:Indometacin farnesil 4911:Magnesium salicylate 4542:Pinane thromboxane A 4303:Iloprost (ciloprost) 3923:Iloprost (ciloprost) 3729:Iloprost (ciloprost) 3290:Docosahexaenoic acid 2670:Sulfacetamide/sulfur 1621:10.1084/jem.20240519 1571:"Vitamin A Toxicity" 1537:10.1084/jem.20240519 1153:10.1084/jem.20240519 992:. October 21, 2019. 828:Dermatologic Therapy 656:10.1084/jem.20240519 434:hypercholesterolemia 430:hypertriglyceridemia 415:13-cis retinoic acid 237:Retinoid X receptors 219:13-cis retinoic acid 56:and bone disorders. 4886:Carbasalate calcium 2510:Cyproterone acetate 1668:10.1093/jnci/djh320 703:10.1093/jnci/djh320 407:pseudotumor cerebri 215:9-cis-retinoic acid 138:and its metabolite 5748:selenium disulfide 5380:4-Aminoquinolines: 2972:Never to phase III 2710:Never to phase III 2358:Blue light therapy 2353:8-Hydroxyquinoline 2324:-treating agents ( 1842:. 20 December 2022 1384:10.2147/OTT.S61308 462:Hypervitaminosis A 391:hepatosplenomegaly 375:hypervitaminosis A 343:retinoid receptors 207:retinoid receptors 46:chemical compounds 38: 6000: 5999: 5916: 5915: 4951:Sodium salicylate 4921:Methyl salicylate 4844: 4829: 4828: 4150: 4149: 3676: 3675: 3493: 3436: 3435: 3016:Retinoid receptor 2982: 2981: 2941: 2940: 2881: 2880: 2720: 2719: 2429:Red light therapy 2406:Anti-inflammatory 2288: 2287: 2280:Zuretinol acetate 1726:Clinical Lymphoma 1697:(15): 1029–1035. 1662:(23): 1743–1750. 841:10.1111/dth.12483 697:(23): 1743–1750. 499:10.1021/cr400107q 335:mycosis fungoides 235:binding only the 192:conjugated system 179: 178: 167:Fourth generation 129:Second generation 16:(Redirected from 6020: 5951:Arachidonic acid 5826: 5822: 5807: 5803: 5784: 5780: 5765: 5761: 5724: 5720: 5547:Others/unsorted: 5122:Propionic acids: 5103:Sulindac sulfide 4868:Salicylic acids: 4859: 4854: 4848: 4838: 4391: 4387: 4263: 4259: 4166: 4162: 4008: 4004: 3893: 3889: 3816: 3812: 3709: 3705: 3696: 3692: 3688: 3585: 3581: 3528: 3524: 3515: 3511: 3507: 3497: 3487: 3463: 3456: 3449: 3440: 3295:Fluorobexarotene 3247: 3243: 3176:Tazarotenic acid 3033: 3029: 3009: 3002: 2995: 2986: 2890: 2770: 2747: 2740: 2733: 2724: 2543:Ethinylestradiol 2396:Benzoyl peroxide 2348:Benzoyl peroxide 2315: 2308: 2301: 2292: 1943: 1936: 1929: 1920: 1896: 1895: 1893: 1892: 1878: 1872: 1871: 1869: 1868: 1857: 1851: 1850: 1848: 1847: 1840:Little Baby Gear 1832: 1826: 1825: 1823: 1822: 1804: 1798: 1797: 1795: 1794: 1780: 1774: 1773: 1771: 1770: 1764: 1756: 1750: 1749: 1721: 1715: 1714: 1686: 1680: 1679: 1650: 1644: 1643: 1633: 1623: 1599: 1593: 1592: 1590: 1589: 1566: 1560: 1559: 1549: 1539: 1515: 1509: 1508: 1498: 1488: 1464: 1458: 1457: 1447: 1437: 1413: 1407: 1406: 1396: 1386: 1362: 1356: 1355: 1326: 1320: 1319: 1309: 1285: 1279: 1278: 1268: 1258: 1234: 1228: 1227: 1225: 1223: 1208: 1202: 1201: 1199: 1197: 1182: 1176: 1175: 1165: 1155: 1131: 1125: 1124: 1096: 1090: 1089: 1061: 1055: 1054: 1044: 1012: 1006: 1005: 1003: 1001: 982: 976: 975: 943: 937: 936: 926: 916: 892: 883: 882: 880: 879: 860: 854: 853: 843: 819: 813: 812: 802: 770: 764: 763: 753: 721: 715: 714: 685: 679: 678: 668: 658: 649:(9): e20240519. 634: 628: 627: 617: 607: 583: 577: 576: 566: 534: 528: 527: 526: 520: 510: 487:Chemical Reviews 478: 258:Pharmacokinetics 146:Third generation 96:First generation 82: 21: 6028: 6027: 6023: 6022: 6021: 6019: 6018: 6017: 6003: 6002: 6001: 5996: 5971: 5967: 5964:Prostaglandin H 5959: 5956:Prostaglandin G 5912: 5824: 5814: 5812:Tranylcypromine 5805: 5801: 5791: 5782: 5772: 5763: 5753: 5744:sodium selenite 5722: 5718: 5708: 5654:Rosmarinic acid 5618: 5426:Sulfonanilides: 5329:Oxyphenbutazone 4855: 4837: 4825: 4604: 4545: 4417: 4404: 4389: 4385: 4375: 4335: 4332:Prostaglandin E 4327:, epoprostenol) 4326: 4261: 4257: 4247: 4222: 4219:Prostaglandin F 4214: 4211:Prostaglandin D 4164: 4160: 4146: 4131: 4128:Prostaglandin F 4093: 4075: 4040: 4037:Prostaglandin E 4031: 4028:Prostaglandin E 4006: 4003: 3993: 3974:Ricinoleic acid 3963: 3960:Prostaglandin E 3954: 3951:Prostaglandin E 3946: 3943:Prostaglandin D 3891: 3888: 3878: 3848: 3845:Prostaglandin E 3839: 3836:Prostaglandin E 3814: 3811: 3801: 3761: 3758:Prostaglandin E 3752: 3749:Prostaglandin E 3707: 3704: 3690: 3686: 3672: 3603: 3600:Prostaglandin D 3583: 3580: 3570: 3541: 3538:Prostaglandin D 3526: 3523: 3509: 3505: 3486: 3478: 3467: 3437: 3432: 3414: 3245: 3235: 3031: 3021: 3013: 2983: 2978: 2977: 2962:Clinical trials 2937: 2914: 2877: 2829: 2806: 2788: 2761: 2751: 2721: 2716: 2715: 2700:Clinical trials 2679: 2628: 2592: 2549: 2486: 2433: 2400: 2367: 2329: 2319: 2289: 2284: 2221: 2199: 2191: 2149: 2138: 2041: 2030: 1963: 1952: 1947: 1905: 1900: 1899: 1890: 1888: 1880: 1879: 1875: 1866: 1864: 1859: 1858: 1854: 1845: 1843: 1834: 1833: 1829: 1820: 1818: 1806: 1805: 1801: 1792: 1790: 1782: 1781: 1777: 1768: 1766: 1762: 1758: 1757: 1753: 1723: 1722: 1718: 1688: 1687: 1683: 1652: 1651: 1647: 1601: 1600: 1596: 1587: 1585: 1568: 1567: 1563: 1517: 1516: 1512: 1466: 1465: 1461: 1415: 1414: 1410: 1364: 1363: 1359: 1328: 1327: 1323: 1287: 1286: 1282: 1236: 1235: 1231: 1221: 1219: 1214:. Mayo Clinic. 