1226:. This enzyme, anchored to the endoplasmic reticulum, is found in platelets, monocytes, and several other cell types. The NH2 terminus contains two hydrophobic segments whose secondary structure is believed to be helical. Evidence suggests that the peptides serve as a membrane anchor for the enzyme. Moreover, the study of cDNA clones made possible by polymerase chain reaction techniques has further elucidated the TXA synthase's primary structure. Similar to other members in the cytochrome P450 family, TXA synthase has a heme group coordinated to the thiolate group of a cysteine residue, specifically cysteine 480. Mutagenesis studies that made substitutions at that position resulted in loss of catalytic activity and minimal heme binding. Other residues that had similar results were W133, R478, N110, and R413. Located near the heme propionate groups or the distal face of the heme, these residues are also important for proper integration of heme into the apoprotein. Unfortunately, researchers have found it difficult to obtain a crystal structure of TXA synthase due to the requirement of detergent treatment extraction from the membrane but they have utilized homology modeling to create a 3D structure. One model showed two domains, an alpha-helix-rich domain and a beta-sheet-rich domain. The heme was found to be sandwiched between helices I and L.
1254:
homolytic cleavage of the O-O bond in the endoperoxide, which represents the rate-limiting step, and undergoes a change in redox state from Fe(III) to Fe(IV). A free oxygen radical forms at C-11, and this intermediate undergoes ring cleavage. With the free radical now at C-12, the iron heme then oxidizes this radical to a carbocation. The molecule is now ready for intramolecular ring formation. The negatively charged oxygen attacks the carbonyl, and the electrons from one of the double bonds are drawn to the carbocation, thus closing the ring.
255:
232:
129:
154:
1235:
506:
1339:
1327:
261:
160:
7256:
1270:
exert opposing effects. In catalyzing the synthesis of thromboxanes, TXA synthase is involved in a flux pathway that can modulate the amount of thromboxane produced. This control becomes an important factor in several processes, such as blood pressure regulation, clotting, and inflammatory responses.
1249:(PGH2) molecule. PGH2 contains a relatively weak epidioxy bond, and a possible mechanism is known to involve homolytic cleavage of the epidioxide and a rearrangement to TXA. A heme group in the active site of TXA synthase plays an important role in the mechanism. Stopped-flow kinetic studies with a
1253:
and recombinant TXA synthase revealed that substrate binding occurs in two steps. First, there is a fast initial binding to the protein and then a subsequent ligation to the heme iron. In the first step of the mechanism, the heme iron coordinates to the C-9 endoperoxide oxygen. It participates in
1108:
many reactions involved in drug metabolism and synthesis of cholesterol, steroids, and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein
2132:
Itoh S, Yanagimoto T, Tagawa S, Hashimoto H, Kitamura R, Nakajima Y, et al. (March 1992). "Genomic organization of human fetal specific P-450IIIA7 (cytochrome P-450HFLa)-related gene(s) and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region".
1283:
vascular events. Furthermore, the importance of thromboxanes and their syntheses in vascular homeostasis is illustrated by findings that patients whose platelets were unresponsive to TXA displayed hemostatic defects and that a deficiency of platelet TXA production led to bleeding disorders.
1300:. Cancer cells are known for their limitless cellular replicative potential, and it has been hypothesized that changes in eicosanoid profile affect cancer growth. Research has led to the proposal that TXA synthase contributes to a range of tumor survival pathways, including growth,
1287:
Furthermore, it has been found that the expression of TXA synthase may be of critical importance to the development and progression of cancer. An overall increase in TXA synthase expression has been observed in a variety of cancers, such as
1238:
This isomerization mechanism shows prostaglandin H2 being converted to thromboxane. A heme group coordinated to a cysteine residue from the enzyme, thromboxane synthase, is involved in the mechanism.
2472:
Chase MB, Baek SJ, Purtell DC, Schwartz S, Shen RF (June 1993). "Mapping of the human thromboxane synthase gene (TBXAS1) to chromosome 7q34-q35 by two-color fluorescence in situ hybridization".
2536:
Tazawa R, Green ED, Ohashi K, Wu KK, Wang LH (October 1996). "Characterization of the complete genomic structure of human thromboxane synthase gene and functional analysis of its promoter".
4139:
6703:
3934:
3300:
1999:
Cathcart MC, Reynolds JV, O'Byrne KJ, Pidgeon GP (April 2010). "The role of prostacyclin synthase and thromboxane synthase signaling in the development and progression of cancer".
2594:
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".
1632:
Ratti S, Quarato P, Casagrande C, Fumagalli R, Corsini A (August 1998). "Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes".
1175:
actions. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. The gene expresses two transcript variants.
268:
167:
6865:
3765:
4132:
6696:
3349:
3927:
3521:
90:
749:
730:
6669:
3503:
3499:
2662:
4125:
3188:
1271:
Dysregulation of TXA synthase and an imbalance in the prostacyclin-thromboxane ratio are thought to underlie many pathological conditions, such as
6820:
6689:
2414:
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".
3920:
3772:
3481:
3005:
2313:
Mestel F, Oetliker O, Beck E, Felix R, Imbach P, Wagner HP (January 1980). "Severe bleeding associated with defective thromboxane synthetase".
1443:
1783:
Hsu PY, Tsai AL, Wang LH (November 2000). "Identification of thromboxane synthase amino acid residues involved in heme-propionate binding".
1425:
7276:
3868:
3425:
3341:
3666:
3365:
2078:
Smith G, Stubbins MJ, Harries LW, Wolf CR (December 1998). "Molecular genetics of the human cytochrome P450 monooxygenase superfamily".
1005:
254:
4106:
6975:
4062:
1012:
3405:
231:
6860:
3744:
2565:
Baek SJ, Lee KD, Shen RF (September 1996). "Genomic structure and polymorphism of the human thromboxane synthase-encoding gene".
1513:
Baek SJ, Lee KD, Shen RF (September 1996). "Genomic structure and polymorphism of the human thromboxane synthase-encoding gene".
1464:
1363:
1133:
2162:
Yokoyama C, Miyata A, Ihara H, Ullrich V, Tanabe T (August 1991). "Molecular cloning of human platelet thromboxane A synthase".
1478:
Yokoyama C, Miyata A, Ihara H, Ullrich V, Tanabe T (August 1991). "Molecular cloning of human platelet thromboxane A synthase".
6870:
6845:
6825:
5115:
3542:
3383:
3262:
2961:
1412:
1391:
1197:
6880:
3728:
3535:
7131:
1408:
153:
128:
6830:
4085:
3439:
3409:
3369:
3357:
2655:
7246:
1387:
6796:
6750:
6662:
4030:
3593:
3507:
3495:
70:
6899:
6835:
6755:
4254:
4197:
4066:
3645:
3345:
3013:
1289:
267:
166:
4768:
2443:
Lee KD, Baek SJ, Shen RF (May 1994). "Cloning and characterization of the human thromboxane synthase gene promoter".
2640:
1326:
6786:
6619:
4677:
4562:
4485:
4378:
3528:
3467:
3463:
3451:
3447:
3443:
2255:
Wang LH, Ohashi K, Wu KK (May 1991). "Isolation of partial complementary DNA encoding human thromboxane synthase".
260:
159:
7116:
2284:
NĂĽsing R, Schneider-Voss S, Ullrich V (August 1990). "Immunoaffinity purification of human thromboxane synthase".
7232:
7219:
7206:
7193:
7180:
7167:
7154:
6923:
6914:
6890:
6850:
6806:
6770:
6745:
6729:
4360:
4179:
4018:
3831:
3716:
3485:
1338:
7126:
5079:
2226:
Jones DA, Fitzpatrick FA, Malcolm KC (October 1991). "Thromboxane A2 synthesis in human erythroleukemia cells".
7080:
7023:
6932:
6927:
6839:
6791:
6720:
6456:
6437:
6392:
4834:
4090:
4073:
4025:
3912:
3900:
3638:
3585:
3580:
3435:
3286:
2683:
2648:
2634:
1066:
794:
78:
1669:"Characterization of the structure and membrane interaction of NH2-terminal domain of thromboxane A2 synthase"
1894:
Brugger R, Ullrich V (2003). "Prostacyclin and
Thromboxane Synthase: New Aspects of Hemethiolate Catalysis".
7028:
6815:
4162:
4080:
3687:
3560:
2385:
Wang LH, Tazawa R, Lang AQ, Wu KK (December 1994). "Alternate splicing of human thromboxane synthase mRNA".
1163:
1101:
775:
5220:
6875:
6498:
6418:
3514:
3459:
3455:
3421:
3353:
1272:
7049:
6968:
6937:
6475:
4931:
4168:
4037:
3981:
3751:
3257:
7121:
2107:
Wang LH, Kulmacz RJ (August 2002). "Thromboxane synthase: structure and function of protein and gene".
1752:
Wang LH, Kulmacz RJ (August 2002). "Thromboxane synthase: structure and function of protein and gene".
6681:
5980:
5950:
5781:
6614:
5736:
5589:
5059:
4897:
4806:
3709:
3606:
3477:
3376:
3017:
1128:
573:
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
142:
57:
4986:
4606:
1550:"12(S)-Hydroxyheptadeca-5Z, 8E, 10E-trienoic acid is a natural ligand for leukotriene B4 receptor 2"
7085:
6855:
5833:
5813:
5564:
5369:
5319:
3861:
3567:
3395:
967:
963:
949:
945:
941:
937:
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888:
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858:
6139:
5604:
5494:
5489:
5474:
5409:
5359:
5314:
4879:
3209:
2630:
1234:
7018:
6546:
6426:
6377:
6367:
5791:
5469:
5449:
5434:
5424:
5404:
5399:
5354:
5329:
5294:
5140:
4971:
4749:
4647:
4586:
4547:
4346:
4336:
4244:
4154:
3361:
2338:
1946:
1465:"Entrez Gene: TBXAS1 thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A)"
102:
6576:
6571:
6536:
6511:
6372:
6233:
6090:
5691:
5686:
5484:
5464:
5459:
5454:
5439:
5429:
5419:
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5384:
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5304:
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5243:
5200:
5195:
5180:
5170:
5165:
5150:
5029:
4951:
4906:
4820:
4796:
4786:
4234:
988:
959:
933:
913:
884:
862:
6561:
6516:
6327:
6273:
6258:
6107:
5818:
5766:
5651:
5499:
5444:
5414:
5389:
5339:
5334:
5324:
5309:
5258:
5253:
5210:
5145:
5135:
5105:
5049:
5019:
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4815:
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4504:
4301:
505:
6566:
6541:
6531:
6382:
6357:
6342:
6307:
6283:
6278:
6029:
5960:
5629:
5599:
5479:
5299:
5233:
5205:
5190:
5185:
5160:
4776:
4744:
4724:
4667:
4552:
4475:
4470:
4465:
4460:
4296:
4291:
2611:
2582:
2553:
2524:
2489:
2460:
2431:
2402:
2373:
2330:
2301:
2272:
2243:
2214:
2179:
2150:
2120:
2095:
2066:
2026:
1981:
1938:
1876:
1841:
1800:
1765:
1731:
1690:
1649:
1614:
1579:
1530:
1495:
1189:
50:
6586:
6302:
6248:
6243:
5278:
5125:
5034:
4991:
4542:
4455:
4341:
4321:
4316:
4311:
2839:
7064:
7059:
7033:
6961:
6760:
6642:
6634:
6629:
6448:
6352:
6347:
5933:
5519:
5155:
5120:
5010:
4996:
4956:
4889:
4715:
4706:
4638:
4629:
4621:
4523:
4514:
4436:
4427:
4278:
4216:
3969:
3947:
2708:
2603:
2574:
2545:
2514:
2481:
2452:
2423:
2394:
2363:
2322:
2293:
2264:
2235:
2204:
2171:
2142:
2112:
2087:
2058:
2016:
2008:
1973:
1930:
1903:
1868:
1831:
1792:
1757:
1721:
1680:
1641:
1606:
1569:
1561:
1522:
1487:
1276:
1250:
1246:
1223:
1110:
347:
278:
222:
177:
98:
5238:
5087:
2350:
Miyata A, Yokoyama C, Ihara H, Bandoh S, Takeda O, Takahashi E, Tanabe T (September 1994).
