108:
133:
341:
139:
949:
879:
is located in the short arm of chromosome 1 (Ensembl database code: ENSG00000162572) and starts at nucleotide 1,280,436 on the forward strand. Its length is about 11,583 bp. The gene encodes several alternative transcripts with different transcription and translation initiation sites. In mRNA samples
920:
The structure of ENaC has not been yet determined. Yet, the structure of a homologous protein ASIC1 has been resolved. The chicken ASIC1 structure revealed that ASIC1 is assembled as a homotrimer of three identical subunits. The authors of the original study suggested that the ASIC1 trimer resembles
916:
All four ENaC subunit sequences have two hydrophobic stretches that form two transmembrane segments named as TM1 and TM2. In the membrane-bound form, the TM segments are embedded in the membrane bilayer, the amino- and carboxy-terminal regions are located inside the cell, and the segment between the
912:
The primary structures of all four ENaC subunits show strong similarity. Thus, these four proteins represent a family of proteins that share a common ancestor. In global alignment (meaning alignments of sequences along their entire length and not just a partial segment), the human δ subunit shares
835:
In most vertebrates, sodium ions are the major determinant of the osmolarity of the extracellular fluid. ENaC allows transfer of sodium ions across the epithelial cell membrane in so-called "tight-epithelia" that have low permeability. The flow of sodium ions across epithelia affects osmolarity of
924:
Alignment of ENaC subunit sequences with ASIC1 sequence reveals that TM1 and TM2 segments and palm domain are conserved, and the knuckle, finger and thumb domains have insertions in ENaC. Site-directed mutagenesis studies on ENaC subunits provide evidence that many basic features of the ASIC1
831:
ENaC is expressed in epithelial cells and is different from the voltage-gated sodium channel that is involved in the generation of action potentials in neurons. The abbreviation for the genes encoding for voltage-gated sodium channel starts with three letters: SCN. In contrast to these sodium
904:. While the α, β, and γ subunits are expressed mainly in the kidney tubular epithelia, the respiratory airway, the female reproductive tract, colon, salivary and sweat glands, the δ-subunit is expressed mainly in the brain, pancreas, testis and ovary.
4162:
917:
two TMs remains outside of the cell as the extracellular region of ENaC. This extracellular region includes about 70% of the residues of each subunit. Thus, in the membrane-bound form, the bulk of each subunit is located outside of the cell.
4167:
1482:"Cell-specific expression of epithelial sodium channel alpha, beta, and gamma subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immunocytochemistry"
1437:
Enuka Y, Hanukoglu I, Edelheit O, Vaknine H, Hanukoglu A (March 2012). "Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways".
2710:
3620:
3355:
2607:
2540:
146:
867:. The serial number of each transcript is shown above the transcript. Clicking on the figure will direct the reader to the list of transcripts in the Ensembl database.
1300:"Cloning and functional expression of a new epithelial sodium channel delta subunit isoform differentially expressed in neurons of the human and monkey telencephalon"
832:
channels, ENaC is constitutively active and is not voltage-dependent. The second N in the abbreviation (SCNN1D) represents that these are NON-voltage-gated channels.
1187:
Rossier BC, Baker ME, Studer RA (January 2015). "Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited".
836:
the extracellular fluid. Thus, ENaC plays a central role in the regulation of body fluid and electrolyte homeostasis and consequently affects blood pressure.
810:
in vertebrates. ENaC is assembled as a heterotrimer composed of three homologous subunits α, β, and γ or δ, β, and γ. The other ENAC subunits are encoded by
1263:
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S (October 2006). "A novel spliced variant of the epithelial Na+ channel delta-subunit in the human brain".
860:
69:
530:
3551:
3534:
3529:
3524:
3519:
1399:
Giraldez T, Rojas P, Jou J, Flores C, Alvarez de la Rosa D (August 2012). "The epithelial sodium channel δ-subunit: new notes for an old song".
3556:
2654:
1926:
1070:
4157:
3608:
2789:
3506:
2527:
1943:
1854:"Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction"
1569:
Jasti J, Furukawa H, Gonzales EB, Gouaux E (September 2007). "Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH".
3292:
925:
structural model apply to ENaC as well. Yet, ENaC is an obligate heterotrimer composed of three subunits as an αβγ or a βγδ trimer.
743:
859:
1097:"Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases"
974:"Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases"
3885:
2884:
2662:
1978:
1057:
1298:
Giraldez T, Afonso-Oramas D, Cruz-Muros I, Garcia-Marin V, Pagel P, González-Hernández T, Alvarez de la Rosa D (August 2007).
3907:
1529:
Canessa CM, Merillat AM, Rossier BC (December 1994). "Membrane topology of the epithelial sodium channel in intact cells".
132:
107:
4116:
2027:
921:
a hand holding a ball. Hence distinct domains of ASIC1 have been referred to as palm, knuckle, finger, thumb, and β-ball.
1053:
3482:
2394:
57:
3757:
851:
The first cDNA encoding the delta subunit of ENaC was cloned and sequenced by
Waldmann et al. from human kidney mRNA.
145:
48:, ENaCd, ENaCdelta, SCNED, dNaCh, sodium channel epithelial 1 delta subunit, sodium channel epithelial 1 subunit delta
956:
The 2016 version of this article was updated by an external expert under a dual publication model. The corresponding
1935:
1919:
1614:"X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na(+)-selective channel"
892:
The tissue specific expression of the δ-subunit is very different from that of the other three subunits encoded by
138:
4111:
2321:
4172:
4101:
2362:
2238:
1898:
1663:"ASIC and ENaC type sodium channels: Conformational states and the structures of the ion selectivity filters"
4106:
573:
4137:
2129:
2116:
2103:
2083:
2070:
2035:
1912:
957:
2010:
1578:
121:
44:
1904:
1894:
707:
658:
880:
from human brain, alternative splicing products have been detected, cloned and characterized. The
3477:
2353:
2000:
1690:
1462:
1329:
1169:
81:
662:
2515:
1875:
1840:
1805:
1770:
1735:
1682:
1643:
1594:
1546:
1511:
1454:
1416:
1378:
1321:
1280:
1245:
1204:
1161:
1126:
1013:
995:
37:
3284:
2265:
1865:
1830:
1795:
1760:
1725:
1674:
1633:
1625:
1586:
1538:
1501:
1493:
1446:
1408:
1368:
1360:
1311:
1272:
1235:
1196:
1153:
1116:
1108:
1021:
1003:
987:
969:
884:
gene is found in most vertebrates, but the gene has been lost in the mouse and rat genomes.
340:
225:
156:
77:
1819:"Capsazepine is a novel activator of the delta subunit of the human epithelial Na+ channel"
1144:
Bourque CW (July 2008). "Central mechanisms of osmosensation and systemic osmoregulation".
