22:
222:
consists of a zone of hyalinized collagen between dead cells and preserved cells, commonly eosinophilic. If dead nuclei present, they are uniform and the chromatin is often. Necrosis secondary to ulceration in submucous leiomyomas features acute inflammatory cells and a peripheral reparative process, whereas ghost outlines of nuclei are usually inconspicuous or absent.
221:
tumor cell necrosis is common in clinically malignant smooth muscle cell tumors. It consists of an abrupt transition between necrotic cells and preserved cells. Ghost nuclei from necrotic cells are often seen, but inflammatory cells are uncommon. Hyalinizing necrosis is more common in leiomyomas. It
444:
234:
No or mild atypia, no tumor cell necrosis ⇒ leiomyoma. If 5 or more mitotic figures are present in 10 high powered fields but the behavior still appears benign, may append “with significant mitotic activity”.
490:
1025:
268:
101:
51:
483:
352:
Ip PP, Cheung AN, Clement PB (July 2009). "Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases".
181:. Hairy extensions from an empty center favor a non-mitosis. Count 4 sets of 10 fields in the area of highest mitotic activity and use the highest count
476:
381:
Chen WY, Yang AH, Liu HC (April 1991). "Spindle cell stromal tumors of gastrointestinal tract: a histological and immunohistochemical study".
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73:
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326:"A clinicopathologic study of uterine smooth muscle tumours of uncertain malignant potential (STUMP)"
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Hairy extensions of chromatin must be present, extending from a central clot-like dense mass of
111:
The Bell criteria were developed to help categorize them and differentiate them from their main
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875:
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499:
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120:
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185:
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283:"Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis"
173:
Evaluation of the mitotic figures in a STUMP requires evaluation of 3 specific criteria
1112:
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1005:
940:
851:
789:
769:
307:
282:
255:
246:
158:
116:
1150:
281:
Guntupalli SR, Ramirez PT, Anderson ML, Milam MR, Bodurka DC, Malpica A (June 2009).
94:
144:, smooth contours, minimal variation in nuclear size, shape, and evenly distributed
1130:
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141:
365:
1122:
960:
834:
829:
729:
503:
298:
206:
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191:
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154:
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severe: obvious pleomorphism, enlarged bizarre nuclei with dense chromatin,
993:
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885:
145:
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316:
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162:
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912:
150:
moderate: many large, plump, irregular nuclei, 1-2 mitotic figures
472:
15:
97:
that may behave like a benign tumor or a cancerous tumor.
269:
Prostatic stromal tumor of uncertain malignant potential
102:
prostatic stromal tumor of uncertain malignant potential
404:"Smooth muscle tumors of uncertain malignant potential"
1026:
Multiple cutaneous and uterine leiomyomatosis syndrome
237:
Moderate to severe atypia without tumor cell necrosis
426:
254:
Moderate to severe atypia and tumor cell necrosis ⇒
87:
Smooth muscle tumor of uncertain malignant potential
1121:
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816:
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760:
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231:
Bell's criteria do not apply to extrauterine tumors
243:if < 10 mitotic figures per high power field or
43:but its sources remain unclear because it lacks
484:
8:
324:Ng JS, Han A, Chew SH, Low J (August 2010).
249:if ≥ 10 mitotic figures per high power field
100:This tumor should not be confused with the
900:
558:
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491:
477:
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306:
74:Learn how and when to remove this message
104:which may be abbreviated the same way (
93:, is an uncommon tumor of the uterine
7:
530:Desmoplastic small-round-cell tumor
14:
607:Aggressive infantile fibromatosis
1098:Clear-cell sarcoma of the kidney
402:Pernick, Nat (August 11, 2020).
20:
866:Intradermal spindle cell lipoma
575:Dermatofibrosarcoma protuberans
383:Zhonghua Yi Xue Za Zhi (Taipei)
258:(mitotic figures don’t matter).
694:Malignant fibrous histiocytoma
642:Infantile digital fibromatosis
627:Familial myxovascular fibromas
622:Diffuse infantile fibromatosis
1:
740:Superficial acral fibromyxoma
647:Juvenile hyaline fibromatosis
1041:Solitary cutaneous leiomyoma
1031:Multiple cutaneous leiomyoma
752:Ossifying fibromyxoid tumour
366:10.1097/PAS.0b013e3181a02d1c
689:Benign fibrous histiocytoma
299:10.1016/j.ygyno.2009.02.020
1173:
969:Embryonal rhabdomyosarcoma
545:Connective tissue neoplasm
1093:Malignant rhabdoid tumour
1060:Complex mixed and stromal
989:
981:Alveolar rhabdomyosarcoma
408:www.pathologyoutlines.com
202:, degenerated cells, and
632:Fibroma of tendon sheath
29:This article includes a
662:Oral submucous fibrosis
602:Aggressive fibromatosis
518:Not otherwise specified
58:more precise citations.