1210: 1209: 1205: 1195: 1193: 1192:on 13 June 2010 1184: 1183: 1179: 1133: 1132: 1128: 1098: 1097: 1093: 1063: 1062: 1058: 1014: 1013: 1009: 999: 997: 984: 983: 979: 945: 944: 940: 894: 893: 886: 877: 875: 862: 861: 857: 821: 820: 816: 772: 771: 767: 723: 722: 718: 687: 686: 682: 636: 635: 631: 585: 584: 580: 536: 535: 531: 521: 480: 479: 475: 470: 458: 363: 315: 303:Cytochrome p450 260: 184: 77: 44:are a class of 28: 23: 22: 15: 12: 11: 5: 6026: 6024: 6016: 6015: 6005: 6004: 5998: 5997: 5995: 5994: 5987: 5980: 5976: 5973: 5972: 5970: 5969: 5965: 5961: 5957: 5953: 5948: 5946:Diacylglycerol 5943: 5938: 5933: 5924: 5922: 5918: 5917: 5914: 5913: 5911: 5910: 5905: 5900: 5895: 5890: 5885: 5880: 5875: 5870: 5865: 5860: 5855: 5850: 5845: 5840: 5835: 5829: 5827: 5816: 5815: 5810: 5808: 5799: 5793: 5792: 5787: 5785: 5774: 5773: 5768: 5766: 5755: 5754: 5752: 5751: 5733: 5727: 5725: 5716: 5710: 5709: 5707: 5706: 5701: 5696: 5691: 5686: 5681: 5676: 5671: 5666: 5661: 5656: 5651: 5646: 5641: 5636: 5631: 5626: 5621: 5616: 5612: 5607: 5602: 5597: 5592: 5587: 5582: 5577: 5572: 5567: 5562: 5557: 5552: 5540: 5535: 5530: 5525: 5520: 5515: 5510: 5505: 5500: 5495: 5490: 5485: 5480: 5468: 5463: 5458: 5453: 5448: 5443: 5431: 5419: 5414: 5402: 5390: 5385: 5373: 5368: 5363: 5358: 5353: 5348: 5343: 5334:Phenylbutazone 5331: 5326: 5321: 5316: 5304: 5299: 5294: 5289: 5284: 5279: 5274: 5269: 5257: 5252: 5247: 5242: 5237: 5232: 5227: 5222: 5217: 5212: 5207: 5202: 5197: 5192: 5187: 5182: 5177: 5172: 5167: 5162: 5157: 5152: 5147: 5142: 5137: 5132: 5127: 5115: 5110: 5105: 5100: 5095: 5090: 5085: 5080: 5075: 5070: 5065: 5060: 5055: 5050: 5045: 5040: 5035: 5030: 5025: 5020: 5015: 5010: 5005: 5000: 4995: 4990: 4985: 4980: 4975: 4970: 4965: 4953: 4948: 4943: 4938: 4933: 4928: 4923: 4918: 4913: 4908: 4903: 4898: 4893: 4888: 4883: 4878: 4873: 4864: 4862: 4845: 4831: 4830: 4827: 4826: 4824: 4823: 4818: 4813: 4808: 4803: 4798: 4793: 4788: 4783: 4778: 4773: 4768: 4763: 4758: 4753: 4748: 4743: 4738: 4733: 4728: 4723: 4718: 4713: 4708: 4703: 4698: 4693: 4688: 4683: 4678: 4673: 4668: 4663: 4658: 4653: 4648: 4643: 4638: 4633: 4628: 4623: 4618: 4612: 4610: 4606: 4605: 4603: 4602: 4597: 4592: 4587: 4582: 4577: 4572: 4567: 4562: 4557: 4552: 4547: 4543: 4539: 4534: 4529: 4524: 4519: 4514: 4509: 4504: 4499: 4494: 4489: 4484: 4479: 4474: 4469: 4464: 4459: 4454: 4449: 4444: 4439: 4430: 4429: 4424: 4419: 4415: 4411: 4406: 4402: 4394: 4392: 4383: 4377: 4376: 4374: 4373: 4364: 4363: 4358: 4353: 4348: 4343: 4338: 4333: 4329: 4324: 4320: 4315: 4310: 4308:Isocarbacyclin 4305: 4300: 4295: 4290: 4285: 4280: 4275: 4266: 4264: 4255: 4249: 4248: 4246: 4245: 4240: 4235: 4230: 4225: 4220: 4216: 4212: 4208: 4203: 4198: 4193: 4188: 4183: 4178: 4169: 4167: 4158: 4152: 4151: 4148: 4147: 4145: 4144: 4139: 4134: 4129: 4125: 4120: 4115: 4110: 4105: 4100: 4095: 4091: 4083: 4081: 4077: 4076: 4074: 4073: 4068: 4063: 4058: 4049: 4048: 4043: 4041:(dinoprostone) 4038: 4034: 4029: 4025: 4020: 4011: 4009: 4001: 3995: 3994: 3992: 3991: 3982: 3981: 3976: 3971: 3966: 3964:(dinoprostone) 3961: 3957: 3952: 3948: 3944: 3940: 3935: 3930: 3928:Isocarbacyclin 3925: 3920: 3915: 3910: 3905: 3896: 3894: 3886: 3880: 3879: 3877: 3876: 3871: 3866: 3857: 3856: 3851: 3849:(dinoprostone) 3846: 3842: 3837: 3833: 3828: 3819: 3817: 3809: 3803: 3802: 3800: 3799: 3794: 3789: 3784: 3779: 3770: 3769: 3764: 3762:(dinoprostone) 3759: 3755: 3750: 3746: 3741: 3736: 3731: 3726: 3721: 3712: 3710: 3702: 3693: 3684: 3678: 3677: 3674: 3673: 3671: 3670: 3665: 3660: 3655: 3650: 3645: 3640: 3635: 3630: 3625: 3620: 3615: 3606: 3605: 3601: 3597: 3588: 3586: 3578: 3572: 3571: 3569: 3568: 3563: 3558: 3549: 3548: 3543: 3539: 3531: 3529: 3521: 3512: 3503: 3494: 3480: 3479: 3468: 3466: 3465: 3458: 3451: 3443: 3434: 3433: 3431: 3430: 3423: 3419: 3416: 3415: 3413: 3412: 3407: 3402: 3397: 3392: 3387: 3382: 3377: 3372: 3367: 3362: 3357: 3352: 3347: 3338: 3337: 3332: 3322: 3317: 3312: 3307: 3302: 3297: 3292: 3287: 3282: 3277: 3268: 3259: 3250: 3248: 3237: 3236: 3234: 3233: 3224: 3223: 3218: 3213: 3208: 3203: 3198: 3189: 3188: 3183: 3178: 3173: 3168: 3163: 3153: 3148: 3143: 3138: 3133: 3128: 3123: 3118: 3113: 3108: 3103: 3098: 3093: 3088: 3083: 3074: 3069: 3064: 3059: 3054: 3045: 3036: 3034: 3023: 3022: 3014: 3012: 3011: 3004: 2997: 2989: 2980: 2979: 2976: 2975: 2974: 2973: 2970: 2959: 2953: 2947: 2946: 2943: 2942: 2939: 2938: 2936: 