3820:
1960:
200:
1582:
1224:"Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel"
933:
So far mutations in the delta subunit have not been associated with a specific disease.
3616:
2303:
1784:"Degenerin sites mediate proton activation of deltabetagamma-epithelial sodium channel"
1638:
1613:
1506:
1481:
1373:
1348:
1121:
1096:
1008:
978:
973:
464:
459:
454:
449:
444:
439:
423:
418:
413:
408:
392:
387:
382:
4151:
3570:
3243:
1714:"Identification of Murr1 as a regulator of the human delta epithelial sodium channel"
1542:
1316:
1299:
1173:
369:
1694:
1466:
1333:
3923:
3314:
1852:
Ji HL, Su XF, Kedar S, Li J, Barbry P, Smith PR, Matalon S, Benos DJ (March 2006).
218:
98:
85:
3853:
3848:
3843:
3838:
3725:
3564:
1939:
1412:
1075:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1629:
1364:
1276:
1200:
1112:
991:
3833:
3199:
2567:
2535:
1450:
1222:
Waldmann R, Champigny G, Bassilana F, Voilley N, Lazdunski M (November 1995).
115:
65:
1240:
1223:
999:
913:
34% identity with the α subunit and 23% identity with the β and γ subunits.
3918:
3828:
1749:"Protons activate the delta-subunit of the epithelial Na+ channel in humans"
840:
494:
318:
239:
184:
171:
73:
4163:
Knowledge (XXG) articles with corresponding academic peer reviewed articles
1879:
1870:
1853:
1844:
1835:
1818:
1809:
1800:
1783:
1774:
1765:
1748:
1739:
1730:
1713:
1686:
1647:
1598:
1497:
1458:
1420:
1382:
1325:
1284:
1208:
1165:
1130:
1017:
1550:
1515:
1249:
1025:
786:
3931:
3279:
2258:
2253:
2248:
2243:
2175:
2170:
948:
775:
616:
1612:
Baconguis I, Bohlen CJ, Goehring A, Julius D, Gouaux E (February 2014).
1590:
806:
gene encodes for the δ (delta) subunit of the epithelial sodium channel
4058:
3815:
3651:
2152:
2147:
2142:
1678:
1347:
Ji HL, Zhao RZ, Chen ZX, Shetty S, Idell S, Matalon S (December 2012).
602:
559:
4168:
Knowledge (XXG) articles with corresponding articles published in Gene
1480:
Duc C, Farman N, Canessa CM, Bonvalet JP, Rossier BC (December 1994).
1353:
American
Journal of Physiology. Lung Cellular and Molecular Physiology
3735:
3730:
3464:
3459:
3405:
3400:
3216:
3204:
3194:
3189:
3177:
3172:
3167:
3054:
3049:
3044:
2936:
2872:
2867:
2862:
2857:
2852:
2847:
2842:
2777:
2772:
2762:
2757:
2752:
2703:
2698:
2688:
2683:
2560:
2555:
2550:
2545:
2451:
2446:
2441:
2431:
2426:
2416:
2411:
2336:
2331:
2326:
2229:
2224:
2219:
2214:
2202:
2197:
2192:
2187:
2096:
2063:
2058:
2053:
2048:
843:, it is also referred to as an "amiloride-sensitive sodium channel".
824:
818:
812:
756:
516:
1157:
1662:
3969:
3900:
3895:
3890:
3807:
3794:
3789:
3784:
3779:
3774:
3769:
3720:
3713:
3708:
3703:
3698:
3693:
3688:
3683:
3678:
3666:
3661:
3656:
3646:
3641:
3636:
3631:
3546:
3490:
3447:
3442:
3437:
3432:
3427:
3422:
3417:
3395:
3390:
3385:
3380:
3375:
3370:
3365:
3346:
3341:
3336:
3331:
3319:
3236:
3231:
3226:
3211:
3149:
3144:
3139:
3130:
3125:
3111:
3106:
3097:
3092:
3087:
3078:
3073:
3064:
3059:
3026:
3021:
3016:
3011:
3002:
2993:
2988:
2983:
2974:
2969:
2964:
2959:
2950:
2945:
2931:
2926:
2921:
2916:
2911:
2906:
2901:
2837:
2832:
2827:
2822:
2817:
2812:
2807:
2802:
2767:
2737:
2732:
2727:
2722:
2693:
2642:
2637:
2632:
2627:
2617:
2612:
2592:
2577:
2572:
2487:
2482:
2477:
2472:
2456:
2436:
2421:
2382:
2377:
2372:
2367:
2275:
2270:
1993:
1988:
1983:
858:
479:
475:
4049:
4044:
4039:
4029:
4024:
4019:
4009:
4004:
3999:
3994:
3989:
3984:
3979:
3964:
3959:
3954:
3949:
3944:
3939:
3878:
3873:
3868:
3863:
3858:
3764:
3752:
3747:
3742:
3673:
3626:
3590:
3585:
3580:
3575:
3302:
3120:
2678:
2015:
2005:
1817:
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S (October 2004).
1349:"δ ENaC: a novel divergent amiloride-inhibitable sodium channel"
807:
61:
4079:
3264:
2510:
2298:
1955:
1908:
349:
3603:
3501:
2622:
2582:
1747:
Yamamura H, Ugawa S, Ueda T, Nagao M, Shimada S (March 2004).
942:
1712:
Biasio W, Chang T, McIntosh CJ, McDonald FJ (February 2004).
208:
863:
Exon-intron structure of the major transcript of human
875:
gene was first revealed by the Human Genome
Project.
330:
4092:
3916:
3805:
3601:
3499:
3475:
3277:
2883:
2788:
2653:
2526:
2393:
2352:
2314:
2026:
1971:
1265:
721:
700:
676:
651:
1049:
1047:
1045:
155:
1401:American Journal of Physiology. Renal Physiology
1394:
1392:
1090:
1088:
1086:
1084:
16:Protein-coding gene in the species Homo sapiens
1920:
1564:
1562:
1560:
1432:
1430:
8:
1054:GRCh38: Ensembl release 89: ENSG00000162572
4089:
4076:
3274:
3261:
2523:
2507:
2311:
2295:
1968:
1952:
1927:
1913:
1905:
490:
365:
196:
93:
1897:at the U.S. National Library of Medicine
1869:
1834:
1799:
1764:
1729:
1637:
1505:
1372:
1315:
1239:
1120:
1095:Hanukoglu I, Hanukoglu A (January 2016).
