40:
1203:
260:. The resulting fusion protein brings together the transcriptional activating domain of SS18 and the transcriptional repressor domains of SSX. It also incorporates into the SWI/SNF chromatin remodeling complex, a well known tumor suppressor. SS18-SSX is thought to underlie synovial sarcoma pathogenesis through dysregulation of gene expression.
173:
in appearance. Classical synovial sarcoma has a biphasic appearance with both types present. Synovial sarcoma can also appear to be poorly differentiated or to be monophasic fibrous, consisting only of sheets of spindle cells. Some authorities state that, extremely rarely, there can be a monophasic
599:; Zaborowski, Matthew; Vargas, Ana C.; et al. (19 June 2020). "When used together SS18–SSX fusion-specific and SSX C-terminus immunohistochemistry are highly specific and sensitive for the diagnosis of synovial sarcoma and can replace FISH or molecular testing in most cases".
1095:
1136:
197:, and tumour necrosis, between 0 and 6 and then converts this into a grade of between 1 and 3, with 1 representing a less aggressive tumour. The NCI system is also a three-grade one, but takes a number of other factors into account.
483:
Coindre, Jean-Michel; Pelmus, Manuela; Hostein, Isabelle; Lussan, Catherine; Bui, Binh N.; Guillou, Louis (2003). "Should molecular testing be required for diagnosing synovial sarcoma? A prospective study of 204 cases".
200:
Immunohistochemistry (IHC): SS18-fusion specific antibody and SSX-CT antibody are highly sensitive and specific for synovial sarcoma and when used together may obviate the need for molecular testing in most cases.
290:, to remove the tumor and a safety margin of healthy tissue. This is the mainstay of synovial sarcoma treatment and is curative in approximately 20–70% of patients, depending on the particular study being quoted.
789:"Malignant Peripheral Nerve Sheath Tumors are t(X;18)-Negative Sarcomas. Molecular Analysis of 25 Cases Occurring in Neurofibromatosis Type 1 Patients, Using Two Different RT-PCR-Based Methods of Detection"
1065:
1965:
137:
Synovial sarcoma occurs in about 1–2 per 1,000,000 people a year. They occur most commonly in the third decade of life, with males being affected more often than females (ratio around 1.2:1).
169:
Two cell types can be seen microscopically in synovial sarcoma. One fibrous type, known as a spindle or sarcomatous cell, is relatively small and uniform, and found in sheets. The other is
1245:
1780:
699:
Pfeifer, John D.; Hill, D. Ashley; O'Sullivan, Maureen J.; Dehner, Louis P. (4 January 2002). "Diagnostic gold standard for soft tissue tumours: morphology or molecular genetics?".
313:
remains unclear, although a recent study has shown that survival of patients with advanced, poorly differentiated disease marginally improves with doxorubicin/ifosfamide treatment.
1148:
111:, and its propensity to arise adjacent to joints, indicated a synovial origin; however, the actual cells from which the tumor develops are unknown and not necessarily synovial.
1800:
1923:
145:
Synovial sarcoma usually presents with an otherwise asymptomatic swelling or mass, although general symptoms related to malignancies can be reported such as fatigue.
526:
1238:
2492:
654:
1096:"Adaptimmune Receives U.S. FDA Accelerated Approval of Tecelra (afamitresgene autoleucel), the First Approved Engineered Cell Therapy for a Solid Tumor"
1231:
1916:
51:
917:
107:
The name "synovial sarcoma" was coined early in the 20th century, as some researchers thought that the microscopic similarity of some tumors to
830:
Middeljans, Evelien; Wan, Xi; Jansen, Pascal W.; Sharma, Vikram; Stunnenberg, Hendrik G.; Logie, Colin (March 2012). Freitag, Michael (ed.).
1601:
1448:
997:(2000). "Synovial sarcoma: a multivariate analysis of prognostic factors in 112 patients with primary localized tumors of the extremity".
2605:
1284:
1160:
893:"Impact of SS18-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients"
2736:
1909:
381:
744:
O'Sullivan, Maureen J.; Kyriakos, M.; Zhu, X.; Wick, M.R.; Swanson, P.E.; Dehner, Louis P.; Humphrey, P.A.; Pfeifer, John D. (2000).
2595:
1361:
561:
Paul, A.S.; Charalambous, C.; Maltby, B.; Whitehouse, R. (April 2003). "The management of soft-tissue sarcomas of the extremities".
2178:
1852:
2577:
2520:
2110:
1620:
1329:
193:
grading system is more common in the United States. The
Trojani system scores the sample, depending on tumour differentiation,
2571:
2510:
2448:
1396:
1381:
1376:
419:
241:
229:
t(x;18)(p11.2;q11.2). There is some debate about whether the molecular observation itself is definitive of synovial sarcoma.