2935: 2930: 2924: 2922: 2916: 2915: 2913: 2912: 2907: 2902: 2896: 2894: 2887: 2883: 2882: 2879: 2878: 2876: 2875: 2870: 2864: 2859: 2854: 2843: 2837: 2835: 2831: 2830: 2828: 2827: 2822: 2816: 2814: 2808: 2807: 2805: 2804: 2798: 2796: 2790: 2789: 2787: 2786: 2776: 2774: 2767: 2763: 2762: 2752: 2750: 2749: 2742: 2735: 2727: 2718: 2717: 2714: 2713: 2712: 2711: 2708: 2697: 2691: 2685: 2684: 2681: 2680: 2678: 2677: 2672: 2667: 2662: 2657: 2652: 2647: 2642: 2636: 2634: 2630: 2629: 2627: 2626: 2621: 2616: 2611: 2606: 2600: 2598: 2594: 2593: 2591: 2590: 2585: 2580: 2575: 2570: 2565: 2559: 2557: 2551: 2550: 2548: 2547: 2546: 2545: 2540: 2530: 2529: 2528: 2525:Spironolactone 2522: 2517: 2512: 2507: 2496: 2494: 2488: 2487: 2485: 2484: 2478: 2473: 2464: 2459: 2454: 2449: 2443: 2441: 2435: 2434: 2432: 2431: 2426: 2421: 2416: 2410: 2408: 2402: 2401: 2399: 2398: 2393: 2388: 2386:Salicylic acid 2383: 2377: 2375: 2369: 2368: 2366: 2365: 2360: 2355: 2350: 2345: 2339: 2337: 2331: 2330: 2320: 2318: 2317: 2310: 2303: 2295: 2286: 2285: 2283: 2282: 2277: 2272: 2267: 2262: 2257: 2252: 2247: 2242: 2237: 2231: 2229: 2227:Retinoid drugs 2223: 2222: 2220: 2219: 2214: 2209: 2203: 2201: 2197: 2193: 2192: 2190: 2189: 2184: 2179: 2174: 2169: 2164: 2159: 2153: 2151: 2147: 2144:Apocarotenoids 2140: 2139: 2137: 2136: 2131: 2126: 2121: 2116: 2111: 2106: 2101: 2096: 2091: 2086: 2081: 2076: 2074:Diadinoxanthin 2071: 2066: 2064:Citranaxanthin 2061: 2056: 2051: 2049:Antheraxanthin 2045: 2043: 2039: 2032: 2031: 2029: 2028: 2023: 2018: 2013: 2008: 2003: 1998: 1993: 1988: 1983: 1978: 1973: 1967: 1965: 1961: 1954: 1953: 1948: 1946: 1945: 1938: 1931: 1923: 1917: 1916: 1904: 1903:External links 1901: 1898: 1897: 1886:What To Expect 1873: 1852: 1827: 1799: 1775: 1751: 1732:(4): 249–252. 1716: 1681: 1645: 1594: 1561: 1510: 1459: 1408: 1357: 1338:(5): 575–581. 1321: 1300:(5): 606–612. 1280: 1249:(4): 327–348. 1229: 1203: 1177: 1126: 1107:(1): 110–119. 1091: 1072:(1): 110–119. 1056: 1007: 977: 958:(2): S18–S24. 938: 907:(4): 327–348. 884: 870:. 2013-12-02. 855: 814: 785:(6): 921–931. 765: 716: 680: 629: 578: 529: 493:(1): 194–232. 472: 471: 469: 466: 465: 464: 457: 454: 442:hypothyroidism 440:causes severe 362: 359: 314: 311: 259: 256: 183: 180: 177: 176: 171: 168: 164: 163: 150: 147: 143: 142: 133: 130: 126: 125: 100: 97: 93: 92: 89: 86: 76: 73: 26: 24: 14: 13: 10: 9: 6: 4: 3: 2: 6025: 6014: 6011: 6010: 6008: 5993: 5992: 5988: 5986: 5985: 5981: 5978: 5977: 5974: 5968: 5962: 5960: 5954: 5952: 5949: 5947: 5944: 5942: 5939: 5937: 5934: 5932: 5931:Linoleic acid 5929: 5926: 5925: 5923: 5919: 5909: 5906: 5904: 5901: 5899: 5896: 5894: 5891: 5889: 5886: 5884: 5881: 5879: 5876: 5874: 5871: 5869: 5866: 5864: 5861: 5859: 5856: 5854: 5851: 5849: 5846: 5844: 5841: 5839: 5836: 5834: 5831: 5830: 5828: 5823: 5817: 5813: 5809: 5804: 5794: 5790: 5786: 5781: 5775: 5771: 5767: 5762: 5756: 5749: 5745: 5741: 5737: 5734: 5732: 5729: 5728: 5726: 5721: 5711: 5705: 5702: 5700: 5697: 5695: 5692: 5690: 5687: 5685: 5682: 5680: 5677: 5675: 5672: 5670: 5667: 5665: 5662: 5660: 5657: 5655: 5652: 5650: 5647: 5645: 5642: 5640: 5637: 5635: 5632: 5630: 5627: 5625: 5622: 5620: 5613: 5611: 5608: 5606: 5603: 5601: 5598: 5596: 5593: 5591: 5588: 5586: 5583: 5581: 5578: 5576: 5573: 5571: 5568: 5566: 5563: 5561: 5558: 5556: 5553: 5551: 5548: 5544: 5541: 5539: 5536: 5534: 5531: 5529: 5526: 5524: 5521: 5519: 5516: 5514: 5511: 5509: 5506: 5504: 5501: 5499: 5496: 5494: 5491: 5489: 5486: 5484: 5481: 5479: 5476: 5472: 5469: 5467: 5464: 5462: 5459: 5457: 5454: 5452: 5449: 5447: 5444: 5442: 5439: 5435: 5432: 5430: 5427: 5423: 5420: 5418: 5415: 5413: 5410: 5406: 5403: 5401: 5400:Fluproquazone 5398: 5397:Quinazolines: 5394: 5391: 5389: 5386: 5384: 5381: 5377: 5374: 5372: 5369: 5367: 5364: 5362: 5359: 5357: 5354: 5352: 5349: 5347: 5344: 5342: 5339: 5335: 5332: 5330: 5327: 5325: 5322: 5320: 5317: 5315: 5312: 5308: 5305: 5303: 5300: 5298: 5295: 5293: 5290: 5288: 5285: 5283: 5280: 5278: 5275: 5273: 5270: 5268: 5265: 5261: 5258: 5256: 5253: 5251: 5248: 5246: 5243: 5241: 5238: 5236: 5233: 5231: 5228: 5226: 5223: 5221: 5218: 5216: 5213: 5211: 5208: 5206: 5203: 5201: 5198: 5196: 5193: 5191: 5188: 5186: 5183: 5181: 5178: 5176: 5175:Flunoxaprofen 5173: 5171: 5168: 5166: 5163: 5161: 5160:Dexketoprofen 5158: 5156: 5155:Dexindoprofen 5153: 5151: 5148: 5146: 5143: 5141: 5138: 5136: 5133: 5131: 5128: 5126: 5123: 5119: 5116: 5114: 5111: 5109: 5106: 5104: 5101: 5099: 5096: 5094: 5093:Proglumetacin 5091: 5089: 5086: 5084: 5081: 5079: 5076: 5074: 5071: 5069: 5066: 5064: 5061: 5059: 5056: 5054: 5051: 5049: 5046: 5044: 5041: 5039: 5036: 5034: 5031: 5029: 5026: 5024: 5023:Difenpiramide 5021: 5019: 5016: 5014: 5011: 5009: 5006: 5004: 5001: 4999: 4996: 4994: 4991: 4989: 