1007:
1041:
18:
160:
119:
114:
7:
383:ligand-gated sodium channel activity
3293:Calcium-activated chloride channels
1858:The Journal of Biological Chemistry
1823:The Journal of Biological Chemistry
1788:The Journal of Biological Chemistry
1753:The Journal of Biological Chemistry
1718:The Journal of Biological Chemistry
1228:The Journal of Biological Chemistry
2363:Amiloride-sensitive cation channel
1531:The American Journal of Physiology
972:; Aaron Hanukoglu (1 April 2016).
718:
697:
673:
648:
626:
607:
583:
564:
540:
521:
460:sodium ion transmembrane transport
335:
296:
234:
213:
14:
839:As ENaC is strongly inhibited by
1543:10.1152/ajpcell.1994.267.6.C1682
1317:10.1111/j.1471-4159.2007.04622.x
947:
339:
144:
137:
131:
106:
3886:Voltage-dependent anion channel
1979:Inositol trisphosphate receptor
1439:Histochemistry and Cell Biology
3908:General bacterial porin family
409:integral component of membrane
350:More reference expression data
319:More reference expression data
250:right hemisphere of cerebellum
1:
1782:Ji HL, Benos DJ (June 2004).
129:
1146:Nature Reviews. Neuroscience
4158:Genes on human chromosome 1
1486:The Journal of Cell Biology
1413:10.1152/ajprenal.00116.2012
982:. Gene Wiki Review Series.
465:ion transmembrane transport
445:sensory perception of taste
4189:
3327:Chloride Channel Accessory
1936:Membrane transport protein
1630:10.1016/j.cell.2014.01.011
1365:10.1152/ajplung.00206.2012
1277:10.1016/j.bbrc.2006.08.043
1201:10.1152/physrev.00011.2014
1113:10.1016/j.gene.2015.12.061
992:10.1016/J.GENE.2015.12.061
888:Tissue-specific expression
4133:
4088:
4075:
3273:
3260:
2522:
2506:
2322:Epithelial sodium channel
2310:
2294:
1967:
1951:
1451:10.1007/s00418-011-0904-1
1304:Journal of Neurochemistry
1071:"Human PubMed Reference:"
960:article was published in
790:
785:
781:
774:
755:
738:
725:
704:
693:
680:
655:
644:
633:
629:
614:
610:
601:
590:
586:
571:
567:
558:
547:
543:
528:
524:
515:
500:
493:
489:
473:
368:
364:
347:
338:
329:
316:
303:
299:
246:
237:
207:
199:
195:
178:
165:
128:
105:
96:
92:
55:
52:
42:
35:
30:
26:
21:
2239:Cation channels of sperm
1899:Medical Subject Headings
1241:10.1074/jbc.270.46.27411
388:sodium channel activity
1871:10.1074/jbc.M512293200
1836:10.1074/jbc.M408929200
1801:10.1074/jbc.M401143200
1766:10.1074/jbc.M400274200
1731:10.1074/jbc.M311155200
1498:10.1083/jcb.127.6.1907
958:academic peer reviewed
868:
2315:Constitutively active
1895:SCNN1D+protein,+human
1189:Physiological Reviews
862:
744:Chr 1: 1.28 – 1.29 Mb
1661:Hanukoglu I (2017).
1537:(6 Pt 1): C1682–90.
966:and can be cited as:
871:The sequence of the
455:sodium ion transport
450:response to stimulus
122:Chromosome 1 (human)
4082:By gating mechanism
1591:10.1038/nature06163
1583:2007Natur.449..316J
1492:(6 Pt 2): 1907–21.
929:Associated diseases
3609:TRP cation channel
3507:CNG cation channel
2790:Tandem pore domain
2001:Ryanodine receptor
1679:10.1111/febs.13840
869:
433:Biological process
424:actin cytoskeleton
402:Cellular component
376:Molecular function
274:anterior pituitary
266:right frontal lobe
262:right uterine tube
86:SCNN1D - orthologs
4145:
4144:
4129:
4128:
4125:
4124:
4117:Stretch-activated
4094:Ion channel class
4071:
4070:
4067:
4066:
3256:
3255:
3252:
3251:
2528:Calcium-activated
2516:Potassium channel
2502:
2501:
2498:
2497:
2290:
2289:
2286:
2285:
1034:
1033:
908:Protein structure
798:
797:
794:
793:
770:
769:
734:
733:
715:
714:
689:
688:
670:
669:
640:
639:
623:
622:
597:
596:
580:
579:
554:
553:
537:
536:
485:
484:
360:
359:
356:
355:
325:
324:
312:
311:
293:
292:
191:
190:
4180:
4090:
4077:
3285:Chloride channel
3275:
3262:
2655:Inward-rectifier
2524:
2508:
2312:
2296:
2266:Two-pore channel
1969:
1953:
1929:
1922:
1915:
1906:
1883:
1873:
1848:
1838:
1813:
1803:
1794:(26): 26939–47.
1778:
1768:
1759:(13): 12529–34.
1743:
1733:
1699:
1698:
1667:The FEBS Journal
1658:
1652:
1651:
1641:
1609:
1603:
1602:
1577:(7160): 316–23.
1566:
1555:
1554:
1526:
1520:
1519:
1509:
1477:
1471:
1470:
1434:
1425:
1424:
1396:
1387:
1386:
1376:
1359:(12): L1013–26.
1344:
1338:
1337:
1319:
1295:
1289:
1288:
1260:
1254:
1253:
1243:
1219:
1213:
1212:
1184:
1178:
1177:
1141:
1135:
1134:
1124:
1092:
1079:
1078:
1067:
1061:
1051:
1029:
1011:
970:Israel Hanukoglu
951:
943:
783:
782:
766:
751:
746:
729:
719:
710:
698:
694:RefSeq (protein)
684:
674:
665:
649:
627:
608:
584:
565:
541:
522:
491:
366:
352:
343:
336:
321:
297:
242:
240:Top expressed in
235:
214:
197:
187:
174:
163:
148:
141:
135:
124:
110:
94:
88:
47:
40:
19:
4188:
4187:
4183:
4182:
4181:
4179:
4178:
4177:
4173:Sodium channels
4148:
4147:
4146:
4141:
4121:
4084:
4063:
3912:
3811:
3801:
3597:
3495:
3471:
3269:
3248:
3162:
3039:
2896:
2879:
2784:
2748:
2718:
2674:
2666:
2649:
2603:
2518:
2494:
2467:
2406:
2389:
2348:
2306:
2282:
2165:
2137:
2124:
2111:
2091:
2078:
2043:
2022:
1963:
1961:Calcium channel
1947:
1933:
1891:
1886:
1864:(12): 8233–41.
1851:
1829:(43): 44483–9.