175:
263:
There is some association between the SS18-SSX1 or SS18-SSX2 fusion type and both tumour morphology and five-year survival.
2065:
1494:
1401:
319:
to reduce the chance of local recurrence. The benefit of radiotherapy in this disease is less clear than for chemotherapy.
2094:
2514:
2506:
2462:
2154:
2029:
2007:
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1785:
1506:
1071:
999:
2705:
2693:
2073:
1960:
1443:
986:
2150:
2146:
1207:
787:
Coindre, Jean-Michel; Hostein, Isabelle; Benhattar, Jean; Lussan, Cathy; Rivel, Janine; Guillou, Louis (June 2002).
2452:
1723:
1299:
645:
2215:
2619:
2581:
2380:
1847:
1735:
1516:
900:
298:
226:
190:
189:
for reporting histopathology results. In Europe, the
Trojani or French system is gaining in popularity while the
174:
epithelial form which causes difficulty in differential diagnosis. Depending on the site, there is similarity to
158:
2069:
1386:
1171:
701:
601:
596:
323:
1832:
1066:"FDA grants accelerated approval to afamitresgene autoleucel for unresectable or metastatic synovial sarcoma"
2635:
2627:
2613:
2599:
2557:
2478:
2190:
1814:
1572:
1416:
1356:
1308:
943:
Thway, Khin; Fisher, Cyril (December 2014). "Synovial sarcoma: defining features and diagnostic evolution".
39:
2081:
1932:
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1501:
1458:
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892:
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101:
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2205:
1985:
1790:
1765:
1728:
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1558:
1391:
746:"Malignant peripheral nerve sheath tumors with t(X;18). A pathologic and molecular genetic study"
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67:
50:
of a monophasic synovial sarcoma. The histologic appearance is non-specific and overlaps with
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343:
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of the arm and leg but have been documented in most human tissues and organs, including the
1218:
1213:
524:
Coindre, Jean-Michel (October 2006). "Grading of soft tissue sarcomas: review and update".
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1990:
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1606:
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994:
990:
891:
Ladanyi, Marc; Antonescu, Christina R.; Leung, Denis H.Y.; et al. (January 2002).
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2195:
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2171:
2159:
2139:
2044:
2022:
2017:
1995:
832:"SS18 together with animal-specific factors defines human BAF-type SWI/SNF complexes"
714:
630:
194:
97:
93:
92:
which occurs primarily in the extremities of the arms or legs, often in proximity to
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2247:
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369:
316:
294:
276:
55:
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and is confirmed by the presence of t(X;18). This translocation event between the
225:
Most, and perhaps all, cases of synovial sarcoma are associated with a reciprocal
59:
1176:
858:
667:
650:"A Novel SS18-SSX Fusion-specific Antibody for the Diagnosis of Synovial Sarcoma"
539:
2366:
2337:
2332:
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1715:
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1258:
1012:
257:
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115:
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2012:
2002:
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306:
302:
170:
47:
964:
644:
Baranov, Esther; McBride, Matthew J.; Bellizzi, Andrew M.; Ligon, Azra Hadi;
582:
2327:
2283:
1975:
1970:
1748:
1691:
1640:
326:(Tecelra) was approved for medical use in the United States in August 2024.
233:
154:
1901:
1020:
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773:
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685:
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574:
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272:
614:
1580:
1480:
1472:
1140:
89:
376:(Sixth ed.). St Louis, Missouri: CV Mosby. pp. 1052–1070.
16:
Rare cancer of the extremities, often near joints or tendon sheaths
2585:
2524:
2500:
2430:
1667:
391:
210:
131:
123:
119:
414:. American Cancer Society Atlas of Clinical Oncology. BC Decker.
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2623:
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2553:
2528:
2456:
2426:
2416:
1165:
249:
245:
237:
214:
206:
1905:
1227:
989:; Antonescu, Cristina R.; Leung, Denis Hy.Y.; Blumberg, David;
2412:
1034:
Ren, Xiao-Hua; WU, Xiao-Min; JIN, Cheng; CUI, Yong-An (2009).
1036:"Advances in the diagnosis and treatment of synovial sarcoma"
232:
The diagnosis of synovial sarcoma is typically made based on
153:
The diagnosis of synovial sarcoma is typically made based on
1781:
Multiple cutaneous and uterine leiomyomatosis syndrome
309:. The benefit of chemotherapy in synovial sarcoma to
256:) on chromosome X causes the presence of an SS18-SSX
1118:
2649:
2542:
2471:
2401:
2388:
2379:
2278:
2260:
2246:
2055:
1948:
1939:
1876:
1813:
1704:
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1658:
1649:
1571:
1543:
1515:
1471:
1430:
1343:
1316:
1307:
1298:
1272:
1122:
66:
29:
24:
648:; Kadoch, Cigall; Hornick, Jason L. (July 2020).
