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of developing SCT is through the squamous metaplasia of cells. However, that theory is also controversial since
Hashimoto's thyroiditis and chronic lymphocytic thyroiditis (neoplasms to be shown squamous metaplasia) are not associated with SCT. Primary STC is usually diagnosed in both lobes of the thyroid gland. The histopathology of STC shows a squamous differentiation of tumor cells.
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Squamous epithelial cells are not found in a normal thyroid, so the origin of SCT is not clear. However, it might be derived from embryonic remnants such as thyroglossal ducts or branchial clefts. Often, SCT is diagnosed in one of the thyroid lobes but not in the pyramidal lobe. Another possible way
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and neck dissection show good results in early stages of SCT. However, due to highly aggressive phenotype, surgical treatment is not always possible. The SCT is a radioiodine-refractory tumor. Radiotherapy might be effective in certain cases, resulting in relatively better survival rate and quality
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Struller F, Senne M, Falch C, Kirschniak A, Konigsrainer A, Muller S. Primary squamous cell carcinoma of the thyroid: Case report and systematic review of the literature. Int J Surg Case Rep. 2017;37:36-40. doi: 10.1016/j.ijscr.2017.06.011. Epub 2017 Jun 13. PMID: 28633125; PMCID:
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Squamous-cell carcinoma of the thyroid exhibits a highly aggressive phenotype, thus prognosis of that malignancy is extremely poor. The overall survival is less than 1 year in most of cases.
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MI Syed; M Stewart; S Syed; S Dahill; C Adams; DR Mclellan; LJ Clark (2011). "Squamous cell carcinoma of the thyroid gland: primary or secondary disease?".
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The tools required to diagnosis primary squamous cell carcinoma of the thyroid are panendoscopy, CT-Scan or PET-CT and immunohistological analysis.
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Booya F, Sebo TJ, Kasperbauer JL, Fatourechi V (2006). "Primary squamous cell carcinoma of the thyroid: report of ten cases".
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Squamous-cell carcinoma of the thyroid is biologically aggressive malignant neoplasm which is associated with rapid growth of
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which shows tumor cells with distinct squamous differentiation. The incidence of SCT is less than 1% out of
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are used for adjuvant chemotherapy, but their effects are not good enough according to publications.
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followed by infiltration of thyroid-adjacent structures. Patients usually demonstrate
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Thyroid squamous-cell carcinoma, squamous-cell thyroid carcinoma
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and voice changes, as well as local pain in the neck.
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161:Learn how and when to remove this message
249:The Journal of Laryngology & Otology
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81:Squamous-cell carcinoma of the thyroid
33:Squamous-cell carcinoma of the thyroid
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139:adding citations to reliable sources
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522:ACTH-secreting pituitary adenoma
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91:, is rare malignant neoplasm of
454:Pancreatic neuroendocrine tumor
89:thyroid squamous-cell carcinoma
18:Squamous-cell thyroid carcinoma
527:GH-secreting pituitary adenoma
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58:of squamous-cell carcinoma (
433:Tumours of endocrine glands
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261:10.1017/S0022215110002070
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650:Adrenocortical carcinoma
607:Squamous-cell carcinoma
645:Adrenocortical adenoma
314:10.1089/thy.2006.16.89
692:Parathyroid neoplasm
135:improve this section
97:thyroid malignancies
585:Parafollicular cell
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532:Craniopharyngioma
513:Pituitary adenoma
449:Pancreatic cancer
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151:February 2024
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120:This section
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784:Rare cancers
712:Pineal gland
578:Hurthle cell
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517:Prolactinoma
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308:(1): 89–93.
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133:Please help
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730:Pineocytoma
684:Parathyroid
537:Pituicytoma
463:Glucagonoma
290:PMC5479948.
216:doxorubicin
212:Vincristine
38:Other names
773:Categories
597:Anaplastic
574:Follicular
490:Gastrinoma
472:Insulinoma
255:(1): 3–9.
234:References
56:Micrograph
720:Pinealoma
702:Carcinoma
590:Medullary
569:Papillary
564:carcinoma
505:Pituitary
226:Prognosis
220:bleomycin
210:of life.
202:Treatment
188:dysphagia
184:neck mass
178:Diagnosis
122:does not
68:Specialty
602:Lymphoma
441:Pancreas
322:16487020
277:28225556
269:20950510
73:Oncology
697:Adenoma
657:Medulla
611:Benign
547:Thyroid
390:D002294
302:Thyroid
192:dyspnea
143:removed
128:sources
640:Cortex
495:VIPoma
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87:), or
273:S2CID
385:MeSH
374:9-CM
318:PMID
265:PMID
218:and
126:any
124:cite
740:MEN
379:193
370:ICD
364:C73
355:ICD
310:doi
257:doi
253:125
137:by
85:SCT
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