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could have link since cell envelope is a researched topic. Lamina is also mentioned near the same part and also does not have a link. I would also like to talk a little about the fluidity of the section. Would there be a way to still provide clarity to the cycles of the cell assembly and disassembly but make the apoptosis link at the beginning closer to the paragraph that describes it below? Lastly, the section below it, discussions potential sources of illness, could have some more information or be added to another section.
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diffuse away from the speckles to interact with nascent pre-mRNAs. When a nascent pre-mRNA is located near a nuclear speckle, the volume through which these splicing factors need to diffuse is reduced. This reduction in diffusion volume increases the local concentration of splicing factors around genes positioned near speckles, leading to enhanced spliceosome binding to these pre-mRNAs and more efficient conversion into spliced mRNA ."
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Each section has a heading to let the reader know what that particular section is going to be about. It is easy for the reader to pinpoint exactly what section they need to read to find the information they are looking for. Each section is also split up into subheadings for more indepth information about each topic. Overall, the article has decent organization to make it flow for the reader.
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paragraph above, or not in it at all, since it is informative. I do like the part that talks about cells coming from cells then goes to a paragraph about sex cells creating a cell. This transition is very smooth. Near the very end should there be a description or a link to the chromosome theory of heredity since it is the concluding finding of the information given above it?
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clearly explained and easy to comprehend for just about anyone. Some of the descriptions can get slightly word with the terminology, but with links provided to certain terms that are not common knowledge the article is easier to understand. Overall, this article on the cell nucleus is a great way for people to learn more about the nucleus.
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A little ways down there is reference to work of Franz Bauer but no inclusion of his findings despite all of the other names mentioned having one. Shortly after that there is a sentence that reads "he did not suggest a potential function". If it has to be there I think it should be mentioned in the
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for your detailed review. I have asked WT:MOLBIO for additional volunteers to help. I will also work to update citations to the 5th edition (2004) of Lodish with the most recent editions of
Alberts (2015) and Lodish (2016). My time is also limited, but I will see what I can do to address some of
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The article is fairily easy for people with or without backgrounds in biology to understand. The terminology is not too technical for people without advanced knowledge in biology to understand. When the article starts getting into more detail about the nucleus such as the structures, everything is
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The above isn't an exhaustive list, just first impressions. But I think this article needs more than just a dusting-off to meet the modern FA criteria. The good news is that there's tons of literature on the nucleus and it's an interesting topic. I think if a few of us have a bit of time to put in,
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I understood sections on the structure and function of the nucleus, nuclear envelope and pores, chromosomes, and nucleolus, but became lost with subnuclear bodies. Gene expression was clear but could be more detailed, as with the process of transcription. Processing of pre-mRNA could also be made
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In this section the links for closed and open cytosis links do not work. It takes you to a page that has not yet been created. I would also like to mention that I think the adage of the relationship between prophase and mitosis is a good addition. Reading further down I think that cell envelope
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Hi, the standard of referencing for this article is not of that expected for a
Featured Article. It has been over thirteen years since it was promoted and since then FA requirements have become far more stringent in this regard. Is there an editor prepared to update the citations? There are whole
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The article is well organized for the most part. The introduction is a bit lengthy and contains information that could be put into a different section. After the introduction, the article is broken up into sections containing different information about the cell nucleus which I think is great.