1816:
1781:
1746:
1711:
1707:
1705:Further reading
1702:
1660:
1659:
1655:
1611:
1610:
1606:
1568:
1567:
1558:
1528:
1527:
1523:
1479:
1478:
1474:
1436:
1435:
1428:
1398:
1397:
1390:
1346:
1345:
1341:
1297:
1296:
1292:
1262:
1261:
1257:
1234:(46): 27411–4.
1221:
1220:
1216:
1186:
1185:
1181:
1158:10.1038/nrn2400
1143:
1142:
1138:
1094:
1093:
1082:
1069:
1068:
1064:
1052:
1043:
1039:
1030:
968:
967:
952:
939:
931:
910:
890:
857:
849:
787:View/Edit Human
764:
749:
742:
739:Location (UCSC)
727:
706:
682:
661:
657:
574:ENSG00000162572
469:
428:
414:plasma membrane
397:
393:protein binding
348:
317:
308:
289:
286:cingulate gyrus
284:
280:
276:
272:
268:
264:
260:
256:
252:
238:
182:
169:
161:
151:
150:
149:
142:
120:
97:Gene location (
56:
43:
36:
17:
12:
11:
5:
4186:
4184:
4176:
4175:
4170:
4165:
4160:
4150:
4149:
4143:
4142:
4134:
4131:
4130:
4127:
4126:
4123:
4122:
4120:
4119:
4114:
4109:
4104:
4098:
4096:
4086:
4085:
4080:
4073:
4072:
4069:
4068:
4065:
4064:
4062:
4061:
4056:
4055:
4054:
4053:
4052:
4047:
4042:
4034:
4033:
4032:
4027:
4022:
4014:
4013:
4012:
4007:
4002:
3997:
3992:
3987:
3982:
3974:
3973:
3972:
3967:
3962:
3957:
3952:
3947:
3942:
3928:
3926:
3914:
3913:
3911:
3910:
3905:
3904:
3903:
3898:
3893:
3883:
3882:
3881:
3876:
3871:
3866:
3861:
3856:
3851:
3846:
3841:
3836:
3825:
3823:
3809:
3803:
3802:
3800:
3799:
3798:
3797:
3792:
3787:
3782:
3777:
3772:
3762:
3761:
3760:
3755:
3745:
3740:
3739:
3738:
3733:
3728:
3718:
3717:
3716:
3711:
3706:
3701:
3696:
3691:
3686:
3681:
3671:
3670:
3669:
3664:
3659:
3654:
3649:
3644:
3639:
3634:
3624:
3613:
3611:
3599:
3598:
3596:
3595:
3594:
3593:
3588:
3583:
3578:
3573:
3561:
3560:
3559:
3554:
3549:
3539:
3538:
3537:
3532:
3527:
3522:
3511:
3509:
3497:
3496:
3494:
3493:
3487:
3485:
3483:Proton channel
3473:
3472:
3470:
3469:
3468:
3467:
3462:
3452:
3451:
3450:
3445:
3440:
3435:
3430:
3425:
3420:
3410:
3409:
3408:
3403:
3398:
3393:
3388:
3383:
3378:
3373:
3368:
3358:
3353:
3352:
3351:
3350:
3349:
3344:
3339:
3334:
3324:
3323:
3322:
3317:
3307:
3306:
3305:
3289:
3287:
3271:
3270:
3265:
3258:
3257:
3254:
3253:
3250:
3249:
3247:
3246:
3241:
3240:
3239:
3234:
3229:
3219:
3214:
3209:
3208:
3207:
3202:
3197:
3192:
3182:
3181:
3180:
3175:
3170:
3160:
3155:
3154:
3153:
3152:
3147:
3142:
3135:
3134:
3133:
3128:
3123:
3116:
3115:
3114:
3109:
3102:
3101:
3100:
3095:
3090:
3083:
3082:
3081:
3076:
3069:
3068:
3067:
3062:
3057:
3052:
3047:
3037:
3032:
3031:
3030:
3029:
3024:
3019:
3014:
3007:
3006:
3005:
2998:
2997:
2996:
2991:
2986:
2979:
2978:
2977:
2972:
2967:
2962:
2955:
2954:
2953:
2948:
2941:
2940:
2939:
2934:
2929:
2924:
2919:
2914:
2909:
2904:
2894:
2889:
2887:
2881:
2880:
2878:
2877:
2876:
2875:
2870:
2865:
2860:
2855:
2850:
2845:
2840:
2835:
2830:
2825:
2820:
2815:
2810:
2805:
2794:
2792:
2786:
2785:
2783:
2782:
2781:
2780:
2775:
2770:
2765:
2760:
2755:
2746:
2742:
2741:
2740:
2735:
2730:
2725:
2716:
2708:
2707:
2706:
2701:
2696:
2691:
2686:
2681:
2672:
2668:
2664:
2659:
2657:
2651:
2650:
2648:
2647:
2646:
2645:
2640:
2635:
2630:
2625:
2620:
2615:
2610:
2601:
2597:
2596:
2595:
2587:
2586:
2585:
2580:
2575:
2565:
2564:
2563:
2558:
2553:
2548:
2543:
2532:
2530:
2520:
2519:
2511:
2504:
2503:
2500:
2499:
2496:
2495:
2493:
2492:
2491:
2490:
2485:
2480:
2475:
2465:
2461:
2460:
2459:
2454:
2449:
2444:
2439:
2434:
2429:
2424:
2419:
2414:
2404:
2399:
2397:
2391:
2390:
2388:
2387:
2386:
2385:
2380:
2375:
2370:
2359:
2357:
2350:
2349:
2347:
2346:
2345:
2344:
2339:
2334:
2329:
2318:
2316:
2308:
2307:
2304:Sodium channel
2299:
2292:
2291:
2288:
2287:
2284:
2283:
2281:
2280:
2279:
2278:
2273:
2263:
2262:
2261:
2256:
2251:
2246:
2235:
2234:
2233:
2232:
2227:
2222:
2217:
2207:
2206:
2205:
2200:
2195:
2190:
2180:
2179:
2178:
2173:
2163:
2158:
2157:
2156:
2155:
2150:
2145:
2135:
2127:
2122:
2114:
2109:
2101:
2100:
2099:
2089:
2081:
2076:
2068:
2067:
2066:
2061:
2056:
2051:
2041:
2032:
2030:
2024:
2023:
2021:
2020:
2019:
2018:
2013:
2008:
1998:
1997:
1996:
1991:
1986:
1975:
1973:
1965:
1964:
1956:
1949:
1948:
1934:
1932:
1931:
1924:
1917:
1909:
1903:
1902:
1890:
1889:External links
1887:
1885:
1884:
1849:
1814:
1779:
1744:
1724:(7): 5429–34.
1708:
1706:
1703:
1701:
1700:
1673:(4): 525–545.