305:), to reduce the number of remaining microscopic
178:, although the genetic findings are distinctive.
114:Primary synovial sarcomas are most common in the
527:Archives of Pathology & Laboratory Medicine
519:
517:
433:
431:
2671:46,XX testicular disorders of sex development
1917:
1239:
478:
476:
8:
405:
403:
401:
363:
361:
157:and is confirmed by the presence of t(X;18)
2493:Acute myeloblastic leukemia with maturation
1098:(Press release). Adaptimmune. 2 August 2024
271:Treatment is usually multimodal, involving
2398:
2385:
2257:
1945:
1924:
1910:
1902:
1655:
1313:
1304:
1246:
1232:
1224:
1119:
938:
936:
934:
932:
930:
655:The American Journal of Surgical Pathology
205:is typically expressed, at least focally.
38:
21:
867:
857:
806:
763:
675:
1214:Sarcoma Help: What is Synovial Sarcoma?
374:Enzinger and Weiss's Soft Tissue Tumors
335:
217:may be positive but lack specificity.
461:楊照彬 (2010). "青少年骨髓性肉瘤初期以背痛呈現: 病例報告".
368:Goldblum, John R.; Folpe, Andrew L.;
7:
923:from the original on 26 August 2017.
2606:Desmoplastic small-round-cell tumor
1285:Desmoplastic small-round-cell tumor
240:gene on chromosome 18 and one of 3
14:
1362:Aggressive infantile fibromatosis
957:10.1016/j.anndiagpath.2014.09.002
410:Pollock, Raphael E., ed. (2002).
2179:22q11.2 distal deletion syndrome
1853:Clear-cell sarcoma of the kidney
1219:WebMD: Synovial Sarcoma Overview
1201:
715:10.1046/j.1365-2559.2000.01107.x
346:. Encyclopædia Britannica Online
2578:Dermatofibrosarcoma protuberans
2521:Acute megakaryoblastic leukemia
2449:Anaplastic large-cell lymphoma
2111:Chromosome 5q deletion syndrome
1621:Intradermal spindle cell lipoma
1330:Dermatofibrosarcoma protuberans
1040:Journal of Medical Biomechanics
1449:Malignant fibrous histiocytoma
1397:Infantile digital fibromatosis
1382:Familial myxovascular fibromas
1377:Diffuse infantile fibromatosis
945:Annals of Diagnostic Pathology
176:biphenotypic sinonasal sarcoma
1:
2301:Klinefelter syndrome (47,XXY)
2066:1q21.1 copy number variations
1495:Superficial acral fibromyxoma
1402:Juvenile hyaline fibromatosis
2507:Acute promyelocytic leukemia
2463:Acute lymphoblastic leukemia
2155:17q12 microdeletion syndrome
2030:22q11.2 duplication syndrome
2008:16p11.2 duplication syndrome
1796:Solitary cutaneous leiomyoma
1786:Multiple cutaneous leiomyoma
1507:Ossifying fibromyxoid tumour
1072:Food and Drug Administration
1000:Journal of Clinical Oncology
859:10.1371/journal.pone.0033834
668:10.1097/PAS.0000000000001447
540:10.5858/2006-130-1448-GOSTSR
438:Ferrari and Collini (2012).
2074:1q21.1 duplication syndrome
1961:1q21.1 duplication syndrome
1444:Benign fibrous histiocytoma
1013:10.1200/JCO.2000.18.10.2087
646:Fletcher, Christopher D. M.
2758:
1724:Embryonal rhabdomyosarcoma
1300:Connective tissue neoplasm
1106:– via Business Wire.