1921:
Praticò D, Dogné JM (September 2009). "Vascular biology of eicosanoids and atherogenesis".
7281:
7111:
7095:
7008:
6490:
6422:
6332:
6007:
5985:
5955:
4652:
3976:
3810:
2679:
1293:
1216:
1124:
1079:
322:
1069:
7260:
7149:
7090:
6716:
6012:
5965:
5530:
5092:
4151:
3999:
3118:
1574:
1549:
1117:
2607:
2519:
2502:
2326:
2239:
2209:
2192:
2116:
1836:
1819:
1761:
1726:
1709:
1685:
1668:
1645:
664:
659:
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649:
644:
639:
634:
618:
613:
608:
603:
587:
582:
577:
572:
567:
562:
557:
552:
547:
7270:
7054:
7013:
6609:
6293:
6078:
5975:
5853:
5838:
5771:
5701:
3893:
3797:
3758:
3680:
3673:
3659:
3619:
3600:
3574:
2578:
2427:
2368:
2351:
2297:
2268:
2175:
2146:
1950:
1872:
1526:
1491:
1279:
and platelet aggregation, their dominance can disrupt vascular homeostasis and cause
1172:
534:
2342:
1597:
Yokomizo T (February 2015). "Two distinct leukotriene B4 receptors, BLT1 and BLT2".
7003:
6149:
6066:
5992:
5970:
5923:
5858:
5828:
5808:
5803:
5726:
5614:
5039:
5001:
4869:
4696:
4532:
4417:
4224:
3416:
3390:
3294:
3280:
3273:
3179:
3159:
3152:
3135:
3077:
3060:
3053:
3046:
3039:
3032:
3000:
2993:
2193:"Primary structure of human thromboxane synthase determined from the cDNA sequence"
1710:"Primary structure of human thromboxane synthase determined from the cDNA sequence"
1305:
1297:
1263:
340:
119:
4117:
82:
106:
7227:
7162:
6998:
6624:
6526:
6467:
6337:
6322:
6263:
6228:
6206:
6186:
6134:
6119:
6061:
6019:
5945:
5913:
5898:
5731:
5716:
5641:
5579:
5574:
5248:
4921:
4884:
4859:
4854:
4701:
4657:
4616:
4611:
4509:
4445:
4422:
4412:
4331:
4306:
4273:
4239:
4054:
2986:
2942:
2012:
1448:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1430:
National Center for
Biotechnology Information, U.S. National Library of Medicine
1267:
1242:
1209:
7255:
423:
6556:
6317:
6288:
6268:
6221:
6216:
6201:
6176:
6144:
6112:
6083:
6039:
5938:
5888:
5883:
5878:
5873:
5848:
5761:
5756:
5696:
5681:
5661:
5646:
5619:
5594:
5584:
5569:
5559:
5273:
5228:
5215:
5130:
4916:
4911:
4864:
4801:
4781:
4734:
4326:
4148:
3991:
3951:
3943:
2671:
2503:"Amino-terminal topology of thromboxane synthase in the endoplasmic reticulum"
1859:
Tanabe T, Ullrich V (October 1995). "Prostacyclin and thromboxane synthases".
1358:
1309:
1280:
1193:
1100:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The
239:
136:
86:
61:, BDPLT14, CYP5, CYP5A1, GHOSAL, THAS, TS, TXAS, TXS, thromboxane A synthase 1
1548:
Okuno T, Iizuka Y, Okazaki H, Yokomizo T, Taguchi R, Shimizu T (April 2008).
7201:
7175:
6712:
6581:
6521:
6253:
6211:
6196:
6191:
6181:
6171:
6166:
6161:
6156:
6071:
6054:
6049:
6044:
5928:
5908:
5903:
5868:
5863:
5823:
5796:
5751:
5746:
5741:
5721:
5676:
5671:
5634:
5624:
5549:
5268:
5175:
5024:
4961:
4874:
4791:
4596:
4581:
4402:
4397:
3886:
3087:
2675:
2091:
1301:
694:
483:
361:
306:
293:
205:
192:
94:
2549:
2485:
2456:
2398:
2352:"Characterization of the human gene (TBXAS1) encoding thromboxane synthase"
2124:
2030:
1942:
1907:
1804:
1796:
1769:
1618:
1583:
2615:
2586:
2557:
2528:
2493:
2464:
2435:
2406:
2377:
2334:
2305:
2276:
2247:
2218:
2183:
2154:
2099:
2070:
1985:
1880:
1845:
1735:
1694:
1653:
1534:
1499:
1052:
1047:
6414:
6409:
6238:
6100:
6095:
6034:
6024:
6002:
5997:
5918:
5893:
5843:
5786:
5776:
5711:
5706:
5666:
4981:
4601:
4407:
3843:
3803:
3790:
3735:
3702:
3652:
3630:
3625:
3611:
1565:
1105:
1036:
839:
820:
1610:
6551:
6362:
6129:
5656:
5609:
5554:
5100:
3312:
3239:
3229:
3219:
3202:
3192:
3184:
3172:
3168:
3164:
3145:
3097:
3070:
3025:
3021:
3009:
2900:
2895:
2890:
2865:
2860:
2844:
2764:
2759:
2739:
2062:
1977:
806:
761:
2021:
1934:
17:
7214:
6984:
6774:
6737:
6733:
6312:
5513:
3955:
2979:
2975:
2965:
2951:
2947:
2915:
2910:
2905:
2885:
2880:
2875:
2870:
2834:
2829:
2824:
2804:
2799:
2794:
2789:
2784:
2779:
2774:
2769:
2754:
2749:
2744:
2734:
2729:
2713:
2703:
2698:
1082:
1020:
716:
1747:
1745:
7188:
6903:
6124:
4009:
4004:
3266:
3128:
2815:
1820:"On the mechanism of prostacyclin and thromboxane A2 biosynthesis"
1233:
679:
675:
6778:
3320:
2080:
Xenobiotica; the Fate of
Foreign Compounds in Biological Systems
2049:
Shen RF, Tai HH (1998). "Thromboxanes: synthase and receptors".
1964:
Shen RF, Tai HH (1998). "Thromboxanes: synthase and receptors".
1220:
1089:
74:
6957:
6685:
4121:
3916:
2644:
514:
2191:
Ohashi K, Ruan KH, Kulmacz RJ, Wu KK, Wang LH (January 1992).
1708:
Ohashi K, Ruan KH, Kulmacz RJ, Wu KK, Wang LH (January 1992).
1213:
6953:
1266:
is important in the body, particularly because these two
330:
2001:
Biochimica et
Biophysica Acta (BBA) - Reviews on Cancer
1196:
acts both as a thromboxane synthase inhibitor and as a
2501:
Ruan KH, Wang LH, Wu KK, Kulmacz RJ (September 1993).
7244:
495:
7140:
7104:
7073:
7042:
6991:
6913:
6889:
6805:
6769:
6728:
6599:
6497:
6474:
6455:
6436:
6391:
5529:
5512:
5287:
5058:
4930:
4833:
4758:
4676:
4561:
4484:
4377:
4359:
4255:
4253:
4198:
4196:
4178:
4161:
4099:
4053:
3990:
3962:
3878:
3853:
3782:
3552:
3330:
3249:
3107:
2924:
2853:
2813:
2722:
2691:
2445:
2257:
2228:
2164:
1480:
1072:, platelet, cytochrome P450, family 5, subfamily A)
981:
932:
906:
857:
5536:
4678:
4563:
4486:
4379:
1404:
1402:
1400:
1383:
1381:
1379:
583:12-hydroxyheptadecatrienoic acid synthase activity
4361:
4180:
277:
176:
6457:
6438:
6393:
4835:
1667:Ruan KH, Li P, Kulmacz RJ, Wu KK (August 1994).
1262:Maintaining a balance between prostacyclins and
6499:
1861:Journal of Lipid Mediators and Cell Signalling
1409:GRCm38: Ensembl release 89: ENSMUSG00000029925
6969:
6866:5-carboxymethyl-2-hydroxymuconate D-isomerase
6697:
6476:
4932:
4133:
3928:
2656:
8:
5060:
1388:GRCh38: Ensembl release 89: ENSG00000059377
6976:
6962:
6954:
6704:
6690:
6682:
5526:
4374:
4193:
4175:
4140:
4126:
4118:
3935:
3921:
3913:
2663:
2649:
2641:
2109:Prostaglandins & Other Lipid Mediators
1754:Prostaglandins & Other Lipid Mediators
929:
854:
690:
530:
318:
217:
114:
2633:at the U.S. National Library of Medicine
2518:
2367:
2208:
2020:
1835:
1725:
1684:
1573:
1459:
1457:
7251:
6821:Isopentenyl-diphosphate delta isomerase
2538:Archives of Biochemistry and Biophysics
2387:Archives of Biochemistry and Biophysics
2286:Archives of Biochemistry and Biophysics
1923:Expert Review of Cardiovascular Therapy
1785:Archives of Biochemistry and Biophysics
1375:
1322:
27:Mammalian protein found in Homo sapiens
5531:
1275:. Because thromboxanes play a role in
31:
282:
243:
238:
181:
140:
135:
7:
6154:Selective COX-2 inhibitors (coxibs):
1818:Hecker M, Ullrich V (January 1989).
