341:, had been used many years previously and continue to be used, although the efficacy of GM-CSF modified tumor lines as a cancer vaccine remain extremely modest, at best. There has been some debate as to the role of the T cells in treating the cancer in these studies as high-dose IL-2 and chemotherapy have also been shown to have anti-cancer properties. Nevertheless, the combination of chemotherapy, T cells and high-dose IL-2 was shown to be effective even in patients who had previously failed high-dose IL-2 treatment.
162:
36:
328:. He has shown that expanding immune cells (known as tumor infiltrating lymphocytes) in the lab can be used to treat patients with melanoma and has published two important studies describing their use. The first in 2002, demonstrated that some patients with advanced melanoma can be treated to complete remission with a combination of
336:
can be transferred to immune cells and in combination with chemotherapy and high doses of IL-2 can be used to treat patients with melanoma. Although, this was the first time that the T cell receptor was used for gene therapy, it was not the first time that gene therapy was used in cancer. Tumor
265:
830:
469:
1019:
917:
812:
261:
751:"Novel allogeneic granulocyte-macrophage colony-stimulating factor-secreting tumor vaccine for pancreatic cancer: a phase I trial of safety and immune activation"
481:
493:
1004:
895:
853:
64:
44:
957:
584:
Wrangle, JM; Patterson, A; Johnson, CB; Neitzke, DJ; Mehrotra, S; Denlinger, CE; Paulos, CM; Li, Z; Cole, DJ; Rubinstein, MP (February 2018).
989:
984:
551:
994:
137:
1014:
798:
428:
118:
848:
90:
831:"2019 Edogawa NICHE Prize Awarded to Dr. Steven Rosenberg for His Pioneering Feat in Tackling Cancer with Immunotherapy"
755:
487:
97:
456:
377:
305:
999:
566:
444:
68:
60:
24:
104:
510:
438:
411:
245:
369:
190:
49:
813:"Trailblazing Researchers in Immunotherapy Selected to Receive Americas Most Distinguished Prize in Medicine"
86:
520:
450:
415:
53:
1009:
434:
325:
918:"NIH immunotherapy pioneer Steven Rosenberg awarded nation's highest honor for technology and innovation"
463:
887:
635:"Cancer regression and autoimmunity in patients after clonal re-population with antitumor lymphocytes"
161:
979:
705:
648:
381:
373:
301:
849:"Pioneering Physician-Scientist to Receive 2019 Szent-Györgyi Prize for Progress in Cancer Research"
389:
365:
249:
194:
750:
790:
482:
Pezcoller
Foundation-AACR International Award for Extraordinary Achievements in Cancer Research
772:
731:
674:
639:
615:
332:, immune cells and high doses of IL-2. The second, in 2006, demonstrated that the receptor of
241:
111:
764:
721:
713:
664:
656:
605:
597:
357:
406:(in 1968/1969). Following the completion of his surgical residency, he became the Chief of
475:
308:, who was the chief nurse at the time. They got married in 1968 and have three daughters.
75:
20:
709:
652:
726:
693:
669:
634:
610:
585:
973:
515:
345:
317:
269:
694:"Cancer regression in patients after transfer of genetically engineered lymphocytes"
505:
329:
297:
273:
945:
399:
272:
that has resulted in the first effective immunotherapies and the development of
237:
215:
768:
385:
717:
660:
552:"Steven A. Rosenberg Works to Unmask Cancer's Achilles Heel - the ASCO Post"
356:
Rosenberg graduated from the Bronx High School of
Science. He received his
253:
776:
735:
678:
619:
601:
950:
402:
321:
407:
361:
333:
276:. He is the first researcher to successfully insert foreign genes into
257:
567:"Setting the Body's 'Serial Killers' Loose on Cancer (Published 2016)"
962:
393:
338:
293:
277:
208:
414:, a position he continues to hold. His research has focused on the
266:
George
Washington University School of Medicine and Health Sciences
633:
Dudley ME, Wunderlich JR, Robbins PF, et al. (October 2002).
289:
875:
692:
Morgan RA, Dudley ME, Wunderlich JR, et al. (October 2006).
749:
Jaffee EM, Hruban RH, Biedrzycki B, et al. (January 2001).
