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Synthetic ribosome

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Lewandowski, B; De Bo, G; Ward, JW; Papmeyer, M; Kuschel, S; Aldegunde, MJ; Gramlich, PM; Heckmann, D; Goldup, SM; D'Souza, DM; Fernandes, AE; Leigh, DA (2013).
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Orelle, Cédric; Carlson, Erik D.; Szal, Teresa; Florin, Tanja; Jewett, Michael C.; Mankin, Alexander S. (2015).
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are artificial small-molecules that can synthesize peptides in a sequence-specific matter.
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research group created ribosomes with tethered and inseparable subunits (or
170: 131: 92: 26: 162: 74: 25:'s lab built synthetic ribosome using a chemical structure based on a 146: 147:"Protein synthesis by ribosomes with tethered subunits" 8: 82: 49: 7: 14: 1: 207: 124:10.1126/science.1229753 59:"Synthetic ribosomes" 57:Sleator, RD (2013). 163:10.1038/nature14862 17:Synthetic ribosomes 75:10.4161/bioe.23640 191:Synthetic biology 157:(7563): 119–124. 198: 175: 174: 142: 136: 135: 118:(6116): 189–93. 103: 97: 96: 86: 54: 23:David Alan Leigh 206: 205: 201: 200: 199: 197: 196: 195: 181: 180: 179: 178: 144: 143: 139: 105: 104: 100: 56: 55: 51: 46: 12: 11: 5: 204: 202: 194: 193: 183: 182: 177: 176: 137: 98: 48: 47: 45: 42: 13: 10: 9: 6: 4: 3: 2: 203: 192: 189: 188: 186: 172: 168: 164: 160: 156: 152: 148: 141: 138: 133: 129: 125: 121: 117: 113: 109: 102: 99: 94: 90: 85: 80: 76: 72: 68: 64: 63:Bioengineered 60: 53: 50: 43: 41: 39: 35: 34:Cédric Orelle 30: 28: 24: 20: 18: 154: 150: 140: 115: 111: 101: 66: 62: 52: 31: 21: 16: 15: 69:(2): 63–4. 44:References 185:Category 171:26222032 132:23307739 93:23324614 27:rotaxane 112:Science 84:3609622 169:  151:Nature 130:  91:  81:  38:Ribo-T 167:PMID 128:PMID 89:PMID 32:The 159:doi 155:524 120:doi 116:339 79:PMC 71:doi 40:). 187:: 165:. 153:. 149:. 126:. 114:. 110:. 87:. 77:. 65:. 61:. 29:. 173:. 161:: 134:. 122:: 95:. 73:: 67:4

Index

David Alan Leigh
rotaxane
Cédric Orelle
Ribo-T
"Synthetic ribosomes"
doi
10.4161/bioe.23640
PMC
3609622
PMID
23324614
"Sequence-specific peptide synthesis by an artificial small-molecule machine"
doi
10.1126/science.1229753
PMID
23307739
"Protein synthesis by ribosomes with tethered subunits"
doi
10.1038/nature14862
PMID
26222032
Category
Synthetic biology

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