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References - Could use an update. The most cited reference is the 5th edition (2004) of Harvey Lodish's
Molecular Cell Biology. I have a PDF of the 6th edition (2008) that I'm happy to share, but I can reach out my tentacles and see if anyone has the current version (a quick Google suggest we're
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The article is full of useful information on the subject, making it easier to understand the topic. The nucleus is a complex organelle that is needed in the basic understanding of cellular function. The sections the article covers is clear and gives a summary of the sections in detail. A student
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Well-written - The prose is not engaging (and I love molecular biology!). It needs a serious copyedit. The fact that SandyGeorgia – regular editor of medicine articles – can't follow parts of the article suggests it could stand to be clarified. There are several places where factoids of varying
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Change to: "Although IGCs were previously thought to be storage sites for splicing factors , new genomics technologies have revealed a functional role for nuclear speckles in pre-mRNA splicing. Specifically, nuclear speckles serve as hubs containing high concentrations of splicing factors that
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Are further citations necessary under the subnuclear bodies topic? The first sentence mentioning Cajal bodies is very specific but does not contain a citation to a reputable source. The source occurs later under the next sub heading, but should it also be cited when Cajal bodies are first
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needing to understand the nucleus would find this article useful. However, there are some minor details. The questions asked above will help give the article more information on the subject by answering them, ultimately, giving the intended reader a better understanding of the nucleus.
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Here I'll show my biases since I'm a unicellular-eukaryotes guy, but could we spare a few more words for multinucleated eukaryotic cells? It's pretty common across eukaryotes. For instance ciliates typically have a quiescent germ nucleus and an actively transcribed expression
1115:, 6th edition (2015), which may still be the current version. Happy to share that as well. Otherwise, we'll just have to do some scraping for recent reviews et al. I've not kept up with broad literature on the nucleus, so I don't really have a head-up over anyone else.
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so that we can discuss page improvements here instead of there. This can serve as a rough starting to-do list. Feel free to add more to-do items or check-off items as you get to them. For comments on whether or not this should remain listed as an FA, go to the
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Focused - on the flipside of the above, some material seems to have crept in that is probably better explained elsewhere (sometimes just in other parts of the article, sometimes in other articles). Examples include the small paragraph on lupus in
Structure:
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Nucleolus, and more. Also a huge amount of space is devoted to the 7 least important structures in the nucleus (the "Other nuclear bodies" subsection). I'm sure we can come up with a more concise way to describe these structures and their
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more clear. There is another article for post-translational modificaiton, but the section on the cell nucleus page could be clarified; additionally, it only contains 1 citation despite being specific, should it be cited further?
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It seems we have a lot more on the structure of the nucleus than the function of the nucleus. I'm not sure if the balance should be corrected by having less structure information, or more function information. I'm guessing the
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Mammals were often used as examples throughout the article, do the nuclei of plants or any other class of animals share the same nuclei functions or do they differ in any ways? The same can be asked for
Eukaryotic organisms.
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if you're interested, we can post at WT:MOLBIO and see if anyone else is willing to help out? I'm a bit swamped in real life at the moment, but I can certainly put some time into this article over the next couple of weeks.
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I believe the title should be nucleus, since in biology it is mainly used as in the second form; as a biologist I never came across the phrase "cell nucleus". perhaps, "cellular nucleus", though it is also rare.
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This is an excellent citation. I just read it. But the 8% are related to a fission yeast experiment! It is not in all cell types typical, that the nucleus occupies 8% of the cell volume.
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I became lost regarding the subnuclear bodies and their relations to each other, although their individual functions seemed pretty specific. Could their relationshios be clarified?
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Under "Structures" is written:"The size of the nucleus depends on the size of the cell it is contained in, with a nucleus typically occupying about 8% of the total cell volume."
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With multinucleated cells, do the multiple nuclei function within the cell the same as a single nucleated cell, or are certain functions distributed among the other nuclei?
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In my opinion, I would just delete "with a nucleus typically occupying about 8% of the total cell volume". The rest, inclusive citation, I would leave as it is.
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Actually, I am working currently with two mammalian cell types. The NC ratio of this cell is about 20%. And these are not abnormal cells I am working with.
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The dynamic behaviour of structures in the nucleus, such as the nuclear rotation that occurs prior to mitosis, can be visualized using label-free
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Comprehensive - I'm by no means a nucleus expert, but it seems a few things are missing or could be tweaked to make the article comprehensive:
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Chromosomes maybe we could replace some of euchromatin/heterochromatin material with a more detailed description of chromosome structure?
