Knowledge

TERN-501

Source 📝

455: 25: 83: 545: 256: 394:"Resmetirom: An Orally Administered, Smallmolecule, Liver-directed, β-selective THR Agonist for the Treatment of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis" 515: 270: 298:
InChI=1S/C17H15Cl2N5O5/c1-7(2)9-6-12(22-24(3)16(9)26)28-13-10(18)4-8(5-11(13)19)20-15(25)14-21-17(27)29-23-14/h4-7H,1-3H3,(H,20,25)(H,21,23,27)
496: 321: 290: 119: 95: 540: 550: 489: 177: 520: 530: 525: 482: 535: 431: 413: 374: 421: 405: 364: 354: 193: 35: 426: 393: 466: 369: 342: 157: 509: 462: 317: 359: 54: 232: 417: 409: 44: 435: 378: 24: 454: 74: 143: 343:"Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH" 168: 82: 546:
Experimental drugs developed for non-alcoholic fatty liver disease
255: 246: 18: 341:
Finan, Brian; Parlee, Sebastian D.; Yang, Bin (April 2021).
278:
CC(C)C1=CC(=NN(C1=O)C)OC2=C(C=C(C=C2Cl)NC(=O)C3=NOC(=O)N3)Cl
470: 49: 39: 244: 231: 192: 187: 167: 142: 110: 94: 89: 320:drug that is being developed for the treatment of 156: 490: 8: 73: 497: 483: 81: 425: 368: 358: 333: 295: 275: 124: 516:Thyroid hormone receptor beta agonists 72: 392:Karim, Gres; Bansal, Meena B (2023). 176: 7: 451: 449: 147: 14: 322:non-alcoholic fatty liver disease 453: 216: 210: 204: 23: 303:Key:WFIWVDVCNWOMQV-UHFFFAOYSA-N 134:-1,2,4-oxadiazole-3-carboxamide 222: 198: 1: 398:TouchREVIEWS in Endocrinology 469:. You can help Knowledge by 360:10.1016/j.molmet.2020.101153 567: 448: 188:Chemical and physical data 286: 266: 115: 80: 410:10.17925/EE.2023.19.1.60 38:, as no other articles 465:-related article is a 347:Molecular Metabolism 541:Isopropyl compounds 77: 551:Pharmacology stubs 57:for suggestions. 47:to this page from 478: 477: 311: 310: 257:Interactive image 71: 70: 16:Chemical compound 558: 499: 492: 485: 457: 450: 440: 439: 429: 389: 383: 382: 372: 362: 338: 259: 239: 224: 218: 212: 206: 200: 180: 160: 150: 149: 85: 78: 76: 66: 63: 52: 50:related articles 27: 19: 566: 565: 561: 560: 559: 557: 556: 555: 506: 505: 504: 503: 446: 444: 443: 391: 390: 386: 340: 339: 335: 330: 316:is a selective 307: 304: 299: 294: 293: 282: 279: 274: 273: 262: 237: 227: 221: 215: 209: 203: 183: 163: 146: 138: 135: 123: 122: 106: 103:Investigational 67: 61: 58: 48: 45:introduce links 28: 17: 12: 11: 5: 564: 562: 554: 553: 548: 543: 538: 533: 528: 523: 518: 508: 507: 502: 501: 494: 487: 479: 476: 475: 458: 442: 441: 384: 332: 331: 329: 326: 309: 308: 306: 305: 302: 300: 297: 289: 288: 287: 284: 283: 281: 280: 277: 269: 268: 267: 264: 263: 261: 260: 252: 250: 242: 241: 235: 229: 228: 225: 219: 213: 207: 201: 196: 190: 189: 185: 184: 182: 181: 173: 171: 165: 164: 162: 161: 153: 151: 140: 139: 137: 136: 126: 118: 117: 116: 113: 112: 108: 107: 105: 104: 100: 98: 92: 91: 87: 86: 69: 68: 62:September 2023 55:Find link tool 31: 29: 22: 15: 13: 10: 9: 6: 4: 3: 2: 563: 552: 549: 547: 544: 542: 539: 537: 534: 532: 529: 527: 524: 522: 519: 517: 514: 513: 511: 500: 495: 493: 488: 486: 481: 480: 474: 472: 468: 464: 459: 456: 452: 447: 437: 433: 428: 423: 419: 415: 411: 407: 403: 399: 395: 388: 385: 380: 376: 371: 366: 361: 356: 352: 348: 344: 337: 334: 327: 325: 323: 319: 315: 301: 296: 292: 285: 276: 272: 265: 258: 254: 253: 251: 248: 243: 236: 234: 230: 197: 195: 191: 186: 179: 178:ChEMBL4782668 175: 174: 172: 170: 166: 159: 155: 154: 152: 145: 141: 133: 129: 125: 121: 114: 109: 102: 101: 99: 97: 93: 88: 84: 79: 65: 56: 51: 46: 42: 41: 37: 32:This article 30: 26: 21: 20: 521:Chloroarenes 471:expanding it 463:pharmacology 460: 445: 404:(1): 60–70. 401: 397: 387: 350: 346: 336: 318:thyromimetic 313: 312: 131: 127: 96:Legal status 90:Legal status 59: 33: 531:Pyridazines 526:Oxadiazoles 240: g·mol 111:Identifiers 510:Categories 353:: 101153. 328:References 245:3D model ( 233:Molar mass 120:IUPAC name 53:; try the 40:link to it 418:2752-5457 158:146402726 130:--5-oxo-4 43:. Please 536:Anilides 436:37313239 427:10258622 379:33359400 314:TERN-501 75:TERN-501 370:8085542 194:Formula 144:PubChem 434:  424:  416:  377:  367:  271:SMILES 238:440.24 169:ChEMBL 36:orphan 34:is an 461:This 291:InChI 247:JSmol 467:stub 432:PMID 414:ISSN 375:PMID 422:PMC 406:doi 365:PMC 355:doi 148:CID 512:: 430:. 420:. 412:. 402:19 400:. 396:. 373:. 363:. 351:46 349:. 345:. 324:. 211:Cl 208:15 202:17 498:e 491:t 484:v 473:. 438:. 408:: 381:. 357:: 249:) 226:5 223:O 220:5 217:N 214:2 205:H 199:C 132:H 128:N 64:) 60:(

Index


orphan
link to it
introduce links
related articles
Find link tool

Legal status
IUPAC name
PubChem
146402726
ChEMBL
ChEMBL4782668
Formula
Molar mass
JSmol
Interactive image
SMILES
InChI
thyromimetic
non-alcoholic fatty liver disease
"Nuclear hormone and peptide hormone therapeutics for NAFLD and NASH"
doi
10.1016/j.molmet.2020.101153
PMC
8085542
PMID
33359400
"Resmetirom: An Orally Administered, Smallmolecule, Liver-directed, β-selective THR Agonist for the Treatment of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis"
doi

Text is available under the Creative Commons Attribution-ShareAlike License. Additional terms may apply.