1554:The Journal of Experimental Medicine
4263:Tooltip Prostaglandin D2 receptor 2
4206:Tooltip Prostaglandin D2 receptor 1
2507:The Journal of Biological Chemistry
2197:The Journal of Biological Chemistry
1824:The Journal of Biological Chemistry
1714:The Journal of Biological Chemistry
1673:The Journal of Biological Chemistry
1219:protein with 533 amino acids and a
1171:receptors) and mediator of certain
1085:that, in humans, is encoded by the
6125:AM-404 (N-arachidonoylaminophenol)
5943:Anthranilic acids (fenamic acids):
5595:Mesalazine (5-aminosalicylic acid)
4686:Tooltip Prostaglandin EP4 receptor
4571:Tooltip Prostaglandin EP3 receptor
4494:Tooltip Prostaglandin EP2 receptor
4387:Tooltip Prostaglandin EP1 receptor
978:
903:
830:
811:
785:
766:
740:
721:
665:prostaglandin biosynthetic process
500:
418:
356:
335:
25:
6615:Îł-Linolenic acid (gamolenic acid)
5961:Meclofenamic acid (meclofenamate)
4370:Tooltip Prostaglandin E2 receptor
4189:Tooltip Prostaglandin D2 receptor
4063:5-Lipoxygenase activating protein
1104:proteins are monooxygenases that
7254:
6861:Prostaglandin-A1 Delta-isomerase
6670:Leukotriene signaling modulators
6462:Tooltip Prostaglandin F synthase
6443:Tooltip Prostaglandin E synthase
6402:Tooltip Prostaglandin D synthase
4844:Tooltip Prostaglandin F receptor
2369:10.1111/j.1432-1033.1994.00273.x
2356:European Journal of Biochemistry
1634:European Journal of Pharmacology
1364:12-Hydroxyheptadecatrienoic acid
1337:
1325:
1134:12-Hydroxyheptadecatrienoic acid
504:
266:
259:
253:
230:
165:
158:
152:
127:
5981:Talinflumic acid (talinflumate)
5971:Morniflumic acid (morniflumate)
5951:Floctafenic acid (floctafenate)
5934:Tiaprofenic acid (tiaprofenate)
1198:thromboxane receptor antagonist
1185:Thromboxane synthase inhibitors
1179:Thromboxane synthase inhibitors
660:fatty acid biosynthetic process
635:prostaglandin metabolic process
588:thromboxane-A synthase activity
6881:Polyenoic fatty acid isomerase
6504:Tooltip Thromboxane A synthase
5555:Aspirin (acetylsalicylic acid)
4769:16,16-Dimethyl Prostaglandin E
609:endoplasmic reticulum membrane
604:integral component of membrane
515:More reference expression data
484:More reference expression data
1:
6663:Receptor/signaling modulators
6485:Tooltip Prostacyclin synthase
5986:Tolfenamic acid (tolfenamate)
5956:Flufenamic acid (flufenamate)
5946:Etofenamic acid (etofenamate)
5002:Prostacyclin (prostaglandin I
4941:Tooltip Prostacyclin receptor
4086:Gamma-glutamyl transpeptidase
4074:LTA4 hydrolase (B4 synthesis)
2608:10.1016/S0378-1119(97)00411-3
2520:10.1016/S0021-9258(19)36541-X
2327:10.1016/S0140-6736(80)90642-X
2240:10.1016/S0006-291X(05)81247-1
2210:10.1016/S0021-9258(18)48353-6
2135:Biochimica et Biophysica Acta
2117:10.1016/S0090-6980(02)00045-X
2051:Journal of Biomedical Science
1966:Journal of Biomedical Science
1837:10.1016/S0021-9258(17)31235-8
1762:10.1016/s0090-6980(02)00045-x
1727:10.1016/S0021-9258(18)48353-6
1686:10.1016/S0021-9258(17)31912-9
1646:10.1016/S0014-2999(98)00467-1
251:
150:
6797:4-Oxalocrotonate tautomerase
6751:Ribose-5-phosphate isomerase
5069:Tooltip Thromboxane receptor
4031:Prostaglandin-E2 9-reductase
2579:10.1016/0378-1119(95)00881-0
2428:10.1016/0378-1119(94)90802-8
2298:10.1016/0003-9861(90)90337-X
2269:10.1016/0006-291X(91)91980-Q
2176:10.1016/0006-291X(91)91060-P
2147:10.1016/0167-4781(92)90520-a
1873:10.1016/0929-7855(95)00031-k
1527:10.1016/0378-1119(95)00881-0
1492:10.1016/0006-291X(91)91060-P
1245:A (TXA) is derived from the
1109:catalyzes the conversion of
655:fatty acid metabolic process
7277:Genes on human chromosome 7
6900:Protein disulfide-isomerase
6871:Isopiperitenone D-isomerase
6846:Methylitaconate D-isomerase
6836:Cholestenol Delta-isomerase
6826:Vinylacetyl-CoA D-isomerase
6756:Mannose phosphate isomerase
6135:Paracetamol (acetaminophen)
5966:Mefenamic acid (mefenamate)
5620:Salicylate (salicylic acid)
4067:Arachidonate 5-lipoxygenase
2013:10.1016/j.bbcan.2010.01.006
1290:papillary thyroid carcinoma
645:icosanoid metabolic process
7298:
6787:Phenylpyruvate tautomerase
5814:Bucloxic acid (blucloxate)
5732:Indometacin (indomethacin)
1065:Thromboxane A synthase 1 (
7132:Michaelis–Menten kinetics
6924:Prostaglandin D2 synthase
6851:Aconitate Delta-isomerase
6831:Muconolactone D-isomerase
6746:Triosephosphate isomerase
6654:
5976:Niflumic acid (niflumate)
5080:Carbocyclic thromboxane A
1444:"Mouse PubMed Reference:"
1426:"Human PubMed Reference:"
1212:A (TXA) synthase is a 60
1051:
1046:
1042:
1035:
1019:
1006:Chr 7: 139.78 – 140.02 Mb
1000:
985:
956:
925:
910:
881:
850:
837:
833:
818:
814:
805:
792:
788:
773:
769:
760:
747:
743:
728:
724:
715:
700:
693:
689:
673:
533:
529:
512:
503:
494:
481:
430:
421:
368:
359:
329:
321:
317:
300:
287:
250:
229:
220:
216:
199:
186:
149:
126:
117:
113:
68:
65:
55:
48:
43:
39:
34:
7024:Diffusion-limited enzyme
6933:Prostaglandin E synthase
6928:Prostaglandin-D synthase
6792:Oxaloacetate tautomerase
6294:Menatetrenone (vitamin K
6117:Aminophenols (anilines):
2635:Medical Subject Headings
1164:Leukotriene B4 receptors
6620:Dihomo-Îł-linolenic acid
6017:Enolic acids (oxicams):
5560:Benorilate (benorylate)
2092:10.1080/004982598238868
1599:Journal of Biochemistry
1258:Biological significance
1155:-heptadecatrienoic acid
1013:Chr 6: 38.85 – 39.06 Mb
578:oxidoreductase activity
396:upper lobe of left lung
6943:Thromboxane-A synthase
6876:L-dopachrome isomerase
6419:selenium tetrachloride
2631:Thromboxane-A+Synthase
2550:10.1006/abbi.1996.0464
2486:10.1006/geno.1993.1264
2457:10.1006/bbrc.1994.1712
2399:10.1006/abbi.1994.1500
1908:10.1002/anie.199419111
1797:10.1006/abbi.2000.2041
1273:pulmonary hypertension
1239:
650:cyclooxygenase pathway
563:monooxygenase activity
454:mesenteric lymph nodes
7117:Eadie–Hofstee diagram
7050:Allosteric regulation
6938:Prostacyclin synthase
6088:Aminonicotinic acids:
3982:Diacylglycerol lipase
1332:Thromboxane synthesis
1237:
619:endoplasmic reticulum
438:stroma of bone marrow
408:minor salivary glands
7127:Lineweaver–Burk plot
5737:Indometacin farnesil
5590:Magnesium salicylate
5221:Pinane thromboxane A
4982:Iloprost (ciloprost)
4602:Iloprost (ciloprost)
4408:Iloprost (ciloprost)
1566:10.1084/jem.20072329
1344:Eicosanoid synthesis
1129:platelet aggregation
284:6 B1|6 17.85 cM
245:Chromosome 6 (mouse)
143:Chromosome 7 (human)
6856:Enoyl CoA isomerase
6816:Steroid D-isomerase
5565:Carbasalate calcium
2513:(26): 19483–19490.
1679:(33): 20938–20942.
7086:Enzyme superfamily
7019:Enzyme promiscuity
6427:selenium disulfide
6059:4-Aminoquinolines:
2111:. 68–69: 409–422.
2063:10.1007/BF02253465
1978:10.1007/bf02253465
1756:. 68–69: 409–422.
1240:
1190:antiplatelet drugs
795:ENSMUSG00000029925
628:Biological process
597:Cellular component
553:isomerase activity
541:Molecular function
107:TBXAS1 - orthologs
7242:
7241:
6951:
6950:
6761:Glucose isomerase
6715:: intramolecular
6679:
6678:
6595:
6594:
5630:Sodium salicylate
5600:Methyl salicylate
5523:
5508:
5507:
4829:
4828:
4355:
4354:
4172:
4115:
4114:
3910:
3909:
2086:(12): 1129–1165.
1935:10.1586/erc.09.91
1902:(19): 1911–1919.
1896:Angewandte Chemie
1611:10.1093/jb/mvu078
1062:
1061:
1058:
1057:
1031:
1030:
996:
995:
975:
974:
921:
920:
900:
899:
846:
845:
827:
826:
801:
800:
782:
781:
756:
755:
737:
736:
685:
684:
558:metal ion binding
525:
524:
521:
520:
490:
489:
477:
476:
415:
414:
313:
312:
212:
211:
16:(Redirected from
7289:
7259:
7258:
7250:
7122:Hanes–Woolf plot
7065:Enzyme activator
7060:Enzyme inhibitor
7034:Enzyme catalysis
6978:
6971:
6964:
6955:
6706:
6699:
6692:
6683:
6630:Arachidonic acid
6505:
6501:
6486:
6482:
6463:
6459:
6444:
6440:
6403:
6399:
6226:Others/unsorted:
5801:Propionic acids:
5782:Sulindac sulfide
5547:Salicylic acids:
5538:
5533:
5527:
5517:
5070:
5066:
4942:
4938:
4845:
4841:
4687:
4683:
4572:
4568:
4495:
4491:
4388:
4384:
4375:
4371:
4367:
4264:
4260:
4207:
4203:
4194:
4190:
4186:
4176:
4166:
4142:
4135:
4128:
4119:
3970:Phospholipase A2
3948:lipid metabolism
3937:
3930:
3923:
3914:
2682:(Most belong to
2665:
2658:
2651:
2642:
2619:
2602:(1–2): 149–156.
2590:
2561:
2532:
2522:
2497:
2468:
2439:
2422:(1–2): 171–174.
2410:
2381:
2371:
2346:
2309:
2280:
2251:
2222:
2212:
2187:
2170:(3): 1479–1484.
2158:
2128:
2103:
2074:
2035:
2034:
2024:
1996:
1990:
1989:
1961:
1955:
1954:
1929:(9): 1079–1089.
1918:
1912:
1911:
1891:
1885:
1884:
1867:(2–3): 243–255.
1856:
1850:
1849:
1839:
1815:
1809:
1808:
1780:
1774:
1773:
1749:
1740:
1739:
1729:
1705:
1699:
1698:
1688:
1664:
1658:
1657:
1629:
1623:
1622:
1594:
1588:
1587:
1577:
1545:
1539:
1538:
1510:
1504:
1503:
1486:(3): 1479–1484.
