83:). Frequency was estimated to be about 1 in 100,000 cancers; however, this proportion might be an under- or an overestimate. For one, not all cases of spontaneous regression can be apprehended, either because the case was not well documented or the physician was not willing to publish, or simply because the patient ceased to attend a clinic any more. On the other hand, for the past 100 years almost all cancer patients have received some form of treatment, and the influence of that treatment cannot always be excluded.
123:(growth of new blood vessels) are sometimes discussed as possible causes of spontaneous regression. But both mechanisms need appropriate biochemical triggers and cannot initiate on their own. Indeed, in many cancer cells apoptosis is defective, and angiogenesis is activated, both of these effects being caused by mutations in cancer cells; cancer exists because both mechanisms are malfunctioning.
58:
The spontaneous regression and remission from cancer was defined by
Everson and Cole in their 1966 book as "the partial or complete disappearance of a malignant tumour in the absence of all treatment, or in the presence of therapy which is considered inadequate to exert significant influence on
134:, suggesting a possible causal connection. If this coincidence in time would be a causal connection, it should as well precipitate as prophylactic effect, i.e. feverish infections should lower the risk to develop cancer later. This could be confirmed by collecting epidemiological studies.
112:
Challis and Stam, even more at a loss, concluded in 1989, "In summary, we are left to conclude that, although a great number of interesting and unusual cases continue to be published annually, there is still little conclusive data that explains the occurrence of spontaneous regression."
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it must be acknowledged that the factors or mechanisms responsible for spontaneous regression are obscure or unknown in the light of present knowledge. However, in some of the cases, available knowledge permits one to infer that hormonal influences probably were
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It is likely that the frequency of spontaneous regression in small tumors has been drastically underrated. In a carefully designed study on mammography it was found that 22% of all breast cancer cases underwent spontaneous regression.
543:
67:
It has long been assumed that spontaneous regressions, let alone cures, from cancer are rare phenomena, and that some forms of cancer are more prone to unexpected courses (
39:
30:, is an unexpected improvement or cure from a disease that usually progresses. These terms are commonly used for unexpected transient or final improvements in
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Rohdenburg, G. L. (1 April 1918). "Fluctuations in the Growth Energy of
Malignant Tumors in Man, with Especial Reference to Spontaneous Recession".
728:
633:
700:
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Zahl, P. H.; Maehlen, J.; Welch, H. G. (2008). "The natural history of invasive breast cancers detected by screening mammography".
458:"Mistletoe lectin has a shiga toxin-like structure and should be combined with other Toll-like receptor ligands in cancer therapy"
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Hobohm, U.; Stanford, J. L.; Grange, J. M. (2008). "Pathogen-associated molecular pattern in cancer immunotherapy".
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Cole, W. H. (1976). "Spontaneous regression of cancer and the importance of finding its cause".
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O'Regan
Brendan, Carlyle Hirschberg collected over 3,500 references from the medical literature
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Spontaneous
Remission of Cancer: Theories from Healers, Physicians, and Cancer Survivors
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There are several case reports of spontaneous regressions from cancer occurring after a
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In other cases, the protocols strongly suggest that an immune mechanism was responsible.
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Fauvet, J.; Roujeau, J.; Piet, R. (1964). "Spontaneous Cancer Cures and
Regressions".
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Everson and Cole offered as explanation for spontaneous regression from cancer:
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study, conducted interviews with 20 patients with spontaneous remissions
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Diminution or abatement of a disease over time, without formal treatment
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655:(Thesis). Berkeley: UC Berkeley Electronic Theses and Dissertations.
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Maletzki, C.; Linnebacher, M.; Savai, R.; Hobohm, U. (2013).
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tumors; however, both terms are often used interchangeably.
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Everson and Cole described 176 cases between 1900 and 1960
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Rohdenburg (1918) summarized 185 spontaneous regressions
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Spontaneous remissions and an immunological explanation
628:. Sausalito, California: Institute of Noetic Sciences.
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Charles Thomas, Publ., Springfield Ill. 1966 (Book)
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155:Challis summarized 489 cases between 1900 and 1987
542:: CS1 maint: DOI inactive as of September 2024 (
626:Spontaneous Remission. An Annotated Bibliography
34:. Spontaneous remissions concern cancers of the
146:Fauvet reported 202 cases between 1960 and 1964
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743:The Body Can Beat Terminal Cancer — Sometimes.
624:O'Regan, Brendan; Hirschberg, Carlyle (1993).
63:Frequency of spontaneous regression in cancer
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737:, American Scientist January–February 2009
687:Caryle Hirshberg; Marc Ian Barasch (1996).
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208:Philadelphia, JB Saunder & Co (Book)
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585:The spontaneous regression of cancer.
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735:Harnessing Infection to Fight Cancer
318:Challis, G. B.; Stam, H. J. (1990).
599:National Cancer Institute Monograph
666:Geoggrey Cowley (March 13, 1995).
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225:"Fever and cancer in perspective"
465:Cancer Immunology, Immunotherapy
435:10.1615/critrevimmunol.v28.i2.10
229:Cancer Immunology, Immunotherapy
206:Spontaneous Regression of Cancer
165:, investigated about 1000 cases
518:The Journal of Cancer Research
423:Critical Reviews in Immunology
149:Boyd reported 98 cases in 1966
99:In many of the collected cases
1:
282:Archives of Internal Medicine
668:"Surviving Against All Odds"
294:10.1001/archinte.168.21.2311
119:(programmed cell death) and
204:Everson T., Cole W. (1968)
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649:Turner, Kelly Ann (2010).
358:Robert A. Weinberg (2007)
176:Surviving Against All Odds
477:10.1007/s00262-013-1455-1
378:British Journal of Cancer
374:"Fever therapy revisited"
337:10.3109/02841869009090048
180:a gamma interferon study
178:- re sole survivor in "
532:(inactive 2024-09-12).
390:10.1038/sj.bjc.6602386
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28:spontaneous regression
559:La Revue du Praticien
360:The Biology of Cancer
241:10.1007/s002620100216
59:neoplastic disease."
36:haematopoietic system
20:Spontaneous remission
530:10.1158/jcr.1918.193
170:qualitative research
776:Medical terminology
689:Remarkable Recovery
372:Hobohm, U. (2005).
223:Hobohm, U. (2001).
24:spontaneous healing
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565:: 2177–80.
770:Categories
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104:important.
54:Definition
132:infection
117:Apoptosis
81:carcinoma
781:Oncology
723:, 2014,
673:Newsweek
583:Boyd W:
571:14157391
503:26031460
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486:11028761
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77:lymphoma
69:melanoma
48:palpable
44:leukemia
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128:fever
725:ISBN
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630:ISBN
607:PMID
567:PMID
544:link
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