380:, completing it in 1974. During his residency he also earned a
791:"Golden Plate Awardees of the American Academy of Achievement"
74:
from the article and its talk page, especially if potentially
29:
954:(2006 coverage of cancer breakthrough discovered by his team)
337:
cells modified with a gene for immune growth factors such as
292:, the youngest of three children of Jewish immigrants from
437:
320:
and immune cells for the treatment of patients with
300:. He met his wife to be, Alice O’Connell during his
470:
Szent-Györgyi Prize for
Progress in Cancer Research
207:
186:
168:
152:
888:"Citation Laureates 2023_Physiology or Medicine"
262:Uniformed Services University of Health Sciences
19:For the BBC Moscow foreign correspondent, see
590:Journal of Interferon & Cytokine Research
23:. For the Major League Baseball pitcher, see
8:
344:Rosenberg has pioneered the use of adoptive
1020:Members of the National Academy of Medicine
494:National Medal of Technology and Innovation
546:
544:
542:
540:
538:
536:
316:He is credited with developing the use of
160:
149:
67:about living persons that is unsourced or
725:
668:
609:
586:"IL-2 and Beyond in Cancer Immunotherapy"
138:Learn how and when to remove this message
898:from the original on September 19, 2023
854:National Foundation for Cancer Research
532:
372:. He served a surgical internship and
7:
459:in Medicine and Biomedical Research
236:(born 2 August 1940) is an American
922:National Institutes of Health (NIH)
288:Rosenberg was born in 1940, in the
565:Pollack, Andrew (August 1, 2016).
268:. He pioneered the development of
14:
34:
1005:Johns Hopkins University alumni
946:Gene therapy rids men of cancer
799:American Academy of Achievement
429:American Academy of Achievement
427:1992 Golden Plate Award of the
1:
756:Journal of Clinical Oncology
488:Clarivate Citation Laureates
45:biography of a living person
990:Fellows of the AACR Academy
985:American cancer researchers
457:Albany Medical Center Prize
449:2015 Medal of Honor of the
378:Peter Bent Brigham Hospital
306:Peter Bent Brigham Hospital
72:must be removed immediately
1036:
445:Keio Medical Science Prize
244:, chief of Surgery at the
25:Steve Rosenberg (baseball)
18:
16:American cancer researcher
995:Harvard University alumni
769:10.1200/jco.2001.19.1.145
511:Chimeric antigen receptor
439:Cancer Research Institute
412:National Cancer Institute
246:National Cancer Institute
227:
200:
159:
370:Johns Hopkins University
191:Johns Hopkins University
1015:Massry Prize recipients
718:10.1126/science.1129003
661:10.1126/science.1076514
521:Iovance Biotherapeutics
451:American Cancer Society
416:immunotherapy of cancer
835:www.marketscreener.com
435:William B. Coley Award
398:The proteins of human
326:adoptive cell transfer
324:in a procedure termed
214:The proteins of human
59:Please help by adding
602:10.1089/jir.2017.0101
876:Dan David Prize 2021
368:(1964) degrees from
65:Contentious material
960:, Robert Langreth,
795:www.achievement.org
710:2006Sci...314..126M
653:2002Sci...298..850D
464:Edogawa NICHE Prize
234:Steven A. Rosenberg
892:Citation Laureates
857:. 12 February 2019
571:The New York Times
390:Harvard University
250:Bethesda, Maryland
195:Harvard University
87:"Steven Rosenberg"
1000:Jewish physicians
958:"Cancer Miracles"
837:. 15 August 2019.
422:Awards and honors
238:cancer researcher
231:
230:
202:Scientific career
148:
147:
140:
122:
48:needs additional
1027:
933:
932:
930:
929:
914:
908:
907:
905:
903:
884:
878:
873:
867:
866:
864:
862:
845:
839:
838:
827:
821:
820:
809:
803:
802:
787:
781:
780:
746:
740:
739:
729:
689:
683:
682:
672:
630:
624:
623:
613:
581:
575:
574:
562:
556:
555:
548:
223:
182:
178:
176:
164:
154:Steven Rosenberg
150:
143:
136:
132:
129:
123:
121:
80:
61:reliable sources
38:
37:
30:
1035:
1034:
1030:
1029:
1028:
1026:
1025:
1024:
970:
969:
942:
937:
936:
927:
925:
916:
915:
911:
901:
899:
886:
885:
881:
874:
870:
860:
858:
847:
846:
842:
829:
828:
824:
811:
810:
806:
789:
788:
784:
748:
747:
743:
704:(5796): 126–9.
691:
690:
686:
647:(5594): 850–4.
632:
631:
627:
583:
582:
578:
564:
563:
559:
550:
549:
534:
529:
502:
476:Dan David Prize
424:
354:
314:
286:
221:
193:
187:Alma mater
180:
174:
172:
155:
144:
133:
127:
124:
81:
79:
58:
39:
35:
28:
21:Steve Rosenberg
17:
12:
11:
5:
1033:
1031:
1023:
1022:
1017:
1012:
1007:
1002:
997:
992:
987:
982:
972:
971:
968:
967:
955:
941:
940:External links
938:
935:
934:
909:
879:
868:
840:
822:
804:
782:
741:
684:
625:
576:
557:
531:
530:
528:
525:
524:
523:
518:
513:
508:
501:
498:
497:
496:
490:
484:
478:
472:
466:
460:
453:
447:
441:
431:
423:
420:
353:
350:
313:
310:
296:, who owned a
285:
282:
229:
228:
225:
224:
211:
205:
204:
198:
197:
188:
184:
183:
179:August 2, 1940
170:
166:
165:
157:
156:
153:
146:
145:
69:poorly sourced
42:
40:
33:
15:
13:
10:
9:
6:
4:
3:
2:
1032:
1021:
1018:
1016:
1013:
1011:
1010:Living people
1008:
1006:
1003:
1001:
998:
996:
993:
991:
988:
986:
983:
981:
978:
977:
975:
965:
964:
959:
956:
953:
952:
947:
944:
943:
939:
923:
919:
913:
910:
902:September 19,
897:
894:. Clarivate.