1653:
1604:
1556:
1521:
1472:
1426:
1407:(3): F328–38.
1388:
1339:
1310:(4): 1304–15.
1290:
1255:
1214:
1195:(1): 297–340.
1179:
1136:
1080:
1062:
1040:
1038:
1035:
1032:
1031:
955:
953:
946:
938:
935:
930:
927:
909:
906:
889:
886:
856:
855:Gene structure
853:
848:
845:
796:
795:
792:
791:
789:
779:
778:
772:
771:
768:
767:
762:
760:
753:
752:
747:
740:
736:
735:
732:
731:
723:
722:
716:
713:
712:
702:
701:
695:
691:
690:
687:
686:
678:
677:
671:
668:
667:
653:
652:
646:
642:
641:
638:
637:
631:
630:
624:
621:
620:
612:
611:
605:
599:
598:
595:
594:
588:
587:
581:
578:
577:
569:
568:
562:
556:
555:
552:
551:
545:
544:
538:
535:
534:
526:
525:
519:
513:
512:
507:
502:
498:
497:
487:
486:
483:
482:
471:
470:
468:
467:
462:
457:
452:
447:
442:
436:
434:
430:
429:
427:
426:
421:
416:
411:
405:
403:
399:
398:
396:
395:
390:
385:
379:
377:
373:
372:
362:
361:
358:
357:
354:
353:
345:
344:
333:
327:
326:
323:
322:
314:
313:
310:
309:
307:
304:
301:
300:
294:
291:
290:
288:
287:
283:
279:
275:
271:
267:
263:
259:
255:
251:
247:
244:
243:
231:
230:
222:
211:
205:
204:
201:RNA expression
193:
192:
189:
188:
180:
176:
175:
167:
164:
159:
153:
152:
143:
136:
130:
126:
125:
118:
112:
111:
103:
102:
90:
89:
54:
50:
49:
41:
33:
32:
28:
27:
24:
23:
15:
13:
10:
9:
6:
4:
3:
2:
4185:
4174:
4171:
4169:
4166:
4164:
4161:
4159:
4156:
4155:
4153:
4140:
4139:
4132:
4118:
4115:
4113:
4112:Voltage-gated
4110:
4108:
4105:
4103:
4100:
4099:
4097:
4095:
4091:
4087:
4083:
4078:
4074:
4060:
4057:
4051:
4048:
4046:
4043:
4041:
4038:
4037:
4035:
4031:
4028:
4026:
4023:
4021:
4018:
4017:
4015:
4011:
4008:
4006:
4003:
4001:
3998:
3996:
3993:
3991:
3988:
3986:
3983:
3981:
3978:
3977:
3975:
3971:
3968:
3966:
3963:
3961:
3958:
3956:
3953:
3951:
3948:
3946:
3943:
3941:
3938:
3937:
3935:
3934:
3933:
3930:
3929:
3927:
3925:
3922:
3920:
3915:
3909:
3906:
3902:
3899:
3897:
3894:
3892:
3889:
3888:
3887:
3884:
3880:
3877:
3875:
3872:
3870:
3867:
3865:
3862:
3860:
3857:
3855:
3852:
3850:
3847:
3845:
3842:
3840:
3837:
3835:
3832:
3831:
3830:
3827:
3826:
3824:
3822:
3819:
3817:
3813:
3804:
3796:
3793:
3791:
3788:
3786:
3783:
3781:
3778:
3776:
3773:
3771:
3768:
3767:
3766:
3763:
3759:
3756:
3754:
3751:
3750:
3749:
3746:
3744:
3741:
3737:
3734:
3732:
3729:
3727:
3724:
3723:
3722:
3719:
3715:
3712:
3710:
3707:
3705:
3702:
3700:
3697:
3695:
3692:
3690:
3687:
3685:
3682:
3680:
3677:
3676:
3675:
3672:
3668:
3665:
3663:
3660:
3658:
3655:
3653:
3650:
3648:
3645:
3643:
3640:
3638:
3635:
3633:
3630:
3629:
3628:
3625:
3622:
3618:
3615:
3614:
3612:
3610:
3607:
3605:
3600:
3592:
3589:
3587:
3584:
3582:
3579:
3577:
3574:
3572:
3569:
3568:
3567:
3566:
3562:
3558:
3555:
3553:
3550:
3548:
3545:
3544:
3543:
3540:
3536:
3533:
3531:
3528:
3526:
3523:
3521:
3518:
3517:
3516:
3513:
3512:
3510:
3508:
3505:
3503:
3498:
3492:
3489:
3488:
3486:
3484:
3481:
3479:
3474:
3466:
3463:
3461:
3458:
3457:
3456:
3453:
3449:
3446:
3444:
3441:
3439:
3436:
3434:
3431:
3429:
3426:
3424:
3421:
3419:
3416:
3415:
3414:
3411:
3407:
3404:
3402:
3399:
3397:
3394:
3392:
3389:
3387:
3384:
3382:
3379:
3377:
3374:
3372:
3369:
3367:
3364:
3363:
3362:
3359:
3357:
3354:
3348:
3345:
3343:
3340:
3338:
3335:
3333:
3330:
3329:
3328:
3325:
3321:
3318:
3316:
3313:
3312:
3311:
3308:
3304:
3301:
3300:
3299:
3296:
3295:
3294:
3291:
3290:
3288:
3286:
3283:
3281:
3276:
3272:
3268:
3267:Miscellaneous
3263:
3259:
3245:
3244:Shaker (gene)
3242:
3238:
3235:
3233:
3230:
3228:
3225:
3224:
3223:
3220:
3218:
3217:minK/ISK-like
3215:
3213:
3210:
3206:
3203:
3201:
3198:
3196:
3193:
3191:
3188:
3187:
3186:
3183:
3179:
3176:
3174:
3171:
3169:
3166:
3165:
3164:
3157:
3156:
3151:
3148:
3146:
3143:
3141:
3138:
3137:
3136:
3132:
3129:
3127:
3124:
3122:
3119:
3118:
3117:
3113:
3110:
3108:
3105:
3104:
3103:
3099:
3096:
3094:
3091:
3089:
3086:
3085:
3084:
3080:
3077:
3075:
3072:
3071:
3070:
3066:
3063:
3061:
3058:
3056:
3053:
