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what forms hydrogen bonds with the AUG of the mRNA transcript formed by RNA polymerase. The ATG on the opposite strand stores information, in a way, but doesn't actually participate. I just found this kind of ambiguous. If the polymerase acted on ATG, it would form the complementary strand UAC, which would code for a different amino acid, tyrosine, rather than methionine. Here is the Met-tRNA, from 5' to 3', I think (it never said, and I'm pretty sure I assumed it was 3' to 5'): AGTAAGGTCAGCTAAATAAGCTATCGGGCC CAT ACCCCGAAAATGTTGGTTATACCCTTCCCGTACTA. If RNA polymerase acts on that sequence, the tRNA created would be UCAUUCCAGUCGAUUUAUUCGAUAGCCCGG GUA UGGGGCUUUUACAACCAAUAUGGGAAGGGCAUGAU, but apparently this is wrong, and I need to "just replace T with U" because it's sense, rather than the antisense template that I've been assuming... And the final tRNA is really AGUAAGGUCAGCUAAAUAAGCUAUCGGGCC CAU ACCCCGAAAAUGUUGGUUAUACCCUUCCCGUACUA, which does have the anticodon for the correct mRNA codon, AUG, but the original DNA that made that sequence still had to be TAC, but if I translated again to get the sense version, it would be ATG. So I guess I've been making things harder for myself this whole time, assuming I needed to find the complementary strand to find an mRNA transcript, when all I need to do is "replace T with U" because we're biased toward 5' to 3'? The thing is, I've read DNA and translated it to RNA and then proteins, using TAC as a start codon and ATT/ATC/ACT as end codons, since those are what are complementary to the AUG start codon and UAA/UAG/UGA end codons in RNA. If I had used ATG (Tyr) as a start codon and TAA/TAG/TGA(Ile/Thr) as end codons, I would have got a completely different set of proteins. And I have the entire antisense DNA codon chart memorized (as well as the sense RNA codon chart), apparently. --
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difference being Uracil versus Thymin anyway. Isn't there a standard body that has recommended which way to go about? By the way, the DNA codon table is what I found first via google, so perhaps other people also are led first to this page, rather than the RNA codon table, in particular because there is no standalone RNA codon table on wikipedia, so there is bias created towards this page here.
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1194:. Either I'm going crazy or someone really messed up on this codon chart, probably because they just decided to take the RNA chart and replace U with T. Again, TAC should be start and ATT/ATC/ACT should be stop. (Edit: Apparently I am going crazy and have always been using antisense and making things more difficult for myself) --
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It is rather confusing for visitors, including myself, why there are now both RNA codon tables and DNA codon tables. I was so used to a RNA codon table, since that is the one that is read by the ribosome on the mRNA, and now the page seems to arbitrarily claim that the DNA codon table is more proper.
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The topic of the page is supposed to be relatively technical. While it's not rocket science, it is also not meant for anyone who doesn't know anything about basic molecular biology. Anyway, I redid the context. If someone disagrees with the way that is written, then he/she is welcomed to edit it. And
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Well, perhaps, but that translation is only appropriate if the "genetic code" is actually for a sequence of amino acids; there are plenty of non-coding sequences. Or was this a subtle piece of wording, so it's only a "code" if it does code for a sequence, as opposed to all the other functions of DNA
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Yeah, I realized that. Apparently I've been using 3' to 5' arbitrarily unknowingly for a while now. But I still think there should be an antisense version of the table available, since the antisense strand is what is actually used as a template for the mRNA, and the antisense codon (TAC, not ATG) is
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Not much is "explained" in the intro sentence at all, it merely claims that it is that way. I agree with the poster before me, it simply is confusing as it is. Why are there now two different codon tables? Also, a bit aside from the point, translating from one to the other is trivial due to the only
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This page is created because people might deem a RNA codon table to be more appropriate than a DNA codon table in the "Genetic Code" page. However, since a DNA codon table is generally more convenient for people who work with genomic data, then it may be preferred to have this table stored somewhere
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Since the start codon is AUG in RNA, wouldn't it be TAC in DNA, not ATG? Bases have to form hydrogen bonds to pair. G doesn't bond with G. Believe it or not, you can't ONLY swap U for T, because U bonds with A and A bonds with T / T bonds with A, while C bonds to G and G bonds to C. Similarly, the
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it. While merging this to another page is definitely appropriate, the way that you've accomplished that is not very appropriate by my standards. To repeat myself: While the tables are nearly identical to the RNA codon tables, they also represent the genetic code in a form that's more convenient to
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The second image in the introduction (the one showing the DNA double helix) is nice, but it seems incorrect if you look closely. That is, if you follow a single strand it reads GCA ACT CTA AAT TGA rather than GCA AGA GAT AAT TGT. With each turn of the helix, which strand is on top in the image
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It is not clear to me, and I am sufficiently unfamiliar with the subject matter to be the wrong person to improve it. And for heavens sake, look at any other wikipedia article and you'll find that it'll tend to start with an emboldened subject followed by a succinct definition. Why is this the
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That it all explained in the intro sentences. It's true that "all you have to do is replace a U with a T", but having to do that (especially repeatedly, if you're looking at lots of genes) is harder than just having the result already in the table. The RNA table is at
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Sorry, but this article just confuses things. I can see no advantage in having a DNA codon table. Anybody with a working knowledge of this topic will know that, for the equivalent of a codon in the coding strand of DNA, all you have to do is replace a U with a T.