4986: 4984: 4981: 4979: 4976: 4974: 4971: 4969: 4966: 4964: 4961: 4960:Acetic acids: 4957: 4954: 4952: 4949: 4947: 4944: 4942: 4939: 4937: 4934: 4932: 4929: 4927: 4924: 4922: 4919: 4917: 4914: 4912: 4909: 4907: 4904: 4902: 4899: 4897: 4894: 4892: 4889: 4887: 4884: 4882: 4879: 4877: 4874: 4872: 4869: 4866: 4865: 4863: 4861: 4849: 4846: 4842: 4836: 4832: 4822: 4819: 4817: 4814: 4812: 4809: 4807: 4804: 4802: 4799: 4797: 4794: 4792: 4789: 4787: 4784: 4782: 4779: 4777: 4774: 4772: 4769: 4767: 4764: 4762: 4759: 4757: 4754: 4752: 4749: 4747: 4744: 4742: 4739: 4737: 4734: 4732: 4729: 4727: 4724: 4722: 4719: 4717: 4714: 4712: 4709: 4707: 4704: 4702: 4699: 4697: 4694: 4692: 4691:Fenprostalene 4689: 4687: 4684: 4682: 4679: 4677: 4674: 4672: 4669: 4667: 4664: 4662: 4659: 4657: 4654: 4652: 4649: 4647: 4644: 4642: 4641:Delprostenate 4639: 4637: 4634: 4632: 4629: 4627: 4624: 4622: 4619: 4617: 4614: 4613: 4611: 4607: 4601: 4598: 4596: 4593: 4591: 4588: 4586: 4583: 4581: 4578: 4576: 4573: 4571: 4568: 4566: 4563: 4561: 4558: 4556: 4553: 4551: 4548: 4546: 4540: 4538: 4535: 4533: 4530: 4528: 4525: 4523: 4520: 4518: 4515: 4513: 4510: 4508: 4505: 4503: 4500: 4498: 4495: 4493: 4490: 4488: 4485: 4483: 4480: 4478: 4475: 4473: 4470: 4468: 4465: 4463: 4460: 4458: 4455: 4453: 4450: 4448: 4445: 4443: 4440: 4438: 4435: 4432: 4431: 4428: 4425: 4423: 4420: 4418: 4414:Thromboxane A 4412: 4410: 4407: 4405: 4399: 4396: 4395: 4393: 4388: 4378: 4372: 4369: 4366: 4365: 4362: 4359: 4357: 4354: 4352: 4349: 4347: 4344: 4342: 4339: 4337: 4336:(alprostadil) 4330: 4328: 4321: 4319: 4316: 4314: 4311: 4309: 4306: 4304: 4301: 4299: 4296: 4294: 4291: 4289: 4286: 4284: 4281: 4279: 4276: 4274: 4271: 4268: 4267: 4265: 4260: 4250: 4244: 4241: 4239: 4236: 4234: 4231: 4229: 4226: 4224: 4217: 4215: 4209: 4207: 4204: 4202: 4199: 4197: 4194: 4192: 4189: 4187: 4184: 4182: 4179: 4177: 4174: 4171: 4170: 4168: 4163: 4153: 4143: 4140: 4138: 4135: 4133: 4126: 4124: 4121: 4119: 4116: 4114: 4111: 4109: 4106: 4104: 4101: 4099: 4096: 4094: 4088: 4085: 4084: 4082: 4078: 4072: 4069: 4067: 4064: 4062: 4059: 4057: 4054: 4051: 4050: 4047: 4044: 4042: 4035: 4033: 4032:(alprostadil) 4026: 4024: 4021: 4019: 4016: 4013: 4012: 4010: 4005: 3996: 3990: 3987: 3984: 3983: 3980: 3977: 3975: 3972: 3970: 3967: 3965: 3958: 3956: 3955:(alprostadil) 3949: 3947: 3941: 3939: 3936: 3934: 3931: 3929: 3926: 3924: 3921: 3919: 3916: 3914: 3911: 3909: 3906: 3904: 3901: 3898: 3897: 3895: 3890: 3881: 3875: 3872: 3870: 3867: 3865: 3862: 3859: 3858: 3855: 3852: 3850: 3843: 3841: 3840:(alprostadil) 3834: 3832: 3829: 3827: 3824: 3821: 3820: 3818: 3813: 3804: 3798: 3795: 3793: 3790: 3788: 3785: 3783: 3780: 3778: 3775: 3772: 3771: 3768: 3765: 3763: 3756: 3754: 3753:(alprostadil) 3747: 3745: 3742: 3740: 3737: 3735: 3732: 3730: 3727: 3725: 3722: 3720: 3717: 3714: 3713: 3711: 3706: 3697: 3694: 3689: 3679: 3669: 3666: 3664: 3661: 3659: 3656: 3654: 3651: 3649: 3646: 3644: 3641: 3639: 3636: 3634: 3631: 3629: 3626: 3624: 3621: 3619: 3616: 3614: 3611: 3608: 3607: 3604: 3598: 3596: 3593: 3590: 3589: 3587: 3582: 3573: 3567: 3564: 3562: 3559: 3557: 3554: 3551: 3550: 3547: 3544: 3542: 3536: 3533: 3532: 3530: 3525: 3516: 3513: 3508: 3498: 3495: 3491: 3485: 3481: 3477: 3474: 3471: 3464: 3459: 3457: 3452: 3450: 3445: 3444: 3441: 3429: 3428: 3424: 3421: 3420: 3417: 3411: 3408: 3406: 3403: 3401: 3398: 3396: 3393: 3391: 3388: 3386: 3383: 3381: 3378: 3376: 3373: 3371: 3368: 3366: 3363: 3361: 3358: 3356: 3353: 3351: 3348: 3346: 3343: 3340: 3339: 3336: 3333: 3330: 3326: 3323: 3321: 3320:Retinoic acid 3318: 3316: 3313: 3311: 3308: 3306: 3303: 3301: 3298: 3296: 3293: 3291: 3288: 3286: 3283: 3281: 3278: 3276: 3274: 3269: 3267: 3265: 3260: 3258: 3255: 3252: 3251: 3249: 3244: 3238: 3232: 3229: 3226: 3225: 3222: 3219: 3217: 3214: 3212: 3209: 3207: 3204: 3202: 3199: 3197: 3194: 3191: 3190: 3187: 3184: 3182: 3179: 3177: 3174: 3172: 3169: 3167: 3164: 3161: 3157: 3154: 3152: 3151:Retinoic acid 3149: 3147: 3144: 3142: 3139: 3137: 3134: 3132: 3129: 3127: 3124: 3122: 3119: 3117: 3114: 3112: 3109: 3107: 3104: 3102: 3099: 3097: 3094: 3092: 3089: 3087: 3084: 3082: 3080: 3075: 3073: 3070: 3068: 3065: 3063: 3060: 3058: 3055: 3053: 3051: 3046: 3044: 3041: 3038: 3037: 3035: 3030: 3024: 3020: 3017: 3010: 3005: 3003: 2998: 2996: 2991: 2990: 2987: 2971: 2969: 2966: 2965: 2963: 2960: 2957: 2954: 2952: 2949: 2948: 2944: 2934: 2931: 2929: 2926: 2925: 2923: 2921: 2917: 2911: 2908: 2906: 2903: 2901: 2898: 2897: 2895: 2891: 2888: 2884: 2874: 2871: 2868: 2865: 2863: 2860: 2858: 2855: 2853: 2849: 2848: 2844: 2842: 2839: 2838: 2836: 2832: 2826: 2823: 2821: 2818: 2817: 2815: 2813: 2809: 2803: 2800: 2799: 2797: 2795: 2791: 2785: 2781: 2778: 2777: 2775: 2771: 2768: 2764: 2759: 2755: 2748: 2743: 