56:
55:(HMGCR), involved in the biosynthesis of cholesterol. This was the first protein with an SSD to be discovered. Upon binding to cholesterol, this protein undergoes
48:
have shown that these proteins can be grouped in seven different families according to their SSDs. The following SSD-containing proteins represent each family:
44:
Sterol-sensing domains are present in various proteins involved in key aspects of cholesterol homeostasis and signalling. Multiple sequence alignments using
66:
133:
191:
62:
137:
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108:
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120:
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and also cytokinesis. Its SSD binds the cholesterol moiety of hedgehog, and it is essential for its activity.
247:
Pasca di
Magliano, M; Hebrok, M (December 2003). "Hedgehog signalling in cancer formation and maintenance".
117:(DISP1, DISP2, DISP3), also involved in hedgehog signaling. DISP is required for the secretion of hedgehog.
65:(SCAP), which regulates transcription of genes with sterol response elements by proteolytically activating
114:
212:
Kuwabara, PE; Labouesse, M (April 2002). "The sterol-sensing domain: multiple families, a unique role?".
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groups. This type of domain is present in proteins involved in cholesterol metabolism and signalling.
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272:
264:
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52:
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25:
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123:(PTR), structurally similar to patched. Its functions are not fully understood.
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186:
161:
96:
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69:(SREBPs). This was the second SSD-containing protein to be discovered.
84:
33:
260:
104:
100:
140:. Mutations in patched are associated with a variety of cancers (
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75:(7DHCR), involved in the last step of cholesterol biosynthesis.
59:. The SSD is not required for the catalytic activity of HMGCR.
81:(NPC1), involved in intracellular cholesterol transport.
57:
endoplasmic-reticulum-associated protein degradation
136:(SLOS). Mutations in NPC1 have been shown to cause
87:(NPC1L1), a regulator of cholesterol absorption in
28:which consists of 180 amino acids forming five
8:
67:sterol regulatory element-binding proteins
173:
7:
14:
192:European Bioinformatics Institute
132:Mutations in 7DHCR are linked to
63:SREBP cleavage-activating protein
73:7-dehydrocholesterol reductase
1:
226:10.1016/s0168-9525(02)02640-9
138:Niemann–Pick disease, type C
85:Niemann-Pick type C1-like 1
313:
134:Smith–Lemli–Opitz syndrome
109:hedgehog signaling pathway
182:"Sterol-sensing domain"
121:Patched-related protein
249:Nature Reviews. Cancer
30:transmembrane segments
18:sterol-sensing domain
142:basal cell carcinoma
79:Niemann-Pick type C1
107:), involved in the
32:capable of binding
214:Trends in Genetics
53:HMG-CoA reductase
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150:rhabdomyosarcoma
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297:Protein domains
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261:10.1038/nrc1229
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146:medulloblastoma
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12:
11:
5:
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283:
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255:(12): 903–11.
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220:(4): 193–201.
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26:protein domain
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195:. Retrieved
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131:
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21:
17:
15:
89:enterocytes
168:References
115:Dispatched
46:Clustal W
291:Category
277:34050826
269:14737121
234:11932020
197:25 March
187:InterPro
156:See also
40:Function
162:INSIG-1
128:Disease
97:Patched
24:) is a
275:
267:
232:
34:sterol
273:S2CID
105:PTCH2
101:PTCH1
265:PMID
230:PMID
199:2015
257:doi
222:doi
152:).
22:SSD
293::
271:.
263:.
251:.
228:.
218:18
216:.
190:.
184:.
148:,
144:,
103:,
16:A
279:.
259::
253:3
236:.
224::
201:.
99:(
91:.
20:(
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