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of the request, that is, specify what text should be removed and a verbatim copy of the text that should replace it. "Please change
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When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.
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edition, out since 2016! My how time flies) and would be willing to share. I do have a more recent PDF of Bruce
Alberts' competing
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problem everywhere. I suspect that attention to wikilinking is needed, but the topic is too dense for me to follow.
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to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
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to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the
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Tidbits I cut from somewhere that could be re-added, but I haven't sorted out where yet (feel free to decide!)
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History - Can anyone find some secondary sources for the history section? It mostly cites primary work now.
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I believe the introduction is quite wordy and could be more concise while achieving the same goal.----
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Lodish HF, Berk A, Kaiser C, Krieger M, Bretscher A, Ploegh H, Amon A, Martin KC, Darnell JE (2016).
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Nuclear rotation implicated in cellular reorganization before mitosis in mouse breast cancer cells.
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levels of detail have crept in. The prose needs to be ironed out so they don't startle the reader.
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would you be able to give this a quick glance to see if there are significant issues relative to
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before doing mass systematic removals. This message is updated dynamically through the template
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Several sections seem overly human-focused (I'm looking at the beginning of "Structures" now).
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https://web.archive.org/web/20070929104104/http://intl.jcb.org/cgi/content/abstract/135/5/1195
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Is information necessary regarding the process of transcription that occurs in the nucleus?
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I'm sorry to say that in my opinion the article needs some serious work to meet the
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The "History" section should be expanded to include post-19th century material.
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Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, Walter P (2015).
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Chromosomes, the level of detail on ribosome assembly in
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1443:— Preceding
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25:Cell nucleus
19:This is the
1538:article at
1376:. Primary.
1315:. Primary.
1284:granulocyte
1103:importance.
1067:FA criteria
741:—Preceding
285:Peer review
148:free images
31:not a forum
1659:Categories
1609:|answered=
1502:Ulmusfagus
1299:References
1165:References
981:Report bug
871:Report bug
733:Erinmwolfe
718:Erinmwolfe
704:Erinmwolfe
702:mentioned?
689:Erinmwolfe
1532:requested
964:this tool
957:this tool
854:this tool
847:this tool
602:Aruland25
600:Aruland25
369:is rated
88:if needed
71:Be polite
21:talk page
1457:contribs
1445:unsigned
1406:21073711
1345:31856161
1238:Ajpolino
1144:Ajpolino
1130:Ajpolino
1094:nucleus.
1043:WP:WIAFA
1039:Ajpolino
970:Cheers.—
860:Cheers.—
675:Ellis245
653:Ellis245
309:Promoted
290:Reviewed
186:Archives
56:get help
29:This is
27:article.
1553:history
1398:3224570
1384:: 558.
1337:6922317
1292:lobated
1142:Thanks
1090:latter.
1051:Georgia
1014:WP:FARC
894:my edit
766:my edit
743:undated
666:History
632:IPletka
567:before.
371:B-class
328:Demoted
268:Process
154:WP refs
142:scholar
1530:It is
1149:Boghog
1125:Boghog
992:WP:FAR
377:scale.
271:Result
126:Google
1584:" is
1565:links
1048:Sandy
358:This
227:is a
169:JSTOR
130:books
84:Seek
1647:talk
1590:must
1559:last
1547:edit
1506:talk
1478:talk
1453:talk
1420:link
1403:PMID
1359:link
1342:PMID
1286:, a
1242:talk
1207:ISBN
1183:ISBN
1153:talk
1134:talk
1056:Talk
1004:talk
737:talk
722:talk
708:talk
693:talk
679:talk
657:talk
636:talk
606:talk
548:Tip:
265:Date
162:FENS
136:news
73:and
1620:ESp
1616:yes
1600:".
1596:to
1394:PMC
1386:doi
1333:PMC
1325:doi
1109:8th
1100:-->
1058:)
1045:?
938:RfC
908:to
828:RfC
780:to
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459:???
405:MCB
176:TWL
1661::
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