893:
889:
883:
880:
877:
872:
869:
856:
855:
850:
844:
841:
836:
832:
826:
823:
818:
814:
808:
805:
800:
796:
792:
786:
783:
778:
774:
770:
766:
763:(1): 145–56.
762:
758:
757:
752:
745:
742:
737:
733:
728:
723:
719:
715:
711:
707:
703:
699:
695:
688:
685:
680:
676:
671:
666:
662:
658:
654:
650:
646:
642:
641:
636:
629:
626:
621:
617:
612:
607:
603:
599:
595:
591:
587:
580:
577:
572:
568:
561:
558:
553:
547:
545:
543:
541:
539:
537:
533:
526:
522:
519:
517:
516:Immunotherapy
514:
512:
509:
507:
504:
503:
499:
495:
491:
489:
485:
483:
479:
477:
473:
471:
467:
465:
461:
458:
454:
452:
448:
446:
442:
440:
436:
432:
430:
426:
425:
421:
419:
417:
413:
409:
405:
404:
401:
395:
391:
387:
383:
379:
375:
371:
367:
363:
359:
351:
349:
347:
346:immunotherapy
342:
340:
335:
331:
327:
323:
319:
311:
309:
307:
303:
299:
295:
291:
283:
281:
279:
275:
271:
270:immunotherapy
267:
263:
259:
255:
251:
247:
243:
239:
235:
226:
219:
217:
212:
210:
206:
203:
199:
196:
192:
189:
185:
181:(age 84)
171:
167:
163:
158:
151:
142:
139:
131:
128:February 2013
120:
117:
113:
110:
106:
103:
99:
96:
92:
89: –
88:
84:
83:Find sources:
77:
73:
70:
66:
62:
56:
55:
51:
46:
41:
32:
31:
26:
22:
961:
949:
926:. Retrieved
924:. 2023-10-24
921:
912:
900:. Retrieved
891:
882:
871:
859:. Retrieved
852:
843:
834:
825:
816:
807:
794:
785:
760:
754:
744:
701:
697:
687:
644:
638:
628:
596:(2): 45–68.
593:
589:
579:
570:
560:
506:Cell therapy
397:
364:, 1961) and
355:
343:
330:chemotherapy
315:
304:at Boston’s
298:luncheonette
287:
274:gene therapy
233:
232:
213:
201:
134:
125:
115:
108:
101:
94:
82:
71:
54:verification
47:
980:1940 births
861:24 February
817:www.amc.edu
400:erythrocyte
312:Methodology
216:erythrocyte
974:Categories
928:2023-10-24
527:References
386:biophysics
284:Early life
218:membranes
175:1940-08-02
98:newspapers
403:membranes
374:residency
352:Education
302:residency
254:Professor
50:citations
951:BBC News
896:Archived
777:11134207
736:16946036
679:12242449
620:29443657
500:See also
322:melanoma
264:and the
76:libelous
727:2267026
706:Bibcode
698:Science
670:1764179
649:Bibcode
640:Science
611:5815463
410:at the
408:Surgery
396:titled
376:at the
362:biology
334:T cells
260:at the
258:Surgery
242:surgeon
112:scholar
966:, 2009
963:Forbes
775:
734:
724:
677:
667:
618:
608:
394:thesis
339:GM-CSF
294:Poland
278:humans
252:and a
222:(1969)
220:
209:Thesis
114:
107:
100:
93:
85:
492:2023
486:2023
480:2022
474:2021
468:2019
462:2019
455:2018
443:2013
433:2011
392:with
388:from
382:Ph.D.
290:Bronx
119:JSTOR
105:books
43:This
904:2023
863:2021
773:PMID
732:PMID
675:PMID
616:PMID
366:M.D.
358:B.A.
318:IL-2
240:and
169:Born
91:news
52:for
765:doi
722:PMC
714:doi
702:314
665:PMC
657:doi
645:298
606:PMC
598:doi
384:in
256:of
248:in
976::
948:,
920:.
890:.
851:.
833:.
815:.
797:.
793:.
771:.
761:19
759:.
753:.
730:.
720:.
712:.
700:.
696:.
673:.
663:.
655:.
643:.
637:.
614:.
604:.
594:38
592:.
588:.
569:.
535:^
418:.
348:.
280:.
177:)
63:.
931:.
906:.
865:.
819:.
801:.
779:.
767::
738:.
716::
708::
681:.
659::
651::
622:.
600::
573:.
554:.
360:(
173:(
141:)
135:(
130:)
126:(
116:·
109:·
102:·
95:·
78:.
57:.
27:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