2741: 2736: 2734: 2729: 2728: 2725: 2709: 2707: 2704: 2703: 2701: 2698: 2695: 2692: 2690: 2687: 2686: 2682: 2676: 2673: 2671: 2668: 2666: 2663: 2661: 2658: 2656: 2653: 2651: 2648: 2646: 2643: 2641: 2638: 2637: 2635: 2631: 2625: 2622: 2620: 2617: 2615: 2612: 2610: 2607: 2605: 2602: 2601: 2599: 2595: 2589: 2586: 2584: 2581: 2579: 2576: 2574: 2571: 2569: 2566: 2564: 2561: 2560: 2558: 2556: 2552: 2544: 2541: 2539: 2536: 2535: 2534: 2531: 2526: 2523: 2521: 2518: 2516: 2513: 2511: 2508: 2506: 2503: 2502: 2501: 2500:Antiandrogens 2498: 2497: 2495: 2493: 2489: 2482: 2479: 2477: 2474: 2472: 2468: 2467:Tetracyclines 2465: 2463: 2462:Sulfacetamide 2460: 2458: 2455: 2453: 2450: 2448: 2445: 2444: 2442: 2440: 2436: 2430: 2427: 2425: 2422: 2420: 2417: 2415: 2412: 2411: 2409: 2407: 2403: 2397: 2394: 2392: 2389: 2387: 2384: 2382: 2381:Glycolic acid 2379: 2378: 2376: 2374: 2370: 2364: 2361: 2359: 2356: 2354: 2351: 2349: 2346: 2344: 2341: 2340: 2338: 2336: 2335:Antibacterial 2332: 2327: 2323: 2316: 2311: 2309: 2304: 2302: 2297: 2296: 2293: 2281: 2278: 2276: 2273: 2271: 2268: 2266: 2263: 2261: 2258: 2256: 2253: 2251: 2248: 2246: 2243: 2241: 2238: 2236: 2233: 2232: 2230: 2228: 2224: 2218: 2215: 2213: 2212:Retinoic acid 2210: 2208: 2205: 2204: 2202: 2194: 2188: 2185: 2183: 2180: 2178: 2177:Food orange 7 2175: 2173: 2170: 2168: 2165: 2163: 2160: 2158: 2157:Abscisic acid 2155: 2154: 2152: 2145: 2141: 2135: 2132: 2130: 2127: 2125: 2122: 2120: 2117: 2115: 2112: 2110: 2107: 2105: 2102: 2100: 2097: 2095: 2092: 2090: 2087: 2085: 2082: 2080: 2077: 2075: 2072: 2070: 2069:Cryptoxanthin 2067: 2065: 2062: 2060: 2059:Canthaxanthin 2057: 2055: 2052: 2050: 2047: 2046: 2044: 2037: 2033: 2027: 2024: 2022: 2019: 2017: 2014: 2012: 2009: 2007: 2004: 2002: 1999: 1997: 1994: 1992: 1989: 1987: 1984: 1982: 1979: 1977: 1974: 1972: 1969: 1968: 1966: 1959: 1955: 1951: 1944: 1939: 1937: 1932: 1930: 1925: 1924: 1921: 1914: 1910: 1907: 1906: 1902: 1887: 1883: 1877: 1874: 1862: 1856: 1853: 1841: 1837: 1831: 1828: 1817: 1813: 1809: 1803: 1800: 1789: 1785: 1779: 1776: 1761: 1755: 1752: 1747: 1743: 1739: 1735: 1731: 1727: 1720: 1717: 1712: 1708: 1704: 1700: 1696: 1692: 1685: 1682: 1677: 1673: 1669: 1665: 1661: 1657: 1649: 1646: 1641: 1637: 1632: 1627: 1622: 1617: 1613: 1609: 1605: 1598: 1595: 1584: 1580: 1576: 1572: 1565: 1562: 1557: 1553: 1548: 1543: 1538: 1533: 1529: 1525: 1521: 1514: 1511: 1506: 1502: 1497: 1492: 1487: 1482: 1478: 1474: 1470: 1463: 1460: 1455: 1451: 1446: 1441: 1436: 1431: 1427: 1423: 1419: 1412: 1409: 1404: 1400: 1395: 1390: 1385: 1380: 1376: 1372: 1368: 1361: 1358: 1353: 1349: 1345: 1341: 1337: 1333: 1325: 1322: 1317: 1313: 1308: 1303: 1299: 1295: 1291: 1284: 1281: 1276: 1272: 1267: 1262: 1257: 1252: 1248: 1244: 1240: 1233: 1230: 1217: 1213: 1207: 1204: 1191: 1187: 1181: 1178: 1173: 1169: 1164: 1159: 1154: 1149: 1145: 1141: 1137: 1130: 1127: 1122: 1118: 1114: 1110: 1106: 1102: 1095: 1092: 1087: 1083: 1079: 1075: 1071: 1067: 1060: 1057: 1052: 1048: 1043: 1038: 1034: 1030: 1026: 1022: 1018: 1011: 1008: 995: 991: 987: 981: 978: 973: 969: 965: 961: 957: 953: 949: 942: 939: 934: 930: 925: 920: 915: 910: 906: 902: 898: 891: 889: 885: 873: 869: 865: 859: 856: 851: 847: 842: 837: 834:(4): e12483. 833: 829: 825: 818: 815: 810: 806: 801: 796: 792: 788: 784: 780: 776: 769: 766: 761: 757: 752: 747: 743: 739: 735: 731: 727: 720: 717: 712: 708: 704: 700: 696: 692: 684: 681: 676: 672: 667: 662: 657: 652: 648: 644: 640: 633: 630: 625: 621: 616: 611: 606: 601: 597: 593: 589: 582: 579: 574: 570: 565: 560: 556: 552: 548: 544: 540: 533: 530: 525: 518: 514: 509: 504: 500: 496: 492: 488: 484: 477: 474: 467: 463: 460: 459: 455: 453: 449: 445: 443: 439: 435: 431: 427: 426:triglycerides 422: 420: 416: 412: 408: 404: 400: 396: 392: 388: 384: 380: 376: 372: 368: 360: 358: 356: 352: 348: 344: 340: 339:neuroblastoma 336: 332: 331:discoid lupus 328: 324: 320: 312: 310: 308: 304: 300: 296: 292: 288: 283: 281: 277: 273: 269: 265: 257: 255: 252: 250: 246: 242: 238: 234: 230: 225: 222: 220: 216: 212: 208: 205:for retinol, 204: 199: 197: 193: 189: 181: 175: 172: 169: 166: 165: 162: 158: 154: 151: 148: 145: 144: 141: 137: 134: 131: 128: 127: 124: 120: 116: 115:retinoic acid 112: 108: 104: 101: 98: 95: 94: 90: 87: 84: 83: 80: 74: 72: 70: 66: 61: 57: 55: 51: 47: 43: 34: 30: 19: 5989: 5982: 5927: 5730: 5546: 5474: 5471:Propacetamol 5461:Parapropamol 5437: 5425: 5408: 5396: 5388:Floctafenine 5379: 5337: 5314:Azapropazone 5311:Pyrazolones: 5310: 5263: 5245:Tarenflurbil 5180:Flurbiprofen 5150:Dexibuprofen 5130:Benoxaprofen 5125:Alminoprofen 5121: 5048:Glucametacin 4959: 4936:Salicylamide 4926:Salacetamide 4867: 4816:Trimoprostil 4811:Tiprostanide 4796:Spiriprostil 4731:Naxaprostene 4681:Esuberaprost 4636:Cobiprostone 