2737:Musculoskeletal disorders
2620:Alveolar rhabdomyosarcoma
2355:XYYYY syndrome (49,XYYYY)
2321:XXXXY syndrome (49,XXXXY)
2316:XXXYY syndrome (49,XXXYY)
1848:Malignant rhabdoid tumour
1815:Complex mixed and stromal
1744:
1736:Alveolar rhabdomyosarcoma
808:10.1038/modpathol.3880570
765:10.1038/modpathol.3880247
299:doxorubicin hydrochloride
159:chromosomal translocation
46:
37:
2095:Wolf–Hirschhorn syndrome
2070:1q21.1 deletion syndrome
1933:Chromosome abnormalities
1387:Fibroma of tendon sheath
324:Afamitresgene autoleucel
185:, there is no universal
2479:Philadelphia chromosome
2350:XYYY syndrome (48,XYYY)
2311:XXXY syndrome (48,XXXY)
2306:XXYY syndrome (48,XXYY)
2191:22q13 deletion syndrome
1966:2q31.1 microduplication
1417:Oral submucous fibrosis
1357:Aggressive fibromatosis
1273:Not otherwise specified
2338:Pentasomy X (49,XXXXX)
2270:Turner syndrome (45,X)
2151:Smith–Magenis syndrome
2147:Miller–Dieker syndrome
2082:1p36 deletion syndrome
1459:Solitary fibrous tumor
1454:Atypical fibroxanthoma
993:; Woodruff, James M.;
575:10.1054/cuor.2002.0314
2345:XYY syndrome (47,XYY)
2333:Tetrasomy X (48,XXXX)
2216:Prader–Willi syndrome
1833:Mixed Müllerian tumor
2437:Mantle cell lymphoma
2107:Cri du chat syndrome
1838:Mesoblastic nephroma
1407:Plantar fibromatosis
1335:Desmoplastic fibroma
1210:at Wikimedia Commons
563:Current Orthopaedics
412:Soft Tissue Sarcomas
183:soft tissue sarcomas
88:) is a rare form of
2423:Follicular lymphoma
1828:Pleomorphic adenoma
1636:Spindle cell lipoma
1436:histiocytic sarcoma
1412:Pleomorphic fibroma
1372:Collagenous fibroma
1367:Aponeurotic fibroma
1280:Soft-tissue sarcoma
850:2012PLoSO...733834M
102:soft-tissue sarcoma
86:malignant synovioma
33:Malignant synovioma
2662:Uniparental disomy
2657:Fragile X syndrome
2592:Myxoid liposarcoma
2444:t(11 CCND1:14 IGH)
2328:Trisomy X (47,XXX)
2206:genomic imprinting
1986:Distal trisomy 10q
1791:Neural fibrolipoma
1766:Angiolipoleiomyoma
1729:Sarcoma botryoides
1626:Pleomorphic lipoma
1595:Myxoid liposarcoma
1559:Clear-cell sarcoma
1392:Fibromatosis colli
995:Brennan, Murray F.
987:Lewis, Jonathan J.
500:10.1002/cncr.11840
440:"Synovial Sarcoma"
141:Signs and symptoms
100:. It is a type of
2724:
2723:
2676:Marker chromosome
2645:
2644:
2538:
2537:
2375:
2374:
2242:
2241:
2212:Angelman syndrome
2167:DiGeorge syndrome
2135:Jacobsen syndrome
2123:Williams syndrome
1899:
1898:
1891:Adenomatoid tumor
1863:Pancreatoblastoma
1809:
1808:
1771:Genital leiomyoma
1631:Lipoblastomatosis
1567:
1566:
1467:
1466:
1422:Pachydermodactyly
1206:Media related to
1197:
1196:
615:10.1111/his.14190
221:Molecular biology
78:
77:
19:Medical condition
2749:
2667:XX male syndrome
2564:Synovial sarcoma
2441:Multiple myeloma
2409:Burkitt lymphoma
2399:
2386:
2289:other karyotypes
2258:
2040:Cat-eye syndrome
1946:
1926:
1919:
1912:
1903:
1720:rhabdomyosarcoma
1709:
1685:
1661:
1656:
1616:Chondroid lipoma
1554:Synovial sarcoma
1490:Cutaneous myxoma
1314:
1305:
1248:
1241:
1234:
1225:
1208:Synovial sarcoma
1205:
1120:
1108:
1107:
1105:
1103:
1092:
1086:
1085:
1083:
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1062:
1056:
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1051:
1031:
1025:
1024:
983:
977:
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940:
925:
924:
922:
897:
888:
882:
881:
871:
861:
827:
821:
820:
810:
794:Modern Pathology
784:
778:
777:
767:
751:Modern Pathology
741:
735:
734:
696:
690:
689:
679:
641:
635:
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597:Gill, Anthony J.
593:
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512:
511:
480:
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407:
396:
395:
370:Weiss, Sharon W.
365:
356:
355:
353:
351:
340:
311:overall survival
297:, (for example,
82:synovial sarcoma
42:
25:Synovial sarcoma
22:
2757:
2756:
2752:
2751:
2750:
2748:
2747:
2746:
2727:
2726:
2725:
2720:
2681:Ring chromosome
2641:
2534:
2467:
2371:
2287:
2274:
2238:
2051:
1950:
1935:
1930:
1900:
1895:
1872:
1805:
1740:
1707:Skeletal muscle
1705:
1700:
1681:
1676:
1659:
1645:
1563:
1539:
1535:Phyllodes tumor
1517:Fibroepithelial
1511:
1463:
1426:
1339:
1294:
1268:
1252:
1198:
1193:
1192:
1131:
1117:
1112:
1111:
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1099:
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1089:
1079:
1077:
1076:. 2 August 2024
1064:
1063:
1059:
1049:
1047:
1033:
1032:
1028:
1007:(10): 2087–94.