1475:
1469:
1468:
1461:
1452:
1451:
1440:
1434:
1433:
1422:
1416:
1406:
1395:
1385:
1341:
1329:
1277:vasoconstriction
1251:substrate analog
1247:prostaglandin H2
1224:prosthetic group
1187:
1186:
1161:) an agonist of
1074:, also known as
1044:
1043:
1015:
1008:
991:
979:
970:
930:
926:RefSeq (protein)
916:
904:
895:
855:
831:
812:
786:
767:
741:
722:
691:
640:lipid metabolism
548:iron ion binding
531:
517:
508:
501:
486:
426:
424:Top expressed in
419:
364:
362:Top expressed in
357:
336:
319:
309:
296:
285:
270:
263:
257:
246:
234:
218:
208:
195:
184:
169:
162:
156:
145:
131:
115:
109:
60:
53:
32:
21:
7297:
7296:
7292:
7291:
7290:
7288:
7287:
7286:
7267:
7266:
7265:
7253:
7245:
7243:
7238:
7150:Oxidoreductases
7136:
7112:Enzyme kinetics
7100:
7096:List of enzymes
7069:
7038:
7009:Catalytic triad
6987:
6982:
6952:
6947:
6909:
6885:
6801:
6765:
6724:
6717:oxidoreductases
6710:
6680:
6675:
6650:
6646:
6643:Prostaglandin H
6638:
6635:Prostaglandin G
6591:
6503:
6493:
6491:Tranylcypromine
6484:
6480:
6470:
6461:
6451:
6442:
6432:
6423:sodium selenite
6401:
6397:
6387:
6333:Rosmarinic acid
6297:
6105:Sulfonanilides:
6008:Oxyphenbutazone
5534:
5516:
5504:
5283:
5224:
5096:
5083:
5068:
5064:
5054:
5014:
5011:Prostaglandin E
5006:, epoprostenol)
5005:
4940:
4936:
4926:
4901:
4898:Prostaglandin F
4893:
4890:Prostaglandin D
4843:
4839:
4825:
4810:
4807:Prostaglandin F
4772:
4754:
4719:
4716:Prostaglandin E
4710:
4707:Prostaglandin E
4685:
4682:
4672:
4653:Ricinoleic acid
4642:
4639:Prostaglandin E
4633:
4630:Prostaglandin E
4625:
4622:Prostaglandin D
4570:
4567:
4557:
4527:
4524:Prostaglandin E
4518:
4515:Prostaglandin E
4493:
4490:
4480:
4440:
4437:Prostaglandin E
4431:
4428:Prostaglandin E
4386:
4383:
4369:
4365:
4351:
4282:
4279:Prostaglandin D
4262:
4259:
4249:
4220:
4217:Prostaglandin D
4205:
4202:
4188:
4184:
4165:
4157:
4146:
4116:
4111:
4095:
4049:
3986:
3977:Phospholipase C
3958:
3941:
3911:
3906:
3874:
3849:
3811:Halloween genes
3778:
3548:
3326:
3245:
3103:
2920:
2849:
2809:
2718:
2687:
2680:cytochrome P450
2669:
2627:
2622:
2593:
2564:
2535:
2500:
2471:
2442:
2413:
2384:
2349:
2312:
2283:
2254:
2225:
2190:
2161:
2131:
2106:
2077:
2048:
2044:
2042:Further reading
2039:
2038:
1998:
1997:
1993:
1963:
1962:
1958:
1920:
1919:
1915:
1893:
1892:
1888:
1858:
1857:
1853:
1817:
1816:
1812:
1782:
1781:
1777:
1751:
1750:
1743:
1707:
1706:
1702:
1666:
1665:
1661:
1631:
1630:
1626:
1596:
1595:
1591:
1547:
1546:
1542:
1512:
1511:
1507:
1477:
1476:
1472:
1463:
1462:
1455:
1442:
1441:
1437:
1424:
1423:
1419:
1407:
1398:
1386:
1377:
1372:
1355:
1350:
1349:
1348:
1345:
1342:
1333:
1330:
1318:
1294:prostate cancer
1260:
1232:
1217:cytochrome P450
1206:
1184:
1183:
1181:
1127:and inducer of
1125:vasoconstrictor
1121:
1114:
1111:prostaglandin H
1102:cytochrome P450
1098:
1080:cytochrome P450
1053:View/Edit Mouse
1048:View/Edit Human
1011:
1004:
1001:Location (UCSC)
987:
966:
962:
958:
952:
948:
944:
940:
936:
912:
891:
887:
883:
877:
873:
869:
865:
861:
776:ENSG00000059377
669:
623:
592:
513:
482:
473:
468:
464:
462:ascending aorta
460:
456:
452:
448:
444:
440:
436:
422:
411:
406:
402:
398:
394:
390:
386:
382:
378:
374:
360:
304:
291:
283:
273:
272:
271:
264:
244:
221:Gene location (
203:
190:
182:
172:
171:
170:
163:
141:
118:Gene location (
69:
56:
49:
28:
23:
22:
15:
12:
11:
5:
7295:
7293:
7285:
7284:
7279:
7269:
7268:
7264:
7263:
7240:
7239:
7237:
7236:
7223:
7210:
7197:
7184:
7171:
7158:
7144:
7142:
7138:
7137:
7135:
7134:
7129:
7124:
7119:
7114:
7108:
7106:
7102:
7101:
7099:
7098:
7093:
7088:
7083:
7077:
7075:
7074:Classification
7071:
7070:
7068:
7067:
7062:
7057:
7052:
7046:
7044:
7040:
7039:
7037:
7036:
7031:
7026:
7021:
7016:
7011:
7006:
7001:
6995:
6993:
6989:
6988:
6983:
6981:
6980:
6973:
6966:
6958:
6949:
6948:
6946:
6945:
6940:
6935:
6930:
6920:
6918:
6911:
6910:
6908:
6907:
6896:
6894:
6887:
6886:
6884:
6883:
6878:
6873:
6868:
6863:
6858:
6853:
6848:
6843:
6833:
6828:
6823:
6818:
6812:
6810:
6803:
6802:
6800:
6799:
6794:
6789:
6783:
6781:
6767:
6766:
6764:
6763:
6758:
6753:
6748:
6742:
6740:
6726:
6725:
6711:
6709:
6708:
6701:
6694:
6686:
6677:
6676:
6674:
6673:
6666:
6659:
6655:
6652:
6651:
6649:
6648:
6644:
6640:
6636:
6632:
6627:
6625:Diacylglycerol
6622:
6617:
6612:
6603:
6601:
6597:
6596:
6593:
6592:
6590:
6589:
6584:
6579:
6574:
6569:
6564:
6559:
6554:
6549:
6544:
6539:
6534:
6529:
6524:
6519:
6514:
6508:
6506:
6495:
6494:
6489:
6487:
6478:
6472:
6471:
6466:
6464:
6453:
6452:
6447:
6445:
6434:
6433:
6431:
6430:
6412:
6406:
6404:
6395:
6389:
6388:
6386:
6385:
6380:
6375:
6370:
6365:
6360:
6355:
6350:
6345:
6340:
6335:
6330:
6325:
6320:
6315:
6310:
6305:
6300:
6295:
6291:
6286:
6281:
6276:
6271:
6266:
6261:
6256:
6251:
6246:
6241:
6236:
6231:
6219:
6214:
6209:
6204:
6199:
6194:
6189:
6184:
6179:
6174:
6169:
6164:
6159:
6147:
6142:
6137:
6132:
6127:
6122:
6110:
6098:
6093:
6081:
6069:
6064:
6052:
6047:
6042:
6037:
6032:
6027:
6022:
6013:Phenylbutazone
6010:
6005:
6000:
5995:
5983:
5978:
5973:
5968:
5963:
5958:
5953:
5948:
5936:
5931:
5926:
5921:
5916:
5911:
5906:
5901:
5896:
5891:
5886:
5881:
5876:
5871:
5866:
5861:
5856:
5851:
5846:
5841:
5836:
5831:
5826:
5821:
5816:
5811:
5806:
5794:
5789:
5784:
5779:
5774:
5769:
5764:
5759:
5754:
5749:
5744:
5739:
5734:
5729:
5724:
5719:
5714:
5709:
5704:
5699:
5694:
5689:
5684:
5679:
5674:
5669:
5664:
5659:
5654:
5649:
5644:
5632:
5627:
5622:
5617:
5612:
5607:
5602:
5597:
5592:
5587:
5582:
5577:
5572:
5567:
5562:
5557:
5552:
5543:
5541:
5524:
5510:
5509:
5506:
5505:
5503:
5502:
5497:
5492:
5487:
5482:
5477:
5472:
5467:
5462:
5457:
5452:
5447:
5442:
5437:
5432:
5427:
5422:
5417:
5412:
5407:
5402:
5397:
5392:
5387:
5382:
5377:
5372:
5367:
5362:
5357:
5352:
5347:
5342:
5337:
5332:
5327:
5322:
5317:
5312:
5307:
5302:
5297:
5291:
5289:
5285:
5284:
5282:
5281:
5276:
5271:
5266:
5261:
5256:
5251:
5246:
5241:
5236:
5231:
5226:
5222:
5218:
5213:
5208:
5203:
5198:
5193:
5188:
5183:
5178:
5173:
5168:
5163:
5158:
5153:
5148:
5143:
5138:
5133:
5128:
5123:
5118:
5109:
5108:
5103:
5098:
5094:
5090:
5085:
5081:
5073:
5071:
5062:
5056:
5055:
5053:
5052:
5043:
5042:
5037:
5032:
5027:
5022:
5017:
5012:
5008:
5003:
4999:
4994:
4989:
4987:Isocarbacyclin
4984:
4979:
4974:
4969:
4964:
4959:
4954:
4945:
4943:
4934:
4928:
4927:
4925:
4924:
4919:
4914:
4909:
4904:
4899:
4895:
4891:
4887:
4882:
4877:
4872:
4867:
4862:
4857:
4848:
4846:
4837:
4831:
4830:
4827:
4826:
4824:
4823:
4818:
4813:
4808:
4804:
4799:
4794:
4789:
4784:
4779:
4774:
4770:
4762:
4760:
4756:
4755:
4753:
4752:
4747:
4742:
4737:
4728:
4727:
4722:
4720:(dinoprostone)
4717:
4713:
4708:
4704:
4699:
4690:
4688:
4680:
4674:
4673:
4671:
4670:
4661:
4660:
4655:
4650:
4645:
4643:(dinoprostone)
4640:
4636:
4631:
4627:
4623:
4619:
4614:
4609:
4607:Isocarbacyclin
4604:
4599:
4594:
4589:
4584:
4575:
4573:
4565:
4559:
4558:
4556:
4555:
4550:
4545:
4536:
4535:
4530:
4528:(dinoprostone)
4525:
4521:
4516:
4512:
4507:
4498:
4496:
4488:
4482:
4481:
4479:
4478:
4473:
4468:
4463:
4458:
4449:
4448:
4443:
4441:(dinoprostone)
4438:
4434:
4429:
4425:
4420:
4415:
4410:
4405:
4400:
4391:
4389:
4381:
4372:
4363:
4357:
4356:
4353:
4352:
4350:
4349:
4344:
4339:
4334:
4329:
4324:
4319:
4314:
4309:
4304:
4299:
4294:
4285:
4284:
4280:
4276:
4267:
4265:
4257:
4251:
4250:
4248:
4247:
4242:
4237:
4228:
4227:
4222:
4218:
4210:
4208:
4200:
4191:
4182:
4173:
4159:
4158:
4147:
4145:
4144:
4137:
4130:
4122:
4113:
4112:
4110:
4109:
4103:
4101:
4097:
4096:
4094:
4093:
4091:LTD4 hydrolase
4088:
4083:
4077:
4076:
4070:
4069:
4059:
4057:
4051:
4050:
4048:
4047:
4041:
4040:
4034:
4033:
4028:
4022:
4021:
4015:
4014:
4013:
4012:
4007:
4000:Cyclooxygenase
3996:
3994:
3988:
3987:
3985:
3984:
3979:
3973:
3972:
3966:
3964:
3960:
3959:
3942:
3940:
3939:
3932:
3925:
3917:
3908:
3907:
3905:
3904:
3897:
3890:
3882:
3880:
3876:
3875:
3873:
3872:
3865:
3857:
3855:
3851:
3850:
3848:
3847:
3840:
3808:
3807:
3806:
3794:
3786:
3784:
3780:
3779:
3777:
3776:
3769:
3762:
3755:
3748:
3741:
3740:
3739:
3732:
3720:
3713:
3706:
3699:
3698:
3697:
3694:
3684:
3677:
3670:
3663:
3656:
3649:
3642:
3635:
3634:
3633:
3628:
3616:
3615:
3614:
3609:
3597:
3590:
3589:
3588:
3583:
3571:
3564:
3556:
3554:
3550:
3549:
3547:
3546:
3539:
3532:
3525:
3518:
3511:
3489:
3471:
3429:
3413:
3399:
3387:
3380:
3373:
3334:
3332:
3328:
3327:
3325:
3324:
3317:
3316:
3315:
3305:
3304:
3303:
3291:
3290:
3289:
3277:
3270:
3253:
3251:
3247:
3246:
3244:
3243:
3233:
3223:
3213:
3206:
3196:
3176:
3156:
3149:
3139:
3132:
3122:
3111:
3109:
3105:
3104:
3102:
3101:
3091:
3081:
3074:
3064:
3057:
3050:
3043:
3036:
3029:
2997:
2990:
2983:
2969:
2955:
2939:
2928:
2926:
2922:
2921:
2919:
2918:
2913:
2908:
2903:
2898:
2893:
2888:
2883:
2878:
2873:
2868:
2863:
2857:
2855:
2851:
2850:
2848:
2847:
2842:
2837:
2832:
2827:
2821:
2819:
2811:
2810:
2808:
2807:
2802:
2797:
2792:
2787:
2782:
2777:
2772:
2767:
2762:
2757:
2752:
2747:
2742:
2737:
2732:
2726:
2724:
2720:
2719:
2717:
2716:
2711:
2706:
2701:
2695:
2693:
2689:
2688:
2670:
2668:
2667:
2660:
2653:
2645:
2639:
2638:
2626:
2625:External links
2623:
2621:
2620:
2591:
2573:(2): 251–256.