3051:
3048:
3046:
3043:
3042:
3041:
3034:
3033:
3028:
3025:
3023:
3020:
3018:
3015:
3013:
3010:
3009:
3008:
3004:
3001:
3000:
2999:
2995:
2992:
2990:
2987:
2985:
2982:
2981:
2980:
2976:
2973:
2971:
2968:
2966:
2963:
2961:
2958:
2957:
2956:
2952:
2949:
2947:
2944:
2943:
2942:
2938:
2935:
2933:
2930:
2928:
2925:
2923:
2920:
2918:
2915:
2913:
2910:
2908:
2905:
2903:
2900:
2899:
2898:
2891:
2890:
2888:
2886:
2885:Voltage-gated
2882:
2874:
2871:
2869:
2866:
2864:
2861:
2859:
2856:
2854:
2851:
2849:
2846:
2844:
2841:
2839:
2836:
2834:
2831:
2829:
2826:
2824:
2821:
2819:
2816:
2814:
2811:
2809:
2806:
2804:
2801:
2800:
2799:
2796:
2795:
2793:
2791:
2787:
2779:
2776:
2774:
2771:
2769:
2766:
2764:
2761:
2759:
2756:
2754:
2751:
2750:
2749:
2743:
2739:
2736:
2734:
2731:
2729:
2726:
2724:
2721:
2720:
2719:
2712:
2709:
2705:
2702:
2700:
2697:
2695:
2692:
2690:
2687:
2685:
2682:
2680:
2677:
2676:
2675:
2669:
2667:
2661:
2660:
2658:
2656:
2652:
2644:
2641:
2639:
2636:
2634:
2631:
2629:
2626:
2624:
2621:
2619:
2616:
2614:
2611:
2609:
2606:
2605:
2604:
2598:
2594:
2591:
2590:
2588:
2584:
2581:
2579:
2576:
2574:
2571:
2570:
2569:
2566:
2562:
2559:
2557:
2554:
2552:
2549:
2547:
2544:
2542:
2539:
2538:
2537:
2534:
2533:
2531:
2529:
2525:
2521:
2517:
2514:
2509:
2505:
2489:
2486:
2484:
2481:
2479:
2476:
2474:
2471:
2470:
2469:
2462:
2458:
2455:
2453:
2450:
2448:
2445:
2443:
2440:
2438:
2435:
2433:
2430:
2428:
2425:
2423:
2420:
2418:
2415:
2413:
2410:
2409:
2408:
2401:
2400:
2398:
2396:
2395:Voltage-gated
2392:
2384:
2381:
2379:
2376:
2374:
2371:
2369:
2366:
2365:
2364:
2361:
2360:
2358:
2355:
2351:
2343:
2340:
2338:
2335:
2333:
2330:
2328:
2325:
2324:
2323:
2320:
2319:
2317:
2313:
2309:
2305:
2302:
2297:
2293:
2277:
2274:
2272:
2269:
2268:
2267:
2264:
2260:
2257:
2255:
2252:
2250:
2247:
2245:
2242:
2241:
2240:
2237:
2236:
2231:
2228:
2226:
2223:
2221:
2218:
2216:
2213:
2212:
2211:
2208:
2204:
2201:
2199:
2196:
2194:
2191:
2189:
2186:
2185:
2184:
2181:
2177:
2174:
2172:
2169:
2168:
2167:
2160:
2159:
2154:
2151:
2149:
2146:
2144:
2141:
2140:
2139:
2131:
2128:
2126:
2118:
2115:
2113:
2105:
2102:
2098:
2095:
2094:
2093:
2085:
2082:
2080:
2072:
2069:
2065:
2062:
2060:
2057:
2055:
2052:
2050:
2047:
2046:
2045:
2037:
2034:
2033:
2031:
2029:
2028:Voltage-gated
2025:
2017:
2014:
2012:
2009:
2007:
2004:
2003:
2002:
1999:
1995:
1992:
1990:
1987:
1985:
1982:
1981:
1980:
1977:
1976:
1974:
1970:
1966:
1962:
1959:
1954:
1950:
1945:
1941:
1937:
1930:
1925:
1923:
1918:
1916:
1911:
1910:
1907:
1900:
1896:
1893:
1892:
1888:
1881:
1877:
1872:
1867:
1863:
1859:
1855:
1850:
1846:
1842:
1837:
1832:
1828:
1824:
1820:
1815:
1811:
1807:
1802:
1797:
1793:
1789:
1785:
1780:
1776:
1772:
1767:
1762:
1758:
1754:
1750:
1745:
1741:
1737:
1732:
1727:
1723:
1719:
1715:
1710:
1709:
1704:
1696:
1692:
1688:
1684:
1680:
1676:
1672:
1668:
1664:
1657:
1654:
1649:
1645:
1640:
1635:
1631:
1627:
1624:(4): 717–29.
1623:
1619:
1615:
1608:
1605:
1600:
1596:
1592:
1588:
1584:
1580:
1576:
1572:
1565:
1563:
1561:
1557:
1552:
1548:
1544:
1540:
1536:
1532:
1525:
1522:
1517:
1513:
1508:
1503:
1499:
1495:
1491:
1487:
1483:
1476:
1473:
1468:
1464:
1460:
1456:
1452:
1448:
1445:(3): 339–53.
1444:
1440:
1433:
1431:
1427:
1422:
1418:
1414:
1410:
1406:
1402:
1395:
1393:
1389:
1384:
1380:
1375:
1370:
1366:
1362:
1358:
1354:
1350:
1343:
1340:
1335:
1331:
1327:
1323:
1318:
1313:
1309:
1305:
1301:
1294:
1291:
1286:
1282:
1278:
1274:
1271:(1): 317–21.
1270:
1266:
1259:
1256:
1251:
1247:
1242:
1237:
1233:
1229:
1225:
1218:
1215:
1210:
1206:
1202:
1198:
1194:
1190:
1183:
1180:
1175:
1171:
1167:
1163:
1159:
1155:
1152:(7): 519–31.
1151:
1147:
1140:
1137:
1132:
1128:
1123:
1118:
1114:
1110:
1107:(2): 95–132.
1106:
1102:
1098:
1091:
1089:
1087:
1085:
1081:
1076:
1072:
1066:
1063:
1059:
1055:
1050:
1048:
1046:
1042:
1036:
1027:
1023:
1019:
1015:
1010:
1005:
1001:
997:
993:
989:
986:(2): 95–132.