991:Healey, John H.
985:
984:
980:
942:
941:
928:
920:
901:Cancer Research
895:
890:
889:
885:
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828:
824:
786:
785:
781:
758:(12): 1336–46.
743:
742:
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697:
693:
643:
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638:
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590:
560:
559:
555:
534:(10): 1448–53.
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522:
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459:
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429:
422:
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118:near the large
84:(also known as
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2728:
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2446:
2434:
2420:
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2403:
2396:
2383:
2381:Translocations
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2049:
2048:
2047:
2037:
2032:
2027:
2026:
2025:
2015:
2010:
2005:
2000:
1999:
1998:
1991:Patau syndrome
1988:
1983:
1978:
1973:
1968:
1963:
1957:
1955:
1943:
1937:
1936:
1931:
1929:
1928:
1921:
1914:
1906:
1897:
1896:
1894:
1893:
1888:
1882:
1880:
1874:
1873:
1871:
1870:
1868:Carcinosarcoma
1865:
1860:
1858:Hepatoblastoma
1855:
1850:
1845:
1840:
1835:
1830:
1825:
1819:
1817:
1811:
1810:
1807:
1806:
1804:
1803:
1798:
1793:
1788:
1783:
1778:
1776:Leiomyosarcoma
1773:
1768:
1763:
1761:Angioleiomyoma
1758:
1757:
1756:
1745:
1742:
1741:
1739:
1738:
1733:
1732:
1731:
1712:
1710:
1702:
1701:
1699:
1698:
1696:leiomyosarcoma
1688:
1686:
1678:
1677:
1675:
1674:
1664:
1662:
1653:
1647:
1646:
1644:
1643:
1638:
1633:
1628:
1623:
1618:
1612:
1611:
1610:
1609:
1607:Angiomyolipoma
1599:
1598:
1597:
1592:
1577:
1575:
1569:
1568:
1565:
1564:
1562:
1561:
1556:
1550:
1548:
1541:
1540:
1538:
1537:
1532:
1527:
1525:Brenner tumour
1521:
1519:
1513:
1512:
1510:
1509:
1504:
1499:
1498:
1497:
1492:
1477:
1475:
1469:
1468:
1465:
1464:
1462:
1461:
1456:
1451:
1446:
1440:
1438:
1428:
1427:
1425:
1424:
1419:
1414:
1409:
1404:
1399:
1394:
1389:
1384:
1379:
1374:
1369:
1364:
1359:
1353:
1351:
1341:
1340:
1338:
1337:
1332:
1326:
1324:
1311:
1302:
1296:
1295:
1293:
1292:
1287:
1282:
1276:
1274:
1270:
1269:
1253:
1251:
1250:
1243:
1236:
1228:
1222:
1221:
1216:
1211:
1195:
1194:
1191:
1190:
1179:
1168:
1157:
1145:
1132:
1127:
1126:
1124:
1123:Classification
1116:
1115:External links
1113:
1110:
1109:
1087:
1057:
1042:(in Chinese).
1026:
978:
951:(6): 369–380.
926:
883:
822:
779:
736:
709:(6): 485–500.
702:Histopathology
691:
636:
609:(4): 588–600.
602:Histopathology
588:
569:(2): 124–133.
553:
513:
494:(12): 2700–7.
472:
465:(in Chinese).
453:
427:
420:
397:
383:978-0323088343
382:
372:(2001). "33".