704:Solitary fibrous tumor
699:Atypical fibroxanthoma
333:Ann. Acad. Med. Singap
113:differential diagnoses
1078:Mixed MĂĽllerian tumor
161:, enlarged, atypical
1083:Mesoblastic nephroma
652:Plantar fibromatosis
580:Desmoplastic fibroma
1073:Pleomorphic adenoma
881:Spindle cell lipoma
681:histiocytic sarcoma
657:Pleomorphic fibroma
617:Collagenous fibroma
612:Aponeurotic fibroma
525:Soft-tissue sarcoma
354:Am. J. Surg. Pathol
1036:Neural fibrolipoma
1011:Angiolipoleiomyoma
974:Sarcoma botryoides
871:Pleomorphic lipoma
840:Myxoid liposarcoma
804:Clear-cell sarcoma
637:Fibromatosis colli
241:atypical leiomyoma
31:list of references
1144:
1143:
1136:Adenomatoid tumor
1108:Pancreatoblastoma
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1053:
1016:Genital leiomyoma
876:Lipoblastomatosis
812:
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712:
711:
667:Pachydermodactyly
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121:uterine leiomyoma
84:
83:
76:
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965:rhabdomyosarcoma
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861:Chondroid lipoma
799:Synovial sarcoma
735:Cutaneous myxoma
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186:nuclear membrane
140:minimal: smooth
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54:this article by
45:inline citations
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1157:Types of cancer
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952:Skeletal muscle
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780:Phyllodes tumor
762:Fibroepithelial
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360:(7): 992–1005.
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200:stripped nuclei
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169:Mitotic figures
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35:related reading
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1113:Carcinosarcoma
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1103:Hepatoblastoma
1100:
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1038:
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1021:Leiomyosarcoma
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1008:
1006:Angioleiomyoma
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941:leiomyosarcoma
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852:Angiomyolipoma
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770:Brenner tumour
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431:Classification
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423:External links
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287:Gynecol. Oncol
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247:leiomyosarcoma
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159:multinucleated
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117:leiomyosarcoma
89:, abbreviated
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39:external links
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389:(4): 219–27.
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127:Bell criteria
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95:smooth muscle
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32:
27:
18:
17:
1131:Mesothelioma
1088:Wilms' tumor
1045:
775:Fibroadenoma
677:Histiocytoma
594:fibromatosis
567:fibrosarcoma
535:Skin sarcoma
465:
443:
413:November 18,
411:. Retrieved
407:
386:
382:
357:
353:
339:(8): 625–8.
336:
332:
293:(3): 324–6.
290:
286:
217:
204:precipitated
172:
110:
105:
99:
90:
86:
85:
70:
61:
50:Please help
42:
1123:Mesothelial
961:Rhabdomyoma
835:Myelolipoma
830:liposarcoma
747:Angiomyxoma
730:myxosarcoma
554:Fibromatous
504:soft tissue
219:Coagulative
207:hematoxylin
192:lymphocytes
179:chromosomes
155:giant cells
56:introducing
1068:Adenomyoma
917:myosarcoma
818:Lipomatous
718:Myxomatous
500:Connective
275:References
196:mast cells
64:March 2012
999:Cutaneous
994:Leiomyoma
937:Leiomyoma
896:Myomatous
886:Hibernoma
226:Algorithm
190:Rule out
146:chromatin
1151:Category
790:Synovial
511:sarcomas
374:19417585
345:20838704
317:19342083
263:See also
214:Necrosis
163:nucleoli
157:, often
905:General
590:Fibroma
563:Fibroma
395:1710946
308:8248445
52:improve
847:PEComa
826:Lipoma
726:Myxoma
507:tumors
393:
372:
343:
315:
305:
142:nuclei
132:Atypia
1046:STUMP
913:Myoma
792:-like
454:D39.0
329:(PDF)
106:STUMP
91:STUMP
37:, or
509:and
415:2020
391:PMID
370:PMID
341:PMID
313:PMID
137:none
119:and
445:ICD
362:doi
303:PMC
295:doi
291:113
184:No
108:).
1153::
967::
452::
449:10
406:.
387:47
385:.
368:.
358:33
356:.
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492:e
485:t
478:v
447:-
437:D
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347:.
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209:.
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71:(
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62:(
48:.
Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.