985:
981:
980:
975:
971:
965:
964:
959:
954:
950:
945:
944:
941:
936:
934:
928:
926:
922:
918:
914:
907:
905:
903:
899:
895:
887:
885:
883:
878:
874:
866:
861:
854:
852:
846:
844:
842:
837:
833:
829:
827:
826:
821:
820:
815:
814:
809:
805:
804:
788:
784:
780:
777:
773:
763:
761:
758:
754:
748:
745:
741:
737:
730:
724:
720:
717:
711:
709:
703:
699:
696:
692:
685:
679:
675:
672:
666:
664:
660:
654:
650:
647:
645:RefSeq (mRNA)
643:
636:
632:
628:
625:
619:
618:
613:
609:
606:
604:
600:
593:
589:
585:
582:
576:
575:
570:
566:
563:
561:
557:
550:
546:
542:
539:
533:
532:
527:
523:
520:
518:
514:
511:
508:
506:
503:
499:
496:
492:
488:
481:
477:
472:
466:
463:
461:
458:
456:
453:
451:
448:
446:
443:
441:
440:ion transport
438:
437:
435:
432:
431:
425:
422:
420:
417:
415:
412:
410:
407:
406:
404:
401:
400:
394:
391:
389:
386:
384:
381:
380:
378:
375:
374:
371:
370:Gene ontology
367:
363:
351:
346:
342:
337:
334:
332:
328:
320:
315:
305:
302:
298:
295:
285:
281:
277:
273:
270:apex of heart
269:
265:
261:
257:
253:
249:
248:
245:
241:
236:
233:
232:
229:
227:
223:
221:
220:
216:
215:
212:
210:
206:
202:
198:
194:
186:
181:
177:
173:
168:
158:
154:
147:
140:
134:
127:
123:
117:
113:
109:
104:
100:
95:
91:
87:
83:
79:
75:
71:
67:
63:
59:
51:
46:
39:
34:
29:
25:
20:
4135:
4102:Ligand-gated
4093:
4081:
3924:Gap junction
3917:
3806:
3602:
3563:
3541:
3514:
3500:
3476:
3454:
3412:
3360:
3326:
3309:
3297:
3278:
3266:
3221:
3184:
3158:
3035:
2892:
2797:
2744:
2714:
2670:
2599:
2512:
2463:
2402:
2341:
2300:
2209:
2182:
2161:
2133:
2120:
2107:
2087:
2074:
2039:
1972:Ligand-gated
1957:
1940:ion channels
1861:
1857:
1826:
1822:
1791:
1787:
1756:
1752:
1721:
1717:
1670:
1666:
1656:
1621:
1617:
1607:
1574:
1570:
1534:
1530:
1524:
1489:
1485:
1475:
1442:
1438:
1404:
1400:
1356:
1352:
1342:
1307:
1303:
1293:
1268:
1264:
1258:
1231:
1227:
1217:
1192:
1188:
1182:
1149:
1145:
1139:
1104:
1100:
1074:
1065:
983:
977:
962:
961:
940:
932:
923:
919:
915:
911:
901:
897:
893:
891:
881:
876:
872:
870:
864:
850:
838:
834:
830:
823:
817:
811:
802:
801:
799:
726:
708:NP_001123885
705:
681:
659:NM_001130413
656:
634:
615:
591:
572:
548:
529:
509:
504:
254:right testis
224:
217:
53:External IDs
4107:Light-gated
2589:IK channel
282:right ovary
258:left testis
31:Identifiers
4152:Categories
3310:Bestrophin
2568:SK channel
2536:BK channel
2210:γ-subunits
2183:β-subunits
2166:δ-subunits
1060:, May 2017
1037:References
278:left ovary
228:(ortholog)
183:1,292,029
170:1,280,436
66:HomoloGene
4138:disorders
4136:see also
3919:Cytoplasm
3829:Aquaporin
3298:Anoctamin
3121:11.1/hERG
1174:205504313
1026:Q28272095
1000:0378-1119
841:amiloride
663:NM_002978
495:Orthologs
74:GeneCards
3932:Connexin
3212:minK/ISK
1880:16423824
1845:15308635
1810:15084585
1775:14726523
1740:14645214
1695:24402104
1687:27580245
1648:24507937
1599:17882215
1467:15178940
1459:22207244
1421:22573384
1383:22983350
1334:18291486
1326:17472699
1285:16930535
1209:25540145
1166:18509340
1131:26772908
1056:–
1022:Wikidata
1018:26772908
776:Wikidata
474:Sources:
419:membrane
4059:Innexin
3816:solutes
1639:4190031
1579:Bibcode
1551:7810611
1516:7806569
1507:2120291
1374:3532584
1250:7499195
1122:4756657
1058:Ensembl
1009:4756657
847:History
603:UniProt
560:Ensembl
501:Species
480:QuickGO
203:pattern
162:1p36.33
38:Aliases
2356:-gated
2354:Proton
2130:T-type
2117:R-type
2104:Q-type
2084:P-type
2071:N-type
2036:L-type
1901:(MeSH)
1878:
1843:
1808:
1773:
1738:
1693:
1685:
1646:
1636:
1597:
1571:Nature
1549:
1514:
1504:
1465:
1457:
1419:
1381:
1371:
1332:
1324:
1283:
1248:
1207:
1172:
1164:
1129:
1119:
1024:
1016:
1006:
998:
902:SCNN1G
900:, and
898:SCNN1B
894:SCNN1A
882:SCNN1D
877:SCNN1D
873:SCNN1D
865:SCNN1D
825:SCNN1G
822:, and
819:SCNN1B
813:SCNN1A
803:SCNN1D
759:search
757:PubMed
617:P51172
517:Entrez
331:BioGPS
78:SCNN1D
62:601328
45:SCNN1D
22:SCNN1D
3970:GJA10
3821:Porin
3721:TRPML
3491:HVCN1
3185:KCNIP
3040:α7-12
1944:TC 1A
1691:S2CID
1463:S2CID
1330:S2CID
1170:S2CID
963:Gene
937:Notes
510:Mouse
505:Human
476:Amigo
226:Mouse
219:Human
166:Start
99:Human
70:48152
4050:GJD4
4045:GJD3
4040:GJD2
4030:GJC3
4025:GJC2
4020:GJC1
4010:GJB7
4005:GJB6
4000:GJB5
3995:GJB4
3990:GJB3
3985:GJB2
3980:GJB1
3965:GJA9
3960:GJA8
3955:GJA5
3950:GJA4
3945:GJA3
3940:GJA1
3765:TRPV
3748:TRPP
3743:TRPN
3674:TRPM
3627:TRPC
3617:TRPA
3455:CLNS
3413:CLIC
3361:CLCN
3356:CFTR
3303:ANO1
3222:MiRP
3150:12.3
3145:12.2
3140:12.1
3131:11.3
3126:11.2
3112:10.2
3107:10.1
2897:α1-6
2711:GIRK
2125:α2.3
2112:α2.1
2079:α2.2
1876:PMID
1841:PMID
1806:PMID
1771:PMID
1736:PMID
1683:PMID
1644:PMID
1618:Cell
1595:PMID
1547:PMID
1512:PMID
1455:PMID
1417:PMID
1379:PMID
1322:PMID
1281:PMID
1246:PMID
1205:PMID
1162:PMID
1127:PMID
1101:Gene
1014:PMID
996:ISSN
979:Gene
808:ENaC
800:The
531:6339
209:Bgee
157:Band
116:Chr.