357:
334:
333:
331:
328:
321:
320:
314:
291:
268:
265:
222:
219:
187:grading system
166:
165:Histopathology
163:
150:
147:
142:
139:
98:tendon sheaths
94:joint capsules
76:
75:
70:
64:
63:
44:
43:
35:
34:
31:
27:
26:
18:
15:
13:
10:
9:
6:
4:
3:
2:
2754:
2743:
2740:
2738:
2735:
2734:
2732:
2715:
2711:
2707:
2703:
2699:
2695:
2691:
2687:
2684:
2683:
2682:
2679:
2677:
2674:
2672:
2668:
2665:
2663:
2660:
2658:
2655:
2654:
2652:
2648:
2637:
2633:
2629:
2625:
2621:
2618:
2615:
2611:
2607:
2604:
2601:
2597:
2593:
2590:
2587:
2583:
2579:
2576:
2573:
2569:
2565:
2562:
2559:
2555:
2551:
2550:Ewing sarcoma
2548:
2547:
2545:
2541:
2530:
2526:
2522:
2519:
2516:
2512:
2508:
2505:
2502:
2498:
2494:
2491:
2488:
2484:
2480:
2477:
2476:
2474:
2470:
2464:
2461:
2458:
2454:
2450:
2447:
2445:
2442:
2438:
2435:
2432:
2428:
2424:
2421:
2418:
2414:
2410:
2407:
2406:
2404:
2400:
2397:
2395:
2391:
2387:
2384:
2382:
2378:
2368:
2365:
2363:
2360:
2359:
2356:
2353:
2351:
2348:
2346:
2343:
2342:
2339:
2336:
2334:
2331:
2329:
2326:
2325:
2322:
2319:
2317:
2314:
2312:
2309:
2307:
2304:
2302:
2299:
2298:
2296:
2294:
2290:
2285:
2281:
2277:
2271:
2268:
2267:
2265:
2263:
2259:
2256:
2253:
2249:
2245:
2235:
2234:Proximal 18q-
2231:
2228:
2227:
2221:
2217:
2213:
2210:
2209:
2208:
2207:
2203:
2202:
2197:
2194:
2193:
2192:
2189:
2185:
2182:
2181:
2180:
2177:
2173:
2170:
2169:
2168:
2165:
2161:
2158:
2157:
2156:
2152:
2148:
2145:
2141:
2138:
2137:
2136:
2133:
2129:
2126:
2125:
2124:
2121:
2117:
2114:
2113:
2112:
2108:
2105:
2101:
2098:
2097:
2096:
2093:
2089:
2086:
2085:
2083:
2079:
2075:
2071:
2067:
2063:
2062:
2060:
2058:
2054:
2046:
2043:
2042:
2041:
2038:
2036:
2033:
2031:
2028:
2024:
2021:
2020:
2019:
2018:Down syndrome
2016:
2014:
2011:
2009:
2006:
2004:
2001:
1997:
1994:
1993:
1992:
1989:
1987:
1984:
1982:
1979:
1977:
1974:
1972:
1969:
1967:
1964:
1962:
1959:
1958:
1956:
1954:
1949:Duplications,
1947:
1944:
1942:
1938:
1934:
1927:
1922:
1920:
1915:
1913:
1908:
1907:
1904:
1892:
1889:
1887:
1884:
1883:
1881:
1879:
1875:
1869:
1866:
1864:
1861:
1859:
1856:
1854:
1851:
1849:
1846:
1844:
1841:
1839:
1836:
1834:
1831:
1829:
1826:
1824:
1821:
1820:
1818:
1816:
1812:
1802:
1799:
1797:
1794:
1792:
1789:
1787:
1784:
1782:
1779:
1777:
1774:
1772:
1769:
1767:
1764:
1762:
1759:
1755:
1752:
1751:
1750:
1747:
1746:
1743:
1737:
1734:
1730:
1727:
1726:
1725:
1721:
1717:
1714:
1713:
1711:
1708:
1703:
1697:
1693:
1690:
1689:
1687:
1684:
1683:Smooth muscle
1679:
1673:
1669:
1666:
1665:
1663:
1657:
1654:
1652:
1648:
1642:
1639:
1637:
1634:
1632:
1629:
1627:
1624:
1622:
1619:
1617:
1614:
1613:
1608:
1605:
1604:
1603:
1600:
1596:
1593:
1591:
1588:
1587:
1586:
1582:
1579:
1578:
1576:
1574:
1570:
1560:
1557:
1555:
1552:
1551:
1549:
1546:
1542:
1536:
1533:
1531:
1528:
1526:
1523:
1522:
1520:
1518:
1514:
1508:
1505:
1503:
1500:
1496:
1493:
1491:
1488:
1487:
1486:
1482:
1479:
1478:
1476:
1474:
1470:
1460:
1457:
1455:
1452:
1450:
1447:
1445:
1442:
1441:
1439:
1437:
1433:
1429:
1423:
1420:
1418:
1415:
1413:
1410:
1408:
1405:
1403:
1400:
1398:
1395:
1393:
1390:
1388:
1385:
1383:
1380:
1378:
1375:
1373:
1370:
1368:
1365:
1363:
1360:
1358:
1355:
1354:
1352:
1350:
1346:
1342:
1336:
1333:
1331:
1328:
1327:
1325:
1323:
1319:
1315:
1312:
1310:
1306:
1303:
1301:
1297:
1291:
1288:
1286:
1283:
1281:
1278:
1277:
1275:
1271:
1267:
1263:
1260:
1256:
1249:
1244:
1242:
1237:
1235:
1230:
1229:
1226:
1220:
1217:
1215:
1212:
1209:
1204:
1200:
1199:
1189:
1185:
1184:
1180:
1178:
1174:
1173:
1169:
1167:
1163:
1162:
1158:
1155:
1151:
1150:
1146:
1143:
1142:
1138:
1134:
1133:
1130:
1125:
1121:
1114:
1097:
1091:
1088:
1075:
1073:
1067:
1061:
1058:
1045:
1041:
1037:
1030:
1027:
1022:
1018:
1014:
1010:
1006:
1002:
1001:
996:
992:
988:
982:
979:
974:
970:
966:
962:
958:
954:
950:
946:
939:
937:
935:
933:
931:
927:
919:
915:
911:
908:(1): 135–40.