2562:
2544:(2): 349–356.
2533:
2498:
2480:(3): 771–773.
2469:
2451:(1): 379–387.
2440:
2411:
2393:(2): 273–278.
2382:
2362:(2): 273–279.
2347:
2310:
2292:(2): 325–330.
2281:
2263:(1): 286–291.
2252:
2223:
2203:(2): 789–793.
2188:
2159:
2141:(2): 133–138.
2129:
2104:
2075:
2057:(3): 153–172.
2045:
2043:
2040:
2037:
2036:
2007:(2): 153–166.
1991:
1972:(3): 153–172.
1956:
1913:
1886:
1851:
1830:(1): 141–150.
1810:
1791:(1): 119–127.
1775:
1741:
1720:(2): 789–793.
1700:
1659:
1624:
1589:
1560:(4): 759–766.
1540:
1521:(2): 251–256.
1505:
1470:
1453:
1435:
1417:
1396:
1374:
1373:
1371:
1368:
1367:
1366:
1361:
1354:
1351:
1347:
1346:
1343:
1336:
1334:
1331:
1324:
1321:
1320:
1319:
1317:
1314:
1259:
1256:
1231:
1228:
1205:
1202:
1180:
1177:
1131:, and also to
1119:
1112:
1097:
1094:
1060:
1059:
1056:
1055:
1050:
1040:
1039:
1033:
1032:
1029:
1028:
1026:
1024:
1017:
1016:
1009:
1002:
998:
997:
994:
993:
983:
982:
976:
973:
972:
954:
953:
927:
923:
922:
919:
918:
908:
907:
901:
898:
897:
879:
878:
852:
848:
847:
844:
843:
835:
834:
828:
825:
824:
816:
815:
809:
803:
802:
799:
798:
790:
789:
783:
780:
779:
771:
770:
764:
758:
757:
754:
753:
745:
744:
738:
735:
734:
726:
725:
719:
713:
712:
707:
702:
698:
697:
687:
686:
683:
682:
671:
670:
668:
667:
662:
657:
652:
647:
642:
637:
631:
629:
625:
624:
622:
621:
616:
611:
606:
600:
598:
594:
593:
591:
590:
585:
580:
575:
570:
565:
560:
555:
550:
544:
542:
538:
537:
527:
526:
523:
522:
519:
518:
510:
509:
498:
492:
491:
488:
487:
479:
478:
475:
474:
472:
471:
467:
463:
459:
455:
451:
447:
443:
439:
435:
431:
428:
427:
416:
413:
412:
410:
409:
405:
401:
397:
393:
389:
385:
381:
377:
373:
369:
366:
365:
353:
352:
344:
333:
327:
326:
323:RNA expression
315:
314:
311:
310:
302:
298:
297:
289:
286:
281:
275:
274:
265:
258:
252:
248:
247:
242:
236:
235:
227:
226:
214:
213:
210:
209:
201:
197:
196:
188:
185:
180:
174:
173:
164:
157:
151:
147:
146:
139:
133:
132:
124:
123:
111:
110:
67:
63:
62:
54:
46:
45:
41:
40:
37:
36:
26:
24:
14:
13:
10:
9:
6:
4:
3:
2:
7294:
7283:
7280:
7278:
7275:
7274:
7272:
7262:
7257:
7252:
7248:
7234:
7230:
7229:
7224:
7221:
7217:
7216:
7211:
7208:
7204:
7203:
7198:
7195:
7191:
7190:
7185:
7182:
7178:
7177:
7172:
7169:
7165:
7164:
7159:
7156:
7152:
7151:
7146:
7145:
7143:
7139:
7133:
7130:
7128:
7125:
7123:
7120:
7118:
7115:
7113:
7110:
7109:
7107:
7103:
7097:
7094:
7092:
7091:Enzyme family
7089:
7087:
7084:
7082:
7079:
7078:
7076:
7072:
7066:
7063:
7061:
7058:
7056:
7055:Cooperativity
7053:
7051:
7048:
7047:
7045:
7041:
7035:
7032:
7030:
7027:
7025:
7022:
7020:
7017:
7015:
7014:Oxyanion hole
7012:
7010:
7007:
7005:
7002:
7000:
6997:
6996:
6994:
6990:
6986:
6979:
6974:
6972:
6967:
6965:
6960:
6959:
6956:
6944:
6941:
6939:
6936:
6934:
6931:
6929:
6925:
6922:
6921:
6919:
6916:
6912:
6905:
6901:
6898:
6897:
6895:
6892:
6888:
6882:
6879:
6877:
6874:
6872:
6869:
6867:
6864:
6862:
6859:
6857:
6854:
6852:
6849:
6847:
6844:
6841:
6837:
6834:
6832:
6829:
6827:
6824:
6822:
6819:
6817:
6814:
6813:
6811:
6808:
6804:
6798:
6795:
6793:
6790:
6788:
6785:
6784:
6782:
6780:
6776:
6772:
6768:
6762:
6759:
6757:
6754:
6752:
6749:
6747:
6744:
6743:
6741:
6739:
6735:
6731:
6727:
6722:
6718:
6714:
6707:
6702:
6700:
6695:
6693:
6688:
6687:
6684:
6672:
6671:
6667:
6665:
6664:
6660:
6657:
6656:
6653:
6647:
6641:
6639:
6633:
6631:
6628:
6626:
6623:
6621:
6618:
6616:
6613:
6611:
6610:Linoleic acid
6608:
6605:
6604:
6602:
6598:
6588:
6585:
6583:
6580:
6578:
6575:
6573:
6570:
6568:
6565:
6563:
6560:
6558:
6555:
6553:
6550:
6548:
6545:
6543:
6540:
6538:
6535:
6533:
6530:
6528:
6525:
6523:
6520:
6518:
6515:
6513:
6510:
6509:
6507:
6502:
6496:
6492:
6488:
6483:
6473:
6469:
6465:
6460:
6454:
6450:
6446:
6441:
6435:
6428:
6424:
6420:
6416:
6413:
6411:
6408:
6407:
6405:
6400:
6390:
6384:
6381:
6379:
6376:
6374:
6371:
6369:
6366:
6364:
6361:
6359:
6356:
6354:
6351:
6349:
6346:
6344:
6341:
6339:
6336:
6334:
6331:
6329:
6326:
6324:
6321:
6319:
6316:
6314:
6311:
6309:
6306:
6304:
6301:
6299:
6292:
6290:
6287:
6285:
6282:
6280:
6277:
6275:
6272:
6270:
6267:
6265:
6262:
6260:
6257:
6255:
6252:
6250:
6247:
6245:
6242:
6240:
6237:
6235:
6232:
6230:
6227:
6223:
6220:
6218:
6215:
6213:
6210:
6208:
6205:
6203:
6200:
6198:
6195:
6193:
6190:
6188:
6185:
6183:
6180:
6178:
6175:
6173:
6170:
6168:
6165:
6163:
6160:
6158:
6155:
6151:
6148:
6146:
6143:
6141:
6138:
6136:
6133:
6131:
6128:
6126:
6123:
6121:
6118:
6114:
6111:
6109:
6106:
6102:
6099:
6097:
6094:
6092:
6089:
6085:
6082:
6080:
6079:Fluproquazone
6077:
6076:Quinazolines:
6073:
6070:
6068:
6065:
6063:
6060:
6056:
6053:
6051:
6048:
6046:
6043:
6041:
6038:
6036:
6033:
6031:
6028:
6026:
6023:
6021:
6018:
6014:
6011:
6009:
6006:
6004:
6001:
5999:
5996:
5994:
5991:
5987:
5984:
5982:
5979:
5977:
5974:
5972:
5969:
5967:
5964:
5962:
5959:
5957:
5954:
5952:
5949:
5947:
5944:
5940:
5937:
5935:
5932:
5930:
5927:
5925:
5922:
5920:
5917:
5915:
5912:
5910:
5907:
5905:
5902:
5900:
5897:
5895:
5892:
5890:
5887:
5885:
5882:
5880:
5877:
5875:
5872:
5870:
5867:
5865:
5862:
5860:
5857:
5855:
5854:Flunoxaprofen
5852:
5850:
5847:
5845:
5842:
5840:
5839:Dexketoprofen
5837:
5835:
5834:Dexindoprofen
5832:
5830:
5827:
5825:
5822:
5820:
5817:
5815:
5812:
5810:
5807:
5805:
5802:
5798:
5795:
5793:
5790:
5788:
5785:
5783:
5780:
5778:
5775:
5773:
5772:Proglumetacin
5770:
5768:
5765:
5763:
5760:
5758:
5755:
5753:
5750:
5748:
5745:
5743:
5740:
5738:
5735:
5733:
5730:
5728:
5725:
5723:
5720:
5718:
5715:
5713:
5710:
5708:
5705:
5703:
5702:Difenpiramide
5700:
5698:
5695:
5693:
5690:
5688:
5685:
5683:
5680:
5678:
5675:
5673:
5670:
5668:
5665:
5663:
5660:
5658:
5655:
5653:
5650:
5648:
5645:
5643:
5640:
5639:Acetic acids:
5636:
5633:
5631:
5628:
5626:
5623:
5621:
5618:
5616:
5613:
5611:
5608:
5606:
5603:
5601:
5598:
5596:
5593:
5591:
5588:
5586:
5583:
5581:
5578:
5576:
5573:
5571:
5568:
5566:
5563:
5561:
5558:
5556:
5553:
5551:
5548:
5545:
5544:
5542:
5540:
5528:
5525:
5521:
5515:
5511:
5501:
5498:
5496:
5493:
5491:
5488:
5486:
5483:
5481:
5478:
5476:
5473:
5471:
5468:
5466:
5463:
5461:
5458:
5456:
5453:
5451:
5448:
5446:
5443:
5441:
5438:
5436:
5433:
5431:
5428:
5426:
5423:
5421:
5418:
5416:
5413:
5411:
5408:
5406:
5403:
5401:
5398:
5396:
5393:
5391:
5388:
5386:
5383:
5381:
5378:
5376:
5373:
5371:
5370:Fenprostalene
5368:
5366:
5363:
5361:
5358:
5356:
5353:
5351:
5348:
5346:
5343:
5341:
5338:
5336:
5333:
5331:
5328:
5326:
5323:
5321:
5320:Delprostenate
5318:
5316:
5313:
5311:
5308:
5306:
5303:
5301:
5298:
5296:
5293:
5292:
5290:
5286:
5280:
5277:
5275:
5272:
5270:
5267:
5265:
5262:
5260:
5257:
5255:
5252:
5250:
5247:
5245:
5242:
5240:
5237:
5235:
5232:
5230:
5227:
5225:
5219:
5217:
5214:
5212:
5209:
5207:
5204:
5202:
5199:
5197:
5194:
5192:
5189:
5187:
5184:
5182:
5179:
5177:
5174:
5172:
5169:
5167:
5164:
5162:
5159:
5157:
5154:
5152:
5149:
5147:
5144:
5142:
5139:
5137:
5134:
5132:
5129:
5127:
5124:
5122:
5119:
5117:
5114:
5111:
5110:
5107:
5104:
5102:
5099:
5097:
5093:Thromboxane A
5091:
5089:
5086:
5084:
5078:
5075:
5074:
5072:
5067:
5057:
5051:
5048:
5045:
5044:
5041:
5038:
5036:
5033:
5031:
5028:
5026:
5023:
5021:
5018:
5016:
5015:(alprostadil)
5009:
5007:
5000:
4998:
4995:
4993:
4990:
4988:
4985:
4983:
4980:
4978:
4975:
4973:
4970:
4968:
4965:
4963:
4960:
4958:
4955:
4953:
4950:
4947:
4946:
4944:
4939:
4929:
4923:
4920:
4918:
4915:
4913:
4910:
4908:
4905:
4903:
4896:
4894:
4888:
4886:
4883:
4881:
4878:
4876:
4873:
4871:
4868:
4866:
4863:
4861:
4858:
4856:
4853:
4850:
4849:
4847:
4842:
4832:
4822:
4819:
4817:
4814:
4812:
4805:
4803:
4800:
4798:
4795:
4793:
4790:
4788:
4785:
4783:
4780:
4778:
4775:
4773:
4767:
4764:
4763:
4761:
4757:
4751:
4748:
4746:
4743:
4741:
4738:
4736:
4733:
4730:
4729:
4726:
4723:
4721:
4714:
4712:
4711:(alprostadil)
4705:
4703:
4700:
4698:
4695:
4692:
4691:
4689:
4684:
4675:
4669:
4666:
4663:
4662:
4659:
4656:
4654:
4651:
4649:
4646:
4644:
4637:
4635:
4634:(alprostadil)
4628:
4626:
4620:
4618:
4615:
4613:
4610:
4608:
4605:
4603:
4600:
4598:
4595:
4593:
4590:
4588:
4585:
4583:
4580:
4577:
4576:
4574:
4569:
4560:
4554:
4551:
4549:
4546:
4544:
4541:
4538:
4537:
4534:
4531:
4529:
4522:
4520:
4519:(alprostadil)
4513:
4511:
4508:
4506:
4503:
4500:
4499:
4497:
4492:
4483:
4477:
4474:
4472:
4469:
4467:
4464:
4462:
4459:
4457:
4454:
4451:
4450:
4447:
4444:
4442:
4435:
4433:
4432:(alprostadil)
4426:
4424:
4421:
4419:
4416:
4414:
4411:
4409:
4406:
4404:
4401:
4399:
4396:
4393:
4392:
4390:
4385:
4376:
4373:
4368:
4358:
4348:
4345:
4343:
4340:
4338:
4335:
4333:
4330:
4328:
4325:
4323:
4320:
4318:
4315:
4313:
4310:
4308:
4305:
4303:
4300:
4298:
4295:
4293:
4290:
4287:
4286:
4283:
4277:
4275:
4272:
4269:
4268:
4266:
4261:
4252:
4246:
4243:
4241:
4238:
4236:
4233:
4230:
4229:
4226:
4223:
4221:
4215:
4212:
4211:
4209:
4204:
4195:
4192:
4187:
4177:
4174:
4170:
4164:
4160:
4156:
4153:
4150:
4143:
4138:
4136:
4131:
4129:
4124:
4123:
4120:
4108:
4105:
4104:
4102:
4098:
4092:
4089:
4087:
4084:
4082:
4081:LTC4 synthase
4079:
4078:
4075:
4072:
4071:
4068:
4064:
4061:
4060:
4058:
4056:
4052:
4046:
4043:
4042:
4039:
4038:PGI2 synthase
4036:
4035:
4032:
4029:
4027:
4024:
4023:
4020:
4019:PGD2 synthase
4017:
4016:
4011:
4008:
4006:
4003:
4002:
4001:
3998:
3997:
3995:
3993:
3989:
3983:
3980:
3978:
3975:
3974:
3971:
3968:
3967:
3965:
3961:
3957:
3953:
3949:
3945:
3938:
3933:
3931:
3926:
3924:
3919:
3918:
3915:
3903:
3902:
3898:
3896:
3895:
3891:
3889:
3888:
3884:
3883:
3881:
3877:
3871:
3870:
3866:
3864:
3863:
3859:
3858:
3856:
3852:
3846:
3845:
3841:
3838:
3834:
3833:
3828:
3824:
3820:
3816:
3812:
3809:
3805:
3802:
3801:
3800:
3799:
3795:
3793:
3792:
3788:
3787:
3785:
3781:
3775:
3774:
3770:
3768:
3767:
3763:
3761:
3760:
3756:
3754:
3753:
3749:
3747:
3746:
3742:
3738:
3737:
3733:
3731:
3730:
3726:
3725:
3724:
3721:
3719:
3718:
3714:
3712:
3711:
3707:
3705:
3704:
3700:
3695:
3692:
3691:
3690:
3689:
3685:
3683:
3682:
3678:
3676:
3675:
3671:
3669:
3668:
3664:
3662:
3661:
3657:
3655:
3654:
3650:
3648:
3647:
3643:
3641:
3640:
3636:
3632:
3629:
3627:
3624:
3623:
3622:
3621:
3617:
3613:
3610:
3608:
3605:
3604:
3603:
3602:
3598:
3596:
3595:
3591:
3587:
3584:
3582:
3579:
3578:
3577:
3576:
3572:
3570:
3569:
3565:
3563:
3562:
3558:
3557:
3555:
3551:
3545:
3544:
3540:
3538:
3537:
3533:
3531:
3530:
3526:
3524:
3523:
3519:
3517:
3516:
3512:
3509:
3505:
3501:
3497:
3493:
3490:
3487:
3483:
3479:
3475:
3472:
3469:
3465:
3461:
3457:
3453:
3449:
3445:
3441:
3437:
3433:
3430:
3427:
3423:
3419:
3418:
3414:
3411:
3407:
3403:
3400:
3397:
3393:
3392:
3388:
3386:
3385:
3381:
3379:
3378:
3374:
3371:
3367:
3363:
3359:
3355:
3351:
3347:
3343:
3339:
3336:
3335:
3333:
3329:
3323:
3322:
3318:
3314:
3311:
3310:
3309:
3306:
3302:
3299:
3298:
3297:
3296:
3292:
3288:
3285:
3284:
3283:
3282:
3278:
3276:
3275:
3271:
3268:
3264:
3260:
3259:
3255:
3254:
3252:
3248:
3241:
3237:
3234:
3231:
3227:
3224:
3221:
3217:
3214:
3212:
3211:
3207:
3204:
3200:
3197:
3194:
3190:
3186:
3182:
3181:
3177:
3174:
3170:
3166:
3162:
3161:
3157:
3155:
3154:
3150:
3147:
3143:
3140:
3138:
3137:
3133:
3130:
3126:
3123:
3120:
3116:
3113:
3112:
3110:
3106:
3099:
3095:
3092:
3089:
3085:
3082:
3080:
3079:
3075:
3072:
3068:
3065:
3063:
3062:
3058:
3056:
3055:
3051:
3049:
3048:
3044:
3042:
3041:
3037:
3035:
3034:
3030:
3027:
3023:
3019:
3015:
3011:
3007:
3003:
3002:
2998:
2996:
2995:
2991:
2989:
2988:
2984:
2981:
2977:
2973:
2970:
2967:
2963:
2959:
2956:
2953:
2949:
2945:
2944:
2940:
2937:
2933:
2930:
2929:
2927:
2923:
2917:
2914:
2912:
2909:
2907:
2904:
2902:
2899:
2897:
2894:
2892:
2889:
2887:
2884:
2882:
2879:
2877:
2874:
2872:
2869:
2867:
2864:
2862:
2859:
2858:
2856:
2852:
2846:
2843:
2841:
2838:
2836:
2833:
2831:
2828:
2826:
2823:
2822:
2820:
2817:
2812:
2806:
2803:
2801:
2798:
2796:
2793:
2791:
2788:
2786:
2783:
2781:
2778:
2776:
2773:
2771:
2768:
2766:
2763:
2761:
2758:
2756:
2753:
2751:
2748:
2746:
2743:
2741:
2738:
2736:
2733:
2731:
2728:
2727:
2725:
2721:
2715:
2712:
2710:
2707:
2705:
2702:
2700:
2697:
2696:
2694:
2690:
2685:
2681:
2677:
2673:
2666:
2661:
2659:
2654:
2652:
2647:
2646:
2643:
2636:
2632:
2629:
2628:
2624:
2617:
2613:
2609:
2605:
2601:
2597:
2592:
2588:
2584:
2580:
2576:
2572:
2568:
2563:
2559:
2555:
2551:
2547:
2543:
2539:
2534:
2530:
2526:
2521:
2516:
2512:
2508:
2504:
2499:
2495:
2491:
2487:
2483:
2479:
2475:
2470:
2466:
2462:
2458:
2454:
2450:
2446:
2441:
2437:
2433:
2429:
2425:
2421:
2417:
2412:
2408:
2404:
2400:
2396:
2392:
2388:
2383:
2379:
2375:
2370:
2365:
2361:
2357:
2353:
2348:
2344:
2340:
2336:
2332:
2328:
2324:
2321:(8160): 157.