4434:Antagonists: 4433: 4397: 4368:Antagonists: 4367: 4361:Treprostinil 4269: 4201:Fluprostenol 4191:Cloprostenol 4172: 4086: 4053:Antagonists: 4052: 4018:Lubiprostone 4014: 3986:Antagonists: 3985: 3899: 3861:Antagonists: 3860: 3854:Treprostinil 3822: 3774:Antagonists: 3773: 3739:Lubiprostone 3715: 3610:Antagonists: 3609: 3591: 3553:Antagonists: 3552: 3546:Treprostinil 3534: 3425: 3342:Antagonists: 3341: 3300:Isotretinoin 3272: 3263: 3253: 3227: 3193:Antagonists: 3192: 3166:Tamibarotene 3146:Palovarotene 3141:Isotretinoin 3078: 3049: 3039: 2919: 2852:Calcipotriol 2845: 2841:Fumaric acid 2633:Combinations 2568:Isotretinoin 2554: 2515:Drospirenone 2505:Bicalutamide 2457:Erythromycin 2363:Tea tree oil 2343:Azelaic acid 2260:Isotretinoin 2240:Alitretinoin 2226: 2162:Apocarotenal 2134:Zeinoxanthin 2124:Violaxanthin 2114:Rhodoxanthin 2094:Flavoxanthin 2079:Diatoxanthin 2036:Xanthophylls 2006:Neurosporene 1889:. Retrieved 1885: 1876: 1865:. Retrieved 1855: 1844:. Retrieved 1839: 1830: 1819:. Retrieved 1815: 1802: 1791:. Retrieved 1787: 1778: 1767:. Retrieved 1754: 1729: 1725: 1719: 1694: 1690: 1684: 1659: 1655: 1648: 1611: 1607: 1597: 1586:. Retrieved 1574: 1564: 1527: 1523: 1513: 1476: 1472: 1462: 1425: 1421: 1411: 1374: 1370: 1360: 1335: 1331: 1324: 1297: 1293: 1283: 1246: 1242: 1232: 1220:. Retrieved 1206: 1194:. Retrieved 1190:the original 1180: 1143: 1139: 1129: 1104: 1100: 1094: 1069: 1065: 1059: 1027:(1): 13–22. 1024: 1020: 1010: 998:. Retrieved 989: 980: 955: 951: 941: 904: 900: 876:. Retrieved 867: 858: 831: 827: 817: 782: 778: 768: 733: 729: 719: 694: 690: 683: 646: 642: 632: 595: 591: 581: 549:(1): 13–22. 546: 542: 532: 490: 486: 476: 450: 446: 423: 395:papilloedema 383:skin lesions 367:medical sign 364: 316: 307:Cyp26 family 295:chylomicrons 284: 261: 253: 243:binding the 229:isotretinoin 226: 223: 200: 196:chromophores 185: 123:alitretinoin 119:isotretinoin 78: 62: 58: 41: 39: 29: 5928:Precursors: 5868:Nicogrelate 5848:Furegrelate 5789:Bimatoprost 5699:Trifenagrel 5689:Tiflamizole 5659:Rutecarpine 5644:Resveratrol 5585:Glimepiride 5550:Anitrazafen 5528:Robenacoxib 5508:Lumiracoxib 5441:Acetanilide 5383:Antrafenine 5341:Ampiroxicam 5235:Pranoprofen 5220:Naproxcinod 5113:Zidometacin 5038:Fenclofenac 4963:Aceclofenac 4901:Ethenzamide 4896:Dipyrocetyl 4791:Rosaprostol 4771:Posaraprost 4756:Penprostene 4746:Ornoprostil 4726:Mexiprostil 4721:Meteneprost 4676:Eptaloprost 4651:Dimoxaprost 4616:Arbaprostil 4570:Seratrodast 4462:BMS-180,291 4293:Carbacyclin 4243:Unoprostone 4223:(dinoprost) 4206:Latanoprost 4181:Bimatoprost 4176:Alfaprostol 4132:(dinoprost) 4071:ONO-AE3-208 4023:Misoprostol 3979:Sulprostone 3969:Remiprostol 3938:Misoprostol 3933:Latanoprost 3908:Carbacyclin 3869:PF-04418948 3831:Misoprostol 3767:Sulprostone 3744:Misoprostol 3734:Latanoprost 3668:Vidupiprant 3658:Timapiprant 3653:Setipiprant 3628:Fevipiprant 3595:Indometacin 3566:Vidupiprant 3561:Laropiprant 3181:Trifarotene 3136:Fenretinide 2958:from market 2905:Methoxsalen 2900:Trioxysalen 2825:Methoxsalen 2820:Trioxysalen 2696:from market 2604:Epristeride 2588:Trifarotene 2573:Motretinide 2481:Doxycycline 2476:Minocycline 2471:Lymecycline 2447:Clindamycin 2439:Antibiotics 2414:Niacinamide 2373:Keratolytic 2255:Fenretinide 2119:Rubixanthin 2099:Fucoxanthin 2084:Dinoxanthin 2054:Astaxanthin 2026:Lycopersene 2016:Phytofluene 1950:Carotenoids 1377:: 367–373. 1000:31 December 428:leading to 268:chylomicron 174:Trifarotene 88:Description 5898:Samixogrel 5893:Rolafagrel 5878:Picotamide 5858:Midazogrel 5833:Camonagrel 5694:Timegadine 5639:Pamicogrel 5610:Licofelone 5590:Hyperforin 5555:Clobuzarit 5543:Valdecoxib 5538:Tilmacoxib 5523:Polmacoxib 5498:Etoricoxib 5466:Phenacetin 5434:Nimesulide 5412:Clonixeril 5405:Proquazone 5361:Lornoxicam 5260:Vedaprofen 5210:Miroprofen 5205:Loxoprofen 5200:Ketoprofen 5195:Indoprofen 5170:Fenoprofen 5083:Oxametacin 5078:Nabumetone 5018:Diclofenac 5013:Clometacin 5008:Cinmetacin 5003:Bumadizone 4983:Alclofenac 4968:Acemetacin 4906:Guacetisal 4891:Diflunisal 4841:inhibitors 4806:Tilsuprost 4786:Rivenprost 4781:Rioprostil 4776:Prostalene 4761:Pimilprost 4751:Oxoprostol 4741:Nocloprost 4716:Luprostiol 4706:Lanproston 4701:Froxiprost 4696:Flunoprost 4686:Etiproston 4671:Enisoprost 4666:Eganoprost 4626:Ciprostene 4595:Terutroban 4585:Sulotroban 4565:Samixogrel 4550:Ramatroban 4537:Picotamide 4522:Mipitroban 4517:Linotroban 4502:Imitrodast 4492:ICI-192605 4487:ICI-185282 4472:Domitroban 4452:Argatroban 4351:Taprostene 4273:ACT-333679 4238:Travoprost 4233:Tafluprost 4228:Sulotroban 4186:Carboprost 4142:Taprenepag 4123:Omidenepag 4118:Nocloprost 4108:Evatanepag 4103:Carboprost 4056:Grapiprant 3648:Ramatroban 3556:Asapiprant 3476:modulators 3470:Prostanoid 3280:Bexarotene 3196:BMS-195614 3171:Tazarotene 3131:Etretinate 3019:modulators 2928:Etretinate 2873:Tazarotene 2867:Tacalcitol 2862:Calcitriol 2578:Tazarotene 2270:Temarotene 2265:Tazarotene 2250:Etretinate 2245:Bexarotene 2129:Zeaxanthin 2109:Neoxanthin 2089:Echinenone 1996:ΞΆ-Carotene 1991:Ξ΅-Carotene 1986:Ξ΄-Carotene 1981:Ξ³-Carotene 1976:Ξ²-Carotene 1971:Ξ±-Carotene 1891:2023-10-10 1867:2023-10-10 1846:2023-10-10 1821:2023-10-10 1793:2023-10-10 1769:2023-10-10 1588:2024-08-15 1575:StatPearls 1479:(3): 544. 