907:
903:
902:
894:
887:
884:
879:
875:
870:
865:
860:
855:
851:
847:
844:(3): e33834.
843:
839:
838:
833:
826:
823:
818:
814:
809:
804:
801:(6): 589–92.
800:
796:
795:
790:
783:
780:
775:
771:
766:
761:
757:
753:
752:
747:
740:
737:
732:
728:
724:
720:
716:
712:
708:
704:
703:
695:
692:
687:
683:
678:
673:
669:
665:
662:(7): 922–33.
661:
657:
656:
651:
647:
640:
637:
632:
628:
624:
620:
616:
612:
608:
604:
603:
598:
592:
589:
584:
580:
576:
572:
568:
564:
557:
554:
549:
545:
541:
537:
533:
529:
528:
520:
518:
514:
509:
505:
501:
497:
493:
489:
488:
479:
477:
473:
469:(4): 269–275.
468:
464:
457:
454:
449:
445:
441:
434:
432:
428:
423:
417:
413:
406:
404:
402:
398:
393:
389:
385:
379:
375:
371:
364:
362:
358:
345:
339:
336:
329:
327:
325:
318:
315:
312:
308:
304:
300:
296:
293:Conventional
292:
289:
286:
285:
284:
282:
278:
274:
266:
264:
261:
259:
255:
251:
247:
243:
239:
235:
230:
228:
227:translocation
220:
218:
216:
212:
208:
204:
198:
196:
195:mitotic index
192:
188:
184:
179:
177:
172:
164:
162:
160:
156:
148:
146:
140:
138:
135:
133:
129:
125:
121:
117:
112:
110:
105:
103:
99:
95:
91:
87:
83:
74:
71:
69:
65:
61:
60:H&E stain
57:
53:
49:
45:
41:
36:
32:
28:
23:
2563:
2204:
2078:TAR syndrome
1981:Tetrasomy 9p
1886:Mesothelioma
1843:Wilms' tumor
1553:
1530:Fibroadenoma
1432:Histiocytoma
1349:fibromatosis
1322:fibrosarcoma
1290:Skin sarcoma
1181:
1170:
1159:
1147:
1135:
1100:. Retrieved
1090:
1078:. Retrieved
1069:
1060:
1048:. Retrieved
1046:(4): 541–542
1043:
1039:
1029:
1004:
998:
981:
948:
944:
905:
899:
886:
841:
835:
825:
798:
792:
782:
755:
749:
739:
706:
700:
694:
659:
653:
639:
606:
600:
591:
566:
562:
556:
531:
525:
491:
485:
466:
462:
456:
447:
443:
411:
373:
348:. Retrieved
338:
322:
317:Radiotherapy
295:chemotherapy
281:radiotherapy
277:chemotherapy
270:
262:
231:
224:
199:
180:
168:
152:
144:
136:
113:
106:
85:
81:
79:
56:fibrosarcoma
2367:46,XX/46,XY
2284:tetrasomies
2230:Distal 18q-
1878:Mesothelial
1716:Rhabdomyoma
1590:Myelolipoma
1585:liposarcoma
1502:Angiomyxoma
1485:myxosarcoma
1309:Fibromatous
1259:soft tissue
344:"Synovioma"
258:fusion gene
203:Cytokeratin
181:Like other
116:soft tissue
30:Other names
2731:Categories
2362:45,X/46,XY
2262:Monosomies
2035:Trisomy 22
2013:Trisomy 18
2003:Trisomy 16
1951:including
1823:Adenomyoma
1672:myosarcoma
1573:Lipomatous
1473:Myxomatous
1255:Connective
1183:DiseasesDB
421:155009128X
392:2013010770
330:References
307:metastases
303:ifosfamide
171:epithelial
48:Micrograph
2280:Trisomies
2057:Deletions
1976:Trisomy 9
1971:Trisomy 8
1953:trisomies
1941:Autosomal
1754:Cutaneous
1749:Leiomyoma
1692:Leiomyoma
1651:Myomatous
1641:Hibernoma
965:1092-9134
631:219949018
583:0268-0890
267:Treatment
234:histology
155:histology
149:Diagnosis
68:Specialty
2402:Lymphoid
2394:lymphoma
2390:Leukemia
1545:Synovial