816:" ... or somesuch form of words, to provide a clear definition of the table. For me, the current wording entirely fails to do that. I understand why you thik this article is important. I do not understand why the article does not make clear to me what it is. --
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Look in any molecular biology text book, and by definition a codon is found in RNA, specifically messenger RNA. A codon is not found in DNA, although an equivalent triplet sequence is found in the coding strand of a polypeptide-encoding gene.
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page to retrieve the table and replace uracils with thymines, I assure you that it gets tiresome after doing this for the n-th time. If you feel a strong urge to apply your wiki standards, then maybe you should start with merging/redirecting
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shows the wrong transcription, and I think the error is significantly misleading since it's important to the transcription process that a single strand is followed, rather than jumping between strands every half cycle.
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end codons in RNA are UAA, UAG, and UGA, which correspond to DNA sequences of ATT, ATC, and ACT. In other words, this table is pretty messed up. The way it currently stands, it says ATG is start when ATG = UAC =
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By convention, the DNA sequence of a gene is given as the "sense", "+", "non-transcribed" or "non-template" strand. This strand is complementary to the antisense strand, which is itself complementary to the
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The compressed codon for
Glutamine is given in the table as CCR, whilst the compressed codon for Proline is CCN. These seem to conflict- I believe the codon for Glutamine should be CAR, not CCR.
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No, this detail is important and it is trivial to change. The codons appliy only to mRNA, due to so many RNAs being popular these days, it would not help to denote it as mRNA rather than RNA.
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Thanks for the comments. I've provided a citation and re-worded the lead in an attempt to provide some clarification. I've also clarified that DNA codon tables are more common now
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To put it another way, the 5'-AUG-3' start codon is complementary to the DNA sequence 3'-TAC-5'. But here we're giving the sequence of the other DNA strand, which is 5'-ATG-3'.
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this genetic code (i.e. DNA and RNA codon tables). Now, I hope the next criticism will come from someone who actually knows about the topic (i.e. a scientist).
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Using this source? Absolutely not, this writing is completely unhinged. Some other image to illustrate the effect of a one-base mutation? Maybe, we have
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exception? And is starting with the definite article sensible? As far as I'm aware, there are at least two genetic codes, one for RNA and one for DNA. --
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I'm not sure there's much we can do about the way Google works, but I've added an additional link to the RNA codon table in the first sentence.
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Potentially, this page can be merged to a short reference page for bioinformatics where tables of general amino acid properties are stored.
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extracted from the article so we could see and update them in a central place. We should get that arrangement back.
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The wording seems clear enough to me. However, feel free to change the introduction if you can make it better.
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on
Knowledge (XXG). If you would like to participate, please visit the project page, where you can join
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Hello I want to suggest a 3D version of the RNA to better understand the relationships of the codons.
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sequences? If so, it really does need explanation, as that sort of thing would pass by many readers.
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I can't find any links or articles discussing this, so perhaps more links could be added, please?
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Do you have a suggestion for improving the article? I think those sorts of details belong at
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I've taken the liberty of undoing your redirect, since that had little difference to a
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It would help enormously if you rephrased the lead paragraph such that it started "
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side note: By RNA it is mRNA. There are different kinds of RNA (tRNA, mRNA, ect.)
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known naturally-occurring genetic code but there are a number of common ways of
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Do you have multiple high quality reliable sources to support the addition? ~
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most biologists. And even though it is definitely trivial to scroll down the
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sort of explains this, though it could really use a clearer diagram, like
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Refs will still work if the names are managed correctly. Same for notes.
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How can my suggestion be added without upsetting all editors?
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