1428:(3): 544. 878:2024-08-30 598:: 871225. 468:References 438:bexarotene 401:, general 327:photoaging 241:tazarotene 233:bexarotene 161:tazarotene 157:bexarotene 136:etretinate 91:Compounds 85:Generation 6013:Retinoids 5903:Terbogrel 5883:Pirmagrel 5843:Dazoxiben 5838:Dazmegrel 5731:Retinoids 5649:Romazarit 5595:Itazigrel 5580:FR-122047 5575:Flumizole 5533:Rofecoxib 5518:Parecoxib 5513:Mavacoxib 5503:Firocoxib 5493:Deracoxib 5488:Cimicoxib 5483:Celecoxib 5478:Apricoxib 5429:Flosulide 5393:Glafenine 5376:Tenoxicam 5371:Piroxicam 5366:Meloxicam 5250:Tepoxalin 5230:Pirprofen 5225:Oxaprozin 5190:Ibuproxam 5185:Ibuprofen 5145:Carprofen 5140:Butibufen 5118:Zomepirac 5088:Oxindanac 5073:Mofezolac 5068:Lonazolac 5063:Ketorolac 5043:Fentiazac 4998:Bufexamac 4993:Bromfenac 4973:Aclofenac 4956:Triflusal 4946:Salsalate 4871:Aloxiprin 4821:Viprostol 4766:Piriprost 4736:Nileprost 4711:Limaprost 4661:Ecraprost 4656:Doxaprost 4646:Deprostil 4631:Clinprost 4590:Terbogrel 4580:SQ-29,548 4575:SQ-28,668 4532:ONO-11120 4497:Ifetroban 4467:Daltroban 4457:Bay U3405 4427:Vapiprost 4398:Agonists: 4371:RO1138452 4346:Selexipag 4341:Ralinepag 4298:Cicaprost 4288:BMY-45778 4283:Beraprost 4270:Agonists: 4196:Enprostil 4173:Agonists: 4137:Simenepag 4113:Gemeprost 4087:Agonists: 4061:GW-627368 4015:Agonists: 3918:Enprostil 3913:Cicaprost 3903:Beraprost 3900:Agonists: 3826:Butaprost 3823:Agonists: 3724:Enprostil 3719:Beraprost 3716:Agonists: 3623:Bay U3405 3592:Agonists: 3535:Agonists: 3473:signaling 3355:LG-100754 3329:vitamin A 3315:LG-100754 3310:LG-101506 3305:LG-100268 3254:Agonists: 3231:Liarozole 3160:vitamin A 3072:Adapalene 3067:Acitretin 3057:AC-261066 3040:Agonists: 2968:Phase III 2956:Withdrawn 2933:Acitretin 2920:Retinoids 2910:Bergapten 2893:Psoralens 2847:vitamin D 2812:Psoralens 2802:Dithranol 2794:Antracens 2706:Phase III 2694:Withdrawn 2624:Tioxolone 2583:Tretinoin 2563:Adapalene 2555:Retinoids 2538:Estradiol 2533:Estrogens 2520:Flutamide 2419:Ibuprofen 2275:Tretinoin 2235:Acitretin 2187:Peridinin 1958:Carotenes 1909:Retinoids 972:0190-9622 419:adapalene 387:hair loss 323:psoriasis 276:carotenes 264:carotenes 182:Structure 153:adapalene 140:acitretin 111:tretinoin 67:(APL) or 50:vitamin A 42:retinoids 18:Retinoids 6007:Category 5979:See also 5888:Ridogrel 5863:Nafagrel 5853:Isbogrel 5736:Selenium 5704:Tropesin 5679:SC-58125 5664:Satigrel 5629:NCX-4040 5605:L-670596 5600:L-655240 5560:Curcumin 5422:Flunixin 5417:Clonixin 5356:Isoxicam 5351:Enolicam 5346:Droxicam 5324:Isopyrin 5319:Dipyrone 5240:Suprofen 5215:Naproxen 5165:Fenbufen 5108:Tolmetin 5098:Sulindac 5033:Felbinac 5028:Etodolac 4988:Bendazac 4801:Tiaprost 4621:Ataprost 4609:Unsorted 4555:Ridogrel 4527:ONO-3708 4512:L-670596 4507:L-655240 4482:GR-32191 4098:Aganepag 4080:Unsorted 4066:L-161982 4046:TCS-2510 3989:L-798106 3874:TG 4-155 3797:SC-51322 3792:SC-51089 3787:SC-19220 3782:ONO-8130 3618:AZD-1981 3613:ADC-3680 3484:Receptor 3422:See also 3365:UVI-3003 3335:SR-11237 3221:MM-11253 3211:ER-50891 3062:AC-55649 2886:Systemic 2784:Coal tar 2614:Pelretin 2609:Mesulfen 2492:Hormonal 2172:Crocetin 2021:Torulene 2011:Phytoene 2001:Lycopene 1788:Medscape 1746:12672276 1676:15572756 1640:39133222 1631:11318670 1583:30422511 1556:39133222 1547:11318670 1505:38339295 1496:10854948 1454:38339295 1445:10854948 1403:25678803 1352:35306922 1316:17515510 1275:18046911 1222:16 March 1216:Archived 1196:16 March 1172:39133222 1163:11318670 1121:15325918 1086:15325918 1051:21777796 1021:Immunity 994:Archived 933:18046911 872:Archived 850:28295859 809:18805086 760:34292058 711:15572756 675:39133222 666:11318670 624:35574006 573:21777796 543:Immunity 517:23905688 456:See also 399:bleeding 379:Anorexia 361:Toxicity 54:immunity 5908:U63557A 5873:Ozagrel 5684:Tenidap 5624:NCX-466 5570:FK-3311 5565:DuP-697 5451:Bucetin 4978:Amfenac 4931:Salicin 4600:TRA-418 4447:AA-2414 4437:12-HETE 4422:U-46619 4356:TRA-418 4313:MRE-269 3864:AH-6809 3777:AH-6809 3663:TM30089 3643:QAV-680 3638:MK-7246 3633:MK-1029 3490:ligands 3325:Retinol 3285:CD 3254 3206:CD-2665 3201:BMS-493 3156:Retinol 3111:CD-2314 3106:CD-1530 3101:BMS-961 3096:BMS-753 3091:BMS-493 2766:Topical 2619:Stridex 2452:Dapsone 2424:Aspirin 2217:Retinol 2207:Retinal 2182:Ionones 1711:8127329 1473:Cancers 1422:Cancers 1394:4322887 1266:2699641 1042:3418663 924:2699641 800:2632951 751:8750127 615:9097449 564:3418663 508:3858459 403:malaise 371:retinol 287:retinol 272:retinol 251:forms. 