1266:sarcomas
1102:5 August
1080:5 August
1021:10811674
973:25438927
918:Archived
914:11782370
878:22442726
837:PLOS One
817:12065770
774:11144931
723:11122430
686:32141887
623:32559341
548:17090186
508:14669292
463:台灣復健醫學雜誌
128:prostate
109:synovium
73:Oncology
2742:Sarcoma
2630:) t (1
2497:RUNX1T1
2472:Myeloid
2293:mosaics
1660:General
1345:Fibroma
1318:Fibroma
1177:D013584
1156:-9043/3
1154:M9040/3
1144:: C49.9
869:3307773
846:Bibcode
731:6825413
677:7289668
288:Surgery
273:surgery
244:genes (
2582:COL1A1
2254:linked
1602:PEComa
1581:Lipoma
1481:Myxoma
1262:tumors
1166:300813
1019:
971:
963:
912:
876:
866:
815:
772:
729:
721:
684:
674:
629:
621:
581:
546:
506:
487:Cancer
418:
390:
380:
350:20 May
130:, and
120:joints
90:cancer
2650:Other
2636:FOXO1
2634:; 13
2628:FOXO1
2626:; 13
2612:; 22
2608:t(11
2598:; 16
2596:DDIT3
2594:t(12
2586:PDGFB
2580:t(17
2556:; 22
2552:t(11
2543:Other
2525:RBM15
2509:t(15
2501:RUNX1
2485:; 22
2425:t(14
1801:STUMP
1668:Myoma
1547:-like
1188:34577
1149:ICD-O
1074:(FDA)
1070:U.S.
1050:7 May
921:(PDF)
896:(PDF)
727:S2CID
627:S2CID
132:heart
124:brain
52:MPNST
2632:PAX7
2624:PAX3
2622:t(2
2584:;22
2570:;18
2566:t(x
2554:FLI1
2529:MKL1
2527:;22
2523:t(1
2515:RARA
2513:,17
2499:;21
2495:t(8
2481:t(9
2457:NPM1
2451:t(2
2431:BCL2
2429:;18
2415:;14
2411:t(8
1264:and
1172:MeSH
1161:OMIM
1104:2024
1082:2024
1052:2016
1017:PMID
969:PMID
961:ISSN
910:PMID
874:PMID
813:PMID
770:PMID
719:PMID
682:PMID
619:PMID
579:ISSN
544:PMID
504:PMID
450:(5).
444:ESUN
416:ISBN
388:LCCN
378:ISBN
352:2012
301:and
279:and
254:SSX4
252:and
250:SSX2
246:SSX1
238:SS18
215:CD99
213:and
211:BCL2
207:TLE1
96:and
54:and
2614:EWS
2610:WT1
2600:FUS
2572:SSX
2568:SYT
2558:EWS
2511:PML
2487:BCR
2483:ABL
2455:;5
2453:ALK
2427:IGH
2417:IGH
2413:MYC
1137:ICD
1009:doi
953:doi
864:PMC
854:doi
803:doi
760:doi
711:doi
672:PMC
664:doi
611:doi
571:doi
536:doi
532:130
496:doi
242:SSX
191:NCI
2733::
2714:22
2712:,
2710:21
2708:;
2706:20
2704:;
2702:18
2700:;
2698:15
2696:;
2694:14
2692:;
2688:;
2220:15
2196:22
2184:22
2172:22
2160:17
2140:11
2084:)
2045:22
2023:21
1996:13
1722::
1186::
1175::
1164::
1152::
1141:10
1068:.
1044:15
1038:.
1015:.
1005:18
1003:.
967:.
959:.
949:18
947:.
929:^
916:.
906:62
904:.
898:.
872:.
862:.
852:.
840:.
834:.
811:.
799:15
797:.
791:.
768:.
756:13
754:.
748:.
725:.
717:.
707:37
705:.
680:.
670:.
660:44
658:.
652:.
625:.
617:.
607:77
605:.
577:.
567:17
565:.
542:.
530:.
516:^
502:.
492:98
490:.
475:^
467:38
446:.
442:.
430:^
400:^
386:.
360:^
283::
275:,
248:,
209:,
161:.
134:.
126:,
104:.
80:A
58:.
2690:9
2686:6
2669:/
2638:)
2616:)
2602:)
2588:)
2574:)
2560:)
2531:)
2517:)
2503:)
2489:)
2459:)
2439:/
2433:)
2419:)
2392:/
2291:/
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2282:/
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