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to fight it off, the skin around the injection will become red and swollen, indicating a positive result. This swelling disappears after a few days. If the person has an immunity, then little or no swelling and redness will occur, indicating a negative result.
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Combined reaction: Initial picture is like that of the pseudo-reaction but the erythema fades off after four days only in the control arm. It progresses on the test arm to a typical positive. The subject is interpreted to be both susceptible and
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Positive: when the test results in a wheal of 5–10 mm diameter, reaching its peak in four to seven days. The control arm shows no reaction. This indicates that the subject lacks antibodies against the toxin and hence is susceptible to the
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is injected intradermally into one arm of the person and a heat inactivated toxin on the other as a control. If a person does not have enough
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111:) and it disappears within four days. This happens on both the arms since the subject is immune but hypersensitive to the toxin.
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163:"United States standard diphtheria toxin for the Schick text and the erythema potency assay for the Schick text dose"
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The test was created when immunizing agents were scarce and not very safe; however, as newer and safer
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Kilduffe R (1922). "The Schick Test and Its
Practical Application in the Control of Diphtheria".
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The test is a simple procedure. A small amount (0.1 ml) of diluted (1/50
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A boy receives an injection of diluted toxin for the Schick test in 1915.
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became available, susceptibility tests were no longer required.
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Pseudo-positive: when there is only a red-colored inflammation (
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used to determine whether or not a person is susceptible to
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Preventive and Social
Medicine, Park 22nd edition, pg 151
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Negative reaction: Indicates that the person is immune.
75:(1877–1967), a Hungarian-born American pediatrician.
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161:Barile MF, Kolb RW, Pittman M (September 1971).
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339:Enzyme multiplied immunoassay technique
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16:Skin test for diphtheria susceptibility
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217:Taber's Cyclopedic Medical Dictionary
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71:. It was named after its inventor,
289:Ouchterlony double immunodiffusion
14:
144:The American Journal of Nursing
99:Results can be interpreted as:
1:
279:Chromatin immunoprecipitation
324:Chemiluminescent immunoassay
304:Counterimmunoelectrophoresis
179:10.1128/IAI.4.3.295-306.1971
434:Direct fluorescent antibody
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63:, developed in 1913, is a
456:Total complement activity
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419:Complement fixation test
294:Radial immunodiffusion
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409:Diagnostic immunology
299:Immunoelectrophoresis
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429:Immunohistochemistry
424:Immunocytochemistry
393:Latex fixation test
271:Immunoprecipitation
55:A positive reaction
359:Immunofluorescence
354:Radiobinding assay
219:, 20th Ed. (2005).
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42:susceptibility to
497:Immunologic tests
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446:Skin allergy test
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377:Hemagglutination
349:Radioimmunoassay
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89:diphtheria toxin
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441:Epitope mapping
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284:Immunodiffusion
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118:hypersensitive.
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173:(3): 295–306.
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381:Hemagglutinin
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369:Agglutination
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254:Medical tests
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167:Infect. Immun
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150:(4): 254–248.
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414:Nephelometry
264:86000–86849)
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386:Coombs test
316:Immunoassay
73:Béla Schick
61:Schick test
22:Schick test
492:Diphtheria
487:Pediatrics
482:Skin tests
476:Categories
451:Patch test
258:immunology
130:References
93:antibodies
69:diphtheria
44:diphtheria
344:RAST test
79:Procedure
65:skin test
256:used in
109:erythema
104:disease.
334:ELISpot
197:4949493
124:toxoids
39:Purpose
461:MELISA
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188:416303
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402:Other
329:ELISA
193:PMID
59:The
262:CPT
183:PMC
175:doi
85:MLD
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148:22
146:.
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379:/
260:(
246:e
239:t
232:v
199:.
177::
171:4
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