58:OMIM
3814:(+
3652:4AP
3565:HCN
3098:9.3
3093:9.2
3088:9.1
3079:8.2
3074:8.1
3065:7.5
3060:7.4
3055:7.3
3050:7.2
3045:7.1
3027:6.4
3022:6.3
3017:6.2
3012:6.1
3003:5.1
2994:4.3
2989:4.2
2984:4.1
2975:3.4
2970:3.3
2965:3.2
2960:3.1
2951:2.2
2946:2.1
2937:1.8
2932:1.7
2927:1.6
2922:1.5
2917:1.4
2912:1.3
2907:1.2
2902:1.1
2798:K2P
2778:7.1
2773:6.2
2768:6.1
2763:5.1
2758:4.2
2753:4.1
2738:3.4
2733:3.3
2728:3.2
2723:3.1
2704:2.6
2699:2.4
2694:2.3
2689:2.2
2684:2.1
2679:1.1
2665:ATP
2643:5.1
2638:4.2
2633:4.1
2628:3.1
2623:2.3
2618:2.2
2613:2.1
2608:1.1
2593:IK1
2583:SK3
2578:SK2
2573:SK1
2452:1.9
2447:1.8
2442:1.7
2437:1.6
2432:1.5
2427:1.4
2422:1.3
2417:1.2
2412:1.1
2301:Na:
2153:3.3
2148:3.2
2143:3.1
2097:2.1
2064:1.4
2059:1.3
2054:1.2
2049:1.1
1958:Ca:
1866:doi
1862:281
1831:doi
1827:279
1796:doi
1792:279
1761:doi
1757:279
1726:doi
1722:279
1675:doi
1671:284
1634:PMC
1626:doi
1622:156
1587:doi
1575:449
1539:doi
1535:267
1502:PMC
1494:doi
1490:127
1447:doi
1443:137
1409:doi
1405:303
1369:PMC
1361:doi
1357:303
1312:doi
1308:102
1273:doi
1269:349
1236:doi
1232:270
1197:doi
1154:doi
1117:PMC
1109:doi
1105:579
1004:PMC
988:doi
984:579
765:n/a
750:n/a
728:n/a
683:n/a
635:n/a
592:n/a
549:n/a
306:n/a
179:End
82:OMA
4154::
4036:D
4016:C
3976:B
3936:A
3818:):
3571:FC
3465:1B
3460:1A
3448:L1
3406:KB
3401:KA
3280:Cl
2873:18
2868:17
2863:16
2858:15
2853:13
2848:12
2843:10
2747:ir
2717:ir
2673:ir
2602:Ca
2561:β4
2556:β3
2551:β2
2546:β1
2541:α1
2513:K:
2464:Na
2457:7A
2403:Na
2230:γ4
2225:γ3
2220:γ2
2215:γ1
2203:β4
2198:β3
2193:β2
2188:β1
2134:Ca
2121:Ca
2108:Ca
2088:Ca
2075:Ca
2040:Ca
1938::
1874:.
1860:.
1856:.
1839:.
1825:.
1821:.
1804:.
1790:.
1786:.
1769:.
1755:.
1751:.
1734:.
1720:.
1716:.
1689:.
1681:.
1669:.
1665:.
1642:.
1632:.
1620:.
1616:.
1593:.
1585:.
1573:.
1559:^
1545:.
1533:.
1510:.
1500:.
1488:.
1484:.
1461:.
1453:.
1441:.
1429:^
1415:.
1403:.
1391:^
1377:.
1367:.
1355:.
1351:.
1328:.
1320:.
1306:.
1302:.
1279:.
1267:.
1244:.
1230:.
1226:.
1203:.
1193:95
1191:.
1168:.
1160:.
1148:.
1125:.
1115:.
1103:.
1099:.
1083:^
1073:.
1044:^
1020:.
1012:.
1002:.
994:.
976:.
896:,
828:.
816:,
478:/
185:bp
172:bp
80:;
76::
72:;
68::
64:;
60::
3921::
3901:3
3896:2
3891:1
3879:9
3874:8
3869:7
3864:6
3859:5
3854:4
3849:3
3844:2
3839:1
3834:0
3812:O
3810:2
3808:H
3795:6
3790:5
3785:4
3780:3
3775:2
3770:1
3758:2
3753:1
3736:3
3731:2
3726:1
3714:8
3709:7
3704:6
3699:5
3694:4
3689:3
3684:2
3679:1
3667:7
3662:6
3657:5
3647:4
3642:3
3637:2
3632:1
3623:)
3621:1
3619:(
3606::
3604:M
3591:4
3586:3
3581:2
3576:1
3557:3
3552:2
3547:1
3542:β
3535:4
3530:3
3525:2
3520:1
3515:α
3504::
3502:M
3480::
3478:H
3443:6
3438:5
3433:4
3428:3
3423:2
3418:1
3396:7
3391:6
3386:5
3381:4
3376:3
3371:2
3366:1
3347:4
3342:3
3337:2
3332:1
3320:2
3315:1
3282::
3237:3
3232:2
3227:1
3205:4
3200:3
3195:2
3190:1
3178:3
3173:2
3168:1
3163:β
3161:v
3159:K
3038:v
3036:K
2895:v
2893:K
2838:9
2833:7
2828:6
2823:5
2818:4
2813:3
2808:2
2803:1
2745:K
2715:K
2713:/
2671:K
2663:K
2600:K
2488:4
2483:3
2478:2
2473:1
2468:β
2466:v
2407:α
2405:v
2383:4
2378:3
2373:2
2368:1
2342:δ
2337:γ
2332:β
2327:α
2276:2
2271:1
2259:4
2254:3
2249:2
2244:1
2176:2
2171:1
2164:2
2162:α
2138:α
2136:v
2132:/
2123:v
2119:/
2110:v
2106:/
2092:α
2090:v
2086:/
2077:v
2073:/
2044:α
2042:v
2038:/
2016:3
2011:2
2006:1
1994:3
1989:2
1984:1
1946:)
1942:(
1928:e
1921:t
1914:v
1882:.
1868::
1847:.
1833::
1812:.
1798::
1777:.
1763::
1742:.
1728::
1697:.
1677::
1650:.
1628::
1601:.
1589::
1581::
1553:.
1541::
1518:.
1496::
1469:.
1449::
1423:.
1411::
1385:.
1363::
1336:.
1314::
1287:.
1275::
1252:.
1238::
1211:.
1199::
1176:.
1156::
1150:9
1133:.
1111::
1077:.
1028:.
990::
101:)
84::
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.