2320:
2316:
2311:
2307:
2303:
2299:
2295:
2291:
2287:
2282:
2278:
2274:
2270:
2266:
2262:
2258:
2253:
2249:
2245:
2241:
2237:
2233:
2229:
2224:
2220:
2216:
2211:
2206:
2202:
2198:
2194:
2189:
2185:
2181:
2177:
2173:
2169:
2165:
2160:
2156:
2152:
2148:
2144:
2140:
2136:
2130:
2126:
2122:
2118:
2114:
2110:
2105:
2101:
2097:
2093:
2089:
2085:
2081:
2076:
2072:
2068:
2064:
2060:
2056:
2052:
2047:
2046:
2041:
2032:
2028:
2023:
2018:
2014:
2010:
2006:
2002:
1995:
1992:
1987:
1983:
1979:
1975:
1971:
1967:
1960:
1957:
1952:
1948:
1944:
1940:
1936:
1932:
1928:
1924:
1917:
1914:
1909:
1905:
1901:
1897:
1890:
1887:
1882:
1878:
1874:
1870:
1866:
1862:
1855:
1852:
1847:
1843:
1838:
1833:
1829:
1825:
1821:
1814:
1811:
1806:
1802:
1798:
1794:
1790:
1786:
1779:
1776:
1771:
1767:
1763:
1759:
1755:
1748:
1746:
1742:
1737:
1733:
1728:
1723:
1719:
1715:
1711:
1704:
1701:
1696:
1692:
1687:
1682:
1678:
1674:
1670:
1663:
1660:
1655:
1651:
1647:
1643:
1639:
1635:
1628:
1625:
1620:
1616:
1612:
1608:
1604:
1600:
1593:
1590:
1585:
1581:
1576:
1571:
1567:
1563:
1559:
1555:
1551:
1544:
1541:
1536:
1532:
1528:
1524:
1520:
1516:
1509:
1506:
1501:
1497:
1493:
1489:
1485:
1481:
1474:
1471:
1466:
1460:
1458:
1454:
1449:
1445:
1439:
1436:
1431:
1427:
1421:
1418:
1414:
1410:
1405:
1403:
1401:
1397:
1393:
1389:
1384:
1382:
1380:
1376:
1369:
1365:
1362:
1360:
1357:
1356:
1352:
1340:
1335:
1328:
1323:
1315:
1313:
1311:
1307:
1303:
1299:
1295:
1291:
1285:
1282:
1278:
1274:
1269:
1265:
1257:
1255:
1252:
1248:
1244:
1236:
1229:
1227:
1225:
1222:
1218:
1215:
1211:
1203:
1201:
1199:
1195:
1191:
1178:
1176:
1174:
1173:BLT2 receptor
1170:
1166:
1165:
1160:
1156:
1154:
1150:
1146:
1142:
1136:
1135:
1130:
1126:
1122:
1118:thromboxane A
1115:
1107:
1103:
1095:
1093:
1091:
1088:
1084:
1081:
1077:
1073:
1071:
1068:
1054:
1049:
1045:
1041:
1038:
1034:
1027:
1025:
1022:
1018:
1014:
1010:
1007:
1003:
999:
992:
990:
984:
980:
977:
971:
969:
965:
961:
955:
951:
947:
943:
939:
935:
931:
928:
924:
917:
915:
909:
905:
902:
896:
894:
890:
886:
880:
876:
872:
868:
864:
860:
856:
853:
851:RefSeq (mRNA)
849:
842:
841:
836:
832:
829:
823:
822:
817:
813:
810:
808:
804:
797:
796:
791:
787:
784:
778:
777:
772:
768:
765:
763:
759:
752:
751:
746:
742:
739:
733:
732:
727:
723:
720:
718:
714:
711:
708:
706:
703:
699:
696:
692:
688:
681:
677:
672:
666:
663:
661:
658:
656:
653:
651:
648:
646:
643:
641:
638:
636:
633:
632:
630:
627:
626:
620:
617:
615:
612:
610:
607:
605:
602:
601:
599:
596:
595:
589:
586:
584:
581:
579:
576:
574:
571:
569:
566:
564:
561:
559:
556:
554:
551:
549:
546:
545:
543:
540:
539:
536:
535:Gene ontology
532:
528:
516:
511:
507:
502:
499:
497:
493:
485:
480:
469:
465:
461:
457:
453:
449:
445:
441:
437:
433:
432:
429:
425:
420:
417:
407:
403:
399:
395:
391:
387:
383:
379:
375:
371:
370:
367:
363:
358:
355:
354:
351:
349:
345:
343:
342:
338:
337:
334:
332:
328:
324:
320:
316:
308:
303:
299:
295:
290:
280:
276:
269:
262:
256:
249:
241:
237:
233:
228:
224:
219:
215:
207:
202:
198:
194:
189:
179:
175:
168:
161:
155:
148:
144:
138:
134:
130:
125:
121:
116:
112:
108:
104:
100:
96:
92:
88:
84:
80:
76:
72:
64:
59:
52:
47:
42:
38:
33:
30:
19:
7228:Translocases
7225:
7212:
7199:
7186:
7173:
7163:Transferases
7160:
7147:
7004:Binding site
6942:
6668:
6661:
6606:
6225:
6153:
6150:Propacetamol
6140:Parapropamol
6116:
6104:
6087:
6075:
6067:Floctafenine
6058:
6016:
5993:Azapropazone
5990:Pyrazolones:
5989:
5942:
5924:Tarenflurbil
5859:Flurbiprofen
5829:Dexibuprofen
5809:Benoxaprofen
5804:Alminoprofen
5800:
5727:Glucametacin
5638:
5615:Salicylamide
5605:Salacetamide
5546:
5495:Trimoprostil
5490:Tiprostanide
5475:Spiriprostil
5410:Naxaprostene
5360:Esuberaprost
5315:Cobiprostone
5113:Antagonists:
5112:
5076:
5047:Antagonists:
5046:
5040:Treprostinil
4948:
4880:Fluprostenol
4870:Cloprostenol
4851:
4765:
4732:Antagonists:
4731:
4697:Lubiprostone
4693:
4665:Antagonists:
4664:
4578:
4540:Antagonists:
4539:
4533:Treprostinil
4501:
4453:Antagonists:
4452:
4418:Lubiprostone
4394:
4289:Antagonists:
4288:
4270:
4232:Antagonists:
4231:
4225:Treprostinil
4213:
4055:Leukotrienes
4045:TXA synthase
4044:
4026:PGE synthase
3899:
3892:
3885:
3867:
3860:
3842:
3836:
3830:
3826:
3822:
3818:
3814:
3796:
3789:
3771:
3764:
3757:
3750:
3743:
3734:
3727:
3722:
3715:
3708:
3701:
3686:
3679:
3672:
3665:
3658:
3651:
3644:
3637:
3618:
3599:
3592:
3573:
3566:
3559:
3541:
3534:
3527:
3520:
3513:
3491:
3473:
3431:
3415:
3401:
3389:
3382:
3375:
3337:
3319:
3307:
3293:
3279:
3272:
3256:
3235:
3225:
3215:
3208:
3198:
3178:
3158:
3151:
3141:
3134:
3124:
3114:
3093:
3083:
3076:
3066:
3059:
3052:
3045:
3038:
3031:
2999:
2992:
2985:
2971:
2957:
2941:
2935:
2931:
2599:
2595:
2570:
2566:
2541:
2537:
2510:
2506:
2477:
2473:
2448:
2444:
2419:
2415:
2390:
2386:
2359:
2355:
2318:
2314:
2289:
2285:
2260:
2256:
2231:
2227:
2200:
2196:
2167:
2163:
2138:
2134:
2108:
2083:
2079:
2054:
2050:
2004:
2000:
1994:
1969:
1965:
1959:
1926:
1922:
1916:
1899:
1895:
1889:
1864:
1860:
1854:
1827:
1823:
1813:
1788:
1784:
1778:
1753:
1717:
1713:
1703:
1676:
1672:
1662:
1640:(1): 77–83.
1637:
1633:
1627:
1605:(2): 65–71.
1602:
1598:
1592:
1557:
1553:
1543:
1518:
1514:
1508:
1483:
1479:
1473:
1447:
1438:
1429:
1420:
1306:angiogenesis
1304:inhibition,
1298:renal cancer
1286:
1264:thromboxanes
1261:
1241:
1207:
1188:are used as
1182:
1168:
1162:
1158:
1152:
1148:
1144:
1140:
1138:
1132:
1099:
1086:
1075:
1064:
1063:
986:
968:NP_001353467
964:NP_001353466
957:
950:NP_001300957
946:NP_001159726
942:NP_001159725
938:NP_001124438
911:
893:NM_001366538
889:NM_001366537
882:
875:NM_001166254
871:NM_001166253
867:NM_001130966
859:NM_001314028
838:
819:
793:
774:
748:
729:
709:
704:
568:heme binding
466:aortic valve
450:right kidney
346:
339:
204:140,020,325
191:139,777,051
66:External IDs
29:
6999:Active site
6607:Precursors:
6547:Nicogrelate
6527:Furegrelate
6468:Bimatoprost
6378:Trifenagrel
6368:Tiflamizole
6338:Rutecarpine
6323:Resveratrol
6264:Glimepiride
6229:Anitrazafen
6207:Robenacoxib
6187:Lumiracoxib
6120:Acetanilide
6062:Antrafenine
6020:Ampiroxicam
5914:Pranoprofen
5899:Naproxcinod
5792:Zidometacin
5717:Fenclofenac
5642:Aceclofenac
5580:Ethenzamide
5575:Dipyrocetyl
5470:Rosaprostol
5450:Posaraprost
5435:Penprostene
5425:Ornoprostil
5405:Mexiprostil
5400:Meteneprost
5355:Eptaloprost
5330:Dimoxaprost
5295:Arbaprostil
5249:Seratrodast
5141:BMS-180,291
4972:Carbacyclin
4922:Unoprostone
4902:(dinoprost)
4885:Latanoprost
4860:Bimatoprost
4855:Alfaprostol
4811:(dinoprost)
4750:ONO-AE3-208
4702:Misoprostol
4658:Sulprostone
4648:Remiprostol
4617:Misoprostol
4612:Latanoprost
4587:Carbacyclin
4548:PF-04418948
4510:Misoprostol
4446:Sulprostone
4423:Misoprostol
4413:Latanoprost
4347:Vidupiprant
4337:Timapiprant
4332:Setipiprant
4307:Fevipiprant
4274:Indometacin
4245:Vidupiprant
4240:Laropiprant
3992:Prostanoids
3954:metabolism
2672:Cytochromes
2234:(1): 8–14.