188:polyene 107:retinal 103:retinol 5921:Others 5770:HQL-79 5674:SC-560 5669:SC-236 5634:NS-398 4835:Enzyme 4477:EP-045 4442:13-APA 4382:TP (TX 4318:NS-304 4278:AFP-07 3405:HX-711 3395:PA-452 3390:PA-451 3385:CD3254 3380:LE-540 3370:HX-603 3360:PA-452 3350:HX-630 3345:HX-531 3257:9CDHRA 3216:LE-135 3116:CD-437 3086:AM-580 3043:9CDHRA 2951:WHO-EM 2689:WHO-EM 2391:Sulfur 2148:<40 2104:Lutein 1915:(MeSH) 1816:GOV.UK 1744:  1709:  1674:  1638:  1628:  1581:  1554:  1544:  1503:  1493:  1452:  1442:  1401:  1391:  1350:  1314:  1273:  1263:  1170:  1160:  1119:  1084:  1049:  1039:  970:  931:  921:  868:RxList 848:  807:  797:  758:  748:  709:  673:  663:  622:  612:  571:  561:  515:  505:  409:, and 239:, and 159:, and 121:, and 4560:S-145 4409:I-BOP 4254:IP (I 4157:FP (F 3683:EP (E 3502:DP (D 3400:Rhein 3273:trans 3186:TTNPB 3126:EC 23 3121:Ch-55 3079:trans 2834:Other 2597:Other 2167:Bixin 1763:(PDF) 1614:(9). 1530:(9). 1332:Lupus 1146:(9). 411:death 75:Types 5821:TXAS 5779:PGFS 5760:PGES 4858:PTGS 3271:all- 3077:all- 2773:Tars 2322:Acne 1742:PMID 1707:PMID 1672:PMID 1636:PMID 1579:PMID 1552:PMID 1501:PMID 1450:PMID 1399:PMID 1348:PMID 1312:PMID 1271:PMID 1224:2018 1198:2018 1168:PMID 1117:PMID 1082:PMID 1047:PMID 1002:2021 968:ISSN 929:PMID 846:PMID 805:PMID 779:Cell 756:PMID 707:PMID 671:PMID 620:PMID 569:PMID 513:PMID 353:and 333:and 321:and 319:acne 313:Uses 299:VLDL 297:and 291:RBP4 280:LRAT 247:and 209:for 69:acne 40:The 5798:PGI 5715:PGD 4853:COX 3264:cis 3242:RXR 3050:cis 3028:RAR 2780:Tar 2758:D05 2326:D10 1734:doi 1699:doi 1695:330 1664:doi 1626:PMC 1616:doi 1612:221 1542:PMC 1532:doi 1528:221 1491:PMC 1481:doi 1440:PMC 1430:doi 1389:PMC 1379:doi 1340:doi 1302:doi 1298:143 1261:PMC 1251:doi 1158:PMC 1148:doi 1144:221 1109:doi 1105:430 1074:doi 1070:430 1037:PMC 1029:doi 960:doi 919:PMC 909:doi 836:doi 795:PMC 787:doi 783:134 746:PMC 738:doi 699:doi 661:PMC 651:doi 647:221 610:PMC 600:doi 559:PMC 551:doi 503:PMC 495:doi 491:114 373:is 274:or 213:or 117:), 6009:: 5746:, 5742:, 5545:; 5473:; 5436:; 5424:; 5407:; 5395:; 5378:; 5336:; 5309:; 5262:; 5120:; 4958:; 4384:A2 4221:2Ξ± 4159:2Ξ± 4130:2Ξ± 4000:EP 3885:EP 3808:EP 3701:EP 3577:DP 3520:DP 3262:9- 3048:9- 2964:: 2782:/ 2702:: 2198:20 2146:(C 2040:40 2038:(C 1962:40 1960:(C 1884:. 1838:. 1814:. 1810:. 1786:. 1740:. 1728:. 1705:. 1693:. 1670:. 1660:96 1658:. 1634:. 1624:. 1610:. 1606:. 1573:. 1550:. 1540:. 1526:. 1522:. 1499:. 1489:. 1477:16 1475:. 1471:. 1448:. 1438:. 1426:16 1424:. 1420:. 1397:. 1387:. 1373:. 1369:. 1346:. 1336:31 1334:. 1310:. 1296:. 1292:. 1269:. 1259:. 1245:. 1241:. 1166:. 1156:. 1142:. 1138:. 1115:. 1080:. 1045:. 1035:. 1025:35 1023:. 1019:. 988:. 966:. 956:37 954:. 950:. 927:. 917:. 903:. 899:. 887:^ 866:. 844:. 832:30 830:. 826:. 803:. 793:. 781:. 777:. 754:. 744:. 734:26 732:. 728:. 705:. 695:96 693:. 669:. 659:. 645:. 641:. 618:. 608:. 596:13 594:. 590:. 567:. 557:. 547:35 545:. 541:. 511:. 501:. 489:. 485:. 444:. 421:. 405:, 397:, 393:, 389:, 385:, 381:, 357:. 349:, 325:. 293:, 231:, 217:. 155:, 109:, 105:, 5966:2 5958:2 5802:S 5800:2 5750:) 5738:( 5719:S 5717:2 5619:) 5617:2 4860:) 4856:( 4843:) 4839:( 4544:2 4416:2 4403:2 4386:) 4334:1 4325:2 4258:) 4256:2 4213:2 4161:) 4092:2 4039:2 4030:1 4002:4 3962:2 3953:1 3945:2 3887:3 3847:2 3838:1 3810:2 3760:2 3751:1 3703:1 3687:) 3685:2 3602:2 3579:2 3540:2 3522:1 3506:) 3504:2 3492:) 3488:( 3462:e 3455:t 3448:v 3331:) 3327:( 3162:) 3158:( 3008:e 3001:t 2994:v 2869:) 2850:( 2760:) 2756:( 2746:e 2739:t 2732:v 2527:) 2483:) 2469:( 2328:) 2314:e 2307:t 2300:v 2200:) 2150:) 2042:) 1964:) 1942:e 1935:t 1928:v 1894:. 1870:. 1849:. 1824:. 1796:. 1772:. 1748:. 1736:: 1730:3 1713:. 1701:: 1678:. 1666:: 1642:. 1618:: 1591:. 1558:. 1534:: 1507:. 1483:: 1456:. 1432:: 1405:. 1381:: 1375:8 1354:. 1342:: 1318:. 1304:: 1277:. 1253:: 1247:1 1226:. 1200:. 1174:. 1150:: 1123:. 1111:: 1088:. 1076:: 1053:. 1031:: 1004:. 974:. 962:: 935:. 911:: 905:1 881:. 852:. 838:: 811:. 789:: 762:. 740:: 713:. 701:: 677:. 653:: 626:. 602:: 575:. 553:: 519:. 497:: 113:( 20:)

Index

Retinoids

chemical compounds
vitamin A
immunity
acute promyelocytic leukemia
acne
retinol
retinal
tretinoin
retinoic acid
isotretinoin
alitretinoin
etretinate
acitretin
adapalene
bexarotene
tazarotene
Trifarotene
polyene
conjugated system
chromophores
retinol binding protein 4
retinoid receptors
all-trans-retinoic acid
9-cis-retinoic acid
13-cis retinoic acid
isotretinoin
bexarotene
Retinoid X receptors

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