1268:eicosanoids
1243:Thromboxane
1210:thromboxane
1143:)-hydroxy-5
1123:, a potent
434:granulocyte
392:gallbladder
376:granulocyte
305:39,061,519
292:38,852,338
44:Identifiers
7271:Categories
7202:Isomerases
7176:Hydrolases
7043:Regulation
6713:Isomerases
6577:Samixogrel
6572:Rolafagrel
6557:Picotamide
6537:Midazogrel
6512:Camonagrel
6373:Timegadine
6318:Pamicogrel
6289:Licofelone
6269:Hyperforin
6234:Clobuzarit
6222:Valdecoxib
6217:Tilmacoxib
6202:Polmacoxib
6177:Etoricoxib
6145:Phenacetin
6113:Nimesulide
6091:Clonixeril
6084:Proquazone
6040:Lornoxicam
5939:Vedaprofen
5889:Miroprofen
5884:Loxoprofen
5879:Ketoprofen
5874:Indoprofen
5849:Fenoprofen
5762:Oxametacin
5757:Nabumetone
5697:Diclofenac
5692:Clometacin
5687:Cinmetacin
5682:Bumadizone
5662:Alclofenac
5647:Acemetacin
5585:Guacetisal
5570:Diflunisal
5520:inhibitors
5485:Tilsuprost
5465:Rivenprost
5460:Rioprostil
5455:Prostalene
5440:Pimilprost
5430:Oxoprostol
5420:Nocloprost
5395:Luprostiol
5385:Lanproston
5380:Froxiprost
5375:Flunoprost
5365:Etiproston
5350:Enisoprost
5345:Eganoprost
5305:Ciprostene
5274:Terutroban
5264:Sulotroban
5244:Samixogrel
5229:Ramatroban
5216:Picotamide
5201:Mipitroban
5196:Linotroban
5181:Imitrodast
5171:ICI-192605
5166:ICI-185282
5151:Domitroban
5131:Argatroban
5030:Taprostene
4952:ACT-333679
4917:Travoprost
4912:Tafluprost
4907:Sulotroban
4865:Carboprost
4821:Taprenepag
4802:Omidenepag
4797:Nocloprost
4787:Evatanepag
4782:Carboprost
4735:Grapiprant
4327:Ramatroban
4235:Asapiprant
4155:modulators
4149:Prostanoid
3952:eicosanoid
3944:Metabolism
3879:CYP701-999
3854:CYP501-699
3783:CYP301-499
3553:CYP101-281
2676:oxygenases
2022:2262/36848
1415:, May 2017
1394:, May 2017
1370:References
1359:Prostanoid
1310:metastasis
1281:thrombotic
1208:The human
1194:Picotamide
400:C1 segment
388:right lung
350:(ortholog)
87:HomoloGene
7081:EC number
6582:Terbogrel
6562:Pirmagrel
6522:Dazoxiben
6517:Dazmegrel
6410:Retinoids
6328:Romazarit
6274:Itazigrel
6259:FR-122047
6254:Flumizole
6212:Rofecoxib
6197:Parecoxib
6192:Mavacoxib
6182:Firocoxib
6172:Deracoxib
6167:Cimicoxib
6162:Celecoxib
6157:Apricoxib
6108:Flosulide
6072:Glafenine
6055:Tenoxicam
6050:Piroxicam
6045:Meloxicam
5929:Tepoxalin
5909:Pirprofen
5904:Oxaprozin
5869:Ibuproxam
5864:Ibuprofen
5824:Carprofen
5819:Butibufen
5797:Zomepirac
5767:Oxindanac
5752:Mofezolac
5747:Lonazolac
5742:Ketorolac
5722:Fentiazac
5677:Bufexamac
5672:Bromfenac
5652:Aclofenac
5635:Triflusal
5625:Salsalate
5550:Aloxiprin
5500:Viprostol
5445:Piriprost
5415:Nileprost
5390:Limaprost
5340:Ecraprost
5335:Doxaprost
5325:Deprostil
5310:Clinprost
5269:Terbogrel
5259:SQ-29,548
5254:SQ-28,668
5211:ONO-11120
5176:Ifetroban
5146:Daltroban
5136:Bay U3405
5106:Vapiprost
5077:Agonists:
5050:RO1138452
5025:Selexipag
5020:Ralinepag
4977:Cicaprost
4967:BMY-45778
4962:Beraprost
4949:Agonists:
4875:Enprostil
4852:Agonists:
4816:Simenepag
4792:Gemeprost
4766:Agonists:
4740:GW-627368
4694:Agonists:
4597:Enprostil
4592:Cicaprost
4582:Beraprost
4579:Agonists:
4505:Butaprost
4502:Agonists:
4403:Enprostil
4398:Beraprost
4395:Agonists:
4302:Bay U3405
4271:Agonists:
4214:Agonists:
4152:signaling
4100:Ungrouped
3963:Precursor
3887:CYP704B22
1951:207215183
1302:apoptosis
1230:Mechanism
1204:Structure
989:NP_035669
960:NP_112246
934:NP_001052
914:NM_011539
885:NM_030984
863:NM_001061
695:Orthologs
470:CA3 field
95:GeneCards
7105:Kinetics
7029:Cofactor
6992:Activity
6658:See also
6567:Ridogrel
6542:Nafagrel
6532:Isbogrel
6415:Selenium
6383:Tropesin
6358:SC-58125
6343:Satigrel
6308:NCX-4040
6284:L-670596
6279:L-655240
6239:Curcumin
6101:Flunixin
6096:Clonixin
6035:Isoxicam
6030:Enolicam
6025:Droxicam
6003:Isopyrin
5998:Dipyrone
5919:Suprofen
5894:Naproxen
5844:Fenbufen
5787:Tolmetin
5777:Sulindac
5712:Felbinac
5707:Etodolac
5667:Bendazac
5480:Tiaprost
5300:Ataprost
5288:Unsorted
5234:Ridogrel
5206:ONO-3708
5191:L-670596
5186:L-655240
5161:GR-32191
4777:Aganepag
4759:Unsorted
4745:L-161982
4725:TCS-2510
4668:L-798106
4553:TG 4-155
4476:SC-51322
4471:SC-51089
4466:SC-19220
4461:ONO-8130
4297:AZD-1981
4292:ADC-3680
4163:Receptor
3901:CYP720A1
3869:CYP504B1
3844:CYP318A1
3837:CYP315A1
3832:CYP314A1
3827:CYP307A2
3823:CYP307A1
3819:CYP306A1
3815:CYP302A1
3791:CYP303A1
3766:CYP199A2
3745:CYP176A1
3703:CYP154C3
3667:CYP125A1
3653:CYP119A1
3646:CYP113A1
3594:CYP106A2
3568:CYP102A1
3561:CYP101A1
3331:CYP71-99
3250:CYP51-69
3108:CYP21-49
2474:Genomics
2343:29803926
2125:12432933
2031:20122998
1943:19764861
1805:11097184
1770:12432933
1619:25480980
1584:18378794
1411:–
1390:–
1353:See also
1106:catalyze
1096:Function
1070:5.3.99.5
1037:Wikidata
674:Sources:
614:membrane
442:gastrula
372:monocyte
7261:Biology
7215:Ligases
6985:Enzymes
6917:: other
6809:: C = C
6738:Ketoses
6734:Aldoses
6587:U63557A
6552:Ozagrel
6363:Tenidap
6303:NCX-466
6249:FK-3311
6244:DuP-697
6130:Bucetin
5657:Amfenac
5610:Salicin
5279:TRA-418
5126:AA-2414
5116:12-HETE
5101:U-46619
5035:TRA-418
4992:MRE-269
4543:AH-6809
4456:AH-6809
4342:TM30089
4322:QAV-680
4317:MK-7246
4312:MK-1029
4169:ligands
3956:enzymes
3773:CYP255A
3752:CYP183A
3717:CYP161C
3710:CYP158A
3543:CYP99A3
3536:CYP97C1
3529:CYP93E1
3522:CYP90C1
3515:CYP88D6
3384:CYP73A1
3377:CYP72A1
2925:CYP5-20
2616:9373149
2587:8964509
2558:8900410
2529:8366093
2494:8325653
2465:8198598
2436:8125298
2407:7986068
2378:7925341
2335:6101498
2306:2195994
2277:2043115
2248:1930241
2219:1730669
2184:1714723
2155:1562592
2100:9890157
2071:9678486
1986:9678486
1881:8777569
1846:2491846
1736:1730669
1695:8063711
1654:9754941
1575:2292216
1535:8964509
1500:1714723
1413:Ensembl
1392:Ensembl
1316:Pathway
1078:, is a
807:UniProt
762:Ensembl
701:Species
680:QuickGO
325:pattern
51:Aliases
7282:EC 5.3
7247:Portal
7189:Lyases
6915:5.3.99
6600:Others
6449:HQL-79
6353:SC-560
6348:SC-236
6313:NS-398
5514:Enzyme
5156:EP-045
5121:13-APA
5061:TP (TX
4997:NS-304
4957:AFP-07
3894:CYP710
3862:CYP503
3798:CYP305
3759:CYP197
3723:CYP170
3688:CYP152
3681:CYP147
3674:CYP139
3660:CYP123
3639:CYP111
3620:CYP109
3601:CYP107
3575:CYP105
2814:CYP3 (
2637:(MeSH)
2614:
2585:
2556:
2527:
2492:
2463:
2434:
2405:
2376:
2341:
2333:
2315:Lancet
2304:
2275:
2246:
2217:
2182:
2153:
2123:
2098:
2069:
2029:
1984:
1949:
1941:
1879:
1844:
1803:
1768:
1734:
1693:
1652:
1617:
1582:
1572:
1533:
1498:
1308:, and
1296:, and
1167:(i.e.
1159:12-HHT
1137:(i.e.
1087:TBXAS1
1083:enzyme
1076:TBXAS1
1023:search
1021:PubMed
840:P36423
821:P24557
717:Entrez
496:BioGPS
458:spleen
404:rectum
384:spleen
99:TBXAS1
91:130979
75:274180
58:TBXAS1
35:TBXAS1
18:TBXAS1
7141:Types
6904:PDIA3
6893:: S-S
6891:5.3.4
6807:5.3.3
6771:5.3.2
6730:5.3.1
5239:S-145
5088:I-BOP
4933:IP (I
4836:FP (F
4362:EP (E
4181:DP (D
4010:PTGS2
4005:PTGS1
3492:CYP81
3474:CYP80
3432:CYP79
3417:CYP76
3402:CYP75
3391:CYP74
3338:CYP71
3321:CYP61
3308:CYP56
3295:CYP55
3281:CYP53
3274:CYP52
3258:CYP51
3236:CYP46
3226:CYP39
3216:CYP35
3210:CYP29
3199:CYP28
3180:CYP27
3160:CYP26
3153:CYP25
3142:CYP24
3136:CYP23
3125:CYP22
3115:CYP21
3094:CYP20
3084:CYP19
3078:CYP18
3067:CYP17
3061:CYP16
3054:CYP15
3047:CYP14
3040:CYP13
3033:CYP12
3001:CYP11
2994:CYP10
2816:CYP3A
2686:1.14)
2339:S2CID
1947:S2CID
750:21391
710:Mouse
705:Human
676:Amigo
446:blood
380:blood
348:Mouse
341:Human
288:Start
223:Mouse
187:Start
120:Human
83:98497
7233:list
7226:EC7
7220:list
7213:EC6
7207:list
7200:EC5
7194:list
7187:EC4
7181:list
7174:EC3
7168:list
7161:EC2
7155:list
7148:EC1
6779:Enol
6775:Keto
6723:5.3)
6500:TXAS
6458:PGFS
6439:PGES
5537:PTGS
4107:HPGD
2987:CYP9
2972:CYP8
2958:CYP7
2943:CYP6
2932:CYP5
2854:CYP4
2723:CYP2
2692:CYP1
2612:PMID
2596:Gene
2583:PMID
2567:Gene
2554:PMID
2525:PMID
2490:PMID
2461:PMID
2432:PMID
2416:Gene
2403:PMID
2374:PMID
2331:PMID
2302:PMID
2273:PMID
2244:PMID
2215:PMID
2180:PMID
2151:PMID
2139:1130
2121:PMID
2096:PMID
2067:PMID
2027:PMID
2005:1805
1982:PMID
1939:PMID
1877:PMID
1842:PMID
1801:PMID
1766:PMID
1732:PMID
1691:PMID
1650:PMID
1615:PMID
1580:PMID
1531:PMID
1515:Gene
1496:PMID
1221:heme
1169:BLT2
1139:12-(
1090:gene
731:6916
331:Bgee
279:Band
240:Chr.
183:7q34
178:Band
137:Chr.
71:OMIM
6840:EBP
6477:PGI
6394:PGD
5532:COX
3370:BA1
3366:AV1
3362:AJ4
2901:F22
2896:F12
2891:F11
2866:A22
2861:A11
2845:A43
2840:A37
2765:C19
2760:C18
2740:A13
2604:doi
2600:200
2575:doi
2571:173
2546:doi
2542:334
2515:doi
2511:268
2482:doi
2453:doi
2449:201
2424:doi
2420:138
2395:doi
2391:315
2364:doi
2360:224
2323:doi
2294:doi
2290:280
2265:doi
2261:177
2236:doi
2232:180
2205:doi
2201:267
2172:doi
2168:178
2143:doi
2113:doi
2088:doi
2059:doi
2017:hdl
2009:doi
1974:doi
1931:doi
1904:doi
1869:doi
1832:doi
1828:264
1793:doi
1789:383
1758:doi
1722:doi
1718:267
1681:doi
1677:269
1642:doi
1638:355
1607:doi
1603:157
1570:PMC
1562:doi
1558:205
1523:doi
1519:173
1488:doi
1484:178
1214:kDa
1157:or
1151:,10
1116:to
301:End
200:End
103:OMA
79:MGI
7273::
6773::
6732::
6721:EC
6425:,
6421:,
6224:;
6152:;
6115:;
6103:;
6086:;
6074:;
6057:;
6015:;
5988:;
5941:;
5799:;
5637:;
5063:A2
4900:2α
4838:2α
4809:2α
4679:EP
4564:EP
4487:EP
4380:EP
4256:DP
4199:DP
3950:–
3946::
3835:,
3829:,
3825:,
3821:,
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